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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TBX5

Z-value: 0.76

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Transcription factors associated with TBX5

Gene Symbol Gene ID Gene Info
TBX5
ENSG00000089225.15 T-box transcription factor 5

Activity profile of TBX5 motif

Sorted Z-values of TBX5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_46526304 0.47 ENST00000008938.4
PGLYRP1
peptidoglycan recognition protein 1
chr3_+_167453493 0.41 ENST00000295777.5
ENST00000472747.2
SERPINI1
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chrX_-_80377118 0.39 ENST00000373250.3
HMGN5
high mobility group nucleosome binding domain 5
chr11_+_117947724 0.39 ENST00000534111.1
TMPRSS4
transmembrane protease, serine 4
chr19_-_39108568 0.39 ENST00000586296.1
MAP4K1
mitogen-activated protein kinase kinase kinase kinase 1
chr3_-_52719888 0.38 ENST00000458294.1
PBRM1
polybromo 1
chr15_-_55581954 0.33 ENST00000336787.1
RAB27A
RAB27A, member RAS oncogene family
chr11_-_125932685 0.33 ENST00000527967.1
CDON
cell adhesion associated, oncogene regulated
chr21_+_17214724 0.33 ENST00000449491.1
USP25
ubiquitin specific peptidase 25
chr16_-_31454346 0.32 ENST00000564218.1
ENST00000315678.5
ZNF843
zinc finger protein 843
chr9_+_96717821 0.30 ENST00000454594.1
RP11-231K24.2
RP11-231K24.2
chr2_-_191878874 0.29 ENST00000392322.3
ENST00000392323.2
ENST00000424722.1
ENST00000361099.3
STAT1
signal transducer and activator of transcription 1, 91kDa
chr17_-_42188598 0.29 ENST00000591714.1
HDAC5
histone deacetylase 5
chrX_-_80377162 0.29 ENST00000430960.1
ENST00000447319.1
HMGN5
high mobility group nucleosome binding domain 5
chr6_-_26027480 0.28 ENST00000377364.3
HIST1H4B
histone cluster 1, H4b
chr5_-_74348371 0.28 ENST00000503568.1
RP11-229C3.2
RP11-229C3.2
chr19_-_39108643 0.27 ENST00000396857.2
MAP4K1
mitogen-activated protein kinase kinase kinase kinase 1
chr2_-_169769787 0.26 ENST00000451987.1
SPC25
SPC25, NDC80 kinetochore complex component
chr3_-_182703688 0.24 ENST00000466812.1
ENST00000487822.1
ENST00000460412.1
ENST00000469954.1
DCUN1D1
DCN1, defective in cullin neddylation 1, domain containing 1
chr17_+_68164752 0.24 ENST00000535240.1
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr12_+_8849773 0.24 ENST00000541044.1
RIMKLB
ribosomal modification protein rimK-like family member B
chr15_+_85427879 0.24 ENST00000338602.2
ENST00000537216.1
ENST00000538177.1
ENST00000537624.1
SLC28A1
solute carrier family 28 (concentrative nucleoside transporter), member 1
chr8_+_87111059 0.23 ENST00000285393.3
ATP6V0D2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr6_-_72130472 0.23 ENST00000426635.2
LINC00472
long intergenic non-protein coding RNA 472
chr18_-_60985914 0.22 ENST00000589955.1
BCL2
B-cell CLL/lymphoma 2
chrX_-_119693745 0.21 ENST00000371323.2
CUL4B
cullin 4B
chr13_-_48575376 0.21 ENST00000434484.1
SUCLA2
succinate-CoA ligase, ADP-forming, beta subunit
chr2_+_95963052 0.21 ENST00000295225.5
KCNIP3
Kv channel interacting protein 3, calsenilin
chr7_+_107220660 0.20 ENST00000465919.1
ENST00000445771.2
ENST00000479917.1
ENST00000421217.1
ENST00000457837.1
BCAP29
B-cell receptor-associated protein 29
chr11_+_34643600 0.19 ENST00000530286.1
ENST00000533754.1
EHF
ets homologous factor
chr19_-_45826125 0.19 ENST00000221476.3
CKM
creatine kinase, muscle
chr2_+_103089756 0.19 ENST00000295269.4
SLC9A4
solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
chr1_+_155911480 0.19 ENST00000368318.3
RXFP4
relaxin/insulin-like family peptide receptor 4
chr5_+_66124590 0.19 ENST00000490016.2
ENST00000403666.1
ENST00000450827.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr3_+_38035610 0.19 ENST00000465644.1
VILL
villin-like
chr11_+_73358594 0.19 ENST00000227214.6
ENST00000398494.4
ENST00000543085.1
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr17_+_68165657 0.19 ENST00000243457.3
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr20_+_34020827 0.18 ENST00000374375.1
GDF5OS
growth differentiation factor 5 opposite strand
chr2_+_234601512 0.18 ENST00000305139.6
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr17_+_30814707 0.18 ENST00000584792.1
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr3_-_61237050 0.18 ENST00000476844.1
ENST00000488467.1
ENST00000492590.1
ENST00000468189.1
FHIT
fragile histidine triad
chr2_+_101223490 0.18 ENST00000414647.1
ENST00000424342.1
AC068538.4
AC068538.4
chr6_+_122931366 0.18 ENST00000368452.2
ENST00000368448.1
ENST00000392490.1
PKIB
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr14_+_24600484 0.18 ENST00000267426.5
FITM1
fat storage-inducing transmembrane protein 1
chr8_-_145060593 0.18 ENST00000313059.5
ENST00000524918.1
ENST00000313028.7
ENST00000525773.1
PARP10
poly (ADP-ribose) polymerase family, member 10
chr15_+_89182156 0.18 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chrX_+_16804544 0.17 ENST00000380122.5
ENST00000398155.4
TXLNG
taxilin gamma
chr13_-_60738003 0.17 ENST00000400330.1
ENST00000400324.4
DIAPH3
diaphanous-related formin 3
chr12_+_8850277 0.17 ENST00000539923.1
ENST00000537189.1
RIMKLB
ribosomal modification protein rimK-like family member B
chr14_+_90864504 0.17 ENST00000544280.2
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr17_+_9066252 0.17 ENST00000436734.1
NTN1
netrin 1
chr4_-_4249924 0.17 ENST00000254742.2
ENST00000382753.4
ENST00000540397.1
ENST00000538516.1
TMEM128
transmembrane protein 128
chr4_-_142199943 0.17 ENST00000514347.1
RP11-586L23.1
RP11-586L23.1
chr2_-_219925189 0.17 ENST00000295731.6
IHH
indian hedgehog
chr4_+_81118647 0.17 ENST00000415738.2
PRDM8
PR domain containing 8
chr8_-_95907423 0.16 ENST00000396133.3
ENST00000308108.4
CCNE2
cyclin E2
chr7_+_100450328 0.16 ENST00000540482.1
ENST00000418037.1
ENST00000428758.1
ENST00000275729.3
ENST00000415287.1
ENST00000354161.3
ENST00000416675.1
SLC12A9
solute carrier family 12, member 9
chr2_+_201676908 0.16 ENST00000409226.1
ENST00000452790.2
BZW1
basic leucine zipper and W2 domains 1
chr12_+_54519842 0.16 ENST00000508564.1
RP11-834C11.4
RP11-834C11.4
chr1_+_113009163 0.16 ENST00000256640.5
WNT2B
wingless-type MMTV integration site family, member 2B
chr7_+_30951461 0.16 ENST00000311813.4
AQP1
aquaporin 1 (Colton blood group)
chr11_+_6260298 0.16 ENST00000379936.2
CNGA4
cyclic nucleotide gated channel alpha 4
chr8_+_26149007 0.16 ENST00000380737.3
ENST00000524169.1
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr5_-_55290773 0.16 ENST00000502326.3
ENST00000381298.2
IL6ST
interleukin 6 signal transducer (gp130, oncostatin M receptor)
chr2_+_64068074 0.16 ENST00000394417.2
ENST00000484142.1
ENST00000482668.1
ENST00000467648.2
UGP2
UDP-glucose pyrophosphorylase 2
chr8_-_99954788 0.15 ENST00000523601.1
STK3
serine/threonine kinase 3
chr2_-_175869936 0.15 ENST00000409900.3
CHN1
chimerin 1
chr17_-_74533963 0.15 ENST00000293230.5
CYGB
cytoglobin
chr3_-_47205066 0.15 ENST00000412450.1
SETD2
SET domain containing 2
chr5_+_56469843 0.15 ENST00000514387.2
GPBP1
GC-rich promoter binding protein 1
chr12_+_51818555 0.15 ENST00000453097.2
SLC4A8
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr19_+_53761545 0.15 ENST00000341702.3
VN1R2
vomeronasal 1 receptor 2
chr1_-_85930246 0.15 ENST00000426972.3
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr1_+_35734562 0.15 ENST00000314607.6
ENST00000373297.2
ZMYM4
zinc finger, MYM-type 4
chr13_-_34250861 0.15 ENST00000445227.1
ENST00000454681.2
RP11-141M1.3
RP11-141M1.3
chr1_-_15735925 0.15 ENST00000427824.1
RP3-467K16.4
RP3-467K16.4
chr13_+_33160553 0.15 ENST00000315596.10
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr4_+_140222609 0.15 ENST00000296543.5
ENST00000398947.1
NAA15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr14_+_103573853 0.15 ENST00000560304.1
EXOC3L4
exocyst complex component 3-like 4
chr9_-_6015607 0.15 ENST00000259569.5
RANBP6
RAN binding protein 6
chr1_+_26737253 0.14 ENST00000326279.6
LIN28A
lin-28 homolog A (C. elegans)
chr5_-_114515734 0.14 ENST00000514154.1
ENST00000282369.3
TRIM36
tripartite motif containing 36
chr14_+_53196872 0.14 ENST00000442123.2
ENST00000354586.4
STYX
serine/threonine/tyrosine interacting protein
chr17_-_72968837 0.14 ENST00000581676.1
HID1
HID1 domain containing
chr22_-_30662828 0.14 ENST00000403463.1
ENST00000215781.2
OSM
oncostatin M
chr2_+_201676256 0.14 ENST00000452206.1
ENST00000410110.2
ENST00000409600.1
BZW1
basic leucine zipper and W2 domains 1
chr9_-_99381660 0.14 ENST00000375240.3
ENST00000463569.1
CDC14B
cell division cycle 14B
chr14_-_45603657 0.14 ENST00000396062.3
FKBP3
FK506 binding protein 3, 25kDa
chr11_+_114310237 0.14 ENST00000539119.1
REXO2
RNA exonuclease 2
chr11_+_119019722 0.14 ENST00000307417.3
ABCG4
ATP-binding cassette, sub-family G (WHITE), member 4
chr1_+_97187318 0.14 ENST00000609116.1
ENST00000370198.1
ENST00000370197.1
ENST00000426398.2
ENST00000394184.3
PTBP2
polypyrimidine tract binding protein 2
chr19_+_18723660 0.13 ENST00000262817.3
TMEM59L
transmembrane protein 59-like
chr17_-_46507567 0.13 ENST00000584924.1
SKAP1
src kinase associated phosphoprotein 1
chr13_-_60737898 0.13 ENST00000377908.2
ENST00000400319.1
ENST00000400320.1
ENST00000267215.4
DIAPH3
diaphanous-related formin 3
chr5_+_150040403 0.13 ENST00000517768.1
ENST00000297130.4
MYOZ3
myozenin 3
chr2_+_46926048 0.13 ENST00000306503.5
SOCS5
suppressor of cytokine signaling 5
chr14_+_75746781 0.13 ENST00000555347.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chrX_-_109561294 0.13 ENST00000372059.2
ENST00000262844.5
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr15_-_71055769 0.13 ENST00000539319.1
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr14_+_75745477 0.13 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr5_-_145562147 0.12 ENST00000545646.1
ENST00000274562.9
ENST00000510191.1
ENST00000394434.2
LARS
leucyl-tRNA synthetase
chr4_-_69111401 0.12 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr19_-_10213335 0.12 ENST00000592641.1
ENST00000253109.4
ANGPTL6
angiopoietin-like 6
chr5_+_56469939 0.12 ENST00000506184.2
GPBP1
GC-rich promoter binding protein 1
chr9_-_98784042 0.12 ENST00000412122.2
LINC00092
long intergenic non-protein coding RNA 92
chr17_-_8059638 0.12 ENST00000584202.1
ENST00000354903.5
ENST00000577253.1
PER1
period circadian clock 1
chr1_+_26737292 0.12 ENST00000254231.4
LIN28A
lin-28 homolog A (C. elegans)
chr11_+_46402297 0.12 ENST00000405308.2
MDK
midkine (neurite growth-promoting factor 2)
chr2_+_189156638 0.12 ENST00000410051.1
GULP1
GULP, engulfment adaptor PTB domain containing 1
chr14_+_21525981 0.12 ENST00000308227.2
RNASE8
ribonuclease, RNase A family, 8
chr3_-_101232019 0.12 ENST00000394095.2
ENST00000394091.1
ENST00000394094.2
ENST00000358203.3
ENST00000348610.3
ENST00000314261.7
SENP7
SUMO1/sentrin specific peptidase 7
chr19_+_46531127 0.12 ENST00000601033.1
CTC-344H19.4
CTC-344H19.4
chr11_-_2170786 0.12 ENST00000300632.5
IGF2
insulin-like growth factor 2 (somatomedin A)
chr19_+_54385439 0.12 ENST00000536044.1
ENST00000540413.1
ENST00000263431.3
ENST00000419486.1
PRKCG
protein kinase C, gamma
chr21_+_38445539 0.11 ENST00000418766.1
ENST00000450533.1
ENST00000438055.1
ENST00000355666.1
ENST00000540756.1
ENST00000399010.1
TTC3
tetratricopeptide repeat domain 3
chr7_+_143318020 0.11 ENST00000444908.2
ENST00000518791.1
ENST00000411497.2
FAM115C
family with sequence similarity 115, member C
chr11_-_85779971 0.11 ENST00000393346.3
PICALM
phosphatidylinositol binding clathrin assembly protein
chr6_+_150464155 0.11 ENST00000361131.4
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr5_+_56469775 0.11 ENST00000424459.3
GPBP1
GC-rich promoter binding protein 1
chr13_-_52027134 0.11 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
INTS6
integrator complex subunit 6
chr13_-_99404875 0.11 ENST00000376503.5
SLC15A1
solute carrier family 15 (oligopeptide transporter), member 1
chr7_+_40174565 0.11 ENST00000309930.5
ENST00000401647.2
ENST00000335693.4
ENST00000413931.1
ENST00000416370.1
ENST00000540834.1
C7orf10
succinylCoA:glutarate-CoA transferase
chr19_-_4302375 0.11 ENST00000600114.1
ENST00000600349.1
ENST00000595645.1
ENST00000301272.2
TMIGD2
transmembrane and immunoglobulin domain containing 2
chr1_+_147013182 0.11 ENST00000234739.3
BCL9
B-cell CLL/lymphoma 9
chr17_+_37894179 0.11 ENST00000577695.1
ENST00000309156.4
ENST00000309185.3
GRB7
growth factor receptor-bound protein 7
chr9_+_129097479 0.11 ENST00000402437.2
MVB12B
multivesicular body subunit 12B
chr5_-_180229791 0.11 ENST00000504671.1
ENST00000507384.1
MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr2_+_109065634 0.11 ENST00000409821.1
GCC2
GRIP and coiled-coil domain containing 2
chr16_+_777118 0.11 ENST00000562141.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr8_-_21988558 0.11 ENST00000312841.8
HR
hair growth associated
chr8_+_96037205 0.11 ENST00000396124.4
NDUFAF6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr17_+_37821593 0.10 ENST00000578283.1
TCAP
titin-cap
chr16_+_68573640 0.10 ENST00000398253.2
ENST00000573161.1
ZFP90
ZFP90 zinc finger protein
chr3_-_197024394 0.10 ENST00000434148.1
ENST00000412364.2
ENST00000436682.1
ENST00000456699.2
ENST00000392380.2
DLG1
discs, large homolog 1 (Drosophila)
chr19_+_51376505 0.10 ENST00000325321.3
ENST00000600690.1
ENST00000391810.2
ENST00000358049.4
KLK2
kallikrein-related peptidase 2
chr20_+_57875457 0.10 ENST00000337938.2
ENST00000311585.7
ENST00000371028.2
EDN3
endothelin 3
chr18_+_52495426 0.10 ENST00000262094.5
RAB27B
RAB27B, member RAS oncogene family
chr22_-_38539185 0.10 ENST00000452542.1
PLA2G6
phospholipase A2, group VI (cytosolic, calcium-independent)
chr5_+_32712363 0.10 ENST00000507141.1
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr7_+_86974974 0.10 ENST00000419147.2
CROT
carnitine O-octanoyltransferase
chr17_-_46507537 0.10 ENST00000336915.6
SKAP1
src kinase associated phosphoprotein 1
chr2_-_61697862 0.10 ENST00000398571.2
USP34
ubiquitin specific peptidase 34
chr2_+_154728426 0.10 ENST00000392825.3
ENST00000434213.1
GALNT13
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)
chr17_+_8316442 0.10 ENST00000582812.1
NDEL1
nudE neurodevelopment protein 1-like 1
chr17_+_44668387 0.10 ENST00000576040.1
NSF
N-ethylmaleimide-sensitive factor
chr14_+_96858433 0.10 ENST00000267584.4
AK7
adenylate kinase 7
chr4_-_82136114 0.10 ENST00000395578.1
ENST00000418486.2
PRKG2
protein kinase, cGMP-dependent, type II
chr22_+_38597889 0.10 ENST00000338483.2
ENST00000538320.1
ENST00000538999.1
ENST00000441709.1
MAFF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
chr14_+_50065376 0.10 ENST00000298288.6
LRR1
leucine rich repeat protein 1
chr20_+_57209828 0.10 ENST00000598340.1
MGC4294
HCG1785561; MGC4294 protein; Uncharacterized protein
chr8_-_144654918 0.10 ENST00000529971.1
MROH6
maestro heat-like repeat family member 6
chr13_+_78109804 0.10 ENST00000535157.1
SCEL
sciellin
chr16_+_31120429 0.10 ENST00000484226.2
BCKDK
branched chain ketoacid dehydrogenase kinase
chrX_-_134049233 0.09 ENST00000370779.4
MOSPD1
motile sperm domain containing 1
chr2_-_161350305 0.09 ENST00000348849.3
RBMS1
RNA binding motif, single stranded interacting protein 1
chr17_+_77681075 0.09 ENST00000397549.2
CTD-2116F7.1
CTD-2116F7.1
chr6_+_121756809 0.09 ENST00000282561.3
GJA1
gap junction protein, alpha 1, 43kDa
chr5_-_176936844 0.09 ENST00000510380.1
ENST00000510898.1
ENST00000357198.4
DOK3
docking protein 3
chr11_-_57479673 0.09 ENST00000337672.2
ENST00000431606.2
MED19
mediator complex subunit 19
chr1_+_154975258 0.09 ENST00000417934.2
ZBTB7B
zinc finger and BTB domain containing 7B
chr2_+_153191706 0.09 ENST00000288670.9
FMNL2
formin-like 2
chr2_-_85895295 0.09 ENST00000428225.1
ENST00000519937.2
SFTPB
surfactant protein B
chr19_+_17862274 0.09 ENST00000596536.1
ENST00000593870.1
ENST00000598086.1
ENST00000598932.1
ENST00000595023.1
ENST00000594068.1
ENST00000596507.1
ENST00000595033.1
ENST00000597718.1
FCHO1
FCH domain only 1
chr12_+_12764773 0.09 ENST00000228865.2
CREBL2
cAMP responsive element binding protein-like 2
chr15_-_71055878 0.09 ENST00000322954.6
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr22_+_23412479 0.09 ENST00000248996.4
GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr19_-_39108552 0.09 ENST00000591517.1
MAP4K1
mitogen-activated protein kinase kinase kinase kinase 1
chr6_-_31560729 0.09 ENST00000340027.5
ENST00000376073.4
ENST00000376072.3
NCR3
natural cytotoxicity triggering receptor 3
chr12_+_57849048 0.09 ENST00000266646.2
INHBE
inhibin, beta E
chr17_-_26220366 0.09 ENST00000460380.2
ENST00000508862.1
ENST00000379102.3
ENST00000582441.1
LYRM9
RP1-66C13.4
LYR motif containing 9
Uncharacterized protein
chr21_-_46962379 0.09 ENST00000311124.4
ENST00000380010.4
SLC19A1
solute carrier family 19 (folate transporter), member 1
chr6_-_30043539 0.09 ENST00000376751.3
ENST00000244360.6
RNF39
ring finger protein 39
chr8_+_26149274 0.09 ENST00000522535.1
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr16_+_4666475 0.09 ENST00000591895.1
MGRN1
mahogunin ring finger 1, E3 ubiquitin protein ligase
chr2_+_234668894 0.08 ENST00000305208.5
ENST00000608383.1
ENST00000360418.3
UGT1A8
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr11_-_17555421 0.08 ENST00000526181.1
USH1C
Usher syndrome 1C (autosomal recessive, severe)
chr20_+_35201857 0.08 ENST00000373874.2
TGIF2
TGFB-induced factor homeobox 2
chr16_+_12995468 0.08 ENST00000424107.3
ENST00000558583.1
ENST00000558318.1
SHISA9
shisa family member 9
chr7_+_86975001 0.08 ENST00000412227.2
ENST00000331536.3
CROT
carnitine O-octanoyltransferase
chr1_-_235116495 0.08 ENST00000549744.1
RP11-443B7.3
RP11-443B7.3
chr7_-_150675372 0.08 ENST00000262186.5
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr2_+_234875252 0.08 ENST00000456930.1
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr19_+_52074502 0.08 ENST00000545217.1
ENST00000262259.2
ENST00000596504.1
ZNF175
zinc finger protein 175
chr10_+_94352956 0.08 ENST00000260731.3
KIF11
kinesin family member 11
chr12_-_53228079 0.08 ENST00000330553.5
KRT79
keratin 79
chr14_-_82000140 0.08 ENST00000555824.1
ENST00000557372.1
ENST00000336735.4
SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chrX_+_95939711 0.08 ENST00000373049.4
ENST00000324765.8
DIAPH2
diaphanous-related formin 2
chr11_+_7559485 0.08 ENST00000527790.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr17_+_77020325 0.08 ENST00000311661.4
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr11_+_74660278 0.08 ENST00000263672.6
ENST00000530257.1
ENST00000526361.1
ENST00000532972.1
SPCS2
signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr5_-_142784888 0.08 ENST00000514699.1
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr3_+_196295482 0.08 ENST00000440469.1
ENST00000311630.6
FBXO45
F-box protein 45
chr3_-_182880541 0.08 ENST00000470251.1
ENST00000265598.3
LAMP3
lysosomal-associated membrane protein 3
chrX_+_95939638 0.08 ENST00000373061.3
ENST00000373054.4
ENST00000355827.4
DIAPH2
diaphanous-related formin 2
chr19_-_42636617 0.08 ENST00000529067.1
ENST00000529952.1
ENST00000533720.1
ENST00000389341.5
ENST00000342301.4
POU2F2
POU class 2 homeobox 2
chr6_+_292051 0.08 ENST00000344450.5
DUSP22
dual specificity phosphatase 22
chr12_-_52887034 0.08 ENST00000330722.6
KRT6A
keratin 6A
chr2_+_43864387 0.07 ENST00000282406.4
PLEKHH2
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr6_+_31633833 0.07 ENST00000375882.2
ENST00000375880.2
CSNK2B
CSNK2B-LY6G5B-1181
casein kinase 2, beta polypeptide
Uncharacterized protein
chr5_+_154320623 0.07 ENST00000523037.1
ENST00000265229.8
ENST00000439747.3
ENST00000522038.1
MRPL22
mitochondrial ribosomal protein L22

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0002325 natural killer cell differentiation involved in immune response(GO:0002325) regulation of natural killer cell differentiation involved in immune response(GO:0032826)
0.1 0.4 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.1 0.3 GO:0046725 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.1 0.3 GO:1904823 pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.1 0.2 GO:0021722 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.1 0.2 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.1 0.2 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.1 0.2 GO:0030185 nitric oxide transport(GO:0030185) carbon dioxide transmembrane transport(GO:0035378)
0.1 0.2 GO:0006781 succinyl-CoA pathway(GO:0006781)
0.1 0.2 GO:0097198 histone H3-K36 trimethylation(GO:0097198)
0.0 0.3 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.2 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.0 0.1 GO:0006429 leucyl-tRNA aminoacylation(GO:0006429)
0.0 0.1 GO:0042938 dipeptide transport(GO:0042938)
0.0 0.3 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.0 0.2 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.2 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.0 0.1 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.3 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.1 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.0 0.1 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.0 0.1 GO:1903367 cell communication by chemical coupling(GO:0010643) positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.0 0.1 GO:0061760 antifungal innate immune response(GO:0061760)
0.0 0.1 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
0.0 0.1 GO:1902303 regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
0.0 0.2 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.1 GO:0034499 late endosome to Golgi transport(GO:0034499)
0.0 0.1 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.0 0.3 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.2 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.1 GO:0001897 cytolysis by symbiont of host cells(GO:0001897)
0.0 0.1 GO:0019236 response to pheromone(GO:0019236)
0.0 0.2 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.2 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.1 GO:0032425 positive regulation of mismatch repair(GO:0032425)
0.0 0.1 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.0 0.2 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.1 GO:0098838 reduced folate transmembrane transport(GO:0098838)
0.0 0.7 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.1 GO:1904106 protein localization to microvillus(GO:1904106)
0.0 0.3 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.2 GO:0060423 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.1 GO:0030421 defecation(GO:0030421)
0.0 0.2 GO:0048477 oogenesis(GO:0048477)
0.0 0.2 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.1 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.7 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.3 GO:1904293 negative regulation of ERAD pathway(GO:1904293)
0.0 0.1 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.0 0.2 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
0.0 0.1 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.1 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0 0.1 GO:0070295 renal water absorption(GO:0070295)
0.0 0.1 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.1 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.1 GO:1902896 terminal web assembly(GO:1902896)
0.0 0.0 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541) positive regulation of fibrinolysis(GO:0051919)
0.0 0.1 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0 0.1 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
0.0 0.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.1 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.1 GO:0050955 thermoception(GO:0050955)
0.0 0.2 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.0 0.1 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.0 0.2 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.2 GO:0045116 protein neddylation(GO:0045116)
0.0 0.1 GO:0035494 SNARE complex disassembly(GO:0035494)
0.0 0.3 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
0.0 0.0 GO:0006447 regulation of translational initiation by iron(GO:0006447)
0.0 0.0 GO:0002215 defense response to nematode(GO:0002215)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.1 0.2 GO:0020005 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005)
0.1 0.2 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.0 0.3 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.3 GO:0035976 AP1 complex(GO:0035976)
0.0 0.1 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.0 0.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.1 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 0.1 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.1 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.1 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.1 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.0 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.1 GO:0097486 multivesicular body lumen(GO:0097486)
0.0 0.2 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0072591 citrate-L-glutamate ligase activity(GO:0072591)
0.1 0.5 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.1 0.3 GO:0005415 nucleoside:sodium symporter activity(GO:0005415)
0.1 0.3 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
0.1 0.2 GO:0008859 exoribonuclease II activity(GO:0008859)
0.1 0.2 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.1 0.2 GO:0051373 FATZ binding(GO:0051373)
0.1 0.2 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
0.0 0.1 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.0 0.2 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.1 GO:0004823 leucine-tRNA ligase activity(GO:0004823)
0.0 0.2 GO:0004915 interleukin-6 receptor activity(GO:0004915) leukemia inhibitory factor receptor activity(GO:0004923) interleukin-6 binding(GO:0019981)
0.0 0.2 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.1 GO:0015322 proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322)
0.0 0.7 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.3 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.2 GO:0051748 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.0 0.2 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.5 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0 0.1 GO:0070012 oligopeptidase activity(GO:0070012)
0.0 0.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.1 GO:0008518 reduced folate carrier activity(GO:0008518)
0.0 0.1 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.1 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.1 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.1 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.0 0.2 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.3 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.0 0.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.2 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.1 GO:0033906 protein tyrosine kinase inhibitor activity(GO:0030292) hyaluronoglucuronidase activity(GO:0033906)
0.0 0.1 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.0 0.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.2 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.2 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 0.2 GO:0048156 tau protein binding(GO:0048156)
0.0 0.2 GO:0005113 patched binding(GO:0005113)
0.0 0.0 GO:0035034 histone acetyltransferase regulator activity(GO:0035034)
0.0 0.1 GO:0043237 laminin-1 binding(GO:0043237)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.3 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.5 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.2 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions