Motif ID: Aire

Z-value: 0.768


Transcription factors associated with Aire:

Gene SymbolEntrez IDGene Name
Aire ENSMUSG00000000731.9 Aire



Activity profile for motif Aire.

activity profile for motif Aire


Sorted Z-values histogram for motif Aire

Sorted Z-values for motif Aire



Network of associatons between targets according to the STRING database.



Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_61185558 34.721 ENSMUST00000166381.1
Cdr1
cerebellar degeneration related antigen 1
chrM_+_7005 2.880 ENSMUST00000082405.1
mt-Co2
mitochondrially encoded cytochrome c oxidase II
chrM_+_11734 2.493 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chrM_-_14060 2.272 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chrM_+_14138 2.228 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr16_+_36875119 2.151 ENSMUST00000135406.1
ENSMUST00000114812.1
ENSMUST00000134616.1
ENSMUST00000023534.6
Golgb1


Golgb1
golgi autoantigen, golgin subfamily b, macrogolgin 1


golgi autoantigen, golgin subfamily b, macrogolgin 1
chrM_+_7759 2.127 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr5_-_84417359 1.916 ENSMUST00000113401.1
Epha5
Eph receptor A5
chr13_-_62371936 1.574 ENSMUST00000107989.3
Gm3604
predicted gene 3604
chrX_-_38576166 1.414 ENSMUST00000050083.5
Cul4b
cullin 4B
chr10_+_86021961 1.375 ENSMUST00000130320.1
Fbxo7
F-box protein 7
chr13_-_110280103 1.375 ENSMUST00000167824.1
Rab3c
RAB3C, member RAS oncogene family
chrX_-_38576189 1.343 ENSMUST00000115118.1
Cul4b
cullin 4B
chr5_+_43672289 1.324 ENSMUST00000156034.1
Cc2d2a
coiled-coil and C2 domain containing 2A
chr2_+_55435918 1.299 ENSMUST00000067101.3
Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr10_-_111997204 1.273 ENSMUST00000074805.5
Glipr1
GLI pathogenesis-related 1 (glioma)
chr1_+_65186727 1.224 ENSMUST00000097707.4
ENSMUST00000081154.7
Pikfyve

phosphoinositide kinase, FYVE finger containing

chr4_-_19570073 1.209 ENSMUST00000029885.4
Cpne3
copine III
chr6_-_148896150 1.147 ENSMUST00000072324.5
ENSMUST00000111569.2
Caprin2

caprin family member 2

chr14_+_124005355 1.147 ENSMUST00000166105.1
Gm17615
predicted gene, 17615
chr10_+_58446845 1.120 ENSMUST00000003310.5
Ranbp2
RAN binding protein 2
chr9_-_53667429 1.033 ENSMUST00000166367.1
ENSMUST00000034529.7
Cul5

cullin 5

chr9_-_97111117 0.959 ENSMUST00000085206.4
Slc25a36
solute carrier family 25, member 36
chr3_-_62506970 0.944 ENSMUST00000029336.4
Dhx36
DEAH (Asp-Glu-Ala-His) box polypeptide 36
chr5_+_24100578 0.918 ENSMUST00000030841.5
ENSMUST00000163409.1
Klhl7

kelch-like 7

chr8_-_31739763 0.896 ENSMUST00000178878.1
Gm5117
predicted gene 5117
chr8_+_69808672 0.856 ENSMUST00000036074.8
ENSMUST00000123453.1
Gmip

Gem-interacting protein

chr16_-_91618986 0.853 ENSMUST00000143058.1
ENSMUST00000049244.8
ENSMUST00000169982.1
ENSMUST00000133731.1
Dnajc28



DnaJ (Hsp40) homolog, subfamily C, member 28



chr2_-_165400398 0.839 ENSMUST00000029213.4
Ocstamp
osteoclast stimulatory transmembrane protein
chr4_+_42714926 0.795 ENSMUST00000178454.1
Gm21955
predicted gene, 21955
chrX_+_48256854 0.718 ENSMUST00000080713.4
Utp14a
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr16_-_36874806 0.654 ENSMUST00000075946.5
Eaf2
ELL associated factor 2
chr3_-_95217877 0.649 ENSMUST00000136139.1
Gabpb2
GA repeat binding protein, beta 2
chr8_-_54529951 0.636 ENSMUST00000067476.8
Spcs3
signal peptidase complex subunit 3 homolog (S. cerevisiae)
chr2_+_172248492 0.628 ENSMUST00000038532.1
Mc3r
melanocortin 3 receptor
chr7_-_14562171 0.617 ENSMUST00000181796.1
Vmn1r90
vomeronasal 1 receptor 90
chr14_+_21481428 0.534 ENSMUST00000182996.1
Kat6b
K(lysine) acetyltransferase 6B
chr9_+_13662460 0.532 ENSMUST00000177755.1
Maml2
mastermind like 2 (Drosophila)
chr1_+_44119952 0.465 ENSMUST00000114709.2
Bivm
basic, immunoglobulin-like variable motif containing
chr2_-_121473993 0.461 ENSMUST00000056732.3
Mfap1b
microfibrillar-associated protein 1B
chr5_+_130369420 0.460 ENSMUST00000086029.3
Caln1
calneuron 1
chr8_-_4217261 0.437 ENSMUST00000168386.2
BC068157
cDNA sequence BC068157
chr5_-_135251209 0.427 ENSMUST00000062572.2
Fzd9
frizzled homolog 9 (Drosophila)
chr9_+_64235201 0.423 ENSMUST00000039011.3
Uchl4
ubiquitin carboxyl-terminal esterase L4
chr13_+_49504774 0.395 ENSMUST00000051504.7
Ecm2
extracellular matrix protein 2, female organ and adipocyte specific
chr8_-_4216912 0.394 ENSMUST00000177491.1
BC068157
cDNA sequence BC068157
chr3_-_116968969 0.365 ENSMUST00000143611.1
ENSMUST00000040097.7
Palmd

palmdelphin

chr17_-_59013264 0.334 ENSMUST00000174122.1
ENSMUST00000025065.5
Nudt12

nudix (nucleoside diphosphate linked moiety X)-type motif 12

chr9_-_113708209 0.310 ENSMUST00000111861.3
ENSMUST00000035086.6
Pdcd6ip

programmed cell death 6 interacting protein

chr8_-_109962127 0.306 ENSMUST00000001722.7
ENSMUST00000051430.6
Marveld3

MARVEL (membrane-associating) domain containing 3

chr3_+_88835231 0.281 ENSMUST00000107498.2
Gon4l
gon-4-like (C.elegans)
chr8_+_111643425 0.279 ENSMUST00000077791.6
Zfp1
zinc finger protein 1
chr2_-_134644019 0.276 ENSMUST00000110120.1
Tmx4
thioredoxin-related transmembrane protein 4
chr10_+_52358767 0.270 ENSMUST00000180473.1
Gm26741
predicted gene, 26741
chr4_+_154869585 0.244 ENSMUST00000079269.7
ENSMUST00000163732.1
ENSMUST00000080559.6
Mmel1


membrane metallo-endopeptidase-like 1


chr17_-_53463315 0.230 ENSMUST00000024725.4
Efhb
EF hand domain family, member B
chr12_+_4843303 0.230 ENSMUST00000053034.4
BC068281
cDNA sequence BC068281
chr5_+_29378604 0.223 ENSMUST00000181005.1
4632411P08Rik
RIKEN cDNA 4632411P08 gene
chr8_-_4217133 0.219 ENSMUST00000175906.1
BC068157
cDNA sequence BC068157
chr2_-_134644125 0.210 ENSMUST00000038228.4
Tmx4
thioredoxin-related transmembrane protein 4
chr12_+_10390756 0.206 ENSMUST00000020947.5
Rdh14
retinol dehydrogenase 14 (all-trans and 9-cis)
chr3_-_89411781 0.190 ENSMUST00000107429.3
ENSMUST00000129308.2
ENSMUST00000107426.1
ENSMUST00000050398.4
ENSMUST00000162701.1
Flad1




RFad1, flavin adenine dinucleotide synthetase, homolog (yeast)




chr9_+_76014855 0.167 ENSMUST00000008052.6
ENSMUST00000183425.1
ENSMUST00000183979.1
ENSMUST00000117981.2
Hmgcll1



3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1



chr12_-_36156781 0.161 ENSMUST00000020856.4
Bzw2
basic leucine zipper and W2 domains 2
chr2_-_134644079 0.152 ENSMUST00000110119.1
Tmx4
thioredoxin-related transmembrane protein 4
chr4_+_11758147 0.143 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17

cadherin 17

chr4_-_46566432 0.134 ENSMUST00000030021.7
ENSMUST00000107757.1
Coro2a

coronin, actin binding protein 2A

chr17_-_6961156 0.133 ENSMUST00000063683.6
Tagap1
T cell activation GTPase activating protein 1
chr2_-_94010807 0.133 ENSMUST00000111240.1
Alkbh3
alkB, alkylation repair homolog 3 (E. coli)
chr10_+_3872667 0.132 ENSMUST00000136671.1
ENSMUST00000042438.6
Plekhg1

pleckstrin homology domain containing, family G (with RhoGef domain) member 1

chr3_+_54481429 0.129 ENSMUST00000091130.3
Gm5641
predicted gene 5641
chr5_-_100373484 0.095 ENSMUST00000182433.1
Sec31a
Sec31 homolog A (S. cerevisiae)
chr11_+_69914179 0.092 ENSMUST00000057884.5
Gps2
G protein pathway suppressor 2
chr12_+_36157124 0.082 ENSMUST00000041640.3
Ankmy2
ankyrin repeat and MYND domain containing 2
chr2_-_94010729 0.080 ENSMUST00000040005.6
ENSMUST00000126378.1
Alkbh3

alkB, alkylation repair homolog 3 (E. coli)

chr6_-_91515878 0.072 ENSMUST00000032182.3
Xpc
xeroderma pigmentosum, complementation group C
chr12_-_78983476 0.060 ENSMUST00000070174.7
Tmem229b
transmembrane protein 229B
chr19_-_28963863 0.051 ENSMUST00000161813.1
4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr10_-_130280218 0.031 ENSMUST00000061571.3
Neurod4
neurogenic differentiation 4
chr7_+_45896941 0.017 ENSMUST00000069772.7
ENSMUST00000107716.1
Tmem143

transmembrane protein 143

chr10_+_53337686 0.009 ENSMUST00000046221.6
ENSMUST00000163319.1
Pln

phospholamban


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0033762 response to glucagon(GO:0033762)
0.4 1.1 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.3 1.2 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.3 0.8 GO:0034241 positive regulation of macrophage fusion(GO:0034241) regulation of osteoclast proliferation(GO:0090289)
0.2 1.0 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.2 1.3 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.2 2.8 GO:0070914 UV-damage excision repair(GO:0070914)
0.2 1.9 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.2 0.9 GO:0090669 telomerase RNA stabilization(GO:0090669)
0.2 1.3 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.2 1.4 GO:1903207 neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
0.1 0.4 GO:1990523 bone regeneration(GO:1990523)
0.1 0.3 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.1 5.4 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 1.0 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.1 0.3 GO:0006742 NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
0.1 2.1 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.7 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.1 0.9 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.1 0.2 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.1 0.5 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.2 GO:0035552 oxidative single-stranded DNA demethylation(GO:0035552) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 1.2 GO:0032288 myelin assembly(GO:0032288)
0.0 0.1 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.6 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.3 GO:1902414 protein localization to cell junction(GO:1902414)
0.0 0.2 GO:0046950 cellular ketone body metabolic process(GO:0046950)
0.0 0.6 GO:0045475 locomotor rhythm(GO:0045475)
0.0 1.1 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.2 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.7 GO:0030490 maturation of SSU-rRNA(GO:0030490)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.8 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.3 1.4 GO:1990037 Lewy body core(GO:1990037)
0.2 2.2 GO:0045275 respiratory chain complex III(GO:0045275)
0.2 1.0 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 2.9 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 2.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.3 GO:0036038 MKS complex(GO:0036038)
0.1 0.6 GO:0005787 signal peptidase complex(GO:0005787)
0.1 4.8 GO:0070469 respiratory chain(GO:0070469)
0.1 1.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 2.2 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.5 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.5 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.3 GO:0090543 Flemming body(GO:0090543)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.7 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.3 GO:0031527 filopodium membrane(GO:0031527)
0.0 1.3 GO:0030315 T-tubule(GO:0030315)
0.0 0.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.1 GO:0005643 nuclear pore(GO:0005643)
0.0 0.7 GO:0008023 transcription elongation factor complex(GO:0008023)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.3 1.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 1.9 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.2 0.6 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.2 4.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 1.2 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 0.9 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.1 0.4 GO:0070052 collagen V binding(GO:0070052)
0.1 0.3 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.1 0.3 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 0.2 GO:0051747 cytosine C-5 DNA demethylase activity(GO:0051747)
0.1 1.4 GO:0031489 myosin V binding(GO:0031489)
0.1 2.9 GO:0005507 copper ion binding(GO:0005507)
0.0 0.1 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 2.8 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.2 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 1.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 1.0 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.0 0.6 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 1.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0008106 alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.0 1.4 GO:0043130 ubiquitin binding(GO:0043130)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 1.9 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.0 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.6 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 1.1 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.5 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.2 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.0 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G