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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SIX4

Z-value: 0.57

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Transcription factors associated with SIX4

Gene Symbol Gene ID Gene Info
SIX4
ENSG00000100625.8 SIX homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX4hg19_v2_chr14_-_61191049_611910800.651.7e-01Click!

Activity profile of SIX4 motif

Sorted Z-values of SIX4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_123139423 0.34 ENST00000523792.1
RP11-398G24.2
RP11-398G24.2
chr3_-_52488048 0.32 ENST00000232975.3
TNNC1
troponin C type 1 (slow)
chr20_-_4055812 0.27 ENST00000379526.1
RP11-352D3.2
Uncharacterized protein
chr20_+_816695 0.24 ENST00000246100.3
FAM110A
family with sequence similarity 110, member A
chr8_+_144798429 0.24 ENST00000338033.4
ENST00000395107.4
ENST00000395108.2
MAPK15
mitogen-activated protein kinase 15
chr12_-_10282836 0.23 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr20_-_45530365 0.20 ENST00000414085.1
RP11-323C15.2
RP11-323C15.2
chr19_+_13134772 0.20 ENST00000587760.1
ENST00000585575.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr7_+_69064566 0.19 ENST00000403018.2
AUTS2
autism susceptibility candidate 2
chr20_-_52687030 0.19 ENST00000411563.1
BCAS1
breast carcinoma amplified sequence 1
chr2_-_42160486 0.19 ENST00000427054.1
AC104654.2
AC104654.2
chr14_-_107083690 0.19 ENST00000455737.1
ENST00000390629.2
IGHV4-59
immunoglobulin heavy variable 4-59
chrX_+_48687283 0.19 ENST00000338270.1
ERAS
ES cell expressed Ras
chr7_+_69064300 0.18 ENST00000342771.4
AUTS2
autism susceptibility candidate 2
chr12_-_10282742 0.17 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr1_+_156611704 0.17 ENST00000329117.5
BCAN
brevican
chrX_+_54466829 0.17 ENST00000375151.4
TSR2
TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
chr12_+_43086018 0.17 ENST00000550177.1
RP11-25I15.3
RP11-25I15.3
chr12_+_133757995 0.16 ENST00000536435.2
ENST00000228289.5
ENST00000541211.2
ENST00000500625.3
ENST00000539248.2
ENST00000542711.2
ENST00000536899.2
ENST00000542986.2
ENST00000537565.1
ENST00000541975.2
ZNF268
zinc finger protein 268
chr7_-_14880892 0.16 ENST00000406247.3
ENST00000399322.3
ENST00000258767.5
DGKB
diacylglycerol kinase, beta 90kDa
chr19_-_58892389 0.15 ENST00000427624.2
ENST00000597582.1
ZNF837
zinc finger protein 837
chr15_+_41245160 0.15 ENST00000444189.2
ENST00000446533.3
CHAC1
ChaC, cation transport regulator homolog 1 (E. coli)
chr6_-_31704282 0.14 ENST00000375784.3
ENST00000375779.2
CLIC1
chloride intracellular channel 1
chr11_+_117049445 0.14 ENST00000324225.4
ENST00000532960.1
SIDT2
SID1 transmembrane family, member 2
chr1_+_17559776 0.14 ENST00000537499.1
ENST00000413717.2
ENST00000536552.1
PADI1
peptidyl arginine deiminase, type I
chr2_+_128458514 0.13 ENST00000310981.4
SFT2D3
SFT2 domain containing 3
chr6_-_27840099 0.13 ENST00000328488.2
HIST1H3I
histone cluster 1, H3i
chr12_+_133758115 0.13 ENST00000541009.2
ENST00000592241.1
ZNF268
zinc finger protein 268
chr11_-_46615498 0.13 ENST00000533727.1
ENST00000534300.1
ENST00000528950.1
ENST00000526606.1
AMBRA1
autophagy/beclin-1 regulator 1
chr9_-_95298254 0.12 ENST00000444490.2
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr2_+_120687335 0.11 ENST00000544261.1
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr1_+_15736359 0.11 ENST00000375980.4
EFHD2
EF-hand domain family, member D2
chr3_+_11267691 0.11 ENST00000413416.1
HRH1
histamine receptor H1
chr14_-_67981916 0.11 ENST00000357461.2
TMEM229B
transmembrane protein 229B
chr12_+_30948865 0.10 ENST00000547804.1
LINC00941
long intergenic non-protein coding RNA 941
chrX_-_110655391 0.10 ENST00000356915.2
ENST00000356220.3
DCX
doublecortin
chr22_-_39268308 0.10 ENST00000407418.3
CBX6
chromobox homolog 6
chr2_-_74710078 0.10 ENST00000290418.4
CCDC142
coiled-coil domain containing 142
chr22_-_39268192 0.10 ENST00000216083.6
CBX6
chromobox homolog 6
chr1_+_156611960 0.10 ENST00000361588.5
BCAN
brevican
chr3_-_183967296 0.10 ENST00000455059.1
ENST00000445626.2
ALG3
ALG3, alpha-1,3- mannosyltransferase
chr9_-_95298314 0.10 ENST00000344604.5
ENST00000375540.1
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr11_-_18956556 0.09 ENST00000302797.3
MRGPRX1
MAS-related GPR, member X1
chr12_+_4714145 0.09 ENST00000545342.1
DYRK4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr11_-_2906979 0.09 ENST00000380725.1
ENST00000313407.6
ENST00000430149.2
ENST00000440480.2
ENST00000414822.3
CDKN1C
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
chr1_+_156611900 0.09 ENST00000457777.2
ENST00000424639.1
BCAN
brevican
chr1_-_32264250 0.09 ENST00000528579.1
SPOCD1
SPOC domain containing 1
chr3_+_183967409 0.09 ENST00000324557.4
ENST00000402825.3
ECE2
endothelin converting enzyme 2
chr2_-_219134343 0.08 ENST00000447885.1
ENST00000420660.1
AAMP
angio-associated, migratory cell protein
chr5_+_85913721 0.08 ENST00000247655.3
ENST00000509578.1
ENST00000515763.1
COX7C
cytochrome c oxidase subunit VIIc
chr10_+_7860460 0.08 ENST00000344293.5
TAF3
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
chr1_-_231473578 0.08 ENST00000360394.2
ENST00000366645.1
EXOC8
exocyst complex component 8
chr2_+_219135115 0.07 ENST00000248451.3
ENST00000273077.4
PNKD
paroxysmal nonkinesigenic dyskinesia
chr8_+_144295067 0.07 ENST00000330824.2
GPIHBP1
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr8_-_6115044 0.07 ENST00000519555.1
RP11-124B13.1
RP11-124B13.1
chr3_-_183966717 0.07 ENST00000446569.1
ENST00000418734.2
ENST00000397676.3
ALG3
ALG3, alpha-1,3- mannosyltransferase
chr2_-_219134822 0.07 ENST00000444053.1
ENST00000248450.4
AAMP
angio-associated, migratory cell protein
chr1_+_35734616 0.07 ENST00000441447.1
ZMYM4
zinc finger, MYM-type 4
chr19_+_50270219 0.07 ENST00000354293.5
ENST00000359032.5
AP2A1
adaptor-related protein complex 2, alpha 1 subunit
chr4_-_13546632 0.07 ENST00000382438.5
NKX3-2
NK3 homeobox 2
chr19_+_50887585 0.07 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
POLD1
polymerase (DNA directed), delta 1, catalytic subunit
chrX_+_135388147 0.06 ENST00000394141.1
GPR112
G protein-coupled receptor 112
chr8_+_95907993 0.06 ENST00000523378.1
NDUFAF6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr2_+_74710194 0.06 ENST00000410003.1
ENST00000442235.2
ENST00000233623.5
TTC31
tetratricopeptide repeat domain 31
chr1_-_109849612 0.05 ENST00000357155.1
MYBPHL
myosin binding protein H-like
chr17_+_15635561 0.05 ENST00000584301.1
ENST00000580596.1
ENST00000464963.1
ENST00000437605.2
ENST00000579428.1
TBC1D26
TBC1 domain family, member 26
chr6_+_160693591 0.05 ENST00000419196.1
RP1-276N6.2
RP1-276N6.2
chr1_-_152196669 0.05 ENST00000368801.2
HRNR
hornerin
chr20_+_57875658 0.05 ENST00000371025.3
EDN3
endothelin 3
chrX_+_70503037 0.05 ENST00000535149.1
NONO
non-POU domain containing, octamer-binding
chr1_+_226250379 0.05 ENST00000366815.3
ENST00000366814.3
H3F3A
H3 histone, family 3A
chr3_-_49158218 0.05 ENST00000417901.1
ENST00000306026.5
ENST00000434032.2
USP19
ubiquitin specific peptidase 19
chr10_+_102759045 0.05 ENST00000370220.1
LZTS2
leucine zipper, putative tumor suppressor 2
chr17_-_39684550 0.04 ENST00000455635.1
ENST00000361566.3
KRT19
keratin 19
chr20_-_43150601 0.04 ENST00000541235.1
ENST00000255175.1
ENST00000342374.4
SERINC3
serine incorporator 3
chr1_+_149239529 0.04 ENST00000457216.2
RP11-403I13.4
RP11-403I13.4
chr17_+_7465216 0.04 ENST00000321337.7
SENP3
SUMO1/sentrin/SMT3 specific peptidase 3
chr11_-_130184470 0.04 ENST00000357899.4
ENST00000397753.1
ZBTB44
zinc finger and BTB domain containing 44
chr1_-_173176452 0.04 ENST00000281834.3
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr1_-_247335269 0.04 ENST00000543802.2
ENST00000491356.1
ENST00000472531.1
ENST00000340684.6
ZNF124
zinc finger protein 124
chr19_-_47128294 0.04 ENST00000596260.1
ENST00000597185.1
ENST00000598865.1
ENST00000594275.1
ENST00000291294.2
PTGIR
prostaglandin I2 (prostacyclin) receptor (IP)
chr12_-_4488872 0.04 ENST00000237837.1
FGF23
fibroblast growth factor 23
chr11_-_96076334 0.04 ENST00000524717.1
MAML2
mastermind-like 2 (Drosophila)
chr11_+_117049854 0.04 ENST00000278951.7
SIDT2
SID1 transmembrane family, member 2
chr1_+_161123536 0.03 ENST00000368003.5
UFC1
ubiquitin-fold modifier conjugating enzyme 1
chr20_-_52687059 0.03 ENST00000371435.2
ENST00000395961.3
BCAS1
breast carcinoma amplified sequence 1
chr1_+_116915855 0.03 ENST00000295598.5
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr4_-_176828307 0.03 ENST00000513365.1
ENST00000513667.1
ENST00000503563.1
GPM6A
glycoprotein M6A
chr10_+_71444655 0.03 ENST00000434931.2
RP11-242G20.1
Uncharacterized protein
chr11_+_46958248 0.02 ENST00000536126.1
ENST00000278460.7
ENST00000378618.2
ENST00000395460.2
ENST00000378615.3
ENST00000543718.1
C11orf49
chromosome 11 open reading frame 49
chr11_+_117049910 0.02 ENST00000431081.2
ENST00000524842.1
SIDT2
SID1 transmembrane family, member 2
chr12_+_4829507 0.02 ENST00000252318.2
GALNT8
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
chr11_+_2415061 0.02 ENST00000481687.1
CD81
CD81 molecule
chr7_-_111428957 0.02 ENST00000417165.1
DOCK4
dedicator of cytokinesis 4
chr11_+_33279850 0.02 ENST00000531504.1
ENST00000456517.1
HIPK3
homeodomain interacting protein kinase 3
chr4_-_42154895 0.02 ENST00000502486.1
ENST00000504360.1
BEND4
BEN domain containing 4
chr12_+_30948600 0.02 ENST00000550292.1
LINC00941
long intergenic non-protein coding RNA 941
chr11_+_125462690 0.02 ENST00000392708.4
ENST00000529196.1
ENST00000531491.1
STT3A
STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
chr1_-_154934200 0.02 ENST00000368457.2
PYGO2
pygopus family PHD finger 2
chr11_+_7273181 0.02 ENST00000318881.6
SYT9
synaptotagmin IX
chr12_-_58135903 0.01 ENST00000257897.3
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr7_-_99063769 0.01 ENST00000394186.3
ENST00000359832.4
ENST00000449683.1
ENST00000488775.1
ENST00000523680.1
ENST00000292475.3
ENST00000430982.1
ENST00000555673.1
ENST00000413834.1
ATP5J2
PTCD1
ATP5J2-PTCD1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
pentatricopeptide repeat domain 1
ATP5J2-PTCD1 readthrough
chr17_-_18547731 0.01 ENST00000575220.1
ENST00000405044.1
ENST00000572213.1
ENST00000573652.1
TBC1D28
TBC1 domain family, member 28
chr16_+_640201 0.01 ENST00000563109.1
RAB40C
RAB40C, member RAS oncogene family
chr14_-_94984181 0.01 ENST00000341228.2
SERPINA12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
chr19_+_19174795 0.01 ENST00000318596.7
SLC25A42
solute carrier family 25, member 42
chr7_+_2687173 0.01 ENST00000403167.1
TTYH3
tweety family member 3
chr12_+_8975061 0.01 ENST00000299698.7
A2ML1
alpha-2-macroglobulin-like 1
chr1_-_224624730 0.01 ENST00000445239.1
WDR26
WD repeat domain 26
chr14_-_67981870 0.01 ENST00000555994.1
TMEM229B
transmembrane protein 229B
chr8_+_56014949 0.01 ENST00000327381.6
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr9_+_132427883 0.00 ENST00000372469.4
PRRX2
paired related homeobox 2
chr1_+_231473990 0.00 ENST00000008440.9
SPRTN
SprT-like N-terminal domain

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0046022 positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.1 0.4 GO:0098582 innate vocalization behavior(GO:0098582)
0.1 0.3 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.0 0.1 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 0.1 GO:0051596 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.4 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.4 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.1 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 0.1 GO:0034371 chylomicron remodeling(GO:0034371)
0.0 0.2 GO:0033227 dsRNA transport(GO:0033227)
0.0 0.0 GO:2000525 negative regulation of regulatory T cell differentiation(GO:0045590) regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.0 0.1 GO:0001927 exocyst assembly(GO:0001927)
0.0 0.0 GO:0031508 pericentric heterochromatin assembly(GO:0031508) regulation of chromosome condensation(GO:0060623)
0.0 0.1 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.0 0.1 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.0 GO:0036457 keratohyalin granule(GO:0036457)
0.0 0.1 GO:0043625 delta DNA polymerase complex(GO:0043625)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0070052 collagen V binding(GO:0070052)
0.0 0.3 GO:0031013 troponin I binding(GO:0031013)
0.0 0.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.2 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.1 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.4 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.1 GO:0035473 lipase binding(GO:0035473)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation