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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ZNF35

Z-value: 0.31

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Transcription factors associated with ZNF35

Gene Symbol Gene ID Gene Info
ZNF35
ENSG00000169981.6 zinc finger protein 35

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF35hg19_v2_chr3_+_44690211_44690267-0.059.3e-01Click!

Activity profile of ZNF35 motif

Sorted Z-values of ZNF35 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_191878162 0.32 ENST00000540176.1
STAT1
signal transducer and activator of transcription 1, 91kDa
chr7_-_83824449 0.31 ENST00000420047.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr3_-_148939598 0.29 ENST00000455472.3
CP
ceruloplasmin (ferroxidase)
chr1_-_161008697 0.23 ENST00000318289.10
ENST00000368023.3
ENST00000368024.1
ENST00000423014.2
TSTD1
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
chr21_+_35553045 0.22 ENST00000416145.1
ENST00000430922.1
ENST00000419881.2
LINC00310
long intergenic non-protein coding RNA 310
chr3_-_148939835 0.16 ENST00000264613.6
CP
ceruloplasmin (ferroxidase)
chrM_+_4431 0.15 ENST00000361453.3
MT-ND2
mitochondrially encoded NADH dehydrogenase 2
chr1_+_84630574 0.11 ENST00000413538.1
ENST00000417530.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_-_243349684 0.10 ENST00000522895.1
CEP170
centrosomal protein 170kDa
chr7_-_83824169 0.10 ENST00000265362.4
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr6_-_133084580 0.10 ENST00000525270.1
ENST00000530536.1
ENST00000524919.1
VNN2
vanin 2
chr17_-_63557309 0.09 ENST00000580513.1
AXIN2
axin 2
chr4_-_99850243 0.09 ENST00000280892.6
ENST00000511644.1
ENST00000504432.1
ENST00000505992.1
EIF4E
eukaryotic translation initiation factor 4E
chr14_-_31889737 0.09 ENST00000382464.2
HEATR5A
HEAT repeat containing 5A
chr1_+_61869748 0.08 ENST00000357977.5
NFIA
nuclear factor I/A
chr3_+_29323043 0.08 ENST00000452462.1
ENST00000456853.1
RBMS3
RNA binding motif, single stranded interacting protein 3
chr12_+_79258444 0.08 ENST00000261205.4
SYT1
synaptotagmin I
chr14_+_76776957 0.08 ENST00000512784.1
ESRRB
estrogen-related receptor beta
chr5_-_39203093 0.07 ENST00000515010.1
FYB
FYN binding protein
chr3_-_169487617 0.07 ENST00000330368.2
ACTRT3
actin-related protein T3
chr7_-_78400598 0.07 ENST00000536571.1
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr14_-_31889782 0.05 ENST00000543095.2
HEATR5A
HEAT repeat containing 5A
chr3_-_58523010 0.05 ENST00000459701.2
ENST00000302819.5
ACOX2
acyl-CoA oxidase 2, branched chain
chr18_+_39535239 0.05 ENST00000585528.1
PIK3C3
phosphatidylinositol 3-kinase, catalytic subunit type 3
chr4_+_78804393 0.05 ENST00000502384.1
MRPL1
mitochondrial ribosomal protein L1
chr7_-_87342564 0.05 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr3_-_171489085 0.04 ENST00000418087.1
PLD1
phospholipase D1, phosphatidylcholine-specific
chr18_+_39535152 0.04 ENST00000262039.4
ENST00000398870.3
ENST00000586545.1
PIK3C3
phosphatidylinositol 3-kinase, catalytic subunit type 3
chr13_-_41240717 0.04 ENST00000379561.5
FOXO1
forkhead box O1
chr3_+_141106458 0.04 ENST00000509883.1
ZBTB38
zinc finger and BTB domain containing 38
chr19_-_56343353 0.04 ENST00000592953.1
ENST00000589093.1
NLRP11
NLR family, pyrin domain containing 11
chr17_-_58042075 0.04 ENST00000305783.8
ENST00000589113.1
ENST00000442346.2
RNFT1
ring finger protein, transmembrane 1
chr13_-_36429763 0.03 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr4_-_89744365 0.03 ENST00000513837.1
ENST00000503556.1
FAM13A
family with sequence similarity 13, member A
chr14_-_92198403 0.03 ENST00000553329.1
ENST00000256343.3
CATSPERB
catsper channel auxiliary subunit beta
chr2_+_196440692 0.03 ENST00000458054.1
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr6_+_32812568 0.03 ENST00000414474.1
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr7_+_27282319 0.03 ENST00000222761.3
EVX1
even-skipped homeobox 1
chr7_+_74072288 0.02 ENST00000443166.1
GTF2I
general transcription factor IIi
chr5_-_58571935 0.02 ENST00000503258.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr15_+_35270552 0.02 ENST00000391457.2
AC114546.1
HCG37415; PRO1914; Uncharacterized protein
chr3_+_141105705 0.02 ENST00000513258.1
ZBTB38
zinc finger and BTB domain containing 38
chr7_-_78400364 0.02 ENST00000535697.1
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr21_+_35552978 0.02 ENST00000428914.2
ENST00000609062.1
ENST00000609947.1
LINC00310
long intergenic non-protein coding RNA 310
chr16_+_21623958 0.02 ENST00000568826.1
METTL9
methyltransferase like 9
chr4_+_129730947 0.02 ENST00000452328.2
ENST00000504089.1
PHF17
jade family PHD finger 1
chr8_-_101157680 0.01 ENST00000428847.2
FBXO43
F-box protein 43
chr6_-_133084564 0.01 ENST00000532012.1
VNN2
vanin 2
chr10_-_131762105 0.01 ENST00000368648.3
ENST00000355311.5
EBF3
early B-cell factor 3
chr4_+_75174180 0.01 ENST00000413830.1
EPGN
epithelial mitogen
chr7_+_80231466 0.00 ENST00000309881.7
ENST00000534394.1
CD36
CD36 molecule (thrombospondin receptor)
chr8_+_85095769 0.00 ENST00000518566.1
RALYL
RALY RNA binding protein-like
chr12_+_54891495 0.00 ENST00000293373.6
NCKAP1L
NCK-associated protein 1-like
chr13_+_109248500 0.00 ENST00000356711.2
MYO16
myosin XVI
chr21_+_17792672 0.00 ENST00000602620.1
LINC00478
long intergenic non-protein coding RNA 478

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF35

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.1 0.3 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.0 0.1 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.0 0.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.5 GO:0006825 copper ion transport(GO:0006825)
0.0 0.1 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.0 0.1 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0097338 response to clozapine(GO:0097338)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.1 GO:0070699 type II activin receptor binding(GO:0070699)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.5 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters