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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TP73

Z-value: 0.79

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Transcription factors associated with TP73

Gene Symbol Gene ID Gene Info
ENSG00000078900.10 tumor protein p73

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TP73hg19_v2_chr1_+_3614591_36146220.805.6e-02Click!

Activity profile of TP73 motif

Sorted Z-values of TP73 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_15783879 1.25 ENST00000551607.1
cytochrome P450, family 4, subfamily F, polypeptide 12
chr2_-_26864228 1.03 ENST00000288861.4
calcium and integrin binding family member 4
chr2_+_114163945 0.69 ENST00000453673.3
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr10_-_105238997 0.61 ENST00000369783.4
calcium homeostasis modulator 3
chr20_-_62203808 0.56 ENST00000467148.1
helicase with zinc finger 2, transcriptional coactivator
chr20_+_35504522 0.51 ENST00000602922.1
ENST00000217320.3
TBC/LysM-associated domain containing 2
chr10_-_99185798 0.48 ENST00000439965.2
LOC644215 protein; Uncharacterized protein
chr17_-_42452063 0.44 ENST00000588098.1
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr5_+_119799927 0.35 ENST00000407149.2
ENST00000379551.2
proline rich 16
chrX_-_38186775 0.33 ENST00000339363.3
ENST00000309513.3
ENST00000338898.3
ENST00000342811.3
ENST00000378505.2
retinitis pigmentosa GTPase regulator
chr22_-_37976082 0.33 ENST00000215886.4
lectin, galactoside-binding, soluble, 2
chrX_-_38186811 0.32 ENST00000318842.7
retinitis pigmentosa GTPase regulator
chr1_+_47137445 0.32 ENST00000569393.1
ENST00000334122.4
ENST00000415500.1
testis expressed 38
chr1_+_204494618 0.31 ENST00000367180.1
ENST00000391947.2
Mdm4 p53 binding protein homolog (mouse)
chr15_-_74043816 0.30 ENST00000379822.4
chromosome 15 open reading frame 59
chr12_-_82752565 0.30 ENST00000256151.7
coiled-coil domain containing 59
chr16_+_222846 0.30 ENST00000251595.6
ENST00000397806.1
hemoglobin, alpha 2
chr1_-_241799232 0.29 ENST00000366553.1
choroideremia-like (Rab escort protein 2)
chr14_+_103566665 0.28 ENST00000559116.1
exocyst complex component 3-like 4
chr5_+_138940742 0.26 ENST00000398733.3
ENST00000253815.2
ENST00000505007.1
ubiquitin-conjugating enzyme E2D 2
chr17_+_4835580 0.25 ENST00000329125.5
glycoprotein Ib (platelet), alpha polypeptide
chr1_-_235324530 0.24 ENST00000447801.1
ENST00000366606.3
ENST00000429912.1
RNA binding motif protein 34
chr8_+_120885949 0.24 ENST00000523492.1
ENST00000286234.5
DEP domain containing MTOR-interacting protein
chr5_+_43120985 0.23 ENST00000515326.1
zinc finger protein 131
chr17_-_80059726 0.23 ENST00000583053.1
coiled-coil domain containing 57
chr17_-_39023462 0.23 ENST00000251643.4
keratin 12
chr3_-_50340996 0.22 ENST00000266031.4
ENST00000395143.2
ENST00000457214.2
ENST00000447605.2
ENST00000418723.1
ENST00000395144.2
hyaluronoglucosaminidase 1
chrX_-_80377162 0.22 ENST00000430960.1
ENST00000447319.1
high mobility group nucleosome binding domain 5
chr17_-_40835076 0.22 ENST00000591765.1
chemokine (C-C motif) receptor 10
chr17_+_52978185 0.21 ENST00000572405.1
ENST00000572158.1
ENST00000540336.1
ENST00000572298.1
ENST00000536554.1
ENST00000575333.1
ENST00000570499.1
ENST00000572576.1
target of myb1 (chicken)-like 1
chr1_+_162467595 0.21 ENST00000538489.1
ENST00000489294.1
U2AF homology motif (UHM) kinase 1
chr7_+_116502527 0.20 ENST00000361183.3
capping protein (actin filament) muscle Z-line, alpha 2
chrX_-_80377118 0.20 ENST00000373250.3
high mobility group nucleosome binding domain 5
chr12_+_82752647 0.20 ENST00000550058.1
methyltransferase like 25
chr14_-_105531759 0.19 ENST00000329797.3
ENST00000539291.2
ENST00000392585.2
G protein-coupled receptor 132
chr18_-_28681950 0.19 ENST00000251081.6
desmocollin 2
chr3_-_100120223 0.19 ENST00000284320.5
translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
chr12_-_82752159 0.19 ENST00000552377.1
coiled-coil domain containing 59
chr1_-_220219775 0.19 ENST00000609181.1
glutamyl-prolyl-tRNA synthetase
chr12_+_44152740 0.18 ENST00000440781.2
ENST00000431837.1
ENST00000550616.1
ENST00000448290.2
ENST00000551736.1
interleukin-1 receptor-associated kinase 4
chr12_-_117319236 0.18 ENST00000257572.5
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr9_-_138391692 0.18 ENST00000429260.2
chromosome 9 open reading frame 116
chr9_-_20382446 0.17 ENST00000380321.1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr6_-_72130472 0.17 ENST00000426635.2
long intergenic non-protein coding RNA 472
chr12_+_113495492 0.17 ENST00000257600.3
deltex homolog 1 (Drosophila)
chr1_-_52344416 0.17 ENST00000544028.1
nardilysin (N-arginine dibasic convertase)
chr14_+_96858433 0.17 ENST00000267584.4
adenylate kinase 7
chr10_+_70661014 0.17 ENST00000373585.3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr14_+_75745477 0.16 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
FBJ murine osteosarcoma viral oncogene homolog
chr5_+_78532003 0.16 ENST00000396137.4
junction mediating and regulatory protein, p53 cofactor
chr8_+_63161491 0.16 ENST00000523211.1
ENST00000524201.1
Na+/K+ transporting ATPase interacting 3
chr16_+_84178874 0.15 ENST00000378553.5
dynein, axonemal, assembly factor 1
chr13_+_48877895 0.15 ENST00000267163.4
retinoblastoma 1
chr16_+_84178850 0.14 ENST00000334315.5
dynein, axonemal, assembly factor 1
chr9_+_131445928 0.14 ENST00000372692.4
SET nuclear oncogene
chr11_-_31833719 0.14 ENST00000524853.1
paired box 6
chr12_+_82752275 0.14 ENST00000248306.3
methyltransferase like 25
chr16_-_14724057 0.14 ENST00000539279.1
ENST00000420015.2
ENST00000437198.2
poly(A)-specific ribonuclease
chr8_+_63161550 0.14 ENST00000328472.5
Na+/K+ transporting ATPase interacting 3
chr11_+_63448918 0.13 ENST00000341307.2
ENST00000356000.3
ENST00000542238.1
reticulon 3
chr4_-_76598544 0.13 ENST00000515457.1
ENST00000357854.3
GTPase activating protein (SH3 domain) binding protein 2
chr6_-_122792919 0.13 ENST00000339697.4
serine incorporator 1
chrX_+_77166172 0.12 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
ATPase, Cu++ transporting, alpha polypeptide
chr19_-_35981358 0.12 ENST00000484218.2
ENST00000338897.3
keratinocyte differentiation-associated protein
chr14_+_52780998 0.11 ENST00000557436.1
prostaglandin E receptor 2 (subtype EP2), 53kDa
chr18_-_53253112 0.11 ENST00000568673.1
ENST00000562847.1
ENST00000568147.1
transcription factor 4
chr11_+_63448955 0.11 ENST00000377819.5
ENST00000339997.4
ENST00000540798.1
ENST00000545432.1
ENST00000543552.1
ENST00000537981.1
reticulon 3
chr12_+_82752283 0.10 ENST00000548200.1
methyltransferase like 25
chr2_-_230135937 0.10 ENST00000392054.3
ENST00000409462.1
ENST00000392055.3
phosphotyrosine interaction domain containing 1
chr9_-_130517309 0.10 ENST00000414380.1
SH2 domain containing 3C
chr9_+_6758024 0.10 ENST00000442236.2
lysine (K)-specific demethylase 4C
chr6_+_155537771 0.10 ENST00000275246.7
T-cell lymphoma invasion and metastasis 2
chr3_-_48936272 0.10 ENST00000544097.1
ENST00000430379.1
ENST00000319017.4
solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
chr1_-_220220000 0.10 ENST00000366923.3
glutamyl-prolyl-tRNA synthetase
chr18_-_53253323 0.09 ENST00000540999.1
ENST00000563888.2
transcription factor 4
chr1_+_156785425 0.09 ENST00000392302.2
neurotrophic tyrosine kinase, receptor, type 1
chr22_+_29168652 0.09 ENST00000249064.4
ENST00000444523.1
ENST00000448492.2
ENST00000421503.2
coiled-coil domain containing 117
chrX_+_9880412 0.09 ENST00000418909.2
shroom family member 2
chr9_+_6758109 0.08 ENST00000536108.1
lysine (K)-specific demethylase 4C
chr6_+_155538093 0.08 ENST00000462408.2
T-cell lymphoma invasion and metastasis 2
chr10_-_97200772 0.08 ENST00000371241.1
ENST00000354106.3
ENST00000371239.1
ENST00000361941.3
ENST00000277982.5
ENST00000371245.3
sorbin and SH3 domain containing 1
chr11_+_63449045 0.08 ENST00000354497.4
reticulon 3
chr19_+_41620335 0.08 ENST00000331105.2
cytochrome P450, family 2, subfamily F, polypeptide 1
chr7_-_100493744 0.08 ENST00000428317.1
ENST00000441605.1
acetylcholinesterase (Yt blood group)
chr20_-_49253425 0.08 ENST00000045083.2
family with sequence similarity 65, member C
chr1_-_160832490 0.08 ENST00000322302.7
ENST00000368033.3
CD244 molecule, natural killer cell receptor 2B4
chr1_-_160832642 0.08 ENST00000368034.4
CD244 molecule, natural killer cell receptor 2B4
chr5_+_38258511 0.08 ENST00000354891.3
ENST00000322350.5
EGF-like, fibronectin type III and laminin G domains
chr7_-_100493482 0.07 ENST00000411582.1
ENST00000419336.2
ENST00000241069.5
ENST00000302913.4
acetylcholinesterase (Yt blood group)
chr1_-_236228417 0.07 ENST00000264187.6
nidogen 1
chrX_+_9880590 0.07 ENST00000452575.1
shroom family member 2
chr12_+_102271436 0.07 ENST00000544152.1
DNA-damage regulated autophagy modulator 1
chr1_-_68698197 0.07 ENST00000370973.2
ENST00000370971.1
wntless Wnt ligand secretion mediator
chr9_-_128003606 0.07 ENST00000324460.6
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
chr1_+_26485511 0.07 ENST00000374268.3
family with sequence similarity 110, member D
chr20_-_52790512 0.07 ENST00000216862.3
cytochrome P450, family 24, subfamily A, polypeptide 1
chr2_+_220283091 0.07 ENST00000373960.3
desmin
chr19_+_45254529 0.06 ENST00000444487.1
B-cell CLL/lymphoma 3
chr19_-_36233332 0.06 ENST00000592537.1
ENST00000246532.1
ENST00000344990.3
ENST00000588992.1
IGF-like family receptor 1
chr2_+_95940220 0.06 ENST00000542147.1
prominin 2
chr18_-_53253000 0.06 ENST00000566514.1
transcription factor 4
chr16_-_8891481 0.06 ENST00000333050.6
transmembrane protein 186
chr1_+_110082487 0.05 ENST00000527748.1
G protein-coupled receptor 61
chr1_-_52344471 0.05 ENST00000352171.7
ENST00000354831.7
nardilysin (N-arginine dibasic convertase)
chr20_-_52790055 0.05 ENST00000395955.3
cytochrome P450, family 24, subfamily A, polypeptide 1
chr7_+_142636603 0.05 ENST00000409607.3
chromosome 7 open reading frame 34
chr9_+_6757634 0.05 ENST00000543771.1
ENST00000401787.3
ENST00000381306.3
ENST00000381309.3
lysine (K)-specific demethylase 4C
chr7_+_142636440 0.05 ENST00000458732.1
chromosome 7 open reading frame 34
chr15_+_76030311 0.05 ENST00000543887.1
AC019294.1
chr1_-_26197744 0.05 ENST00000374296.3
progestin and adipoQ receptor family member VII
chr5_-_135528822 0.05 ENST00000607574.1
AC009014.3
chr2_-_158485387 0.03 ENST00000243349.8
activin A receptor, type IC
chr19_-_39226045 0.03 ENST00000597987.1
ENST00000595177.1
calpain 12
chr15_+_75498739 0.03 ENST00000565074.1
chromosome 15 open reading frame 39
chr1_-_236228403 0.03 ENST00000366595.3
nidogen 1
chr2_+_95940186 0.02 ENST00000403131.2
ENST00000317668.4
ENST00000317620.9
prominin 2
chr18_-_4455260 0.02 ENST00000581527.1
discs, large (Drosophila) homolog-associated protein 1
chr8_-_70745575 0.02 ENST00000524945.1
solute carrier organic anion transporter family, member 5A1
chr1_-_111148241 0.02 ENST00000440270.1
potassium voltage-gated channel, shaker-related subfamily, member 2
chr11_+_31833939 0.02 ENST00000530348.1
reticulocalbin 1, EF-hand calcium binding domain
chr21_+_43442100 0.01 ENST00000455701.1
ENST00000596595.1
ZNF295 antisense RNA 1
chrX_-_138724994 0.01 ENST00000536274.1
MCF.2 cell line derived transforming sequence
chr15_+_41136263 0.01 ENST00000568823.1
serine peptidase inhibitor, Kunitz type 1
chr6_-_46703069 0.01 ENST00000538237.1
ENST00000274793.7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr14_+_75746340 0.00 ENST00000555686.1
ENST00000555672.1
FBJ murine osteosarcoma viral oncogene homolog
chr16_+_21312170 0.00 ENST00000338573.5
ENST00000561968.1
CRYM antisense RNA 1

Network of associatons between targets according to the STRING database.

First level regulatory network of TP73

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0003095 pressure natriuresis(GO:0003095)
0.1 0.3 GO:0006433 glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.1 0.2 GO:0008057 eye pigment granule organization(GO:0008057)
0.1 0.2 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.1 0.2 GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.1 0.2 GO:0045212 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.0 0.2 GO:1900106 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.0 0.3 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.1 GO:0034759 regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759) cellular response to lead ion(GO:0071284)
0.0 0.1 GO:0042369 vitamin D catabolic process(GO:0042369)
0.0 0.3 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.3 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.1 GO:0070346 positive regulation of fat cell proliferation(GO:0070346)
0.0 0.1 GO:1902616 acyl carnitine transport(GO:0006844) acyl carnitine transmembrane transport(GO:1902616)
0.0 0.7 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.2 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0 0.1 GO:0045082 positive regulation of interleukin-10 biosynthetic process(GO:0045082)
0.0 0.1 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0 0.4 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.1 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 0.2 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.2 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.1 GO:0003322 pancreatic A cell development(GO:0003322)
0.0 0.2 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 0.1 GO:0090669 telomerase RNA stabilization(GO:0090669)
0.0 0.1 GO:0021553 olfactory nerve development(GO:0021553)
0.0 0.1 GO:0097501 stress response to metal ion(GO:0097501)
0.0 0.2 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.2 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0036117 hyaluranon cable(GO:0036117)
0.1 0.3 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 0.2 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.3 GO:0097452 GAIT complex(GO:0097452)
0.0 0.2 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.2 GO:0035976 AP1 complex(GO:0035976)
0.0 0.1 GO:0044393 microspike(GO:0044393)
0.0 0.1 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.0 0.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.3 GO:0000145 exocyst(GO:0000145)
0.0 0.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.0 GO:0048179 activin receptor complex(GO:0048179)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.1 0.3 GO:0004827 glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.1 0.4 GO:0070051 fibrinogen binding(GO:0070051)
0.0 0.3 GO:0016936 galactoside binding(GO:0016936)
0.0 0.2 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.2 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.0 0.2 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.1 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532) copper-dependent protein binding(GO:0032767)
0.0 0.2 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 0.1 GO:0015227 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226) acyl carnitine transmembrane transporter activity(GO:0015227)
0.0 0.1 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.2 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.1 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 0.2 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 0.2 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.1 GO:0043237 laminin-1 binding(GO:0043237)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.4 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation