Project

A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

Navigation
Downloads

Results for SREBF2

Z-value: 0.52

Motif logo

logo of

Transcription factors associated with SREBF2

Gene Symbol Gene ID Gene Info
SREBF2
ENSG00000198911.7 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SREBF2hg19_v2_chr22_+_42229100_422291460.711.1e-01Click!

Activity profile of SREBF2 motif

Sorted Z-values of SREBF2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_159656437 0.48 ENST00000402432.3
FABP6
fatty acid binding protein 6, ileal
chr9_+_96928516 0.32 ENST00000602703.1
RP11-2B6.3
RP11-2B6.3
chr15_-_73075964 0.25 ENST00000563907.1
ADPGK
ADP-dependent glucokinase
chr2_-_26205550 0.22 ENST00000405914.1
KIF3C
kinesin family member 3C
chr13_+_24844857 0.22 ENST00000409126.1
ENST00000343003.6
SPATA13
spermatogenesis associated 13
chr5_-_149669612 0.20 ENST00000510347.1
CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr13_+_24844819 0.20 ENST00000399949.2
SPATA13
spermatogenesis associated 13
chr17_-_40075197 0.18 ENST00000590770.1
ENST00000590151.1
ACLY
ATP citrate lyase
chr1_-_42384343 0.18 ENST00000372584.1
HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr9_-_117267717 0.18 ENST00000374057.3
DFNB31
deafness, autosomal recessive 31
chr19_+_11200038 0.18 ENST00000558518.1
ENST00000557933.1
ENST00000455727.2
ENST00000535915.1
ENST00000545707.1
ENST00000558013.1
LDLR
low density lipoprotein receptor
chr6_-_39902160 0.18 ENST00000340692.5
MOCS1
molybdenum cofactor synthesis 1
chrX_-_153237258 0.17 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr11_+_65480222 0.17 ENST00000534681.1
KAT5
K(lysine) acetyltransferase 5
chr2_-_26205340 0.17 ENST00000264712.3
KIF3C
kinesin family member 3C
chrX_-_153236819 0.17 ENST00000354233.3
HCFC1
host cell factor C1 (VP16-accessory protein)
chrX_-_153236620 0.17 ENST00000369984.4
HCFC1
host cell factor C1 (VP16-accessory protein)
chr6_-_31926208 0.16 ENST00000454913.1
ENST00000436289.2
NELFE
negative elongation factor complex member E
chr6_+_41604747 0.16 ENST00000419164.1
ENST00000373051.2
MDFI
MyoD family inhibitor
chr1_-_6659876 0.16 ENST00000496707.1
KLHL21
kelch-like family member 21
chr19_-_11308190 0.16 ENST00000586659.1
ENST00000592903.1
ENST00000589359.1
ENST00000588724.1
ENST00000432929.2
KANK2
KN motif and ankyrin repeat domains 2
chr17_-_40075219 0.15 ENST00000537919.1
ENST00000352035.2
ENST00000353196.1
ENST00000393896.2
ACLY
ATP citrate lyase
chrX_+_27826107 0.15 ENST00000356790.2
MAGEB10
melanoma antigen family B, 10
chr11_+_65479462 0.14 ENST00000377046.3
ENST00000352980.4
ENST00000341318.4
KAT5
K(lysine) acetyltransferase 5
chr15_-_73076030 0.14 ENST00000311669.8
ADPGK
ADP-dependent glucokinase
chr16_+_66914264 0.14 ENST00000311765.2
ENST00000568869.1
ENST00000561704.1
ENST00000568398.1
ENST00000566776.1
PDP2
pyruvate dehyrogenase phosphatase catalytic subunit 2
chr8_+_26434578 0.13 ENST00000493789.2
DPYSL2
dihydropyrimidinase-like 2
chr22_+_42229100 0.13 ENST00000361204.4
SREBF2
sterol regulatory element binding transcription factor 2
chr20_+_58533471 0.12 ENST00000244047.5
ENST00000348616.4
CDH26
cadherin 26
chr18_-_21166841 0.12 ENST00000269228.5
NPC1
Niemann-Pick disease, type C1
chr6_+_79577189 0.12 ENST00000369940.2
IRAK1BP1
interleukin-1 receptor-associated kinase 1 binding protein 1
chr1_+_39796810 0.12 ENST00000289893.4
MACF1
microtubule-actin crosslinking factor 1
chr6_+_151561085 0.12 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr1_+_55505184 0.12 ENST00000302118.5
PCSK9
proprotein convertase subtilisin/kexin type 9
chr17_-_73257667 0.12 ENST00000538886.1
ENST00000580799.1
ENST00000351904.7
ENST00000537686.1
GGA3
golgi-associated, gamma adaptin ear containing, ARF binding protein 3
chr3_-_16554403 0.11 ENST00000449415.1
ENST00000441460.1
RFTN1
raftlin, lipid raft linker 1
chr11_+_65479702 0.11 ENST00000530446.1
ENST00000534104.1
ENST00000530605.1
ENST00000528198.1
ENST00000531880.1
ENST00000534650.1
KAT5
K(lysine) acetyltransferase 5
chr20_+_33464368 0.10 ENST00000484354.1
ENST00000493805.2
ENST00000473172.1
ACSS2
acyl-CoA synthetase short-chain family member 2
chr5_+_137774706 0.10 ENST00000378339.2
ENST00000254901.5
ENST00000506158.1
REEP2
receptor accessory protein 2
chr19_-_18392422 0.10 ENST00000252818.3
JUND
jun D proto-oncogene
chr19_+_36266417 0.10 ENST00000378944.5
ENST00000007510.4
ARHGAP33
Rho GTPase activating protein 33
chr5_-_149535421 0.10 ENST00000261799.4
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr11_-_73309228 0.09 ENST00000356467.4
ENST00000064778.4
FAM168A
family with sequence similarity 168, member A
chr12_-_53343560 0.09 ENST00000548998.1
KRT8
keratin 8
chr12_-_53343633 0.09 ENST00000546826.1
KRT8
keratin 8
chr11_+_65383227 0.09 ENST00000355703.3
PCNXL3
pecanex-like 3 (Drosophila)
chr2_+_120517717 0.09 ENST00000420482.1
ENST00000488279.2
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr14_-_74959978 0.08 ENST00000541064.1
NPC2
Niemann-Pick disease, type C2
chr1_+_206643787 0.08 ENST00000367120.3
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr11_+_2923499 0.08 ENST00000449793.2
SLC22A18
solute carrier family 22, member 18
chr13_+_24844979 0.08 ENST00000454083.1
SPATA13
spermatogenesis associated 13
chr10_-_3827371 0.07 ENST00000469435.1
KLF6
Kruppel-like factor 6
chr12_-_53343602 0.07 ENST00000546897.1
ENST00000552551.1
KRT8
keratin 8
chr17_-_17726907 0.07 ENST00000423161.3
SREBF1
sterol regulatory element binding transcription factor 1
chr19_+_38664224 0.07 ENST00000601054.1
SIPA1L3
signal-induced proliferation-associated 1 like 3
chr19_-_46285646 0.07 ENST00000458663.2
DMPK
dystrophia myotonica-protein kinase
chr19_+_36266433 0.07 ENST00000314737.5
ARHGAP33
Rho GTPase activating protein 33
chr1_+_33219592 0.07 ENST00000373481.3
KIAA1522
KIAA1522
chr16_+_50187556 0.07 ENST00000561678.1
ENST00000357464.3
PAPD5
PAP associated domain containing 5
chr19_-_46285736 0.07 ENST00000291270.4
ENST00000447742.2
ENST00000354227.5
DMPK
dystrophia myotonica-protein kinase
chrX_-_112084043 0.06 ENST00000304758.1
AMOT
angiomotin
chr3_+_5020801 0.06 ENST00000256495.3
BHLHE40
basic helix-loop-helix family, member e40
chr11_+_2923423 0.06 ENST00000312221.5
SLC22A18
solute carrier family 22, member 18
chr10_-_3827417 0.05 ENST00000497571.1
ENST00000542957.1
KLF6
Kruppel-like factor 6
chrX_+_47229982 0.05 ENST00000377073.3
ZNF157
zinc finger protein 157
chr14_-_74960030 0.05 ENST00000553490.1
ENST00000557510.1
NPC2
Niemann-Pick disease, type C2
chr14_-_74959994 0.04 ENST00000238633.2
ENST00000434013.2
NPC2
Niemann-Pick disease, type C2
chr2_+_232573222 0.04 ENST00000341369.7
ENST00000409683.1
PTMA
prothymosin, alpha
chr19_-_55791058 0.04 ENST00000587959.1
ENST00000585927.1
ENST00000587922.1
ENST00000585698.1
HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr6_-_32151999 0.03 ENST00000375069.3
ENST00000538695.1
ENST00000438221.2
ENST00000375065.5
ENST00000450110.1
ENST00000375067.3
ENST00000375056.2
AGER
advanced glycosylation end product-specific receptor
chr5_-_139283982 0.03 ENST00000340391.3
NRG2
neuregulin 2
chr20_+_33464238 0.03 ENST00000360596.2
ACSS2
acyl-CoA synthetase short-chain family member 2
chr20_+_33464407 0.03 ENST00000253382.5
ACSS2
acyl-CoA synthetase short-chain family member 2
chr14_+_74960423 0.03 ENST00000556816.1
ENST00000298818.8
ENST00000554924.1
ISCA2
iron-sulfur cluster assembly 2
chr1_+_206643806 0.03 ENST00000537984.1
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr6_+_43968306 0.03 ENST00000442114.2
ENST00000336600.5
ENST00000439969.2
C6orf223
chromosome 6 open reading frame 223
chrX_-_103087136 0.03 ENST00000243298.2
RAB9B
RAB9B, member RAS oncogene family
chr2_+_27435734 0.03 ENST00000419744.1
ATRAID
all-trans retinoic acid-induced differentiation factor
chr8_+_26435359 0.03 ENST00000311151.5
DPYSL2
dihydropyrimidinase-like 2
chr1_-_155232221 0.02 ENST00000355379.3
SCAMP3
secretory carrier membrane protein 3
chr2_+_232573208 0.02 ENST00000409115.3
PTMA
prothymosin, alpha
chr11_+_2923619 0.02 ENST00000380574.1
SLC22A18
solute carrier family 22, member 18
chr3_+_46742823 0.02 ENST00000326431.3
TMIE
transmembrane inner ear
chr10_-_116444371 0.02 ENST00000533213.2
ENST00000369252.4
ABLIM1
actin binding LIM protein 1
chr2_+_232572361 0.01 ENST00000409321.1
PTMA
prothymosin, alpha
chr17_-_15168624 0.01 ENST00000312280.3
ENST00000494511.1
ENST00000580584.1
PMP22
peripheral myelin protein 22
chr11_-_73309112 0.01 ENST00000450446.2
FAM168A
family with sequence similarity 168, member A
chr17_-_56065484 0.01 ENST00000581208.1
VEZF1
vascular endothelial zinc finger 1
chr6_+_41604620 0.01 ENST00000432027.1
MDFI
MyoD family inhibitor
chr17_+_73257742 0.01 ENST00000579761.1
ENST00000245539.6
MRPS7
mitochondrial ribosomal protein S7
chr4_+_718896 0.00 ENST00000433814.1
PCGF3
polycomb group ring finger 3

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0019046 release from viral latency(GO:0019046)
0.1 0.2 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.2 GO:1903979 negative regulation of microglial cell activation(GO:1903979)
0.0 0.1 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.0 0.1 GO:1905051 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.0 0.2 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747)
0.0 0.1 GO:0060981 cell migration involved in coronary angiogenesis(GO:0060981)
0.0 0.2 GO:0019541 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.0 0.1 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.0 0.1 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.1 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.0 0.2 GO:0046618 drug export(GO:0046618)
0.0 0.5 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.0 0.2 GO:0019720 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.0 0.3 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.0 0.4 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.0 0.1 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.5 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.2 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 0.2 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.0 0.1 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0009346 citrate lyase complex(GO:0009346)
0.1 0.3 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.1 0.2 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.0 0.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.2 GO:0032021 NELF complex(GO:0032021)
0.0 0.5 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.2 GO:0005827 polar microtubule(GO:0005827)
0.0 0.1 GO:0035976 AP1 complex(GO:0035976)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0003878 ATP citrate synthase activity(GO:0003878)
0.0 0.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.5 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.5 GO:0032052 bile acid binding(GO:0032052)
0.0 0.1 GO:0070326 very-low-density lipoprotein particle binding(GO:0034189) very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0 0.2 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.0 0.2 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0005019 platelet-derived growth factor beta-receptor activity(GO:0005019)
0.0 0.1 GO:0008384 IkappaB kinase activity(GO:0008384) K48-linked polyubiquitin binding(GO:0036435)
0.0 0.1 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation