Motif ID: Otx1

Z-value: 0.411


Transcription factors associated with Otx1:

Gene SymbolEntrez IDGene Name
Otx1 ENSMUSG00000005917.9 Otx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx1mm10_v2_chr11_-_22001605_220016310.253.4e-02Click!


Activity profile for motif Otx1.

activity profile for motif Otx1


Sorted Z-values histogram for motif Otx1

Sorted Z-values for motif Otx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Otx1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_108479849 4.018 ENSMUST00000065014.4
Lamb2
laminin, beta 2
chr10_+_3973086 3.184 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr5_-_98566762 2.488 ENSMUST00000086912.4
1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr5_-_37336870 1.907 ENSMUST00000031005.4
Evc
Ellis van Creveld gene syndrome
chr17_+_35861318 1.802 ENSMUST00000074259.8
ENSMUST00000174873.1
Nrm

nurim (nuclear envelope membrane protein)

chr5_-_5749317 1.756 ENSMUST00000015796.2
Steap1
six transmembrane epithelial antigen of the prostate 1
chr5_-_37336837 1.681 ENSMUST00000114148.1
Evc
Ellis van Creveld gene syndrome
chr8_-_47675556 1.679 ENSMUST00000125536.1
Ing2
inhibitor of growth family, member 2
chr12_-_46818749 1.623 ENSMUST00000021438.6
Nova1
neuro-oncological ventral antigen 1
chrX_-_48513518 1.571 ENSMUST00000114945.2
ENSMUST00000037349.7
Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr11_+_94936224 1.472 ENSMUST00000001547.7
Col1a1
collagen, type I, alpha 1
chr1_-_165708088 1.445 ENSMUST00000040357.8
ENSMUST00000097474.3
Rcsd1

RCSD domain containing 1

chr16_-_59632520 1.419 ENSMUST00000118438.1
Arl6
ADP-ribosylation factor-like 6
chr2_-_60963192 1.410 ENSMUST00000028347.6
Rbms1
RNA binding motif, single stranded interacting protein 1
chr3_+_54481429 1.330 ENSMUST00000091130.3
Gm5641
predicted gene 5641
chr7_-_38271310 1.242 ENSMUST00000032585.6
Pop4
processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)
chr14_-_87141114 1.221 ENSMUST00000168889.1
Diap3
diaphanous homolog 3 (Drosophila)
chr17_+_35861343 1.180 ENSMUST00000172931.1
Nrm
nurim (nuclear envelope membrane protein)
chr14_-_87141206 1.152 ENSMUST00000022599.7
Diap3
diaphanous homolog 3 (Drosophila)
chr14_-_122913751 1.097 ENSMUST00000160401.1
Ggact
gamma-glutamylamine cyclotransferase
chr11_+_115564434 1.061 ENSMUST00000021085.4
Nup85
nucleoporin 85
chr7_-_100662315 1.043 ENSMUST00000151123.1
ENSMUST00000107047.2
Plekhb1

pleckstrin homology domain containing, family B (evectins) member 1

chr13_-_60897439 1.015 ENSMUST00000171347.1
ENSMUST00000021884.8
Ctla2b

cytotoxic T lymphocyte-associated protein 2 beta

chr9_+_68653761 0.983 ENSMUST00000034766.7
Rora
RAR-related orphan receptor alpha
chr1_+_131910458 0.951 ENSMUST00000062264.6
Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr2_-_144011202 0.949 ENSMUST00000016072.5
ENSMUST00000037875.5
Rrbp1

ribosome binding protein 1

chr10_-_88605017 0.908 ENSMUST00000119185.1
ENSMUST00000121629.1
Mybpc1

myosin binding protein C, slow-type

chr11_+_78346666 0.884 ENSMUST00000100755.3
Unc119
unc-119 homolog (C. elegans)
chr10_-_7473361 0.867 ENSMUST00000169796.2
ENSMUST00000177585.1
Ulbp1

UL16 binding protein 1

chr7_-_79848191 0.807 ENSMUST00000107392.1
Anpep
alanyl (membrane) aminopeptidase
chr7_-_100662414 0.760 ENSMUST00000079176.6
Plekhb1
pleckstrin homology domain containing, family B (evectins) member 1
chr10_+_127642975 0.738 ENSMUST00000092074.5
ENSMUST00000120279.1
Stat6

signal transducer and activator of transcription 6

chr10_+_61648552 0.734 ENSMUST00000020286.6
Ppa1
pyrophosphatase (inorganic) 1
chr4_-_42661893 0.725 ENSMUST00000108006.3
Il11ra2
interleukin 11 receptor, alpha chain 2
chr11_-_116274102 0.724 ENSMUST00000106425.3
Srp68
signal recognition particle 68
chr4_-_123750236 0.715 ENSMUST00000102636.3
Akirin1
akirin 1
chr19_-_6057736 0.708 ENSMUST00000007482.6
Mrpl49
mitochondrial ribosomal protein L49
chr13_+_21180179 0.702 ENSMUST00000021761.5
Trim27
tripartite motif-containing 27
chr6_-_136828186 0.696 ENSMUST00000116514.1
Wbp11
WW domain binding protein 11
chr19_-_7039987 0.683 ENSMUST00000025918.7
Stip1
stress-induced phosphoprotein 1
chr4_-_41517326 0.679 ENSMUST00000030152.6
ENSMUST00000095126.4
1110017D15Rik

RIKEN cDNA 1110017D15 gene

chr13_+_41016250 0.670 ENSMUST00000021790.5
Tmem14c
transmembrane protein 14C
chr5_+_15516489 0.647 ENSMUST00000178227.1
Gm21847
predicted gene, 21847
chr4_+_58943575 0.603 ENSMUST00000107554.1
Zkscan16
zinc finger with KRAB and SCAN domains 16
chr1_+_118321834 0.588 ENSMUST00000027626.6
ENSMUST00000112688.3
Mki67ip

Mki67 (FHA domain) interacting nucleolar phosphoprotein

chr11_-_116694802 0.572 ENSMUST00000079545.5
St6galnac2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr3_-_105960099 0.569 ENSMUST00000118209.1
Atp5f1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1
chr1_+_187215501 0.561 ENSMUST00000097443.3
ENSMUST00000065573.7
ENSMUST00000110943.2
ENSMUST00000044812.5
Gpatch2



G patch domain containing 2



chr3_+_66985647 0.551 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1

arginine/serine-rich coiled-coil 1

chr11_-_116274197 0.546 ENSMUST00000021133.9
Srp68
signal recognition particle 68
chr7_-_4063195 0.545 ENSMUST00000068865.5
ENSMUST00000086400.6
Lair1

leukocyte-associated Ig-like receptor 1

chr1_+_187215737 0.535 ENSMUST00000160471.1
Gpatch2
G patch domain containing 2
chr19_+_5689131 0.519 ENSMUST00000004156.8
Map3k11
mitogen-activated protein kinase kinase kinase 11
chr10_-_93889758 0.491 ENSMUST00000181091.1
ENSMUST00000181217.1
ENSMUST00000047910.8
ENSMUST00000180688.1
Metap2



methionine aminopeptidase 2



chr11_+_100545607 0.476 ENSMUST00000092684.5
ENSMUST00000006976.7
Ttc25

tetratricopeptide repeat domain 25

chr2_+_28468056 0.458 ENSMUST00000038600.3
Mrps2
mitochondrial ribosomal protein S2
chr10_+_29313164 0.448 ENSMUST00000160399.1
Echdc1
enoyl Coenzyme A hydratase domain containing 1
chr5_-_62765618 0.425 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr9_-_66975387 0.424 ENSMUST00000034929.6
Lactb
lactamase, beta
chr7_-_118129567 0.420 ENSMUST00000032888.7
Arl6ip1
ADP-ribosylation factor-like 6 interacting protein 1
chr11_+_3963970 0.417 ENSMUST00000020705.4
ENSMUST00000109985.1
Pes1

pescadillo homolog 1, containing BRCT domain (zebrafish)

chrM_+_11734 0.412 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr13_-_21750505 0.406 ENSMUST00000102983.1
Hist1h4k
histone cluster 1, H4k
chr2_+_154656959 0.396 ENSMUST00000044277.9
Chmp4b
charged multivesicular body protein 4B
chr9_-_109082372 0.390 ENSMUST00000167504.1
Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chr13_+_90089705 0.388 ENSMUST00000012566.8
Tmem167
transmembrane protein 167
chr2_-_11603192 0.364 ENSMUST00000040314.5
Rbm17
RNA binding motif protein 17
chr17_+_8165501 0.356 ENSMUST00000097419.3
ENSMUST00000024636.8
Fgfr1op

Fgfr1 oncogene partner

chr13_+_93771656 0.343 ENSMUST00000091403.4
Arsb
arylsulfatase B
chr2_-_26933781 0.337 ENSMUST00000154651.1
ENSMUST00000015011.3
Surf4

surfeit gene 4

chr10_+_80054029 0.336 ENSMUST00000097227.3
Gpx4
glutathione peroxidase 4
chr3_+_66985947 0.333 ENSMUST00000161726.1
ENSMUST00000160504.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr15_-_79285502 0.296 ENSMUST00000165408.1
Baiap2l2
BAI1-associated protein 2-like 2
chr15_-_74734313 0.268 ENSMUST00000023260.3
Lypd2
Ly6/Plaur domain containing 2
chr17_-_50094277 0.268 ENSMUST00000113195.1
Rftn1
raftlin lipid raft linker 1
chrX_-_95956890 0.247 ENSMUST00000079987.6
ENSMUST00000113864.2
Las1l

LAS1-like (S. cerevisiae)

chr1_+_133131143 0.207 ENSMUST00000052529.3
Ppp1r15b
protein phosphatase 1, regulatory (inhibitor) subunit 15b
chr17_-_47611449 0.163 ENSMUST00000024783.8
Bysl
bystin-like
chr4_-_126201117 0.162 ENSMUST00000136157.1
Thrap3
thyroid hormone receptor associated protein 3
chr12_-_98259416 0.099 ENSMUST00000021390.7
Galc
galactosylceramidase
chr7_-_104950441 0.096 ENSMUST00000179862.1
Gm5900
predicted pseudogene 5900
chr6_+_145953429 0.026 ENSMUST00000111701.1
Sspn
sarcospan
chr2_+_129800451 0.025 ENSMUST00000165413.2
ENSMUST00000166282.2
Stk35

serine/threonine kinase 35

chr5_-_100373484 0.013 ENSMUST00000182433.1
Sec31a
Sec31 homolog A (S. cerevisiae)
chr1_-_118311132 0.009 ENSMUST00000027623.7
Tsn
translin
chr4_-_132422484 0.008 ENSMUST00000102568.3
Phactr4
phosphatase and actin regulator 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.0 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.6 3.2 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.6 1.8 GO:0097461 ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461)
0.3 1.7 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.3 0.9 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.2 0.7 GO:0002295 T-helper cell lineage commitment(GO:0002295) interleukin-4-mediated signaling pathway(GO:0035771)
0.2 1.4 GO:0046909 intermembrane transport(GO:0046909)
0.2 0.7 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.2 1.5 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.2 1.0 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.2 1.4 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.2 0.9 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286)
0.2 1.6 GO:1903624 regulation of apoptotic DNA fragmentation(GO:1902510) regulation of DNA catabolic process(GO:1903624)
0.1 3.6 GO:0003416 endochondral bone growth(GO:0003416)
0.1 0.6 GO:0097503 sialylation(GO:0097503)
0.1 0.5 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 1.5 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.1 1.1 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.1 0.4 GO:0036438 maintenance of lens transparency(GO:0036438) membrane fission(GO:0090148) ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.1 0.8 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.1 1.0 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628)
0.1 0.3 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 1.2 GO:0006379 mRNA cleavage(GO:0006379)
0.0 0.7 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.4 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.5 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 1.1 GO:0048246 macrophage chemotaxis(GO:0048246)
0.0 0.2 GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.0 0.4 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 0.9 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.3 GO:0051764 actin crosslink formation(GO:0051764) positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.4 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.6 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.7 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.2 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478)
0.0 0.4 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.3 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 1.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.1 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 1.8 GO:0050684 regulation of mRNA processing(GO:0050684)
0.0 0.3 GO:0009268 response to pH(GO:0009268)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.0 GO:0043256 laminin complex(GO:0043256)
0.5 1.5 GO:0005584 collagen type I trimer(GO:0005584)
0.4 1.2 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.3 1.7 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.3 0.8 GO:0031983 vesicle lumen(GO:0031983)
0.2 3.0 GO:0005652 nuclear lamina(GO:0005652)
0.2 1.3 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 0.7 GO:0002177 manchette(GO:0002177)
0.1 1.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.4 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.4 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.4 GO:0000815 ESCRT III complex(GO:0000815)
0.0 1.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 3.6 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.9 GO:0051233 spindle midzone(GO:0051233)
0.0 0.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.7 GO:0030904 retromer complex(GO:0030904)
0.0 0.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.2 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.6 1.8 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.5 1.6 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.4 1.2 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.4 1.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.3 1.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.3 1.3 GO:0005047 signal recognition particle binding(GO:0005047) endoplasmic reticulum signal peptide binding(GO:0030942)
0.2 1.0 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.4 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.1 0.7 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 0.3 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.1 0.9 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 1.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.4 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.3 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.8 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.7 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.6 GO:0008932 lytic endotransglycosylase activity(GO:0008932)
0.0 4.0 GO:0005178 integrin binding(GO:0005178)
0.0 0.5 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 1.7 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.5 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 1.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.7 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.2 GO:0045182 translation regulator activity(GO:0045182)