Motif ID: Atf5
Z-value: 0.894
![logo of Atf5](../logos/Atf5.png)
Transcription factors associated with Atf5:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Atf5 | ENSMUSG00000038539.8 | Atf5 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Atf5 | mm10_v2_chr7_-_44815658_44815682 | -0.29 | 7.0e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 4.4 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
0.9 | 4.5 | GO:0034436 | glycoprotein transport(GO:0034436) |
0.6 | 1.9 | GO:1904339 | negative regulation of dopaminergic neuron differentiation(GO:1904339) |
0.6 | 1.9 | GO:0018103 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
0.6 | 1.7 | GO:0016344 | meiotic chromosome movement towards spindle pole(GO:0016344) |
0.4 | 1.2 | GO:1902336 | neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of retinal ganglion cell axon guidance(GO:1902336) |
0.4 | 1.6 | GO:0007113 | endomitotic cell cycle(GO:0007113) |
0.4 | 4.0 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
0.4 | 3.5 | GO:0030035 | microspike assembly(GO:0030035) |
0.3 | 1.4 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
0.3 | 3.1 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
0.3 | 2.4 | GO:0010793 | regulation of mRNA export from nucleus(GO:0010793) |
0.3 | 3.8 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
0.3 | 12.3 | GO:0001919 | regulation of receptor recycling(GO:0001919) |
0.2 | 1.4 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
0.2 | 2.6 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
0.2 | 1.2 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
0.2 | 1.2 | GO:0035989 | tendon development(GO:0035989) |
0.2 | 1.2 | GO:0046549 | retinal cone cell development(GO:0046549) |
0.2 | 0.7 | GO:0042138 | meiotic DNA double-strand break formation(GO:0042138) |
0.2 | 0.7 | GO:1990743 | protein sialylation(GO:1990743) |
0.2 | 1.0 | GO:0099525 | presynaptic dense core granule exocytosis(GO:0099525) |
0.2 | 0.3 | GO:0010808 | positive regulation of synaptic vesicle priming(GO:0010808) |
0.1 | 0.4 | GO:0003219 | cardiac right ventricle formation(GO:0003219) |
0.1 | 1.4 | GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147) |
0.1 | 0.4 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
0.1 | 0.3 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
0.1 | 0.4 | GO:0035720 | intraciliary anterograde transport(GO:0035720) |
0.1 | 1.0 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
0.1 | 0.7 | GO:0048341 | paraxial mesoderm formation(GO:0048341) |
0.1 | 1.2 | GO:0036120 | cellular response to platelet-derived growth factor stimulus(GO:0036120) |
0.1 | 2.5 | GO:0014912 | negative regulation of smooth muscle cell migration(GO:0014912) |
0.1 | 0.4 | GO:0003431 | growth plate cartilage chondrocyte development(GO:0003431) |
0.1 | 1.5 | GO:0039703 | viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) |
0.1 | 0.2 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
0.1 | 1.1 | GO:0015693 | magnesium ion transport(GO:0015693) |
0.1 | 0.5 | GO:0060536 | cartilage morphogenesis(GO:0060536) |
0.0 | 0.4 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
0.0 | 1.9 | GO:0003170 | heart valve development(GO:0003170) |
0.0 | 0.6 | GO:0060052 | neurofilament cytoskeleton organization(GO:0060052) |
0.0 | 0.3 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
0.0 | 0.3 | GO:0031339 | negative regulation of vesicle fusion(GO:0031339) |
0.0 | 0.5 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
0.0 | 1.0 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
0.0 | 0.2 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
0.0 | 0.2 | GO:0021940 | positive regulation of cerebellar granule cell precursor proliferation(GO:0021940) |
0.0 | 0.1 | GO:1901843 | positive regulation of high voltage-gated calcium channel activity(GO:1901843) |
0.0 | 1.3 | GO:0000422 | mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726) |
0.0 | 0.3 | GO:0002076 | osteoblast development(GO:0002076) |
0.0 | 2.8 | GO:0032869 | cellular response to insulin stimulus(GO:0032869) |
0.0 | 0.1 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 12.3 | GO:0043083 | synaptic cleft(GO:0043083) |
0.4 | 4.5 | GO:0034361 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
0.3 | 1.5 | GO:0044308 | axonal spine(GO:0044308) |
0.2 | 2.4 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
0.2 | 4.4 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
0.2 | 1.7 | GO:0030478 | actin cap(GO:0030478) |
0.2 | 1.9 | GO:1990909 | Wnt signalosome(GO:1990909) |
0.2 | 1.2 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
0.1 | 0.5 | GO:1990415 | Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429) |
0.1 | 2.2 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
0.1 | 3.8 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.1 | 1.0 | GO:1904949 | ATPase complex(GO:1904949) |
0.1 | 3.1 | GO:0016592 | mediator complex(GO:0016592) |
0.1 | 0.3 | GO:0098831 | presynaptic active zone cytoplasmic component(GO:0098831) |
0.1 | 1.0 | GO:0031045 | dense core granule(GO:0031045) |
0.1 | 0.7 | GO:0032584 | growth cone membrane(GO:0032584) |
0.1 | 0.3 | GO:0070531 | BRCA1-A complex(GO:0070531) |
0.0 | 1.3 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
0.0 | 1.9 | GO:0005637 | nuclear inner membrane(GO:0005637) |
0.0 | 0.4 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
0.0 | 0.4 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
0.0 | 0.4 | GO:0097542 | ciliary tip(GO:0097542) |
0.0 | 3.1 | GO:0030175 | filopodium(GO:0030175) |
0.0 | 0.4 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
0.0 | 0.4 | GO:0071564 | npBAF complex(GO:0071564) |
0.0 | 0.1 | GO:0032021 | NELF complex(GO:0032021) |
0.0 | 4.0 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
0.0 | 2.7 | GO:0034399 | nuclear periphery(GO:0034399) |
0.0 | 1.2 | GO:0005604 | basement membrane(GO:0005604) |
0.0 | 1.4 | GO:0072562 | blood microparticle(GO:0072562) |
0.0 | 0.3 | GO:0033270 | paranode region of axon(GO:0033270) |
0.0 | 0.4 | GO:0016235 | aggresome(GO:0016235) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.8 | 12.3 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
1.5 | 4.5 | GO:0034437 | very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437) |
0.4 | 1.2 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
0.4 | 1.2 | GO:0008502 | melatonin receptor activity(GO:0008502) |
0.3 | 1.4 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
0.2 | 1.0 | GO:0017116 | single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) |
0.2 | 0.7 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
0.2 | 1.2 | GO:0001515 | opioid peptide activity(GO:0001515) |
0.1 | 2.5 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
0.1 | 4.4 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.1 | 1.6 | GO:0008641 | small protein activating enzyme activity(GO:0008641) |
0.1 | 0.7 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
0.1 | 1.9 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
0.1 | 0.5 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
0.1 | 3.8 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.1 | 1.5 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
0.1 | 3.1 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
0.1 | 0.3 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
0.1 | 1.9 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
0.1 | 1.4 | GO:0008143 | poly(A) binding(GO:0008143) |
0.1 | 1.2 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
0.1 | 1.1 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
0.0 | 2.2 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
0.0 | 0.4 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
0.0 | 0.2 | GO:0042134 | rRNA primary transcript binding(GO:0042134) |
0.0 | 2.2 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
0.0 | 4.1 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
0.0 | 1.2 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
0.0 | 0.3 | GO:0016884 | carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884) |
0.0 | 0.7 | GO:0017160 | Ral GTPase binding(GO:0017160) |
0.0 | 0.4 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
0.0 | 0.2 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
0.0 | 1.7 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.0 | 0.1 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.0 | 1.0 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
0.0 | 0.6 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
0.0 | 0.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.0 | 0.2 | GO:0005326 | neurotransmitter transporter activity(GO:0005326) |
0.0 | 0.4 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
0.0 | 0.2 | GO:0016594 | glycine binding(GO:0016594) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 3.8 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
0.1 | 1.6 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
0.1 | 1.2 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
0.1 | 4.8 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
0.1 | 1.9 | PID_BETA_CATENIN_DEG_PATHWAY | Degradation of beta catenin |
0.1 | 4.0 | PID_PLK1_PATHWAY | PLK1 signaling events |
0.0 | 1.2 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
0.0 | 2.2 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
0.0 | 1.2 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
0.0 | 2.5 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 0.7 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
0.0 | 0.3 | PID_ARF6_PATHWAY | Arf6 signaling events |
0.0 | 0.4 | NABA_COLLAGENS | Genes encoding collagen proteins |
0.0 | 0.7 | PID_AP1_PATHWAY | AP-1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 12.0 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
0.2 | 4.6 | REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
0.1 | 1.2 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
0.1 | 2.5 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
0.1 | 3.1 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
0.1 | 1.2 | REACTOME_PECAM1_INTERACTIONS | Genes involved in PECAM1 interactions |
0.1 | 1.2 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
0.1 | 4.4 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
0.1 | 0.4 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
0.0 | 3.5 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
0.0 | 0.3 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
0.0 | 0.7 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
0.0 | 3.7 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
0.0 | 1.4 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
0.0 | 0.4 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
0.0 | 1.5 | REACTOME_TOLL_RECEPTOR_CASCADES | Genes involved in Toll Receptor Cascades |