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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TBX20

Z-value: 0.44

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Transcription factors associated with TBX20

Gene Symbol Gene ID Gene Info
TBX20
ENSG00000164532.10 T-box transcription factor 20

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX20hg19_v2_chr7_-_35293740_35293758-0.542.7e-01Click!

Activity profile of TBX20 motif

Sorted Z-values of TBX20 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_142264664 0.42 ENST00000518520.1
RP11-10J21.3
Uncharacterized protein
chr16_+_57662419 0.28 ENST00000388812.4
ENST00000538815.1
ENST00000456916.1
ENST00000567154.1
ENST00000388813.5
ENST00000562558.1
ENST00000566271.2
GPR56
G protein-coupled receptor 56
chr5_+_6448736 0.22 ENST00000399816.3
UBE2QL1
ubiquitin-conjugating enzyme E2Q family-like 1
chr2_+_64068116 0.18 ENST00000480679.1
UGP2
UDP-glucose pyrophosphorylase 2
chr3_+_40428647 0.17 ENST00000301825.3
ENST00000439533.1
ENST00000456402.1
ENTPD3
ectonucleoside triphosphate diphosphohydrolase 3
chr16_+_57662527 0.16 ENST00000563374.1
ENST00000568234.1
ENST00000565770.1
ENST00000564338.1
ENST00000566164.1
GPR56
G protein-coupled receptor 56
chr2_+_207630081 0.15 ENST00000236980.6
ENST00000418289.1
ENST00000402774.3
ENST00000403094.3
FASTKD2
FAST kinase domains 2
chr19_+_35810164 0.14 ENST00000598537.1
CD22
CD22 molecule
chr2_+_176972000 0.12 ENST00000249504.5
HOXD11
homeobox D11
chrX_+_67913471 0.11 ENST00000374597.3
STARD8
StAR-related lipid transfer (START) domain containing 8
chr2_+_61108650 0.11 ENST00000295025.8
REL
v-rel avian reticuloendotheliosis viral oncogene homolog
chr6_-_84937314 0.11 ENST00000257766.4
ENST00000403245.3
KIAA1009
KIAA1009
chr3_-_139396853 0.10 ENST00000406164.1
ENST00000406824.1
NMNAT3
nicotinamide nucleotide adenylyltransferase 3
chr22_+_38219389 0.09 ENST00000249041.2
GALR3
galanin receptor 3
chr20_-_48782639 0.08 ENST00000435301.2
RP11-112L6.3
RP11-112L6.3
chr5_-_89825328 0.08 ENST00000500869.2
ENST00000315948.6
ENST00000509384.1
LYSMD3
LysM, putative peptidoglycan-binding, domain containing 3
chr9_-_72287191 0.08 ENST00000265381.4
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr19_+_7745708 0.07 ENST00000596148.1
ENST00000317378.5
ENST00000426877.2
TRAPPC5
trafficking protein particle complex 5
chr19_+_17579556 0.07 ENST00000442725.1
SLC27A1
solute carrier family 27 (fatty acid transporter), member 1
chr3_-_131221771 0.07 ENST00000510154.1
ENST00000507669.1
MRPL3
mitochondrial ribosomal protein L3
chr2_-_207629997 0.07 ENST00000454776.2
MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr11_-_64703354 0.06 ENST00000532246.1
ENST00000279168.2
GPHA2
glycoprotein hormone alpha 2
chr16_+_31044812 0.06 ENST00000313843.3
STX4
syntaxin 4
chr12_+_15475462 0.06 ENST00000543886.1
ENST00000348962.2
PTPRO
protein tyrosine phosphatase, receptor type, O
chr2_+_85360499 0.06 ENST00000282111.3
TCF7L1
transcription factor 7-like 1 (T-cell specific, HMG-box)
chr2_+_64068074 0.06 ENST00000394417.2
ENST00000484142.1
ENST00000482668.1
ENST00000467648.2
UGP2
UDP-glucose pyrophosphorylase 2
chr1_-_11865982 0.06 ENST00000418034.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr19_-_4540486 0.06 ENST00000306390.6
LRG1
leucine-rich alpha-2-glycoprotein 1
chr11_-_14358620 0.06 ENST00000531421.1
RRAS2
related RAS viral (r-ras) oncogene homolog 2
chr1_+_147013182 0.06 ENST00000234739.3
BCL9
B-cell CLL/lymphoma 9
chr7_+_30185406 0.06 ENST00000324489.5
C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr3_-_139396801 0.06 ENST00000413939.2
ENST00000339837.5
ENST00000512391.1
NMNAT3
nicotinamide nucleotide adenylyltransferase 3
chr4_+_160025300 0.06 ENST00000505478.1
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr2_-_207630033 0.06 ENST00000449792.1
MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr3_-_131221790 0.05 ENST00000512877.1
ENST00000264995.3
ENST00000511168.1
ENST00000425847.2
MRPL3
mitochondrial ribosomal protein L3
chr13_+_113655584 0.05 ENST00000409954.2
MCF2L
MCF.2 cell line derived transforming sequence-like
chr12_-_121476750 0.05 ENST00000543677.1
OASL
2'-5'-oligoadenylate synthetase-like
chr19_+_46171464 0.05 ENST00000590918.1
ENST00000263281.3
ENST00000304207.8
GIPR
gastric inhibitory polypeptide receptor
chr2_-_219134822 0.05 ENST00000444053.1
ENST00000248450.4
AAMP
angio-associated, migratory cell protein
chr22_-_46283597 0.05 ENST00000451118.1
WI2-85898F10.1
WI2-85898F10.1
chr2_-_219134343 0.04 ENST00000447885.1
ENST00000420660.1
AAMP
angio-associated, migratory cell protein
chr10_-_56561022 0.04 ENST00000373965.2
ENST00000414778.1
ENST00000395438.1
ENST00000409834.1
ENST00000395445.1
ENST00000395446.1
ENST00000395442.1
ENST00000395440.1
ENST00000395432.2
ENST00000361849.3
ENST00000395433.1
ENST00000320301.6
ENST00000395430.1
ENST00000437009.1
PCDH15
protocadherin-related 15
chr7_+_30185496 0.04 ENST00000455738.1
C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr14_+_77228532 0.03 ENST00000167106.4
ENST00000554237.1
VASH1
vasohibin 1
chr15_-_74504560 0.03 ENST00000449139.2
STRA6
stimulated by retinoic acid 6
chr19_-_37958318 0.03 ENST00000316950.6
ENST00000591710.1
ZNF569
zinc finger protein 569
chr19_-_10213335 0.03 ENST00000592641.1
ENST00000253109.4
ANGPTL6
angiopoietin-like 6
chr15_-_74504597 0.03 ENST00000416286.3
STRA6
stimulated by retinoic acid 6
chr17_-_3599696 0.03 ENST00000225328.5
P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr12_+_15475331 0.03 ENST00000281171.4
PTPRO
protein tyrosine phosphatase, receptor type, O
chr19_-_9325542 0.02 ENST00000308682.2
OR7D4
olfactory receptor, family 7, subfamily D, member 4
chr17_-_76824975 0.02 ENST00000586066.2
USP36
ubiquitin specific peptidase 36
chr10_+_88414338 0.02 ENST00000241891.5
ENST00000443292.1
OPN4
opsin 4
chr1_+_110655050 0.02 ENST00000334179.3
UBL4B
ubiquitin-like 4B
chr15_+_74421961 0.02 ENST00000565159.1
ENST00000567206.1
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr6_-_107077347 0.02 ENST00000369063.3
ENST00000539449.1
RTN4IP1
reticulon 4 interacting protein 1
chr3_-_183273477 0.02 ENST00000341319.3
KLHL6
kelch-like family member 6
chr5_+_135394840 0.02 ENST00000503087.1
TGFBI
transforming growth factor, beta-induced, 68kDa
chr15_-_38519066 0.01 ENST00000561320.1
ENST00000561161.1
RP11-346D14.1
RP11-346D14.1
chr5_+_133861339 0.01 ENST00000282605.4
ENST00000361895.2
ENST00000402835.1
PHF15
jade family PHD finger 2
chr10_+_88414298 0.01 ENST00000372071.2
OPN4
opsin 4
chr2_+_61108771 0.01 ENST00000394479.3
REL
v-rel avian reticuloendotheliosis viral oncogene homolog
chr10_+_114135004 0.01 ENST00000393081.1
ACSL5
acyl-CoA synthetase long-chain family member 5
chr8_+_27182862 0.01 ENST00000521164.1
ENST00000346049.5
PTK2B
protein tyrosine kinase 2 beta
chr12_-_16762971 0.01 ENST00000540590.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr11_+_15136462 0.01 ENST00000379556.3
ENST00000424273.1
INSC
inscuteable homolog (Drosophila)
chr12_-_16762802 0.01 ENST00000534946.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_-_154909329 0.00 ENST00000368467.3
PMVK
phosphomevalonate kinase
chr3_-_50396978 0.00 ENST00000266025.3
TMEM115
transmembrane protein 115
chr10_-_131762105 0.00 ENST00000368648.3
ENST00000355311.5
EBF3
early B-cell factor 3

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX20

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.1 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.2 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.2 GO:0034628 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.0 0.1 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.0 0.1 GO:0043311 regulation of eosinophil degranulation(GO:0043309) positive regulation of eosinophil degranulation(GO:0043311) regulation of eosinophil activation(GO:1902566) positive regulation of eosinophil activation(GO:1902568)
0.0 0.2 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.0 0.1 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.0 0.2 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
0.0 0.1 GO:0031531 thyrotropin-releasing hormone receptor binding(GO:0031531)
0.0 0.1 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.1 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.0 0.1 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.1 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)