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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for RFX5

Z-value: 0.61

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Transcription factors associated with RFX5

Gene Symbol Gene ID Gene Info
RFX5
ENSG00000143390.13 regulatory factor X5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RFX5hg19_v2_chr1_-_151319283_1513193140.901.6e-02Click!

Activity profile of RFX5 motif

Sorted Z-values of RFX5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_27052892 0.57 ENST00000579671.1
ENST00000579060.1
NEK8
NIMA-related kinase 8
chr6_+_26383404 0.35 ENST00000416795.2
ENST00000494184.1
BTN2A2
butyrophilin, subfamily 2, member A2
chr10_-_82116497 0.35 ENST00000372204.3
DYDC1
DPY30 domain containing 1
chr11_+_45868957 0.34 ENST00000443527.2
CRY2
cryptochrome 2 (photolyase-like)
chr16_-_74808710 0.32 ENST00000219368.3
ENST00000544337.1
FA2H
fatty acid 2-hydroxylase
chr19_+_10527449 0.29 ENST00000592685.1
ENST00000380702.2
PDE4A
phosphodiesterase 4A, cAMP-specific
chr20_+_306221 0.29 ENST00000342665.2
SOX12
SRY (sex determining region Y)-box 12
chr17_-_19265982 0.28 ENST00000268841.6
ENST00000261499.4
ENST00000575478.1
B9D1
B9 protein domain 1
chr1_-_208417620 0.28 ENST00000367033.3
PLXNA2
plexin A2
chr3_+_9851384 0.28 ENST00000419081.1
ENST00000438596.1
ENST00000417065.1
ENST00000439814.1
ENST00000418745.1
TTLL3
tubulin tyrosine ligase-like family, member 3
chr3_+_9850199 0.28 ENST00000452597.1
TTLL3
tubulin tyrosine ligase-like family, member 3
chr20_+_306177 0.26 ENST00000544632.1
SOX12
SRY (sex determining region Y)-box 12
chr6_-_30181133 0.26 ENST00000454678.2
ENST00000434785.1
TRIM26
tripartite motif containing 26
chr19_+_36103631 0.26 ENST00000203166.5
ENST00000379045.2
HAUS5
HAUS augmin-like complex, subunit 5
chr11_+_111385497 0.25 ENST00000375618.4
ENST00000529167.1
ENST00000332814.6
C11orf88
chromosome 11 open reading frame 88
chr22_-_30987837 0.25 ENST00000335214.6
PES1
pescadillo ribosomal biogenesis factor 1
chr7_+_766320 0.25 ENST00000297440.6
ENST00000313147.5
HEATR2
HEAT repeat containing 2
chr1_+_249132512 0.25 ENST00000505503.1
ZNF672
zinc finger protein 672
chr6_+_26383318 0.25 ENST00000469230.1
ENST00000490025.1
ENST00000356709.4
ENST00000352867.2
ENST00000493275.1
ENST00000472507.1
ENST00000482536.1
ENST00000432533.2
ENST00000482842.1
BTN2A2
butyrophilin, subfamily 2, member A2
chr19_-_6057282 0.23 ENST00000592281.1
RFX2
regulatory factor X, 2 (influences HLA class II expression)
chr6_+_26458171 0.23 ENST00000493173.1
ENST00000541522.1
ENST00000429381.1
ENST00000469185.1
BTN2A1
butyrophilin, subfamily 2, member A1
chr6_-_32634425 0.23 ENST00000399082.3
ENST00000399079.3
ENST00000374943.4
ENST00000434651.2
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr6_-_30181156 0.22 ENST00000418026.1
ENST00000416596.1
ENST00000453195.1
TRIM26
tripartite motif containing 26
chr10_-_82116505 0.22 ENST00000372202.1
ENST00000421924.2
ENST00000453477.1
DYDC1
DPY30 domain containing 1
chr6_+_26365443 0.20 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr3_+_9851558 0.19 ENST00000430718.1
TTLL3
tubulin tyrosine ligase-like family, member 3
chr9_-_69380597 0.19 ENST00000414341.2
CR769776.1
LOC441426 protein; Uncharacterized protein
chr6_-_32557610 0.18 ENST00000360004.5
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr17_+_38137050 0.18 ENST00000264639.4
PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr3_-_27410847 0.17 ENST00000429845.2
ENST00000341435.5
ENST00000435750.1
NEK10
NIMA-related kinase 10
chr1_+_36549676 0.17 ENST00000207457.3
TEKT2
tektin 2 (testicular)
chr17_-_19266045 0.16 ENST00000395616.3
B9D1
B9 protein domain 1
chr19_+_10563567 0.16 ENST00000344979.3
PDE4A
phosphodiesterase 4A, cAMP-specific
chr19_-_51014345 0.16 ENST00000391815.3
ENST00000594350.1
ENST00000601423.1
JOSD2
Josephin domain containing 2
chr1_-_202936394 0.15 ENST00000367249.4
CYB5R1
cytochrome b5 reductase 1
chr17_+_38137073 0.15 ENST00000541736.1
PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr11_+_8008867 0.14 ENST00000309828.4
ENST00000449102.2
EIF3F
eukaryotic translation initiation factor 3, subunit F
chr6_-_32731299 0.13 ENST00000435145.2
ENST00000437316.2
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr6_-_32821599 0.12 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr12_-_110841462 0.11 ENST00000455511.3
ENST00000450008.2
ANAPC7
anaphase promoting complex subunit 7
chr6_+_26458152 0.11 ENST00000312541.5
BTN2A1
butyrophilin, subfamily 2, member A1
chr12_-_123565834 0.10 ENST00000546049.1
PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chr6_+_32821924 0.09 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr2_+_242089046 0.09 ENST00000407025.1
ENST00000272983.8
PPP1R7
protein phosphatase 1, regulatory subunit 7
chr6_+_26365387 0.09 ENST00000532865.1
ENST00000530653.1
ENST00000527417.1
BTN3A2
butyrophilin, subfamily 3, member A2
chr1_+_181003067 0.09 ENST00000434571.2
ENST00000367579.3
ENST00000282990.6
ENST00000367580.5
MR1
major histocompatibility complex, class I-related
chr17_-_19265855 0.09 ENST00000440841.1
ENST00000395615.1
ENST00000461069.2
B9D1
B9 protein domain 1
chr9_+_135937365 0.08 ENST00000372080.4
ENST00000351304.7
CEL
carboxyl ester lipase
chr2_-_242088850 0.08 ENST00000358649.4
ENST00000452907.1
ENST00000403638.3
ENST00000539818.1
ENST00000415234.1
ENST00000234040.4
PASK
PAS domain containing serine/threonine kinase
chr11_-_72433346 0.08 ENST00000334211.8
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr1_-_53608249 0.08 ENST00000371494.4
SLC1A7
solute carrier family 1 (glutamate transporter), member 7
chr19_+_45418067 0.08 ENST00000589078.1
ENST00000586638.1
APOC1
apolipoprotein C-I
chr1_+_249132462 0.07 ENST00000306562.3
ZNF672
zinc finger protein 672
chr16_+_57844549 0.07 ENST00000564282.1
CTD-2600O9.1
uncharacterized protein LOC388282
chrX_-_40594755 0.07 ENST00000324817.1
MED14
mediator complex subunit 14
chr3_+_66271489 0.07 ENST00000536651.1
SLC25A26
solute carrier family 25 (S-adenosylmethionine carrier), member 26
chr3_+_66271410 0.07 ENST00000336733.6
SLC25A26
solute carrier family 25 (S-adenosylmethionine carrier), member 26
chr11_+_66624527 0.06 ENST00000393952.3
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr6_+_32812568 0.06 ENST00000414474.1
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr1_+_85527987 0.06 ENST00000326813.8
ENST00000294664.6
ENST00000528899.1
WDR63
WD repeat domain 63
chrX_-_71933888 0.06 ENST00000373542.4
ENST00000339490.3
ENST00000541944.1
ENST00000373539.3
ENST00000373545.3
PHKA1
phosphorylase kinase, alpha 1 (muscle)
chr13_-_47012325 0.06 ENST00000409879.2
KIAA0226L
KIAA0226-like
chr13_-_30424821 0.05 ENST00000380680.4
UBL3
ubiquitin-like 3
chr10_+_14880287 0.05 ENST00000437161.2
HSPA14
heat shock 70kDa protein 14
chr12_-_126467906 0.05 ENST00000507313.1
ENST00000545784.1
LINC00939
long intergenic non-protein coding RNA 939
chrX_+_19362011 0.04 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr20_+_42875935 0.04 ENST00000438466.1
ENST00000372952.3
ENST00000537864.1
ENST00000445952.1
GDAP1L1
ganglioside induced differentiation associated protein 1-like 1
chr6_-_30658745 0.03 ENST00000376420.5
ENST00000376421.5
NRM
nurim (nuclear envelope membrane protein)
chr4_-_143226979 0.03 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr5_-_55412774 0.02 ENST00000434982.2
ANKRD55
ankyrin repeat domain 55
chr6_-_32920794 0.01 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
HLA-DMA
XXbac-BPG181M17.5
major histocompatibility complex, class II, DM alpha
Uncharacterized protein

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.1 0.7 GO:0018094 protein polyglycylation(GO:0018094)
0.0 0.6 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.6 GO:0035330 regulation of hippo signaling(GO:0035330)
0.0 0.1 GO:0046967 cytosol to ER transport(GO:0046967)
0.0 0.1 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.3 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.1 GO:0002399 MHC class II protein complex assembly(GO:0002399)
0.0 0.3 GO:0060174 limb bud formation(GO:0060174)
0.0 0.3 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.5 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 0.2 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 0.1 GO:0015860 purine nucleoside transmembrane transport(GO:0015860)
0.0 0.1 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.0 0.2 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.1 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.0 0.4 GO:0043949 regulation of cAMP-mediated signaling(GO:0043949)
0.0 0.3 GO:0072643 interferon-gamma secretion(GO:0072643)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.3 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.5 GO:0036038 MKS complex(GO:0036038)
0.0 0.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.3 GO:0070652 HAUS complex(GO:0070652)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 0.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0070736 protein-glycine ligase activity, initiating(GO:0070736)
0.1 0.5 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.3 GO:0009881 photoreceptor activity(GO:0009881)
0.0 0.3 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.1 GO:0046979 TAP2 binding(GO:0046979)
0.0 0.1 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.0 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0004771 sterol esterase activity(GO:0004771)
0.0 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion