Motif ID: Foxo4

Z-value: 0.659


Transcription factors associated with Foxo4:

Gene SymbolEntrez IDGene Name
Foxo4 ENSMUSG00000042903.7 Foxo4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo4mm10_v2_chrX_+_101254528_1012545740.551.0e-06Click!


Activity profile for motif Foxo4.

activity profile for motif Foxo4


Sorted Z-values histogram for motif Foxo4

Sorted Z-values for motif Foxo4



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_5796924 5.430 ENSMUST00000174808.1
Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr17_+_78508063 5.143 ENSMUST00000024880.9
Vit
vitrin
chr4_-_97778042 3.965 ENSMUST00000146447.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_+_8690399 3.226 ENSMUST00000127476.1
Chd7
chromodomain helicase DNA binding protein 7
chr7_-_89517576 2.990 ENSMUST00000041761.5
Prss23
protease, serine, 23
chr8_-_105943382 2.810 ENSMUST00000038896.7
Lcat
lecithin cholesterol acyltransferase
chr14_-_25903100 2.598 ENSMUST00000052286.8
Plac9a
placenta specific 9a
chr5_-_70842617 2.513 ENSMUST00000031119.1
Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr14_-_26182480 2.486 ENSMUST00000184142.1
Plac9b
placenta specific 9b
chr8_-_45410539 2.404 ENSMUST00000034056.4
ENSMUST00000167106.1
Tlr3

toll-like receptor 3

chr11_-_102579461 2.291 ENSMUST00000107081.1
Gm11627
predicted gene 11627
chr2_+_181767283 2.275 ENSMUST00000108757.2
Myt1
myelin transcription factor 1
chr2_-_175931051 2.253 ENSMUST00000108949.2
ENSMUST00000109018.2
Gm8898

predicted gene 8898

chr2_+_181767040 2.156 ENSMUST00000108756.1
Myt1
myelin transcription factor 1
chr7_-_25250720 1.964 ENSMUST00000116343.2
ENSMUST00000045847.8
Erf

Ets2 repressor factor

chr2_-_175141999 1.931 ENSMUST00000109062.1
ENSMUST00000109059.1
ENSMUST00000109060.1
Gm14399


predicted gene 14399


chr2_-_175338197 1.878 ENSMUST00000121393.2
Gm4631
predicted gene 4631
chr1_+_6487231 1.865 ENSMUST00000140079.1
ENSMUST00000131494.1
St18

suppression of tumorigenicity 18

chr2_+_176521056 1.863 ENSMUST00000108997.2
ENSMUST00000178443.1
Gm14431

predicted gene 14431

chr2_+_175469985 1.827 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
Gm8923



predicted gene 8923



chr17_-_51831884 1.726 ENSMUST00000124222.1
Satb1
special AT-rich sequence binding protein 1
chr2_-_175703646 1.719 ENSMUST00000109027.2
ENSMUST00000179061.1
ENSMUST00000131041.1
Gm4245


predicted gene 4245


chr4_-_32950813 1.693 ENSMUST00000084750.1
ENSMUST00000084748.2
Ankrd6

ankyrin repeat domain 6

chr2_+_175372436 1.689 ENSMUST00000131676.1
ENSMUST00000109048.2
ENSMUST00000109047.2
Gm4723


predicted gene 4723


chr15_-_97767798 1.654 ENSMUST00000129223.2
ENSMUST00000126854.2
ENSMUST00000135080.1
Rapgef3


Rap guanine nucleotide exchange factor (GEF) 3


chr14_-_98169542 1.613 ENSMUST00000069334.7
ENSMUST00000071533.6
Dach1

dachshund 1 (Drosophila)

chr2_-_177957239 1.597 ENSMUST00000108928.1
ENSMUST00000108932.1
ENSMUST00000108930.2
Gm14326


predicted gene 14326


chr18_-_38918642 1.513 ENSMUST00000040647.4
Fgf1
fibroblast growth factor 1
chr2_-_177840318 1.481 ENSMUST00000108939.2
ENSMUST00000150650.1
Gm14325

predicted gene 14325

chr2_+_178023284 1.456 ENSMUST00000108925.3
ENSMUST00000108926.2
Etohi1

ethanol induced 1

chr4_+_97777606 1.421 ENSMUST00000075448.6
ENSMUST00000092532.6
Nfia

nuclear factor I/A

chr2_+_176670522 1.415 ENSMUST00000121956.1
ENSMUST00000108985.2
Gm14306

predicted gene 14306

chr11_-_77078404 1.378 ENSMUST00000102494.1
Ccdc55
coiled-coil domain containing 55
chr12_+_75308308 1.369 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
Rhoj


ras homolog gene family, member J


chr2_-_175206899 1.124 ENSMUST00000109055.1
ENSMUST00000099028.3
ENSMUST00000109056.1
ENSMUST00000109058.2
Gm14391



predicted gene 14391



chr10_-_53638269 1.102 ENSMUST00000164393.1
Fam184a
family with sequence similarity 184, member A
chr2_-_178078425 1.102 ENSMUST00000108924.2
ENSMUST00000131702.1
ENSMUST00000108923.1
Zfp931


zinc finger protein 931


chr11_+_101246960 1.095 ENSMUST00000107282.3
Ramp2
receptor (calcitonin) activity modifying protein 2
chr2_+_175965331 1.030 ENSMUST00000109007.1
ENSMUST00000174416.1
Gm2026

predicted gene 2026

chr7_-_4524229 1.030 ENSMUST00000154913.1
Tnni3
troponin I, cardiac 3
chr3_+_107895916 1.013 ENSMUST00000172247.1
ENSMUST00000167387.1
Gstm5

glutathione S-transferase, mu 5

chr2_+_176226569 0.994 ENSMUST00000099009.2
ENSMUST00000136719.1
2210418O10Rik

RIKEN cDNA 2210418O10 gene

chr8_+_79639618 0.970 ENSMUST00000173078.1
ENSMUST00000173286.1
Otud4

OTU domain containing 4

chr2_+_177000956 0.966 ENSMUST00000108975.2
ENSMUST00000156844.1
Gm14419

predicted gene 14419

chr6_+_95117740 0.933 ENSMUST00000032107.7
ENSMUST00000119582.1
Kbtbd8

kelch repeat and BTB (POZ) domain containing 8

chr2_+_176708328 0.844 ENSMUST00000108981.2
ENSMUST00000108980.2
Gm14305

predicted gene 14305

chr8_+_26119361 0.840 ENSMUST00000014022.8
ENSMUST00000153528.1
ENSMUST00000131138.1
ENSMUST00000110575.1
Rnf170



ring finger protein 170



chr2_+_175869219 0.814 ENSMUST00000109011.1
Gm6710
predicted gene 6710
chr2_-_144011202 0.805 ENSMUST00000016072.5
ENSMUST00000037875.5
Rrbp1

ribosome binding protein 1

chr2_+_176798612 0.801 ENSMUST00000118012.2
Gm14295
predicted gene 14295
chr2_-_176636318 0.794 ENSMUST00000108990.2
ENSMUST00000119149.1
ENSMUST00000117267.1
Gm14308


predicted gene 14308


chr2_-_176927809 0.794 ENSMUST00000099007.2
Gm14296
predicted gene 14296
chr2_-_175435782 0.785 ENSMUST00000152941.1
ENSMUST00000109045.2
Gm4724

predicted gene 4724

chr2_-_176486773 0.741 ENSMUST00000120959.1
ENSMUST00000120521.1
Gm14434

predicted gene 14434

chr4_-_6454262 0.663 ENSMUST00000029910.5
Nsmaf
neutral sphingomyelinase (N-SMase) activation associated factor
chr2_-_177206421 0.602 ENSMUST00000108964.1
Gm14410
predicted gene 14410
chr7_-_139582790 0.601 ENSMUST00000106095.2
Nkx6-2
NK6 homeobox 2
chr17_-_23745829 0.559 ENSMUST00000046525.8
Kremen2
kringle containing transmembrane protein 2
chr7_-_4778141 0.546 ENSMUST00000094892.5
Il11
interleukin 11
chr4_+_45972233 0.527 ENSMUST00000102929.1
Tdrd7
tudor domain containing 7
chr5_-_135545108 0.516 ENSMUST00000060311.8
Hip1
huntingtin interacting protein 1
chr14_+_32028989 0.509 ENSMUST00000022460.4
Galnt15
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
chr17_+_80944611 0.504 ENSMUST00000025092.4
Tmem178
transmembrane protein 178
chr8_-_47352348 0.459 ENSMUST00000110367.2
Stox2
storkhead box 2
chr8_+_26119611 0.436 ENSMUST00000140819.1
Rnf170
ring finger protein 170
chr9_+_109096659 0.395 ENSMUST00000130366.1
Plxnb1
plexin B1
chr7_-_133123770 0.342 ENSMUST00000164896.1
ENSMUST00000171968.1
Ctbp2

C-terminal binding protein 2

chr6_+_42286676 0.339 ENSMUST00000031894.6
Clcn1
chloride channel 1
chr15_-_35938009 0.305 ENSMUST00000156915.1
Cox6c
cytochrome c oxidase subunit VIc
chr18_-_6490808 0.297 ENSMUST00000028100.6
ENSMUST00000050542.5
Epc1

enhancer of polycomb homolog 1 (Drosophila)

chr2_-_75938407 0.293 ENSMUST00000099996.3
Ttc30b
tetratricopeptide repeat domain 30B
chr11_+_3290300 0.265 ENSMUST00000057089.6
ENSMUST00000093402.5
Patz1

POZ (BTB) and AT hook containing zinc finger 1

chr16_-_64771146 0.256 ENSMUST00000076991.6
4930453N24Rik
RIKEN cDNA 4930453N24 gene
chr5_-_90366176 0.227 ENSMUST00000014421.8
ENSMUST00000081914.6
ENSMUST00000168058.2
Ankrd17


ankyrin repeat domain 17


chr9_+_57076395 0.200 ENSMUST00000168177.1
Sin3a
transcriptional regulator, SIN3A (yeast)
chr15_-_35938186 0.176 ENSMUST00000014457.8
Cox6c
cytochrome c oxidase subunit VIc
chr5_-_24445166 0.128 ENSMUST00000115043.1
ENSMUST00000115041.1
Fastk

Fas-activated serine/threonine kinase

chr10_-_40257648 0.115 ENSMUST00000019982.7
Gtf3c6
general transcription factor IIIC, polypeptide 6, alpha
chrX_-_134600976 0.097 ENSMUST00000033621.6
Gla
galactosidase, alpha
chr9_+_57076343 0.078 ENSMUST00000168678.1
Sin3a
transcriptional regulator, SIN3A (yeast)
chr11_-_33163072 0.042 ENSMUST00000093201.6
ENSMUST00000101375.4
ENSMUST00000109354.3
ENSMUST00000075641.3
Npm1



nucleophosmin 1



chr12_-_69892989 0.025 ENSMUST00000110567.1
ENSMUST00000171211.1
Map4k5

mitogen-activated protein kinase kinase kinase kinase 5

chr15_-_102625436 0.012 ENSMUST00000184485.1
ENSMUST00000185070.1
ENSMUST00000184616.1
ENSMUST00000108828.2
ATF7



Cyclic AMP-dependent transcription factor ATF-7



chr5_-_24445254 0.007 ENSMUST00000030800.6
Fastk
Fas-activated serine/threonine kinase
chr14_-_32085595 0.002 ENSMUST00000022461.4
ENSMUST00000067955.5
ENSMUST00000124303.1
ENSMUST00000112000.1
Dph3



diphthamine biosynthesis 3




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.4 GO:0035063 nuclear speck organization(GO:0035063)
1.1 3.2 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.8 2.4 GO:0045349 regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.6 2.8 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.5 1.6 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.5 1.5 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.4 1.7 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.4 4.4 GO:0060539 diaphragm development(GO:0060539)
0.4 2.0 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.2 1.0 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.1 1.0 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.1 1.7 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 1.1 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.1 1.7 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 1.4 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 0.4 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.1 0.3 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 0.6 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.1 0.2 GO:0039530 MDA-5 signaling pathway(GO:0039530)
0.0 1.4 GO:0060074 synapse maturation(GO:0060074)
0.0 4.9 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 1.0 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.9 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.5 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.0 0.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.5 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.3 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.0 GO:0006407 rRNA export from nucleus(GO:0006407)
0.0 0.1 GO:0046477 glycosylceramide catabolic process(GO:0046477)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:1990795 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.3 5.1 GO:0005614 interstitial matrix(GO:0005614)
0.2 1.0 GO:0005861 troponin complex(GO:0005861)
0.2 2.8 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 0.5 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 1.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.9 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.4 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 5.3 GO:0016607 nuclear speck(GO:0016607)
0.0 1.7 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.3 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.3 GO:0030992 intraciliary transport particle B(GO:0030992)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.8 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.5 1.6 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.3 1.0 GO:0030172 troponin C binding(GO:0030172)
0.2 1.7 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.2 3.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 0.7 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.1 2.5 GO:0050811 GABA receptor binding(GO:0050811)
0.1 1.5 GO:0044548 S100 protein binding(GO:0044548)
0.1 1.1 GO:0015026 coreceptor activity(GO:0015026)
0.0 3.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.0 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 4.4 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 5.1 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.0 2.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.5 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0016936 galactoside binding(GO:0016936)
0.0 2.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.0 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)