Motif ID: Pax6

Z-value: 0.722


Transcription factors associated with Pax6:

Gene SymbolEntrez IDGene Name
Pax6 ENSMUSG00000027168.15 Pax6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax6mm10_v2_chr2_+_105668888_105668914-0.761.8e-14Click!


Activity profile for motif Pax6.

activity profile for motif Pax6


Sorted Z-values histogram for motif Pax6

Sorted Z-values for motif Pax6



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_103422010 7.594 ENSMUST00000182089.1
Gm26992
predicted gene, 26992
chr19_-_57118981 5.686 ENSMUST00000111528.1
ENSMUST00000111529.1
ENSMUST00000104902.2
Ablim1


actin-binding LIM protein 1


chr19_-_57118897 4.750 ENSMUST00000111526.1
Ablim1
actin-binding LIM protein 1
chr13_-_110280103 4.494 ENSMUST00000167824.1
Rab3c
RAB3C, member RAS oncogene family
chr3_+_65109343 3.980 ENSMUST00000159525.1
ENSMUST00000049230.8
Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr1_-_38836090 3.606 ENSMUST00000147695.1
Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr4_+_85205417 3.583 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
Sh3gl2


SH3-domain GRB2-like 2


chr6_-_60829826 3.356 ENSMUST00000163779.1
Snca
synuclein, alpha
chr3_-_89245159 2.842 ENSMUST00000090924.6
Trim46
tripartite motif-containing 46
chr2_-_162661075 2.791 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
Ptprt



protein tyrosine phosphatase, receptor type, T



chr8_-_57962564 2.762 ENSMUST00000098757.3
Galntl6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr10_+_80356459 2.720 ENSMUST00000039836.8
ENSMUST00000105351.1
Plk5

polo-like kinase 5

chr18_-_34373313 2.612 ENSMUST00000006027.5
Reep5
receptor accessory protein 5
chr17_+_43016536 2.488 ENSMUST00000024708.4
Tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chr11_-_95587691 2.471 ENSMUST00000000122.6
Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr6_-_118780324 2.406 ENSMUST00000112793.3
ENSMUST00000075591.6
ENSMUST00000078320.7
ENSMUST00000112790.2
Cacna1c



calcium channel, voltage-dependent, L type, alpha 1C subunit



chr5_-_18360384 2.404 ENSMUST00000074694.5
Gnai1
guanine nucleotide binding protein (G protein), alpha inhibiting 1
chr7_-_12775658 2.404 ENSMUST00000046245.5
Zscan18
zinc finger and SCAN domain containing 18
chr18_+_37447641 2.342 ENSMUST00000052387.3
Pcdhb14
protocadherin beta 14
chr3_-_89245005 2.315 ENSMUST00000107464.1
Trim46
tripartite motif-containing 46
chr15_+_84669565 1.675 ENSMUST00000171460.1
Prr5
proline rich 5 (renal)
chr9_+_15239045 1.670 ENSMUST00000034413.6
Vstm5
V-set and transmembrane domain containing 5
chr15_-_101850778 1.574 ENSMUST00000023790.3
Krt1
keratin 1
chr13_+_64432479 1.484 ENSMUST00000021939.6
Cdk20
cyclin-dependent kinase 20
chr5_+_149265035 1.294 ENSMUST00000130144.1
ENSMUST00000071130.3
Alox5ap

arachidonate 5-lipoxygenase activating protein

chr5_+_90903864 1.089 ENSMUST00000075433.6
Cxcl2
chemokine (C-X-C motif) ligand 2
chr9_+_50775347 1.061 ENSMUST00000159576.1
Alg9
asparagine-linked glycosylation 9 (alpha 1,2 mannosyltransferase)
chr5_-_142906702 1.020 ENSMUST00000167721.1
ENSMUST00000163829.1
ENSMUST00000100497.4
Actb


actin, beta


chr6_-_88045190 0.911 ENSMUST00000113596.1
ENSMUST00000113600.3
Rab7

RAB7, member RAS oncogene family

chr9_-_10904697 0.906 ENSMUST00000162484.1
Cntn5
contactin 5
chr16_-_22857514 0.903 ENSMUST00000004576.6
Tbccd1
TBCC domain containing 1
chr13_-_113618549 0.890 ENSMUST00000109241.3
Snx18
sorting nexin 18
chr2_+_163602331 0.853 ENSMUST00000152135.1
Ttpal
tocopherol (alpha) transfer protein-like
chr15_+_6299781 0.768 ENSMUST00000078019.6
Dab2
disabled 2, mitogen-responsive phosphoprotein
chr5_+_112255813 0.755 ENSMUST00000031286.6
ENSMUST00000131673.1
ENSMUST00000112375.1
Crybb1


crystallin, beta B1


chr6_-_145048809 0.753 ENSMUST00000032402.5
Bcat1
branched chain aminotransferase 1, cytosolic
chr17_-_57059795 0.749 ENSMUST00000040280.7
Slc25a23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr6_-_124741374 0.739 ENSMUST00000004389.5
Grcc10
gene rich cluster, C10 gene
chr12_+_112976471 0.732 ENSMUST00000165079.1
ENSMUST00000002880.6
Btbd6

BTB (POZ) domain containing 6

chr5_-_38480131 0.727 ENSMUST00000143758.1
ENSMUST00000067886.5
Slc2a9

solute carrier family 2 (facilitated glucose transporter), member 9

chr16_+_4968936 0.720 ENSMUST00000090457.5
4930451G09Rik
RIKEN cDNA 4930451G09 gene
chr7_-_86775860 0.717 ENSMUST00000001824.5
Folh1
folate hydrolase 1
chr11_-_6200411 0.685 ENSMUST00000066496.3
Nudcd3
NudC domain containing 3
chr16_-_52452654 0.661 ENSMUST00000168071.1
Alcam
activated leukocyte cell adhesion molecule
chr17_+_34604262 0.645 ENSMUST00000174041.1
Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr6_-_122856151 0.642 ENSMUST00000042081.8
C3ar1
complement component 3a receptor 1
chr8_+_31150307 0.594 ENSMUST00000098842.2
Tti2
TELO2 interacting protein 2
chr17_-_33718591 0.576 ENSMUST00000174040.1
ENSMUST00000173015.1
ENSMUST00000066121.6
ENSMUST00000172767.1
ENSMUST00000173329.1
March2




membrane-associated ring finger (C3HC4) 2




chr14_+_34170640 0.541 ENSMUST00000104925.3
Rpl23a-ps3
ribosomal protein L23A, pseudogene 3
chrX_+_23693043 0.540 ENSMUST00000035766.6
ENSMUST00000101670.2
Wdr44

WD repeat domain 44

chr2_+_163602294 0.526 ENSMUST00000171696.1
ENSMUST00000109408.3
Ttpal

tocopherol (alpha) transfer protein-like

chr15_+_6299797 0.521 ENSMUST00000159046.1
ENSMUST00000161040.1
Dab2

disabled 2, mitogen-responsive phosphoprotein

chr19_+_34290653 0.520 ENSMUST00000025691.5
ENSMUST00000112472.2
Fas

Fas (TNF receptor superfamily member 6)

chr9_-_22307638 0.516 ENSMUST00000086278.6
Zfp810
zinc finger protein 810
chr11_+_67966442 0.506 ENSMUST00000021286.4
ENSMUST00000108675.1
Stx8

syntaxin 8

chr4_-_3835595 0.485 ENSMUST00000138502.1
Rps20
ribosomal protein S20
chr6_+_123229843 0.464 ENSMUST00000112554.2
ENSMUST00000024118.4
ENSMUST00000117130.1
Clec4n


C-type lectin domain family 4, member n


chr6_+_48395652 0.460 ENSMUST00000077093.4
Krba1
KRAB-A domain containing 1
chr7_-_86775808 0.457 ENSMUST00000107271.3
Folh1
folate hydrolase 1
chr11_-_67965631 0.432 ENSMUST00000021287.5
ENSMUST00000126766.1
Wdr16

WD repeat domain 16

chr17_+_25366550 0.429 ENSMUST00000069616.7
Tpsb2
tryptase beta 2
chr19_+_6400611 0.399 ENSMUST00000113467.1
Rasgrp2
RAS, guanyl releasing protein 2
chr4_-_139832920 0.385 ENSMUST00000174681.1
Pax7
paired box gene 7
chr11_-_84870712 0.373 ENSMUST00000170741.1
ENSMUST00000172405.1
ENSMUST00000100686.3
ENSMUST00000108081.2
Ggnbp2



gametogenetin binding protein 2



chr4_+_155491353 0.373 ENSMUST00000165335.1
ENSMUST00000105616.3
ENSMUST00000030940.7
Gnb1


guanine nucleotide binding protein (G protein), beta 1


chr1_-_195131536 0.288 ENSMUST00000075451.6
Cr1l
complement component (3b/4b) receptor 1-like
chr2_-_75981967 0.285 ENSMUST00000099994.3
Ttc30a1
tetratricopeptide repeat domain 30A1
chr6_+_48395586 0.269 ENSMUST00000114571.1
ENSMUST00000114572.3
ENSMUST00000031815.5
Krba1


KRAB-A domain containing 1


chr7_+_5051515 0.256 ENSMUST00000069324.5
Zfp580
zinc finger protein 580
chr11_-_84870646 0.231 ENSMUST00000018547.2
Ggnbp2
gametogenetin binding protein 2
chr13_-_24937585 0.215 ENSMUST00000037615.6
Aldh5a1
aldhehyde dehydrogenase family 5, subfamily A1
chr13_-_53377355 0.212 ENSMUST00000021920.6
Sptlc1
serine palmitoyltransferase, long chain base subunit 1
chr6_-_113377376 0.210 ENSMUST00000043333.2
Tada3
transcriptional adaptor 3
chr13_+_66905415 0.210 ENSMUST00000099412.2
Gm10767
predicted gene 10767
chr12_-_51829525 0.187 ENSMUST00000179265.1
ENSMUST00000042052.8
Hectd1

HECT domain containing 1

chr15_+_103272893 0.151 ENSMUST00000100162.3
Copz1
coatomer protein complex, subunit zeta 1
chr11_-_84870812 0.123 ENSMUST00000168434.1
Ggnbp2
gametogenetin binding protein 2
chr10_+_26229707 0.110 ENSMUST00000060716.5
ENSMUST00000164660.1
Samd3

sterile alpha motif domain containing 3

chr2_+_105904629 0.110 ENSMUST00000037499.5
Immp1l
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr9_-_62811592 0.062 ENSMUST00000034775.8
Fem1b
feminization 1 homolog b (C. elegans)
chr11_+_78328415 0.039 ENSMUST00000048073.8
Pigs
phosphatidylinositol glycan anchor biosynthesis, class S
chr14_-_43819639 0.030 ENSMUST00000100691.3
Ear1
eosinophil-associated, ribonuclease A family, member 1
chr7_-_80901220 0.029 ENSMUST00000146402.1
ENSMUST00000026816.8
Wdr73

WD repeat domain 73


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.4 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) cellular response to copper ion(GO:0071280) regulation of peroxidase activity(GO:2000468)
0.8 2.5 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-10 secretion(GO:2001180)
0.8 2.5 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.6 2.4 GO:0098912 smooth muscle contraction involved in micturition(GO:0060083) membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
0.4 1.3 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538)
0.3 2.7 GO:0002347 response to tumor cell(GO:0002347)
0.3 0.6 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.3 1.1 GO:0061724 lipophagy(GO:0061724)
0.3 4.0 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.3 1.3 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.2 0.7 GO:0097274 urea homeostasis(GO:0097274)
0.2 1.6 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.2 2.4 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.2 0.9 GO:0051661 maintenance of centrosome location(GO:0051661) maintenance of Golgi location(GO:0051684)
0.1 0.9 GO:0036089 cleavage furrow formation(GO:0036089)
0.1 0.8 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.1 10.4 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 3.6 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.1 0.5 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.1 0.7 GO:0046415 urate metabolic process(GO:0046415)
0.1 1.0 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.1 0.4 GO:0007603 phototransduction, visible light(GO:0007603)
0.1 0.2 GO:0006083 acetate metabolic process(GO:0006083)
0.1 1.1 GO:0071624 positive regulation of granulocyte chemotaxis(GO:0071624) positive regulation of neutrophil chemotaxis(GO:0090023)
0.1 5.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 0.2 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 0.3 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.6 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.4 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 4.5 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 1.2 GO:0006760 folic acid-containing compound metabolic process(GO:0006760)
0.0 0.5 GO:0050832 defense response to fungus(GO:0050832)
0.0 1.7 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.0 0.7 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.2 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.3 GO:0032757 positive regulation of interleukin-8 production(GO:0032757)
0.0 0.5 GO:0008333 endosome to lysosome transport(GO:0008333) early endosome to late endosome transport(GO:0045022)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.7 4.0 GO:1990635 proximal dendrite(GO:1990635)
0.3 1.3 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.2 2.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 1.6 GO:0045095 keratin filament(GO:0045095)
0.1 1.7 GO:0031932 TORC2 complex(GO:0031932)
0.1 1.0 GO:0070688 MLL5-L complex(GO:0070688)
0.1 2.5 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 0.9 GO:0097208 alveolar lamellar body(GO:0097208)
0.1 10.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 0.5 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 2.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.2 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.7 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.5 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.6 GO:0050544 arachidonic acid binding(GO:0050544)
0.5 2.4 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.3 2.4 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.3 5.5 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 0.7 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.2 2.8 GO:0051393 alpha-actinin binding(GO:0051393)
0.2 4.0 GO:0070402 NADPH binding(GO:0070402)
0.2 0.6 GO:0004942 anaphylatoxin receptor activity(GO:0004942)
0.2 4.5 GO:0031489 myosin V binding(GO:0031489)
0.1 1.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 0.8 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 1.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 1.0 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 1.2 GO:0016805 dipeptidase activity(GO:0016805)
0.1 0.2 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758)
0.1 0.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 3.8 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.4 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 1.5 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.6 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 11.2 GO:0003779 actin binding(GO:0003779)
0.0 0.4 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.9 GO:0019003 GDP binding(GO:0019003)