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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SOX1

Z-value: 0.70

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Transcription factors associated with SOX1

Gene Symbol Gene ID Gene Info
SOX1
ENSG00000182968.3 SRY-box transcription factor 1

Activity profile of SOX1 motif

Sorted Z-values of SOX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_110174754 0.48 ENST00000435466.1
AC003088.1
AC003088.1
chr19_-_6057282 0.47 ENST00000592281.1
RFX2
regulatory factor X, 2 (influences HLA class II expression)
chr11_-_111649074 0.43 ENST00000534218.1
RP11-108O10.2
RP11-108O10.2
chr9_-_85882145 0.38 ENST00000328788.1
FRMD3
FERM domain containing 3
chr6_+_26183958 0.35 ENST00000356530.3
HIST1H2BE
histone cluster 1, H2be
chr3_-_107596910 0.31 ENST00000464359.2
ENST00000464823.1
ENST00000466155.1
ENST00000473528.2
ENST00000608306.1
ENST00000488852.1
ENST00000608137.1
ENST00000608307.1
ENST00000609429.1
ENST00000601385.1
ENST00000475362.1
ENST00000600240.1
ENST00000600749.1
LINC00635
long intergenic non-protein coding RNA 635
chr6_+_27833034 0.28 ENST00000357320.2
HIST1H2AL
histone cluster 1, H2al
chr7_-_139756791 0.27 ENST00000489809.1
PARP12
poly (ADP-ribose) polymerase family, member 12
chr9_-_13165457 0.26 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
MPDZ
multiple PDZ domain protein
chr20_-_14318248 0.24 ENST00000378053.3
ENST00000341420.4
FLRT3
fibronectin leucine rich transmembrane protein 3
chr2_+_102615416 0.23 ENST00000393414.2
IL1R2
interleukin 1 receptor, type II
chr6_-_15548591 0.22 ENST00000509674.1
DTNBP1
dystrobrevin binding protein 1
chr14_-_74417096 0.22 ENST00000286544.3
FAM161B
family with sequence similarity 161, member B
chr6_+_148593425 0.22 ENST00000367469.1
SASH1
SAM and SH3 domain containing 1
chr17_-_15519008 0.22 ENST00000261644.8
CDRT1
CMT1A duplicated region transcript 1
chr5_-_16916624 0.21 ENST00000513882.1
MYO10
myosin X
chr1_+_12806141 0.21 ENST00000288048.5
C1orf158
chromosome 1 open reading frame 158
chr11_+_125496619 0.20 ENST00000532669.1
ENST00000278916.3
CHEK1
checkpoint kinase 1
chr3_+_132316081 0.18 ENST00000249887.2
ACKR4
atypical chemokine receptor 4
chr12_+_57810198 0.17 ENST00000598001.1
AC126614.1
HCG1818482; Uncharacterized protein
chr20_-_48747662 0.16 ENST00000371656.2
TMEM189
transmembrane protein 189
chr5_+_158654712 0.16 ENST00000520323.1
CTB-11I22.2
CTB-11I22.2
chr3_+_138327542 0.16 ENST00000360570.3
ENST00000393035.2
FAIM
Fas apoptotic inhibitory molecule
chr15_+_57540230 0.15 ENST00000559703.1
TCF12
transcription factor 12
chr19_+_35842445 0.15 ENST00000246553.2
FFAR1
free fatty acid receptor 1
chrX_+_11129388 0.15 ENST00000321143.4
ENST00000380763.3
ENST00000380762.4
HCCS
holocytochrome c synthase
chr1_+_65613340 0.14 ENST00000546702.1
AK4
adenylate kinase 4
chr12_-_11150474 0.14 ENST00000538986.1
TAS2R20
taste receptor, type 2, member 20
chr4_+_156680153 0.14 ENST00000502959.1
ENST00000505764.1
ENST00000507146.1
ENST00000264424.8
ENST00000503520.1
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr11_-_111649015 0.14 ENST00000529841.1
RP11-108O10.2
RP11-108O10.2
chr14_-_89878369 0.14 ENST00000553840.1
ENST00000556916.1
FOXN3
forkhead box N3
chr19_-_10491130 0.14 ENST00000530829.1
ENST00000529370.1
TYK2
tyrosine kinase 2
chrX_+_129040094 0.14 ENST00000425117.2
UTP14A
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr3_-_189840223 0.14 ENST00000427335.2
LEPREL1
leprecan-like 1
chr6_-_138866823 0.13 ENST00000342260.5
NHSL1
NHS-like 1
chr4_+_172734548 0.13 ENST00000506823.1
GALNTL6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr1_-_43638168 0.13 ENST00000431635.2
EBNA1BP2
EBNA1 binding protein 2
chr19_+_38880252 0.13 ENST00000586301.1
SPRED3
sprouty-related, EVH1 domain containing 3
chr11_-_113577052 0.12 ENST00000540540.1
ENST00000545579.1
ENST00000538955.1
ENST00000299882.5
TMPRSS5
transmembrane protease, serine 5
chr19_+_21324863 0.12 ENST00000598331.1
ZNF431
zinc finger protein 431
chr19_+_21324827 0.12 ENST00000600692.1
ENST00000599296.1
ENST00000594425.1
ENST00000311048.7
ZNF431
zinc finger protein 431
chr6_+_149539767 0.12 ENST00000606202.1
ENST00000536230.1
ENST00000445901.1
TAB2
RP1-111D6.3
TGF-beta activated kinase 1/MAP3K7 binding protein 2
RP1-111D6.3
chr11_-_47400032 0.11 ENST00000533968.1
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr14_+_20811722 0.11 ENST00000429687.3
PARP2
poly (ADP-ribose) polymerase 2
chr10_-_73976884 0.11 ENST00000317126.4
ENST00000545550.1
ASCC1
activating signal cointegrator 1 complex subunit 1
chr14_+_38033252 0.11 ENST00000554829.1
RP11-356O9.1
RP11-356O9.1
chr7_+_36450169 0.10 ENST00000428612.1
ANLN
anillin, actin binding protein
chr12_-_110434096 0.10 ENST00000320063.9
ENST00000457474.2
ENST00000547815.1
ENST00000361006.5
GIT2
G protein-coupled receptor kinase interacting ArfGAP 2
chr3_+_158362299 0.10 ENST00000478576.1
ENST00000264263.5
ENST00000464732.1
GFM1
G elongation factor, mitochondrial 1
chr3_-_33686925 0.10 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr10_-_73976025 0.10 ENST00000342444.4
ENST00000533958.1
ENST00000527593.1
ENST00000394915.3
ENST00000530461.1
ENST00000317168.6
ENST00000524829.1
ASCC1
activating signal cointegrator 1 complex subunit 1
chrX_+_114874727 0.10 ENST00000543070.1
PLS3
plastin 3
chr4_-_74486347 0.10 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr3_-_16524357 0.10 ENST00000432519.1
RFTN1
raftlin, lipid raft linker 1
chr1_+_240255166 0.10 ENST00000319653.9
FMN2
formin 2
chr12_+_7456880 0.09 ENST00000399422.4
ACSM4
acyl-CoA synthetase medium-chain family member 4
chr1_+_144811943 0.09 ENST00000281815.8
NBPF9
neuroblastoma breakpoint family, member 9
chrX_+_129040122 0.08 ENST00000394422.3
ENST00000371051.5
UTP14A
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr10_+_23384435 0.08 ENST00000376510.3
MSRB2
methionine sulfoxide reductase B2
chr2_-_163175133 0.08 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr19_+_17830051 0.08 ENST00000594625.1
ENST00000324096.4
ENST00000600186.1
ENST00000597735.1
MAP1S
microtubule-associated protein 1S
chr4_-_122686261 0.08 ENST00000337677.5
TMEM155
transmembrane protein 155
chr14_+_74417192 0.08 ENST00000554320.1
COQ6
coenzyme Q6 monooxygenase
chr21_-_16126181 0.08 ENST00000455253.2
AF127936.3
AF127936.3
chr4_-_74486217 0.08 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr10_+_47894572 0.08 ENST00000355876.5
FAM21B
family with sequence similarity 21, member B
chr11_-_113577014 0.08 ENST00000544634.1
ENST00000539732.1
ENST00000538770.1
ENST00000536856.1
ENST00000544476.1
TMPRSS5
transmembrane protease, serine 5
chr3_-_171489085 0.07 ENST00000418087.1
PLD1
phospholipase D1, phosphatidylcholine-specific
chr17_+_75316336 0.07 ENST00000591934.1
SEPT9
septin 9
chr10_+_15085895 0.07 ENST00000378228.3
OLAH
oleoyl-ACP hydrolase
chr18_-_51751132 0.07 ENST00000256429.3
MBD2
methyl-CpG binding domain protein 2
chr17_+_80816395 0.07 ENST00000576160.2
ENST00000571712.1
TBCD
tubulin folding cofactor D
chr3_-_126327398 0.07 ENST00000383572.2
TXNRD3NB
thioredoxin reductase 3 neighbor
chr5_+_175740083 0.07 ENST00000332772.4
SIMC1
SUMO-interacting motifs containing 1
chr15_+_59903975 0.06 ENST00000560585.1
ENST00000396065.1
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr13_-_22178284 0.06 ENST00000468222.2
ENST00000382374.4
MICU2
mitochondrial calcium uptake 2
chr14_-_20801427 0.06 ENST00000557665.1
ENST00000358932.4
ENST00000353689.4
CCNB1IP1
cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
chr2_+_11864458 0.06 ENST00000396098.1
ENST00000396099.1
ENST00000425416.2
LPIN1
lipin 1
chr2_+_171036635 0.06 ENST00000484338.2
ENST00000334231.6
MYO3B
myosin IIIB
chr14_+_35514323 0.06 ENST00000555211.1
FAM177A1
family with sequence similarity 177, member A1
chr11_+_29181503 0.05 ENST00000530960.1
RP11-466I1.1
RP11-466I1.1
chr1_-_212004090 0.05 ENST00000366997.4
LPGAT1
lysophosphatidylglycerol acyltransferase 1
chr12_-_110434183 0.05 ENST00000360185.4
ENST00000354574.4
ENST00000338373.5
ENST00000343646.5
ENST00000356259.4
ENST00000553118.1
GIT2
G protein-coupled receptor kinase interacting ArfGAP 2
chr2_-_200320768 0.05 ENST00000428695.1
SATB2
SATB homeobox 2
chr2_+_171034646 0.05 ENST00000409044.3
ENST00000408978.4
MYO3B
myosin IIIB
chr3_-_44519131 0.05 ENST00000425708.2
ENST00000396077.2
ZNF445
zinc finger protein 445
chr15_+_76196234 0.05 ENST00000540507.1
ENST00000565036.1
ENST00000569054.1
FBXO22
F-box protein 22
chr10_-_43892668 0.04 ENST00000544000.1
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr16_-_1538765 0.04 ENST00000447419.2
ENST00000440447.2
PTX4
pentraxin 4, long
chr20_+_49575342 0.04 ENST00000244051.1
MOCS3
molybdenum cofactor synthesis 3
chr17_-_15168624 0.04 ENST00000312280.3
ENST00000494511.1
ENST00000580584.1
PMP22
peripheral myelin protein 22
chr11_+_125496400 0.04 ENST00000524737.1
CHEK1
checkpoint kinase 1
chr1_-_200379104 0.04 ENST00000367352.3
ZNF281
zinc finger protein 281
chr1_-_89641680 0.04 ENST00000294671.2
GBP7
guanylate binding protein 7
chr7_-_76955563 0.04 ENST00000441833.2
GSAP
gamma-secretase activating protein
chr19_+_3762645 0.03 ENST00000330133.4
MRPL54
mitochondrial ribosomal protein L54
chr22_+_32149927 0.03 ENST00000437411.1
ENST00000535622.1
ENST00000536766.1
ENST00000400242.3
ENST00000266091.3
ENST00000400249.2
ENST00000400246.1
ENST00000382105.2
DEPDC5
DEP domain containing 5
chr14_+_62164340 0.03 ENST00000557538.1
ENST00000539097.1
HIF1A
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
chr2_+_234296792 0.03 ENST00000409813.3
DGKD
diacylglycerol kinase, delta 130kDa
chr5_+_135383008 0.03 ENST00000508767.1
ENST00000604555.1
TGFBI
transforming growth factor, beta-induced, 68kDa
chr3_+_127770455 0.03 ENST00000464451.1
SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr9_-_2844058 0.03 ENST00000397885.2
KIAA0020
KIAA0020
chr1_+_46805832 0.02 ENST00000474844.1
NSUN4
NOP2/Sun domain family, member 4
chr20_-_49575058 0.02 ENST00000371584.4
ENST00000371583.5
ENST00000413082.1
DPM1
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
chr1_-_200379129 0.02 ENST00000367353.1
ZNF281
zinc finger protein 281
chr1_+_24646263 0.02 ENST00000524724.1
GRHL3
grainyhead-like 3 (Drosophila)
chrX_+_106163626 0.02 ENST00000336803.1
CLDN2
claudin 2
chr6_-_130543958 0.02 ENST00000437477.2
ENST00000439090.2
SAMD3
sterile alpha motif domain containing 3
chr12_-_10607084 0.02 ENST00000408006.3
ENST00000544822.1
ENST00000536188.1
KLRC1
killer cell lectin-like receptor subfamily C, member 1
chr19_+_49588677 0.02 ENST00000598984.1
ENST00000598441.1
SNRNP70
small nuclear ribonucleoprotein 70kDa (U1)
chr1_-_52499443 0.02 ENST00000371614.1
KTI12
KTI12 homolog, chromatin associated (S. cerevisiae)
chr20_-_49575081 0.02 ENST00000371588.5
ENST00000371582.4
DPM1
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
chr1_+_65613217 0.02 ENST00000545314.1
AK4
adenylate kinase 4
chr3_+_136676707 0.01 ENST00000329582.4
IL20RB
interleukin 20 receptor beta
chr8_-_102181718 0.01 ENST00000565617.1
KB-1460A1.5
KB-1460A1.5
chr11_-_6790286 0.01 ENST00000338569.2
OR2AG2
olfactory receptor, family 2, subfamily AG, member 2
chr6_+_124125286 0.01 ENST00000368416.1
ENST00000368417.1
ENST00000546092.1
NKAIN2
Na+/K+ transporting ATPase interacting 2
chr12_-_10605929 0.01 ENST00000347831.5
ENST00000359151.3
KLRC1
killer cell lectin-like receptor subfamily C, member 1
chr11_-_76381781 0.01 ENST00000260061.5
ENST00000404995.1
LRRC32
leucine rich repeat containing 32
chr11_-_57177586 0.01 ENST00000529411.1
RP11-872D17.8
Uncharacterized protein
chr16_-_18937072 0.01 ENST00000569122.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr3_+_126113734 0.01 ENST00000352312.1
ENST00000393425.1
CCDC37
coiled-coil domain containing 37
chr4_-_170924888 0.01 ENST00000502832.1
ENST00000393704.3
MFAP3L
microfibrillar-associated protein 3-like
chr9_-_123638633 0.01 ENST00000456291.1
PHF19
PHD finger protein 19
chr1_+_202789394 0.01 ENST00000330493.5
RP11-480I12.4
Putative inactive alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein LOC641515
chr9_-_104249400 0.01 ENST00000374848.3
TMEM246
transmembrane protein 246
chr19_-_44388116 0.01 ENST00000587539.1
ZNF404
zinc finger protein 404
chr19_-_10491234 0.00 ENST00000524462.1
ENST00000531836.1
ENST00000525621.1
TYK2
tyrosine kinase 2
chr22_-_17302589 0.00 ENST00000331428.5
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr8_+_80209929 0.00 ENST00000519983.1
RP11-1114I9.1
RP11-1114I9.1
chr1_+_70876926 0.00 ENST00000370938.3
ENST00000346806.2
CTH
cystathionase (cystathionine gamma-lyase)
chr18_+_6834472 0.00 ENST00000581099.1
ENST00000419673.2
ENST00000531294.1
ARHGAP28
Rho GTPase activating protein 28
chr1_-_19578003 0.00 ENST00000375199.3
ENST00000375208.3
ENST00000356068.2
ENST00000477853.1
EMC1
ER membrane protein complex subunit 1

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.0 0.2 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.0 0.1 GO:0031106 septin ring assembly(GO:0000921) septin ring organization(GO:0031106)
0.0 0.1 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.0 0.1 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
0.0 0.2 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) regulation of protein autoubiquitination(GO:1902498)
0.0 0.5 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.1 GO:0002426 immunoglobulin production in mucosal tissue(GO:0002426)
0.0 0.1 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.0 0.1 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0 0.1 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.0 0.2 GO:0003344 pericardium morphogenesis(GO:0003344)
0.0 0.2 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.0 0.0 GO:0021502 neural fold elevation formation(GO:0021502)
0.0 0.1 GO:0044026 DNA hypermethylation(GO:0044026) hypermethylation of CpG island(GO:0044027)
0.0 0.0 GO:0018307 enzyme active site formation(GO:0018307)
0.0 0.2 GO:0060155 platelet dense granule organization(GO:0060155) regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.2 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.3 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 0.2 GO:0032433 filopodium tip(GO:0032433)
0.0 0.1 GO:1990246 uniplex complex(GO:1990246)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 0.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 0.1 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.2 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.0 0.1 GO:0047225 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225)
0.0 0.2 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.1 GO:0016295 oleoyl-[acyl-carrier-protein] hydrolase activity(GO:0004320) myristoyl-[acyl-carrier-protein] hydrolase activity(GO:0016295) palmitoyl-[acyl-carrier-protein] hydrolase activity(GO:0016296) acyl-[acyl-carrier-protein] hydrolase activity(GO:0016297)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.1 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.2 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.1 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.1 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.2 GO:0045499 chemorepellent activity(GO:0045499)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint