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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ZNF282

Z-value: 0.55

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Transcription factors associated with ZNF282

Gene Symbol Gene ID Gene Info
ZNF282
ENSG00000170265.7 zinc finger protein 282

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF282hg19_v2_chr7_+_148892629_148892651-0.621.9e-01Click!

Activity profile of ZNF282 motif

Sorted Z-values of ZNF282 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_-_50970566 0.62 ENST00000405135.1
ENST00000401779.1
ODF3B
outer dense fiber of sperm tails 3B
chr9_+_126777676 0.55 ENST00000488674.2
LHX2
LIM homeobox 2
chr4_+_52709229 0.50 ENST00000334635.5
ENST00000381441.3
ENST00000381437.4
DCUN1D4
DCN1, defective in cullin neddylation 1, domain containing 4
chr22_-_50970506 0.49 ENST00000428989.2
ENST00000403326.1
ODF3B
outer dense fiber of sperm tails 3B
chr16_-_70239683 0.42 ENST00000601706.1
AC009060.1
Uncharacterized protein
chr6_+_151358048 0.40 ENST00000450635.1
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr22_-_50970919 0.38 ENST00000329363.4
ENST00000437588.1
ODF3B
outer dense fiber of sperm tails 3B
chr21_-_35014027 0.36 ENST00000399442.1
ENST00000413017.2
ENST00000445393.1
ENST00000417979.1
ENST00000426935.1
ENST00000381540.3
ENST00000361534.2
ENST00000381554.3
CRYZL1
crystallin, zeta (quinone reductase)-like 1
chr12_-_46766577 0.36 ENST00000256689.5
SLC38A2
solute carrier family 38, member 2
chr3_-_49907323 0.33 ENST00000296471.7
ENST00000488336.1
ENST00000467248.1
ENST00000466940.1
ENST00000463537.1
ENST00000480398.2
CAMKV
CaM kinase-like vesicle-associated
chr7_+_16828866 0.32 ENST00000597084.1
AC073333.1
Uncharacterized protein
chrM_+_9207 0.32 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr6_-_137314371 0.31 ENST00000432330.1
ENST00000418699.1
RP11-55K22.5
RP11-55K22.5
chr1_+_179335101 0.31 ENST00000508285.1
ENST00000511889.1
AXDND1
axonemal dynein light chain domain containing 1
chr19_-_6110555 0.30 ENST00000593241.1
RFX2
regulatory factor X, 2 (influences HLA class II expression)
chr18_-_54318353 0.26 ENST00000590954.1
ENST00000540155.1
TXNL1
thioredoxin-like 1
chr12_+_57828521 0.25 ENST00000309668.2
INHBC
inhibin, beta C
chr6_+_139349903 0.24 ENST00000461027.1
ABRACL
ABRA C-terminal like
chr3_-_170587974 0.22 ENST00000463836.1
RPL22L1
ribosomal protein L22-like 1
chr7_+_6713376 0.22 ENST00000399484.3
ENST00000544825.1
ENST00000401847.1
AC073343.1
Uncharacterized protein
chr13_-_103019744 0.21 ENST00000437115.2
FGF14-IT1
FGF14 intronic transcript 1 (non-protein coding)
chr2_-_188378368 0.20 ENST00000392365.1
ENST00000435414.1
TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr3_-_180707306 0.19 ENST00000479269.1
DNAJC19
DnaJ (Hsp40) homolog, subfamily C, member 19
chr3_-_106959424 0.19 ENST00000607801.1
ENST00000479612.2
ENST00000484698.1
ENST00000477210.2
ENST00000473636.1
LINC00882
long intergenic non-protein coding RNA 882
chr20_-_62493217 0.19 ENST00000601296.1
C20ORF135
C20ORF135
chr6_+_106959718 0.19 ENST00000369066.3
AIM1
absent in melanoma 1
chr1_+_47799446 0.19 ENST00000371873.5
CMPK1
cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
chr1_-_54304212 0.19 ENST00000540001.1
NDC1
NDC1 transmembrane nucleoporin
chr8_-_27630102 0.18 ENST00000356537.4
ENST00000522915.1
ENST00000539095.1
CCDC25
coiled-coil domain containing 25
chr2_-_68479614 0.17 ENST00000234310.3
PPP3R1
protein phosphatase 3, regulatory subunit B, alpha
chr1_+_40723779 0.17 ENST00000372759.3
ZMPSTE24
zinc metallopeptidase STE24
chr12_+_54519842 0.16 ENST00000508564.1
RP11-834C11.4
RP11-834C11.4
chrX_-_49121165 0.16 ENST00000376207.4
ENST00000376199.2
FOXP3
forkhead box P3
chr6_-_32152020 0.16 ENST00000375055.2
AGER
advanced glycosylation end product-specific receptor
chr13_-_95248511 0.15 ENST00000261296.5
TGDS
TDP-glucose 4,6-dehydratase
chr3_-_180707466 0.15 ENST00000491873.1
ENST00000486355.1
ENST00000382564.2
DNAJC19
DnaJ (Hsp40) homolog, subfamily C, member 19
chr2_+_242289502 0.14 ENST00000451310.1
SEPT2
septin 2
chr3_-_170588163 0.13 ENST00000295830.8
RPL22L1
ribosomal protein L22-like 1
chr1_-_54303934 0.13 ENST00000537333.1
NDC1
NDC1 transmembrane nucleoporin
