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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ZNF8

Z-value: 0.55

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Transcription factors associated with ZNF8

Gene Symbol Gene ID Gene Info
ZNF8
ENSG00000083842.8 zinc finger protein 8
ZNF8
ENSG00000273439.1 zinc finger protein 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF8hg19_v2_chr19_+_58790314_58790358-0.424.1e-01Click!

Activity profile of ZNF8 motif

Sorted Z-values of ZNF8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_79258444 0.42 ENST00000261205.4
SYT1
synaptotagmin I
chr12_+_79258547 0.35 ENST00000457153.2
SYT1
synaptotagmin I
chr5_-_43515125 0.28 ENST00000509489.1
C5orf34
chromosome 5 open reading frame 34
chr6_+_29691056 0.26 ENST00000414333.1
ENST00000334668.4
ENST00000259951.7
HLA-F
major histocompatibility complex, class I, F
chr6_+_29691198 0.25 ENST00000440587.2
ENST00000434407.2
HLA-F
major histocompatibility complex, class I, F
chr1_+_186344945 0.23 ENST00000419367.3
ENST00000287859.6
C1orf27
chromosome 1 open reading frame 27
chr17_+_48585794 0.23 ENST00000576179.1
ENST00000419930.1
MYCBPAP
MYCBP associated protein
chr11_+_13690249 0.22 ENST00000532701.1
FAR1
fatty acyl CoA reductase 1
chr1_-_70671216 0.21 ENST00000370952.3
LRRC40
leucine rich repeat containing 40
chr1_+_186344883 0.20 ENST00000367470.3
C1orf27
chromosome 1 open reading frame 27
chr8_-_109260897 0.20 ENST00000521297.1
ENST00000519030.1
ENST00000521440.1
ENST00000518345.1
ENST00000519627.1
ENST00000220849.5
EIF3E
eukaryotic translation initiation factor 3, subunit E
chr9_-_32552551 0.20 ENST00000360538.2
ENST00000379858.1
TOPORS
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
chr11_+_13690200 0.19 ENST00000354817.3
FAR1
fatty acyl CoA reductase 1
chr13_+_45563721 0.19 ENST00000361121.2
GPALPP1
GPALPP motifs containing 1
chr4_-_52904425 0.19 ENST00000535450.1
SGCB
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
chr1_+_70671363 0.18 ENST00000370951.1
ENST00000370950.3
ENST00000405432.1
ENST00000454435.2
SRSF11
serine/arginine-rich splicing factor 11
chr12_-_46662888 0.18 ENST00000546893.1
SLC38A1
solute carrier family 38, member 1
chr4_-_77069573 0.17 ENST00000264883.3
NUP54
nucleoporin 54kDa
chr13_+_53029564 0.16 ENST00000468284.1
ENST00000378034.3
ENST00000258607.5
ENST00000378037.5
CKAP2
cytoskeleton associated protein 2
chr12_-_46662772 0.15 ENST00000549049.1
ENST00000439706.1
ENST00000398637.5
SLC38A1
solute carrier family 38, member 1
chr5_+_102455968 0.15 ENST00000358359.3
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr5_+_138677515 0.14 ENST00000265192.4
ENST00000511706.1
PAIP2
poly(A) binding protein interacting protein 2
chr2_+_172290707 0.14 ENST00000375255.3
ENST00000539783.1
DCAF17
DDB1 and CUL4 associated factor 17
chr8_-_61429315 0.13 ENST00000530725.1
ENST00000532232.1
RP11-163N6.2
RP11-163N6.2
chrX_+_102631248 0.13 ENST00000361298.4
ENST00000372645.3
ENST00000372635.1
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr11_+_46402583 0.12 ENST00000359803.3
MDK
midkine (neurite growth-promoting factor 2)
chr10_+_135192695 0.12 ENST00000368539.4
ENST00000278060.5
ENST00000357296.3
PAOX
polyamine oxidase (exo-N4-amino)
chr17_+_48585902 0.12 ENST00000452039.1
MYCBPAP
MYCBP associated protein
chr16_+_68573116 0.12 ENST00000570495.1
ENST00000563169.2
ENST00000564323.1
ENST00000562156.1
ENST00000573685.1
ZFP90
ZFP90 zinc finger protein
chr10_-_1034237 0.12 ENST00000381466.1
AL359878.1
Uncharacterized protein
chr1_-_100715372 0.12 ENST00000370131.3
ENST00000370132.4
DBT
dihydrolipoamide branched chain transacylase E2
chr13_+_53226963 0.12 ENST00000343788.6
ENST00000535397.1
ENST00000310528.8
SUGT1
SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
chr13_-_21750659 0.11 ENST00000400018.3
ENST00000314759.5
SKA3
spindle and kinetochore associated complex subunit 3
chr2_-_172290482 0.11 ENST00000442541.1
ENST00000392599.2
ENST00000375258.4
METTL8
methyltransferase like 8
chr12_-_74686314 0.11 ENST00000551210.1
ENST00000515416.2
ENST00000549905.1
RP11-81H3.2
RP11-81H3.2
chr6_+_88117683 0.10 ENST00000369562.4
C6ORF165
UPF0704 protein C6orf165
chr1_-_235292250 0.10 ENST00000366607.4
TOMM20
translocase of outer mitochondrial membrane 20 homolog (yeast)
chr4_+_170541678 0.10 ENST00000360642.3
ENST00000512813.1
CLCN3
chloride channel, voltage-sensitive 3
chr8_+_38244638 0.10 ENST00000526356.1
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr4_+_170541835 0.09 ENST00000504131.2
CLCN3
chloride channel, voltage-sensitive 3
chr5_-_137911049 0.09 ENST00000297185.3
HSPA9
heat shock 70kDa protein 9 (mortalin)
chr15_+_85523671 0.09 ENST00000310298.4
ENST00000557957.1
PDE8A
phosphodiesterase 8A
chr2_+_198365122 0.09 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chr8_+_61429416 0.08 ENST00000262646.7
ENST00000531289.1
RAB2A
RAB2A, member RAS oncogene family
chr16_-_53537105 0.08 ENST00000568596.1
ENST00000570004.1
ENST00000564497.1
ENST00000300245.4
ENST00000394657.7
AKTIP
AKT interacting protein
chr10_+_1034338 0.07 ENST00000360803.4
ENST00000538293.1
GTPBP4
GTP binding protein 4
chr1_+_25664408 0.07 ENST00000374358.4
TMEM50A
transmembrane protein 50A
chr13_-_25861530 0.07 ENST00000540661.1
MTMR6
myotubularin related protein 6
chr2_+_169926047 0.07 ENST00000428522.1
ENST00000450153.1
ENST00000421653.1
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr4_-_186347099 0.06 ENST00000505357.1
ENST00000264689.6
UFSP2
UFM1-specific peptidase 2
chr14_+_51706886 0.06 ENST00000457354.2
TMX1
thioredoxin-related transmembrane protein 1
chr16_+_21964662 0.06 ENST00000561553.1
ENST00000565331.1
UQCRC2
ubiquinol-cytochrome c reductase core protein II
chr4_+_170541660 0.06 ENST00000513761.1
ENST00000347613.4
CLCN3
chloride channel, voltage-sensitive 3
chr5_-_93447333 0.06 ENST00000395965.3
ENST00000505869.1
ENST00000509163.1
FAM172A
family with sequence similarity 172, member A
chr10_+_1034646 0.05 ENST00000360059.5
ENST00000545048.1
GTPBP4
GTP binding protein 4
chr17_+_48585745 0.05 ENST00000323776.5
MYCBPAP
MYCBP associated protein
chr1_+_211500129 0.05 ENST00000427925.2
ENST00000261464.5
TRAF5
TNF receptor-associated factor 5
chr1_-_246670519 0.04 ENST00000388985.4
ENST00000490107.1
SMYD3
SET and MYND domain containing 3
chr2_+_173600565 0.04 ENST00000397081.3
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chrX_+_128913906 0.03 ENST00000356892.3
SASH3
SAM and SH3 domain containing 3
chr2_+_173600514 0.03 ENST00000264111.6
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr2_+_240323439 0.03 ENST00000428471.1
ENST00000413029.1
AC062017.1
Uncharacterized protein
chr3_-_46000146 0.03 ENST00000438446.1
FYCO1
FYVE and coiled-coil domain containing 1
chr22_-_30162924 0.03 ENST00000344318.3
ENST00000397781.3
ZMAT5
zinc finger, matrin-type 5
chr6_+_116601265 0.03 ENST00000452085.3
DSE
dermatan sulfate epimerase
chr1_+_6615241 0.03 ENST00000333172.6
ENST00000328191.4
ENST00000351136.3
TAS1R1
taste receptor, type 1, member 1
chr12_-_122750957 0.03 ENST00000451053.2
VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr20_+_37377085 0.02 ENST00000243903.4
ACTR5
ARP5 actin-related protein 5 homolog (yeast)
chrX_+_1387693 0.02 ENST00000381529.3
ENST00000432318.2
ENST00000361536.3
ENST00000501036.2
ENST00000381524.3
ENST00000412290.1
CSF2RA
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
chr6_+_106959718 0.02 ENST00000369066.3
AIM1
absent in melanoma 1
chr2_+_87144738 0.02 ENST00000559485.1
RGPD1
RANBP2-like and GRIP domain containing 1
chr5_+_89854595 0.02 ENST00000405460.2
GPR98
G protein-coupled receptor 98
chr7_+_1748798 0.01 ENST00000561626.1
ELFN1
extracellular leucine-rich repeat and fibronectin type III domain containing 1
chr10_-_13043697 0.01 ENST00000378825.3
CCDC3
coiled-coil domain containing 3
chr11_-_58345569 0.01 ENST00000528954.1
ENST00000528489.1
LPXN
leupaxin
chr19_+_52074502 0.01 ENST00000545217.1
ENST00000262259.2
ENST00000596504.1
ZNF175
zinc finger protein 175
chr11_+_46402482 0.01 ENST00000441869.1
MDK
midkine (neurite growth-promoting factor 2)

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.1 0.4 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.1 0.5 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.0 0.2 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.0 0.1 GO:0033341 regulation of collagen binding(GO:0033341)
0.0 0.2 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.1 GO:0009447 putrescine catabolic process(GO:0009447)
0.0 0.1 GO:0030421 defecation(GO:0030421)
0.0 0.2 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 0.2 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.1 GO:0052422 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.0 0.2 GO:0097084 vascular smooth muscle cell development(GO:0097084)
0.0 0.1 GO:0035927 RNA import into mitochondrion(GO:0035927)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.4 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 0.8 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 0.5 GO:0046979 TAP2 binding(GO:0046979)
0.0 0.2 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.1 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.0 0.1 GO:0052901 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.0 0.2 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.1 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 0.3 GO:0005283 sodium:amino acid symporter activity(GO:0005283)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 SIG CD40PATHWAYMAP Genes related to CD40 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 0.5 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism