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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SIX6

Z-value: 0.57

Motif logo

Transcription factors associated with SIX6

Gene Symbol Gene ID Gene Info
ENSG00000184302.6 SIX homeobox 6

Activity profile of SIX6 motif

Sorted Z-values of SIX6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_122018697 0.58 ENST00000541574.1
RP13-941N14.1
chr6_+_37012607 0.49 ENST00000423336.1
cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2
chr19_+_9203855 0.40 ENST00000429566.3
olfactory receptor, family 1, subfamily M, member 1
chr19_-_16008880 0.35 ENST00000011989.7
ENST00000221700.6
cytochrome P450, family 4, subfamily F, polypeptide 2
chr12_-_71512027 0.33 ENST00000549357.1
Uncharacterized protein
chr3_+_8543561 0.27 ENST00000397386.3
LIM and cysteine-rich domains 1
chr3_+_8543533 0.25 ENST00000454244.1
LIM and cysteine-rich domains 1
chr11_+_74699942 0.24 ENST00000526068.1
ENST00000532963.1
ENST00000531619.1
ENST00000534628.1
ENST00000545272.1
sialidase 3 (membrane sialidase)
chr16_+_22524379 0.23 ENST00000536620.1
nuclear pore complex interacting protein family, member B5
chr3_+_8543393 0.23 ENST00000157600.3
ENST00000415597.1
ENST00000535732.1
LIM and cysteine-rich domains 1
chrX_-_55020511 0.22 ENST00000375006.3
ENST00000374992.2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr14_+_83108955 0.22 ENST00000555798.1
ENST00000553760.1
ENST00000555150.1
ENST00000556970.1
RP11-406A9.2
chr5_+_55147205 0.21 ENST00000396836.2
ENST00000396834.1
ENST00000447346.2
ENST00000359040.5
interleukin 31 receptor A
chr12_-_10601963 0.21 ENST00000543893.1
killer cell lectin-like receptor subfamily C, member 1
chr17_-_6524159 0.20 ENST00000589033.1
KIAA0753
chr22_+_24666763 0.20 ENST00000437398.1
ENST00000421374.1
ENST00000314328.9
ENST00000541492.1
sperm antigen with calponin homology and coiled-coil domains 1-like
chr7_+_117251671 0.19 ENST00000468795.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr22_+_20877924 0.19 ENST00000445189.1
mediator complex subunit 15
chr4_-_6694189 0.18 ENST00000596858.1
Uncharacterized protein
chr19_-_1650666 0.18 ENST00000588136.1
transcription factor 3
chr22_+_18721427 0.18 ENST00000342888.3
Uncharacterized protein
chr2_+_90192768 0.18 ENST00000390275.2
immunoglobulin kappa variable 1D-13
chr19_-_53426700 0.16 ENST00000596623.1
zinc finger protein 888
chr9_-_7800067 0.16 ENST00000358227.4
transmembrane protein 261
chr9_+_93759317 0.16 ENST00000563268.1
RP11-367F23.2
chr5_-_78281775 0.16 ENST00000396151.3
ENST00000565165.1
arylsulfatase B
chr16_-_29517141 0.15 ENST00000550665.1
Uncharacterized protein
chr2_-_100925967 0.15 ENST00000409647.1
LON peptidase N-terminal domain and ring finger 2
chr7_-_44530479 0.15 ENST00000355451.7
NudC domain containing 3
chr2_+_62132781 0.15 ENST00000311832.5
copper metabolism (Murr1) domain containing 1
chr18_+_74240610 0.15 ENST00000578092.1
ENST00000578613.1
ENST00000583578.1
long intergenic non-protein coding RNA 908
chr3_-_9994021 0.15 ENST00000411976.2
ENST00000412055.1
proline-rich transmembrane protein 3
chr1_-_161015663 0.14 ENST00000534633.1
upstream transcription factor 1
chr4_+_113739244 0.14 ENST00000503271.1
ENST00000503423.1
ENST00000506722.1
ankyrin 2, neuronal
chr11_-_104916034 0.14 ENST00000528513.1
ENST00000375706.2
ENST00000375704.3
caspase recruitment domain family, member 16
chr1_+_160709076 0.14 ENST00000359331.4
ENST00000495334.1
SLAM family member 7
chr6_-_26043885 0.14 ENST00000357905.2
histone cluster 1, H2bb
chr16_+_22524844 0.14 ENST00000538606.1
ENST00000424340.1
ENST00000517539.1
ENST00000528249.1
nuclear pore complex interacting protein family, member B5
chr2_+_62132800 0.14 ENST00000538736.1
copper metabolism (Murr1) domain containing 1
chrX_+_64708615 0.14 ENST00000338957.4
ENST00000423889.3
zinc finger CCCH-type containing 12B
chr21_-_43735628 0.14 ENST00000291525.10
ENST00000518498.1
trefoil factor 3 (intestinal)
chr10_+_81891416 0.14 ENST00000372270.2
placenta-specific 9
chr1_+_212738676 0.14 ENST00000366981.4
ENST00000366987.2
activating transcription factor 3
chr20_+_34802295 0.13 ENST00000432603.1
erythrocyte membrane protein band 4.1-like 1
chr1_-_157014865 0.13 ENST00000361409.2
Rho guanine nucleotide exchange factor (GEF) 11
chr12_+_133707570 0.13 ENST00000416488.1
ENST00000540096.2
zinc finger protein 268
Zinc finger protein 268
chr1_-_161015752 0.13 ENST00000435396.1
ENST00000368021.3
upstream transcription factor 1
chr18_-_69246167 0.12 ENST00000566582.1
RP11-510D19.1
chr17_-_67057047 0.12 ENST00000495634.1
ENST00000453985.2
ENST00000585714.1
ATP-binding cassette, sub-family A (ABC1), member 9
chr3_-_196242233 0.12 ENST00000397537.2
single-pass membrane protein with coiled-coil domains 1
chr16_-_21436459 0.12 ENST00000448012.2
ENST00000504841.2
ENST00000419180.2
nuclear pore complex interacting protein family, member B3
chr9_-_67786624 0.11 ENST00000455764.2
family with sequence similarity 27, member E3
chr21_-_19858196 0.11 ENST00000422787.1
transmembrane protease, serine 15
chr17_-_42327236 0.10 ENST00000399246.2
AC003102.1
chr2_-_71222466 0.10 ENST00000606025.1
Uncharacterized protein
chr8_-_124553437 0.10 ENST00000517956.1
ENST00000443022.2
F-box protein 32
chr9_-_21142144 0.10 ENST00000380229.2
interferon, omega 1
chr17_+_7788104 0.10 ENST00000380358.4
chromodomain helicase DNA binding protein 3
chr4_-_13546632 0.10 ENST00000382438.5
NK3 homeobox 2
chr6_+_26204825 0.10 ENST00000360441.4
histone cluster 1, H4e
chr8_-_110660975 0.09 ENST00000528045.1
syntabulin (syntaxin-interacting)
chr18_+_50278430 0.09 ENST00000578080.1
ENST00000582875.1
ENST00000412726.1
deleted in colorectal carcinoma
chr14_-_31926595 0.09 ENST00000547378.1
Uncharacterized protein
chr18_-_69246186 0.09 ENST00000568095.1
RP11-510D19.1
chr10_-_79397479 0.09 ENST00000404771.3
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr12_-_122018859 0.09 ENST00000536437.1
ENST00000377071.4
ENST00000538046.2
lysine (K)-specific demethylase 2B
chrX_-_18238999 0.09 ENST00000380033.4
ENST00000380030.3
BEN domain containing 2
chr22_-_17702729 0.09 ENST00000449907.2
ENST00000441548.1
ENST00000399839.1
cat eye syndrome chromosome region, candidate 1
chr16_+_72090053 0.08 ENST00000576168.2
ENST00000567185.3
ENST00000567612.2
haptoglobin
chr16_-_87350970 0.08 ENST00000567970.1
chromosome 16 open reading frame 95
chr15_+_58430368 0.08 ENST00000558772.1
ENST00000219919.4
aquaporin 9
chr19_-_44031375 0.08 ENST00000292147.2
ethylmalonic encephalopathy 1
chr15_-_51397473 0.08 ENST00000327536.5
tumor necrosis factor, alpha-induced protein 8-like 3
chr10_+_52094298 0.08 ENST00000595931.1
HCG1745369; PRO3073; Uncharacterized protein
chr13_-_20080080 0.08 ENST00000400103.2
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
chr22_+_18043133 0.08 ENST00000327451.6
ENST00000399813.1
solute carrier family 25 (glutamate carrier), member 18
chr16_+_28648975 0.08 ENST00000529716.1
nuclear pore complex interacting protein family, member B8
chr19_-_14628645 0.08 ENST00000598235.1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr2_+_85822857 0.08 ENST00000306368.4
ENST00000414390.1
ENST00000456023.1
ring finger protein 181
chr14_+_20937538 0.08 ENST00000361505.5
ENST00000553591.1
purine nucleoside phosphorylase
chr16_-_21868978 0.08 ENST00000357370.5
ENST00000451409.1
ENST00000341400.7
ENST00000518761.4
nuclear pore complex interacting protein family, member B4
chr1_-_13673511 0.07 ENST00000344998.3
ENST00000334600.6
PRAME family member 14
chr2_-_100939195 0.07 ENST00000393437.3
LON peptidase N-terminal domain and ring finger 2
chr2_-_197457335 0.07 ENST00000260983.3
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr17_-_67057114 0.07 ENST00000370732.2
ATP-binding cassette, sub-family A (ABC1), member 9
chr11_+_112041253 0.07 ENST00000532612.1
AP002884.3
chr8_+_1993152 0.07 ENST00000262113.4
myomesin 2
chr21_-_43735446 0.07 ENST00000398431.2
trefoil factor 3 (intestinal)
chr1_-_20446020 0.07 ENST00000375105.3
phospholipase A2, group IID
chr17_+_61271355 0.07 ENST00000583356.1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr18_+_55018044 0.07 ENST00000324000.3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr2_-_238305397 0.07 ENST00000409809.1
collagen, type VI, alpha 3
chr5_-_177207634 0.07 ENST00000513554.1
ENST00000440605.3
family with sequence similarity 153, member A
chr15_+_58430567 0.07 ENST00000536493.1
aquaporin 9
chr8_-_141774467 0.06 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
protein tyrosine kinase 2
chr12_-_11091862 0.06 ENST00000537503.1
taste receptor, type 2, member 14
chr11_+_122709200 0.06 ENST00000227348.4
cytotoxic and regulatory T cell molecule
chr16_+_21689835 0.06 ENST00000286149.4
ENST00000388958.3
otoancorin
chr6_-_26018007 0.06 ENST00000244573.3
histone cluster 1, H1a
chr16_-_21868739 0.06 ENST00000415645.2
nuclear pore complex interacting protein family, member B4
chr5_+_175490540 0.06 ENST00000515817.1
family with sequence similarity 153, member B
chr12_+_117348742 0.06 ENST00000309909.5
ENST00000455858.2
F-box and WD repeat domain containing 8
chr2_+_181988560 0.06 ENST00000424170.1
ENST00000435411.1
AC104820.2
chr1_+_234509186 0.06 ENST00000366615.4
cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae)
chrX_+_38660704 0.05 ENST00000378474.3
MID1 interacting protein 1
chr1_+_21880560 0.05 ENST00000425315.2
alkaline phosphatase, liver/bone/kidney
chr12_-_28122980 0.05 ENST00000395868.3
ENST00000534890.1
parathyroid hormone-like hormone
chr5_+_40909354 0.05 ENST00000313164.9
complement component 7
chr11_-_104972158 0.05 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr12_-_498620 0.05 ENST00000399788.2
ENST00000382815.4
lysine (K)-specific demethylase 5A
chrX_-_77225135 0.05 ENST00000458128.1
phosphoglycerate mutase family member 4
chr2_-_134326009 0.05 ENST00000409261.1
ENST00000409213.1
NCK-associated protein 5
chr4_-_184241927 0.05 ENST00000323319.5
claudin 22
chr12_+_119616447 0.04 ENST00000281938.2
heat shock 22kDa protein 8
chr9_-_100684845 0.04 ENST00000375119.3
chromosome 9 open reading frame 156
chr4_+_189321881 0.04 ENST00000512839.1
ENST00000513313.1
long intergenic non-protein coding RNA 1060
chr5_+_140201183 0.04 ENST00000529619.1
ENST00000529859.1
ENST00000378126.3
protocadherin alpha 5
chr11_-_102496063 0.04 ENST00000260228.2
matrix metallopeptidase 20
chr6_+_146348782 0.04 ENST00000361719.2
ENST00000392299.2
glutamate receptor, metabotropic 1
chr11_+_126262027 0.04 ENST00000526311.1
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr8_+_24241969 0.04 ENST00000522298.1
ADAM-like, decysin 1
chr3_+_40141502 0.04 ENST00000539167.1
myosin VIIA and Rab interacting protein
chr4_-_139051839 0.04 ENST00000514600.1
ENST00000513895.1
ENST00000512536.1
long intergenic non-protein coding RNA 616
chr17_-_5342380 0.03 ENST00000225698.4
complement component 1, q subcomponent binding protein
chr4_+_74301880 0.03 ENST00000395792.2
ENST00000226359.2
alpha-fetoprotein
chr1_+_160709055 0.03 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
SLAM family member 7
chr1_-_36235559 0.03 ENST00000251195.5
claspin
chr12_+_40787194 0.03 ENST00000425730.2
ENST00000454784.4
mucin 19, oligomeric
chr8_+_67104323 0.03 ENST00000518412.1
ENST00000518035.1
ENST00000517725.1
long intergenic non-protein coding RNA 967
chr12_-_122018346 0.03 ENST00000377069.4
lysine (K)-specific demethylase 2B
chr12_-_14849470 0.03 ENST00000261170.3
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr13_+_42712178 0.03 ENST00000536612.1
diacylglycerol kinase, eta
chr9_-_99382065 0.03 ENST00000265659.2
ENST00000375241.1
ENST00000375236.1
cell division cycle 14B
chr1_+_112016414 0.03 ENST00000343534.5
ENST00000369718.3
chromosome 1 open reading frame 162
chr15_+_69857515 0.03 ENST00000559477.1
RP11-279F6.1
chr13_+_73629107 0.03 ENST00000539231.1
Kruppel-like factor 5 (intestinal)
chr4_-_42154895 0.02 ENST00000502486.1
ENST00000504360.1
BEN domain containing 4
chr8_+_1993173 0.02 ENST00000523438.1
myomesin 2
chr2_-_220197351 0.02 ENST00000392083.1
regulated endocrine-specific protein 18
chr13_-_62001982 0.02 ENST00000409186.1
protocadherin 20
chr20_+_54987305 0.02 ENST00000371336.3
ENST00000434344.1
Cas scaffolding protein family member 4
chr9_-_23821842 0.02 ENST00000544538.1
ELAV like neuron-specific RNA binding protein 2
chr16_+_19467772 0.02 ENST00000219821.5
ENST00000561503.1
ENST00000564959.1
transmembrane channel-like 5
chrX_-_53350522 0.02 ENST00000396435.3
ENST00000375368.5
IQ motif and Sec7 domain 2
chr21_+_22519416 0.02 ENST00000535285.1
neural cell adhesion molecule 2
chr6_+_146348810 0.02 ENST00000492807.2
glutamate receptor, metabotropic 1
chr1_-_150669604 0.02 ENST00000427665.1
ENST00000540514.1
golgi phosphoprotein 3-like
chr8_+_24241789 0.02 ENST00000256412.4
ENST00000538205.1
ADAM-like, decysin 1
chr16_+_66410244 0.01 ENST00000562048.1
ENST00000568155.2
cadherin 5, type 2 (vascular endothelium)
chr11_+_74699703 0.01 ENST00000529024.1
ENST00000544263.1
sialidase 3 (membrane sialidase)
chrX_-_118699325 0.01 ENST00000320339.4
ENST00000371594.4
ENST00000536133.1
chromosome X open reading frame 56
chr17_+_60501228 0.01 ENST00000311506.5
methyltransferase like 2A
chr4_-_71532601 0.01 ENST00000510614.1
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr20_+_54987168 0.01 ENST00000360314.3
Cas scaffolding protein family member 4
chr1_-_182369751 0.00 ENST00000367565.1
transmembrane epididymal protein 1
chr4_-_186682716 0.00 ENST00000445343.1
sorbin and SH3 domain containing 2
chr9_-_100707116 0.00 ENST00000259456.3
hemogen

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0003095 pressure natriuresis(GO:0003095) negative regulation of icosanoid secretion(GO:0032304)
0.1 0.2 GO:0061580 colon epithelial cell migration(GO:0061580)
0.0 0.2 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.0 0.1 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.0 0.1 GO:0046022 positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.3 GO:0000432 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0 0.1 GO:1904823 pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.0 0.2 GO:1903301 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.0 0.1 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.1 GO:0070637 nicotinamide riboside catabolic process(GO:0006738) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638)
0.0 0.1 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.0 0.2 GO:0002326 B cell lineage commitment(GO:0002326) immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.2 GO:0071494 cellular response to UV-C(GO:0071494)
0.0 0.3 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.1 GO:0021993 initiation of neural tube closure(GO:0021993)
0.0 0.3 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.1 GO:0071529 cementum mineralization(GO:0071529)
0.0 0.1 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0 0.1 GO:0070221 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.0 0.1 GO:2000295 regulation of hydrogen peroxide catabolic process(GO:2000295)
0.0 0.0 GO:0034721 histone H3-K4 demethylation, trimethyl-H3-K4-specific(GO:0034721)
0.0 0.0 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.1 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 0.2 GO:0043031 negative regulation of macrophage activation(GO:0043031)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.0 0.2 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.2 GO:0097179 protease inhibitor complex(GO:0097179)
0.0 0.3 GO:0016589 NURF complex(GO:0016589)
0.0 0.1 GO:0038038 G-protein coupled receptor homodimeric complex(GO:0038038)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.2 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0018685 alkane 1-monooxygenase activity(GO:0018685) tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.0 0.2 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.0 0.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.2 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.2 GO:0003943 N-acetylgalactosamine-4-sulfatase activity(GO:0003943)
0.0 0.1 GO:0015254 pyrimidine nucleobase transmembrane transporter activity(GO:0005350) glycerol channel activity(GO:0015254)
0.0 0.1 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.3 GO:0052794 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.1 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 0.1 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.0 0.2 GO:0089720 caspase binding(GO:0089720)
0.0 0.0 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.0 0.0 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.1 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.1 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.0 GO:0030984 kininogen binding(GO:0030984)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins