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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SPDEF

Z-value: 0.83

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Transcription factors associated with SPDEF

Gene Symbol Gene ID Gene Info
SPDEF
ENSG00000124664.6 SAM pointed domain containing ETS transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SPDEFhg19_v2_chr6_-_34524093_34524135-0.592.2e-01Click!

Activity profile of SPDEF motif

Sorted Z-values of SPDEF motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_7108436 0.81 ENST00000493294.1
DLG4
discs, large homolog 4 (Drosophila)
chr2_+_198380763 0.54 ENST00000448447.2
ENST00000409360.1
MOB4
MOB family member 4, phocein
chr12_+_102514019 0.51 ENST00000537257.1
ENST00000358383.5
ENST00000392911.2
PARPBP
PARP1 binding protein
chr2_+_198380289 0.49 ENST00000233892.4
ENST00000409916.1
MOB4
MOB family member 4, phocein
chr12_+_49961990 0.46 ENST00000551063.1
PRPF40B
PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
chr12_+_102513950 0.46 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARPBP
PARP1 binding protein
chr5_+_158690089 0.46 ENST00000296786.6
UBLCP1
ubiquitin-like domain containing CTD phosphatase 1
chr4_-_44728559 0.45 ENST00000509756.1
ENST00000507917.1
ENST00000295448.3
GNPDA2
glucosamine-6-phosphate deaminase 2
chr4_-_44728530 0.43 ENST00000507534.1
GNPDA2
glucosamine-6-phosphate deaminase 2
chr1_-_193028426 0.43 ENST00000367450.3
ENST00000530098.2
ENST00000367451.4
ENST00000367448.1
ENST00000367449.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr8_-_77912431 0.42 ENST00000357039.4
ENST00000522527.1
PEX2
peroxisomal biogenesis factor 2
chr1_-_193028621 0.42 ENST00000367455.4
ENST00000367454.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr2_+_162016827 0.40 ENST00000429217.1
ENST00000406287.1
ENST00000402568.1
TANK
TRAF family member-associated NFKB activator
chr4_-_153700864 0.40 ENST00000304337.2
TIGD4
tigger transposable element derived 4
chr1_+_84944926 0.40 ENST00000370656.1
ENST00000370654.5
RPF1
ribosome production factor 1 homolog (S. cerevisiae)
chr1_-_193028632 0.39 ENST00000421683.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr4_+_48833312 0.38 ENST00000508293.1
ENST00000513391.2
OCIAD1
OCIA domain containing 1
chr18_-_19180681 0.37 ENST00000269214.5
ESCO1
establishment of sister chromatid cohesion N-acetyltransferase 1
chr4_+_48833183 0.37 ENST00000503016.1
OCIAD1
OCIA domain containing 1
chr8_-_100025238 0.37 ENST00000521696.1
RP11-410L14.2
RP11-410L14.2
chr2_+_162016804 0.36 ENST00000392749.2
ENST00000440506.1
TANK
TRAF family member-associated NFKB activator
chr2_+_118846008 0.36 ENST00000245787.4
INSIG2
insulin induced gene 2
chr1_+_193028552 0.36 ENST00000400968.2
ENST00000432079.1
TROVE2
TROVE domain family, member 2
chr4_+_141445311 0.35 ENST00000323570.3
ENST00000511887.2
ELMOD2
ELMO/CED-12 domain containing 2
chr17_-_56082455 0.34 ENST00000578794.1
RP11-159D12.5
Uncharacterized protein
chr14_+_105212297 0.33 ENST00000556623.1
ENST00000555674.1
ADSSL1
adenylosuccinate synthase like 1
chr15_-_65809581 0.32 ENST00000341861.5
DPP8
dipeptidyl-peptidase 8
chr19_+_37178482 0.32 ENST00000536254.2
ZNF567
zinc finger protein 567
chr6_-_150039249 0.32 ENST00000543571.1
LATS1
large tumor suppressor kinase 1
chr1_+_169337172 0.31 ENST00000367807.3
ENST00000367808.3
ENST00000329281.2
ENST00000420531.1
BLZF1
basic leucine zipper nuclear factor 1
chr1_+_169337412 0.31 ENST00000426663.1
BLZF1
basic leucine zipper nuclear factor 1
chr10_-_119806085 0.31 ENST00000355624.3
RAB11FIP2
RAB11 family interacting protein 2 (class I)
chr4_+_48833015 0.31 ENST00000509122.1
ENST00000509664.1
ENST00000505922.2
ENST00000514981.1
OCIAD1
OCIA domain containing 1
chr6_+_134274322 0.30 ENST00000367871.1
ENST00000237264.4
TBPL1
TBP-like 1
chr1_-_184723701 0.30 ENST00000367512.3
EDEM3
ER degradation enhancer, mannosidase alpha-like 3
chr1_-_169337176 0.30 ENST00000472647.1
ENST00000367811.3
NME7
NME/NM23 family member 7
chr2_+_162016916 0.29 ENST00000405852.1
TANK
TRAF family member-associated NFKB activator
chr14_-_67826486 0.29 ENST00000555431.1
ENST00000554236.1
ENST00000555474.1
ATP6V1D
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
chr15_-_65809625 0.29 ENST00000560436.1
DPP8
dipeptidyl-peptidase 8
chr20_-_62199427 0.28 ENST00000427522.2
HELZ2
helicase with zinc finger 2, transcriptional coactivator
chr15_-_55700216 0.28 ENST00000569205.1
CCPG1
cell cycle progression 1
chr4_+_153701081 0.28 ENST00000451320.2
ENST00000429148.2
ENST00000353617.2
ENST00000405727.2
ENST00000356064.3
ARFIP1
ADP-ribosylation factor interacting protein 1
chr14_+_60716159 0.28 ENST00000325658.3
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr17_+_65714018 0.27 ENST00000581106.1
ENST00000535137.1
NOL11
nucleolar protein 11
chr1_-_111506562 0.27 ENST00000485275.2
ENST00000369763.4
LRIF1
ligand dependent nuclear receptor interacting factor 1
chr4_+_48833234 0.27 ENST00000510824.1
ENST00000425583.2
OCIAD1
OCIA domain containing 1
chr4_+_48833160 0.27 ENST00000506801.1
OCIAD1
OCIA domain containing 1
chr8_-_130951940 0.26 ENST00000522250.1
ENST00000522941.1
ENST00000522746.1
ENST00000520204.1
ENST00000519070.1
ENST00000520254.1
ENST00000519824.2
ENST00000519540.1
FAM49B
family with sequence similarity 49, member B
chr1_+_67395922 0.26 ENST00000401042.3
ENST00000355356.3
MIER1
mesoderm induction early response 1, transcriptional regulator
chr15_-_59949693 0.26 ENST00000396063.1
ENST00000396064.3
ENST00000484743.1
ENST00000559706.1
ENST00000396060.2
GTF2A2
general transcription factor IIA, 2, 12kDa
chr7_+_77428066 0.26 ENST00000422959.2
ENST00000307305.8
ENST00000424760.1
PHTF2
putative homeodomain transcription factor 2
chr2_+_54014168 0.25 ENST00000405123.3
ENST00000185150.4
ENST00000378239.5
ERLEC1
endoplasmic reticulum lectin 1
chrX_-_122866874 0.25 ENST00000245838.8
ENST00000355725.4
THOC2
THO complex 2
chr5_-_114961858 0.24 ENST00000282382.4
ENST00000456936.3
ENST00000408996.4
TMED7-TICAM2
TMED7
TICAM2
TMED7-TICAM2 readthrough
transmembrane emp24 protein transport domain containing 7
toll-like receptor adaptor molecule 2
chr17_+_65713925 0.24 ENST00000253247.4
NOL11
nucleolar protein 11
chr6_-_150039170 0.23 ENST00000458696.2
ENST00000392273.3
LATS1
large tumor suppressor kinase 1
chr12_+_29302119 0.23 ENST00000536681.3
FAR2
fatty acyl CoA reductase 2
chr4_+_41992489 0.23 ENST00000264451.7
SLC30A9
solute carrier family 30 (zinc transporter), member 9
chr8_-_101964265 0.23 ENST00000395958.2
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr14_-_69864993 0.23 ENST00000555373.1
ERH
enhancer of rudimentary homolog (Drosophila)
chr1_-_235324772 0.23 ENST00000408888.3
RBM34
RNA binding motif protein 34
chr16_+_22019404 0.23 ENST00000542527.2
ENST00000569656.1
ENST00000562695.1
C16orf52
chromosome 16 open reading frame 52
chr14_+_21566980 0.22 ENST00000418511.2
ENST00000554329.2
TMEM253
transmembrane protein 253
chr15_-_65810042 0.22 ENST00000321147.6
DPP8
dipeptidyl-peptidase 8
chr7_+_77428149 0.22 ENST00000415251.2
ENST00000275575.7
PHTF2
putative homeodomain transcription factor 2
chr15_-_59949667 0.22 ENST00000396061.1
GTF2A2
general transcription factor IIA, 2, 12kDa
chr1_-_28969517 0.22 ENST00000263974.4
ENST00000373824.4
TAF12
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
chr18_+_48556470 0.22 ENST00000589076.1
ENST00000590061.1
ENST00000591914.1
ENST00000342988.3
SMAD4
SMAD family member 4
chr1_-_235324530 0.22 ENST00000447801.1
ENST00000366606.3
ENST00000429912.1
RBM34
RNA binding motif protein 34
chr14_+_35761540 0.22 ENST00000261479.4
PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr3_-_32612263 0.21 ENST00000432458.2
ENST00000424991.1
ENST00000273130.4
DYNC1LI1
dynein, cytoplasmic 1, light intermediate chain 1
chr5_+_31532373 0.21 ENST00000325366.9
ENST00000355907.3
ENST00000507818.2
C5orf22
chromosome 5 open reading frame 22
chr2_+_187350883 0.21 ENST00000337859.6
ZC3H15
zinc finger CCCH-type containing 15
chr14_-_64010046 0.21 ENST00000337537.3
PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr2_-_54014055 0.21 ENST00000263634.3
ENST00000406687.1
GPR75-ASB3
GPR75-ASB3 readthrough
chr12_+_22199108 0.21 ENST00000229329.2
CMAS
cytidine monophosphate N-acetylneuraminic acid synthetase
chr3_+_32023232 0.20 ENST00000360311.4
ZNF860
zinc finger protein 860
chr14_+_35761580 0.20 ENST00000553809.1
ENST00000555764.1
ENST00000556506.1
PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr7_-_91875109 0.20 ENST00000412043.2
ENST00000430102.1
ENST00000425073.1
ENST00000394503.2
ENST00000454017.1
ENST00000440209.1
ENST00000413688.1
ENST00000452773.1
ENST00000433016.1
ENST00000394505.2
ENST00000422347.1
ENST00000458493.1
ENST00000425919.1
KRIT1
KRIT1, ankyrin repeat containing
chr5_+_93954039 0.20 ENST00000265140.5
ANKRD32
ankyrin repeat domain 32
chr5_+_76326187 0.20 ENST00000312916.7
ENST00000506806.1
AGGF1
angiogenic factor with G patch and FHA domains 1
chr7_+_93551011 0.19 ENST00000248564.5
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr10_-_15902449 0.19 ENST00000277632.3
FAM188A
family with sequence similarity 188, member A
chr14_+_67826709 0.19 ENST00000256383.4
EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr3_+_197464046 0.19 ENST00000428738.1
FYTTD1
forty-two-three domain containing 1
chrX_+_117629766 0.18 ENST00000276204.6
ENST00000276202.7
DOCK11
dedicator of cytokinesis 11
chr4_-_83812157 0.18 ENST00000513323.1
SEC31A
SEC31 homolog A (S. cerevisiae)
chr15_-_65809991 0.18 ENST00000559526.1
ENST00000358939.4
ENST00000560665.1
ENST00000321118.7
ENST00000339244.5
ENST00000300141.6
DPP8
dipeptidyl-peptidase 8
chr1_-_184723942 0.18 ENST00000318130.8
EDEM3
ER degradation enhancer, mannosidase alpha-like 3
chr2_+_39103103 0.18 ENST00000340556.6
ENST00000410014.1
ENST00000409665.1
ENST00000409077.2
ENST00000409131.2
MORN2
MORN repeat containing 2
chr4_+_159593418 0.18 ENST00000507475.1
ENST00000307738.5
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr1_+_43637996 0.18 ENST00000528956.1
ENST00000529956.1
WDR65
WD repeat domain 65
chr11_-_46408107 0.17 ENST00000433765.2
CHRM4
cholinergic receptor, muscarinic 4
chr5_+_86564739 0.17 ENST00000456692.2
ENST00000512763.1
ENST00000506290.1
RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr6_+_134274354 0.17 ENST00000367869.1
TBPL1
TBP-like 1
chr7_+_128379346 0.17 ENST00000535011.2
ENST00000542996.2
ENST00000535623.1
ENST00000538546.1
ENST00000249364.4
ENST00000449187.2
CALU
calumenin
chr7_-_38948774 0.17 ENST00000395969.2
ENST00000414632.1
ENST00000310301.4
VPS41
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr14_-_31926623 0.17 ENST00000356180.4
DTD2
D-tyrosyl-tRNA deacylase 2 (putative)
chr1_-_65533390 0.17 ENST00000448344.1
RP4-535B20.1
RP4-535B20.1
chr2_+_63816126 0.17 ENST00000454035.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr8_+_8860314 0.17 ENST00000250263.7
ENST00000519292.1
ERI1
exoribonuclease 1
chr4_-_39640513 0.17 ENST00000511809.1
ENST00000505729.1
SMIM14
small integral membrane protein 14
chr1_+_203765437 0.16 ENST00000550078.1
ZBED6
zinc finger, BED-type containing 6
chr5_+_93954358 0.16 ENST00000504099.1
ANKRD32
ankyrin repeat domain 32
chr2_+_187350973 0.16 ENST00000544130.1
ZC3H15
zinc finger CCCH-type containing 15
chr4_-_159592996 0.15 ENST00000508457.1
C4orf46
chromosome 4 open reading frame 46
chr2_+_27805880 0.15 ENST00000379717.1
ENST00000355467.4
ENST00000556601.1
ENST00000416005.2
ZNF512
zinc finger protein 512
chr4_+_48833119 0.15 ENST00000444354.2
ENST00000509963.1
ENST00000509246.1
OCIAD1
OCIA domain containing 1
chr15_-_55700457 0.15 ENST00000442196.3
ENST00000563171.1
ENST00000425574.3
CCPG1
cell cycle progression 1
chr2_-_54014127 0.15 ENST00000394717.2
GPR75-ASB3
GPR75-ASB3 readthrough
chr2_+_65454926 0.15 ENST00000542850.1
ENST00000377982.4
ACTR2
ARP2 actin-related protein 2 homolog (yeast)
chr17_-_76837499 0.15 ENST00000592275.1
USP36
ubiquitin specific peptidase 36
chr11_-_94706705 0.15 ENST00000279839.6
CWC15
CWC15 spliceosome-associated protein homolog (S. cerevisiae)
chr18_+_21033239 0.15 ENST00000581585.1
ENST00000577501.1
RIOK3
RIO kinase 3
chrX_-_131352152 0.15 ENST00000342983.2
RAP2C
RAP2C, member of RAS oncogene family
chr5_+_110074685 0.15 ENST00000355943.3
ENST00000447245.2
SLC25A46
solute carrier family 25, member 46
chr12_-_102513843 0.14 ENST00000551744.2
ENST00000552283.1
NUP37
nucleoporin 37kDa
chr4_-_159593179 0.14 ENST00000379205.4
C4orf46
chromosome 4 open reading frame 46
chr12_+_50794891 0.14 ENST00000517559.1
LARP4
La ribonucleoprotein domain family, member 4
chr3_+_100428316 0.14 ENST00000479672.1
ENST00000476228.1
ENST00000463568.1
TFG
TRK-fused gene
chr11_+_36616355 0.14 ENST00000532470.2
C11orf74
chromosome 11 open reading frame 74
chr11_+_94706804 0.14 ENST00000335080.5
KDM4D
lysine (K)-specific demethylase 4D
chr14_+_60715928 0.14 ENST00000395076.4
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr7_-_91875358 0.14 ENST00000458177.1
ENST00000394507.1
ENST00000340022.2
ENST00000444960.1
KRIT1
KRIT1, ankyrin repeat containing
chr11_-_57479673 0.13 ENST00000337672.2
ENST00000431606.2
MED19
mediator complex subunit 19
chr4_+_48833070 0.13 ENST00000511662.1
ENST00000508996.1
ENST00000507210.1
ENST00000264312.7
ENST00000396448.2
ENST00000512236.1
ENST00000509164.1
ENST00000511102.1
ENST00000381473.3
OCIAD1
OCIA domain containing 1
chr2_-_68479614 0.13 ENST00000234310.3
PPP3R1
protein phosphatase 3, regulatory subunit B, alpha
chr7_-_135662056 0.13 ENST00000393085.3
ENST00000435723.1
MTPN
myotrophin
chr1_+_235491714 0.13 ENST00000471812.1
ENST00000358966.2
ENST00000282841.5
ENST00000391855.2
GGPS1
geranylgeranyl diphosphate synthase 1
chr16_-_25122785 0.13 ENST00000563962.1
ENST00000569920.1
RP11-449H11.1
RP11-449H11.1
chr2_+_65454863 0.13 ENST00000260641.5
ACTR2
ARP2 actin-related protein 2 homolog (yeast)
chr11_+_73498973 0.13 ENST00000537007.1
MRPL48
mitochondrial ribosomal protein L48
chr19_-_45004556 0.13 ENST00000587047.1
ENST00000391956.4
ENST00000221327.4
ENST00000586637.1
ENST00000591064.1
ENST00000592529.1
ZNF180
zinc finger protein 180
chr2_-_63815628 0.13 ENST00000409562.3
WDPCP
WD repeat containing planar cell polarity effector
chr11_+_94706973 0.13 ENST00000536741.1
KDM4D
lysine (K)-specific demethylase 4D
chr15_-_55700522 0.13 ENST00000564092.1
ENST00000310958.6
CCPG1
cell cycle progression 1
chr11_-_33183006 0.13 ENST00000524827.1
ENST00000323959.4
ENST00000431742.2
CSTF3
cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
chr17_-_47755338 0.13 ENST00000508805.1
ENST00000515508.2
ENST00000451526.2
ENST00000507970.1
SPOP
speckle-type POZ protein
chr1_+_84630053 0.13 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr9_-_72374848 0.13 ENST00000377200.5
ENST00000340434.4
ENST00000472967.2
PTAR1
protein prenyltransferase alpha subunit repeat containing 1
chr4_-_39640700 0.12 ENST00000295958.5
SMIM14
small integral membrane protein 14
chr16_-_25122735 0.12 ENST00000563176.1
RP11-449H11.1
RP11-449H11.1
chr7_-_77427676 0.12 ENST00000257663.3
TMEM60
transmembrane protein 60
chr2_+_37311588 0.12 ENST00000409774.1
ENST00000608836.1
GPATCH11
G patch domain containing 11
chr1_+_24829384 0.12 ENST00000374395.4
ENST00000436717.2
RCAN3
RCAN family member 3
chr7_+_128379449 0.12 ENST00000479257.1
CALU
calumenin
chr2_+_48667983 0.12 ENST00000449090.2
PPP1R21
protein phosphatase 1, regulatory subunit 21
chr18_+_19321281 0.12 ENST00000261537.6
MIB1
mindbomb E3 ubiquitin protein ligase 1
chr3_-_196669371 0.12 ENST00000427641.2
ENST00000321256.5
NCBP2
nuclear cap binding protein subunit 2, 20kDa
chr1_+_110091189 0.12 ENST00000369851.4
GNAI3
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
chr3_-_37218023 0.12 ENST00000416425.1
LRRFIP2
leucine rich repeat (in FLII) interacting protein 2
chr3_-_133380731 0.12 ENST00000260810.5
TOPBP1
topoisomerase (DNA) II binding protein 1
chr14_-_24615523 0.11 ENST00000559056.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr11_-_46142948 0.11 ENST00000257821.4
PHF21A
PHD finger protein 21A
chr6_-_41254403 0.11 ENST00000589614.1
ENST00000334475.6
ENST00000591620.1
ENST00000244709.4
TREM1
triggering receptor expressed on myeloid cells 1
chr2_-_27294500 0.11 ENST00000447619.1
ENST00000429985.1
ENST00000456793.1
OST4
oligosaccharyltransferase 4 homolog (S. cerevisiae)
chr12_+_50794730 0.11 ENST00000523389.1
ENST00000518561.1
ENST00000347328.5
ENST00000550260.1
LARP4
La ribonucleoprotein domain family, member 4
chr3_-_156272924 0.11 ENST00000467789.1
ENST00000265044.2
SSR3
signal sequence receptor, gamma (translocon-associated protein gamma)
chr1_+_65886244 0.11 ENST00000344610.8
LEPR
leptin receptor
chr12_-_69080590 0.11 ENST00000433116.2
ENST00000500695.2
RP11-637A17.2
RP11-637A17.2
chr12_+_69080734 0.11 ENST00000378905.2
NUP107
nucleoporin 107kDa
chr12_+_10366223 0.11 ENST00000545290.1
GABARAPL1
GABA(A) receptor-associated protein like 1
chr15_-_65282274 0.11 ENST00000204566.2
SPG21
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr14_+_89029253 0.11 ENST00000251038.5
ENST00000359301.3
ENST00000302216.8
ZC3H14
zinc finger CCCH-type containing 14
chr18_+_11851383 0.10 ENST00000526991.2
CHMP1B
charged multivesicular body protein 1B
chr14_+_60716276 0.10 ENST00000528241.2
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr2_+_138721850 0.10 ENST00000329366.4
ENST00000280097.3
HNMT
histamine N-methyltransferase
chr11_+_61197508 0.10 ENST00000541135.1
ENST00000301761.2
RP11-286N22.8
SDHAF2
Uncharacterized protein
succinate dehydrogenase complex assembly factor 2
chr3_-_196669248 0.10 ENST00000447325.1
NCBP2
nuclear cap binding protein subunit 2, 20kDa
chr8_+_100025476 0.10 ENST00000355155.1
ENST00000357162.2
ENST00000358544.2
ENST00000395996.1
ENST00000441350.2
VPS13B
vacuolar protein sorting 13 homolog B (yeast)
chr21_-_36421626 0.10 ENST00000300305.3
RUNX1
runt-related transcription factor 1
chr14_+_89029866 0.10 ENST00000557693.1
ENST00000555120.1
ZC3H14
zinc finger CCCH-type containing 14
chr14_+_89029366 0.10 ENST00000555799.1
ENST00000555755.1
ENST00000393514.5
ZC3H14
zinc finger CCCH-type containing 14
chr7_-_6098770 0.10 ENST00000536084.1
ENST00000446699.1
ENST00000199389.6
EIF2AK1
eukaryotic translation initiation factor 2-alpha kinase 1
chr1_+_170501270 0.10 ENST00000367763.3
ENST00000367762.1
GORAB
golgin, RAB6-interacting
chr1_+_213224572 0.10 ENST00000543470.1
ENST00000366960.3
ENST00000366959.3
ENST00000543354.1
RPS6KC1
ribosomal protein S6 kinase, 52kDa, polypeptide 1
chr1_+_39456895 0.10 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
AKIRIN1
akirin 1
chr3_-_69101461 0.09 ENST00000543976.1
TMF1
TATA element modulatory factor 1
chr14_-_31926701 0.09 ENST00000310850.4
DTD2
D-tyrosyl-tRNA deacylase 2 (putative)
chr2_+_162165038 0.09 ENST00000437630.1
PSMD14
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
chrX_-_154299501 0.09 ENST00000369476.3
ENST00000369484.3
MTCP1
CMC4
mature T-cell proliferation 1
C-x(9)-C motif containing 4
chr12_-_48276710 0.09 ENST00000550314.1
VDR
vitamin D (1,25- dihydroxyvitamin D3) receptor
chr9_+_37753795 0.09 ENST00000377753.2
ENST00000537911.1
ENST00000377754.2
ENST00000297994.3
TRMT10B
tRNA methyltransferase 10 homolog B (S. cerevisiae)
chr8_-_101965146 0.09 ENST00000395957.2
ENST00000395948.2
ENST00000457309.1
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr8_-_124665190 0.09 ENST00000325995.7
KLHL38
kelch-like family member 38
chr2_-_128785619 0.09 ENST00000450957.1
SAP130
Sin3A-associated protein, 130kDa
chr17_-_62658186 0.09 ENST00000262435.9
SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr9_+_34458851 0.09 ENST00000545019.1
DNAI1
dynein, axonemal, intermediate chain 1
chr11_+_111957497 0.09 ENST00000375549.3
ENST00000528182.1
ENST00000528048.1
ENST00000528021.1
ENST00000526592.1
ENST00000525291.1
SDHD
succinate dehydrogenase complex, subunit D, integral membrane protein
chr8_-_56987061 0.09 ENST00000009589.3
ENST00000524349.1
ENST00000519606.1
ENST00000519807.1
ENST00000521262.1
ENST00000520627.1
RPS20
ribosomal protein S20
chr12_+_27396901 0.09 ENST00000541191.1
ENST00000389032.3
STK38L
serine/threonine kinase 38 like
chr1_+_84630645 0.09 ENST00000394839.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chrX_-_135962876 0.08 ENST00000431446.3
ENST00000570135.1
ENST00000320676.7
ENST00000562646.1
RBMX
RNA binding motif protein, X-linked
chr20_-_42839378 0.08 ENST00000255174.2
OSER1
oxidative stress responsive serine-rich 1
chr11_-_71751715 0.08 ENST00000535947.1
NUMA1
nuclear mitotic apparatus protein 1
chr18_-_55288973 0.08 ENST00000423481.2
ENST00000587194.1
ENST00000591599.1
ENST00000588661.1
NARS
asparaginyl-tRNA synthetase
chr1_+_22351977 0.08 ENST00000420503.1
ENST00000416769.1
ENST00000404210.2
LINC00339
long intergenic non-protein coding RNA 339
chr3_-_139108475 0.08 ENST00000515006.1
ENST00000513274.1
ENST00000514508.1
ENST00000507777.1
ENST00000512153.1
ENST00000333188.5
COPB2
coatomer protein complex, subunit beta 2 (beta prime)
chr14_-_64010006 0.08 ENST00000555899.1
PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr15_+_55700741 0.08 ENST00000569691.1
C15orf65
chromosome 15 open reading frame 65

Network of associatons between targets according to the STRING database.

First level regulatory network of SPDEF

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0006043 glucosamine catabolic process(GO:0006043)
0.1 1.1 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 0.6 GO:0001827 inner cell mass cell fate commitment(GO:0001827) inner cell mass cellular morphogenesis(GO:0001828)
0.1 0.6 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 0.8 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.1 0.2 GO:0003220 left ventricular cardiac muscle tissue morphogenesis(GO:0003220) cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250)
0.1 1.0 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 0.3 GO:0046833 snRNA export from nucleus(GO:0006408) positive regulation of RNA export from nucleus(GO:0046833)
0.1 0.3 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.1 0.5 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.1 0.2 GO:0033386 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.1 0.4 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.5 GO:1904382 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.1 0.5 GO:0006235 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.1 0.3 GO:0035984 response to trichostatin A(GO:0035983) cellular response to trichostatin A(GO:0035984)
0.1 0.4 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.1 0.2 GO:0035669 TRAM-dependent toll-like receptor signaling pathway(GO:0035668) TRAM-dependent toll-like receptor 4 signaling pathway(GO:0035669)
0.1 0.3 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.1 1.2 GO:0048853 forebrain morphogenesis(GO:0048853)
0.0 0.0 GO:1903423 positive regulation of synaptic vesicle endocytosis(GO:1900244) positive regulation of synaptic vesicle recycling(GO:1903423)
0.0 0.2 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.0 0.2 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.0 0.2 GO:0010166 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.0 0.2 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 0.3 GO:0035709 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.0 0.1 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.0 0.2 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.5 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0 0.1 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.0 0.1 GO:2000845 testosterone secretion(GO:0035936) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845)
0.0 0.2 GO:0016476 regulation of embryonic cell shape(GO:0016476)
0.0 0.2 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.0 0.2 GO:0051025 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.4 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.0 0.1 GO:0010979 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980) apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0 0.1 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.0 0.1 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.0 0.1 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 0.3 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.1 GO:0000915 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.0 0.5 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.1 GO:0006447 regulation of translational initiation by iron(GO:0006447)
0.0 0.1 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.0 0.1 GO:0001692 histamine metabolic process(GO:0001692)
0.0 0.2 GO:0097338 response to clozapine(GO:0097338)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.1 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.0 0.2 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 0.2 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.0 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.3 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 0.4 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.0 0.7 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.0 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.2 GO:0002315 marginal zone B cell differentiation(GO:0002315)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0034455 t-UTP complex(GO:0034455)
0.1 0.4 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.9 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.1 0.2 GO:0043614 multi-eIF complex(GO:0043614)
0.1 0.8 GO:0098839 postsynaptic density membrane(GO:0098839)
0.1 0.3 GO:0005846 nuclear cap binding complex(GO:0005846)
0.1 1.3 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 0.4 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.4 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.2 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.2 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.3 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 0.2 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.1 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.3 GO:0030478 actin cap(GO:0030478)
0.0 0.2 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.6 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.2 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.1 GO:1902560 GMP reductase complex(GO:1902560)
0.0 0.0 GO:0035101 FACT complex(GO:0035101)
0.0 0.7 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.2 GO:0034709 methylosome(GO:0034709)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:0000124 SAGA complex(GO:0000124) STAGA complex(GO:0030914)
0.0 0.3 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.1 GO:0001673 male germ cell nucleus(GO:0001673)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.2 0.8 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 1.1 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 0.4 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.1 0.3 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.1 0.3 GO:0051500 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.1 0.2 GO:0047860 diiodophenylpyruvate reductase activity(GO:0047860)
0.1 0.2 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.0 0.1 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0 0.2 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 1.0 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.3 GO:0023030 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.0 1.3 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.5 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.2 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.1 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.0 0.3 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.2 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.2 GO:0089720 caspase binding(GO:0089720)
0.0 0.7 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.2 GO:0043199 sulfate binding(GO:0043199)
0.0 0.1 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.0 0.1 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0 0.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.1 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.0 0.4 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0008318 protein prenyltransferase activity(GO:0008318)
0.0 0.2 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.0 GO:0004560 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.0 0.2 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.4 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.3 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.6 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.5 REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS Genes involved in TGF-beta receptor signaling activates SMADs
0.0 0.2 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.5 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.5 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 1.0 REACTOME RNA POL II PRE TRANSCRIPTION EVENTS Genes involved in RNA Polymerase II Pre-transcription Events