chr1_+_47799542 0.13 ENST00000471289.2
ENST00000450808.2
CMPK1
cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
chr6_-_32152064 0.13 ENST00000375076.4
ENST00000375070.3
AGER
advanced glycosylation end product-specific receptor
chr15_+_51200871 0.13 ENST00000560508.1
AP4E1
adaptor-related protein complex 4, epsilon 1 subunit
chr10_-_114206649 0.12 ENST00000369404.3
ENST00000369405.3
ZDHHC6
zinc finger, DHHC-type containing 6
chr8_-_21988558 0.11 ENST00000312841.8
HR
hair growth associated
chr19_+_18283959 0.10 ENST00000597802.2
IFI30
interferon, gamma-inducible protein 30
chr8_+_74888417 0.10 ENST00000517439.1
ENST00000312184.5
TMEM70
transmembrane protein 70
chr13_+_31309645 0.10 ENST00000380490.3
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr16_-_62070305 0.10 ENST00000584337.1
CDH8
cadherin 8, type 2
chr4_-_74904398 0.10 ENST00000296026.4
CXCL3
chemokine (C-X-C motif) ligand 3
chr1_-_108735440 0.09 ENST00000370041.4
SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr5_+_65892174 0.09 ENST00000404260.3
ENST00000403625.2
ENST00000406374.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr7_+_1272522 0.09 ENST00000316333.8
UNCX
UNC homeobox
chr1_-_154178803 0.09 ENST00000368525.3
C1orf189
chromosome 1 open reading frame 189
chr22_-_24641027 0.09 ENST00000398292.3
ENST00000263112.7
ENST00000418439.2
ENST00000424217.1
ENST00000327365.4
GGT5
gamma-glutamyltransferase 5
chr5_+_7869217 0.09 ENST00000264668.2
ENST00000514220.1
ENST00000341013.6
ENST00000440940.2
ENST00000502550.1
ENST00000506877.1
MTRR
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
chr6_+_144471643 0.08 ENST00000367568.4
STX11
syntaxin 11
chr2_-_197664366 0.08 ENST00000409364.3
ENST00000263956.3
GTF3C3
general transcription factor IIIC, polypeptide 3, 102kDa
chr17_+_44039704 0.08 ENST00000420682.2
ENST00000415613.2
ENST00000571987.1
ENST00000574436.1
ENST00000431008.3
MAPT
microtubule-associated protein tau
chr17_+_66509019 0.08 ENST00000585981.1
ENST00000589480.1
ENST00000585815.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr17_-_56605341 0.08 ENST00000583114.1
SEPT4
septin 4
chr19_+_7953384 0.08 ENST00000306708.6
LRRC8E
leucine rich repeat containing 8 family, member E
chr15_+_51200859 0.08 ENST00000261842.5
AP4E1
adaptor-related protein complex 4, epsilon 1 subunit
chr19_-_58220517 0.08 ENST00000512439.2
ENST00000426889.1
ZNF154
zinc finger protein 154
chr1_-_54303949 0.07 ENST00000234725.8
NDC1
NDC1 transmembrane nucleoporin
chr20_-_62284766 0.07 ENST00000370053.1
STMN3
stathmin-like 3
chr6_+_139349817 0.07 ENST00000367660.3
ABRACL
ABRA C-terminal like
chr10_+_95753714 0.07 ENST00000260766.3
PLCE1
phospholipase C, epsilon 1
chr17_-_73937028 0.07 ENST00000586631.2
FBF1
Fas (TNFRSF6) binding factor 1
chr6_-_36807762 0.07 ENST00000244751.2
CPNE5
copine V
chrX_-_135849484 0.07 ENST00000370620.1
ENST00000535227.1
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr14_+_58711539 0.06 ENST00000216455.4
ENST00000412908.2
ENST00000557508.1
PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr7_-_158497431 0.06 ENST00000449727.2
ENST00000409339.3
ENST00000409423.1
ENST00000356309.3
NCAPG2
non-SMC condensin II complex, subunit G2
chr1_+_35247859 0.06 ENST00000373362.3
GJB3
gap junction protein, beta 3, 31kDa
chr2_-_9695847 0.06 ENST00000310823.3
ENST00000497134.1
ADAM17
ADAM metallopeptidase domain 17
chr9_+_34652164 0.06 ENST00000441545.2
ENST00000553620.1
IL11RA
interleukin 11 receptor, alpha
chrX_+_101967257 0.06 ENST00000543253.1
ENST00000535209.1
GPRASP2
G protein-coupled receptor associated sorting protein 2
chr6_+_39760783 0.06 ENST00000398904.2
ENST00000538976.1
DAAM2
dishevelled associated activator of morphogenesis 2
chr6_-_136571400 0.05 ENST00000418509.2
ENST00000420702.1
ENST00000451457.2
MTFR2
mitochondrial fission regulator 2
chr10_+_114206956 0.05 ENST00000432306.1
ENST00000393077.2
VTI1A
vesicle transport through interaction with t-SNAREs 1A
chr15_-_44955842 0.05 ENST00000427534.2
ENST00000559193.1
ENST00000261866.7
ENST00000535302.2
ENST00000558319.1
SPG11
spastic paraplegia 11 (autosomal recessive)
chr11_+_63998006 0.04 ENST00000355040.4
DNAJC4
DnaJ (Hsp40) homolog, subfamily C, member 4
chr8_-_28347737 0.04 ENST00000517673.1
ENST00000518734.1
ENST00000346498.2
ENST00000380254.2
FBXO16
F-box protein 16
chr6_+_129204337 0.04 ENST00000421865.2
LAMA2
laminin, alpha 2
chr4_+_39460689 0.04 ENST00000381846.1
LIAS
lipoic acid synthetase
chr16_+_66586461 0.04 ENST00000264001.4
ENST00000351137.4
ENST00000345436.4
ENST00000362093.4
ENST00000417030.2
ENST00000527729.1
ENST00000532838.1
CKLF
CKLF-CMTM1
chemokine-like factor
CKLF-CMTM1 readthrough
chr6_-_32151999 0.04 ENST00000375069.3
ENST00000538695.1
ENST00000438221.2
ENST00000375065.5
ENST00000450110.1
ENST00000375067.3
ENST00000375056.2
AGER
advanced glycosylation end product-specific receptor
chr9_+_139221880 0.04 ENST00000392945.3
ENST00000440944.1
GPSM1
G-protein signaling modulator 1
chr6_-_17706618 0.04 ENST00000262077.2
ENST00000537253.1
NUP153
nucleoporin 153kDa
chr6_+_10748019 0.03 ENST00000543878.1
ENST00000461342.1
ENST00000475942.1
ENST00000379530.3
ENST00000473276.1
ENST00000481240.1
ENST00000467317.1
SYCP2L
TMEM14B
synaptonemal complex protein 2-like
transmembrane protein 14B
chr12_-_13248598 0.03 ENST00000337630.6
ENST00000545699.1
GSG1
germ cell associated 1
chrX_-_13835461 0.03 ENST00000316715.4
ENST00000356942.5
GPM6B
glycoprotein M6B
chr1_+_2005126 0.03 ENST00000495347.1
PRKCZ
protein kinase C, zeta
chr15_-_83736091 0.02 ENST00000261721.4
BTBD1
BTB (POZ) domain containing 1
chr2_+_232260254 0.02 ENST00000287590.5
B3GNT7
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
chr5_-_7869108 0.02 ENST00000264669.5
ENST00000507572.1
ENST00000504695.1
FASTKD3
FAST kinase domains 3
chr3_+_45928029 0.02 ENST00000422395.1
ENST00000355983.2
CCR9
chemokine (C-C motif) receptor 9
chr7_-_155326532 0.02 ENST00000406197.1
ENST00000321736.5
CNPY1
canopy FGF signaling regulator 1
chr6_+_44187334 0.02 ENST00000313248.7
ENST00000427851.2
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr10_+_114135004 0.02 ENST00000393081.1
ACSL5
acyl-CoA synthetase long-chain family member 5
chr11_-_321340 0.02 ENST00000526811.1
IFITM3
interferon induced transmembrane protein 3
chr1_+_145507587 0.02 ENST00000330165.8
ENST00000369307.3
RBM8A
RNA binding motif protein 8A
chr17_+_7942424 0.02 ENST00000573359.1
ALOX15B
arachidonate 15-lipoxygenase, type B
chr10_+_51572408 0.02 ENST00000374082.1
NCOA4
nuclear receptor coactivator 4
chr12_-_13248562 0.02 ENST00000457134.2
ENST00000537302.1
GSG1
germ cell associated 1
chr2_+_219283815 0.02 ENST00000248444.5
ENST00000454069.1
ENST00000392114.2
VIL1
villin 1
chr11_+_82904858 0.02 ENST00000260047.6
ANKRD42
ankyrin repeat domain 42
chr1_+_151171012 0.01 ENST00000349792.5
ENST00000409426.1
ENST00000441902.2
ENST00000368890.4
ENST00000424999.1
ENST00000368888.4
PIP5K1A
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
chr1_+_156551157 0.01 ENST00000368237.3
TTC24
tetratricopeptide repeat domain 24
chr15_+_38276910 0.01 ENST00000558081.2
RP11-1008C21.1
RP11-1008C21.1
chr11_+_111957497 0.01 ENST00000375549.3
ENST00000528182.1
ENST00000528048.1
ENST00000528021.1
ENST00000526592.1
ENST00000525291.1
SDHD
succinate dehydrogenase complex, subunit D, integral membrane protein
chr18_-_47017956 0.01 ENST00000584895.1
ENST00000332968.6
ENST00000580210.1
ENST00000579408.1
RPL17-C18orf32
RPL17
RPL17-C18orf32 readthrough
ribosomal protein L17
chr19_-_40336969 0.01 ENST00000599134.1
ENST00000597634.1
ENST00000598417.1
ENST00000601274.1
ENST00000594309.1
ENST00000221801.3
FBL
fibrillarin
chrX_-_72095622 0.01 ENST00000290273.5
DMRTC1
DMRT-like family C1
chr12_+_93964158 0.01 ENST00000549206.1
SOCS2
suppressor of cytokine signaling 2
chr11_+_100784231 0.01 ENST00000531183.1
ARHGAP42
Rho GTPase activating protein 42
chr17_+_7942335 0.01 ENST00000380183.4
ENST00000572022.1
ENST00000380173.2
ALOX15B
arachidonate 15-lipoxygenase, type B
chr2_-_241497374 0.01 ENST00000373318.2
ENST00000406958.1
ENST00000391987.1
ENST00000373320.4
ANKMY1
ankyrin repeat and MYND domain containing 1
chr16_-_66586365 0.00 ENST00000562484.2
TK2
thymidine kinase 2, mitochondrial
chr17_-_79905109 0.00 ENST00000409745.2
MYADML2
myeloid-associated differentiation marker-like 2
chr14_-_77542485 0.00 ENST00000556781.1
ENST00000557526.1
ENST00000555512.1
RP11-7F17.3
RP11-7F17.3
chr10_+_51572339 0.00 ENST00000344348.6
NCOA4
nuclear receptor coactivator 4

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF282

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0071790 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.1 0.3 GO:1904603 regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904596) negative regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904597) regulation of advanced glycation end-product receptor activity(GO:1904603) negative regulation of advanced glycation end-product receptor activity(GO:1904604) negative regulation of connective tissue replacement(GO:1905204)
0.1 0.4 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.1 0.2 GO:0071586 prenylated protein catabolic process(GO:0030327) CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.1 0.2 GO:0002669 regulation of tolerance induction dependent upon immune response(GO:0002652) positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.0 0.3 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0 0.6 GO:0021978 telencephalon regionalization(GO:0021978)
0.0 0.2 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.5 GO:0045116 protein neddylation(GO:0045116)
0.0 0.1 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0 0.2 GO:0032328 alanine transport(GO:0032328)
0.0 0.1 GO:0033023 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) response to high density lipoprotein particle(GO:0055099)
0.0 0.1 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.0 0.1 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.0 GO:0032240 negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.0 0.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353) homocysteine catabolic process(GO:0043418)
0.0 0.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.1 GO:2001300 lipoxin metabolic process(GO:2001300)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.3 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.1 GO:0045298 tubulin complex(GO:0045298)
0.0 0.2 GO:0097227 sperm annulus(GO:0097227)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1904599 advanced glycation end-product binding(GO:1904599)
0.1 0.3 GO:0009041 uridylate kinase activity(GO:0009041)
0.1 0.4 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.4 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.1 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.0 0.3 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.1 GO:0099609 microtubule lateral binding(GO:0099609)
0.0 0.5 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.1 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.0 GO:0070283 lipoate synthase activity(GO:0016992) radical SAM enzyme activity(GO:0070283)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.4 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle