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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for THRB

Z-value: 0.43

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Transcription factors associated with THRB

Gene Symbol Gene ID Gene Info
THRB
ENSG00000151090.13 thyroid hormone receptor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
THRBhg19_v2_chr3_-_24536453_245365000.671.5e-01Click!

Activity profile of THRB motif

Sorted Z-values of THRB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_131746575 0.29 ENST00000337752.2
ENST00000378947.3
ENST00000407797.1
C5orf56
chromosome 5 open reading frame 56
chr19_-_52643157 0.21 ENST00000597013.1
ENST00000600228.1
ENST00000596290.1
ZNF616
zinc finger protein 616
chr17_+_7533439 0.18 ENST00000441599.2
ENST00000380450.4
ENST00000416273.3
ENST00000575903.1
ENST00000576830.1
ENST00000571153.1
ENST00000575618.1
ENST00000576152.1
SHBG
sex hormone-binding globulin
chr17_+_1646130 0.17 ENST00000453066.1
ENST00000324015.3
ENST00000450523.2
ENST00000453723.1
ENST00000382061.4
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr20_+_3024266 0.16 ENST00000245983.2
ENST00000359100.2
ENST00000359987.1
GNRH2
gonadotropin-releasing hormone 2
chr13_-_24007815 0.16 ENST00000382298.3
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr14_+_32414059 0.15 ENST00000553330.1
RP11-187E13.1
Uncharacterized protein
chr17_-_73840415 0.14 ENST00000592386.1
ENST00000412096.2
ENST00000586147.1
UNC13D
unc-13 homolog D (C. elegans)
chr16_+_8736232 0.14 ENST00000562973.1
METTL22
methyltransferase like 22
chr8_-_100905363 0.13 ENST00000524245.1
COX6C
cytochrome c oxidase subunit VIc
chr11_-_47400032 0.11 ENST00000533968.1
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr8_-_100905850 0.10 ENST00000520271.1
ENST00000522940.1
ENST00000523016.1
ENST00000517682.2
ENST00000297564.2
COX6C
cytochrome c oxidase subunit VIc
chr3_+_50606901 0.09 ENST00000455834.1
HEMK1
HemK methyltransferase family member 1
chr9_-_139268068 0.09 ENST00000371734.3
ENST00000371732.5
ENST00000315908.7
CARD9
caspase recruitment domain family, member 9
chr16_+_72088376 0.09 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
HP
HPR
haptoglobin
haptoglobin-related protein
chr11_-_64014379 0.07 ENST00000309318.3
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr4_+_189321881 0.07 ENST00000512839.1
ENST00000513313.1
LINC01060
long intergenic non-protein coding RNA 1060
chr8_-_100905925 0.06 ENST00000518171.1
COX6C
cytochrome c oxidase subunit VIc
chr2_-_9563319 0.06 ENST00000497105.1
ENST00000360635.3
ENST00000359712.3
ITGB1BP1
integrin beta 1 binding protein 1
chr6_-_99842041 0.06 ENST00000254759.3
ENST00000369242.1
COQ3
coenzyme Q3 methyltransferase
chr2_-_73869508 0.06 ENST00000272425.3
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr17_-_73839792 0.05 ENST00000590762.1
UNC13D
unc-13 homolog D (C. elegans)
chr10_+_62538248 0.05 ENST00000448257.2
CDK1
cyclin-dependent kinase 1
chr13_+_27844464 0.05 ENST00000241463.4
RASL11A
RAS-like, family 11, member A
chr11_-_47400062 0.05 ENST00000533030.1
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr12_+_54378923 0.05 ENST00000303460.4
HOXC10
homeobox C10
chr11_+_73498898 0.05 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr21_-_37914898 0.04 ENST00000399136.1
CLDN14
claudin 14
chr10_+_123970670 0.04 ENST00000496913.2
TACC2
transforming, acidic coiled-coil containing protein 2
chr12_+_54378849 0.04 ENST00000515593.1
HOXC10
homeobox C10
chr11_-_47399942 0.04 ENST00000227163.4
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chrX_+_101854096 0.04 ENST00000246174.2
ENST00000537008.1
ENST00000541409.1
ARMCX5
armadillo repeat containing, X-linked 5
chr4_+_114214125 0.04 ENST00000509550.1
ANK2
ankyrin 2, neuronal
chr20_+_388679 0.04 ENST00000356286.5
ENST00000475269.1
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr12_-_21810726 0.03 ENST00000396076.1
LDHB
lactate dehydrogenase B
chr11_-_47400078 0.03 ENST00000378538.3
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr3_+_50606577 0.03 ENST00000434410.1
ENST00000232854.4
HEMK1
HemK methyltransferase family member 1
chr12_-_21810765 0.03 ENST00000450584.1
ENST00000350669.1
LDHB
lactate dehydrogenase B
chr7_-_100253993 0.03 ENST00000461605.1
ENST00000160382.5
ACTL6B
actin-like 6B
chr7_-_38394118 0.02 ENST00000390345.2
TRGV4
T cell receptor gamma variable 4
chr20_+_388791 0.02 ENST00000441733.1
ENST00000353660.3
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr17_-_73840774 0.02 ENST00000207549.4
UNC13D
unc-13 homolog D (C. elegans)
chr10_+_35456444 0.02 ENST00000361599.4
CREM
cAMP responsive element modulator
chr18_-_47808050 0.02 ENST00000590208.1
MBD1
methyl-CpG binding domain protein 1
chr8_-_124037890 0.02 ENST00000519018.1
ENST00000523036.1
DERL1
derlin 1
chr10_+_62538089 0.02 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
CDK1
cyclin-dependent kinase 1
chr1_-_113498943 0.02 ENST00000369626.3
SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr11_+_46366918 0.01 ENST00000528615.1
ENST00000395574.3
DGKZ
diacylglycerol kinase, zeta
chr2_-_9563216 0.01 ENST00000467606.1
ENST00000494563.1
ENST00000460001.1
ITGB1BP1
integrin beta 1 binding protein 1
chr11_+_46366799 0.01 ENST00000532868.2
DGKZ
diacylglycerol kinase, zeta
chr1_-_154164534 0.01 ENST00000271850.7
ENST00000368530.2
TPM3
tropomyosin 3
chr18_-_47807829 0.01 ENST00000585672.1
ENST00000457839.2
ENST00000353909.3
ENST00000339998.6
ENST00000398493.1
MBD1
methyl-CpG binding domain protein 1
chr8_+_22102626 0.01 ENST00000519237.1
ENST00000397802.4
POLR3D
polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
chr6_+_151042224 0.00 ENST00000358517.2
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of THRB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0044026 DNA hypermethylation(GO:0044026) hypermethylation of CpG island(GO:0044027)
0.0 0.2 GO:0002432 granuloma formation(GO:0002432)
0.0 0.2 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.1 GO:2000295 regulation of hydrogen peroxide catabolic process(GO:2000295)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.2 GO:0070852 cell body fiber(GO:0070852)
0.0 0.1 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.2 GO:0005497 androgen binding(GO:0005497)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.1 GO:0008169 C-methyltransferase activity(GO:0008169)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors