Motif ID: Bhlhe40

Z-value: 0.398


Transcription factors associated with Bhlhe40:

Gene SymbolEntrez IDGene Name
Bhlhe40 ENSMUSG00000030103.5 Bhlhe40

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bhlhe40mm10_v2_chr6_+_108660772_1086608740.297.4e-02Click!


Activity profile for motif Bhlhe40.

activity profile for motif Bhlhe40


Sorted Z-values histogram for motif Bhlhe40

Sorted Z-values for motif Bhlhe40



Network of associatons between targets according to the STRING database.



First level regulatory network of Bhlhe40

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_110095937 1.686 ENSMUST00000106664.3
ENSMUST00000046223.7
ENSMUST00000106662.1
 Abca8a


ATP-binding cassette, sub-family A (ABC1), member 8a


chr11_+_97450136 1.137 ENSMUST00000107601.1
 Arhgap23
Rho GTPase activating protein 23
chr11_-_110095974 1.120 ENSMUST00000100287.2
 Abca8a
ATP-binding cassette, sub-family A (ABC1), member 8a
chr4_-_148038769 0.926 ENSMUST00000030879.5
ENSMUST00000137724.1
 Clcn6

chloride channel 6

chr1_+_166254095 0.846 ENSMUST00000111416.1
 Ildr2
immunoglobulin-like domain containing receptor 2
chrX_-_135210672 0.825 ENSMUST00000033783.1
 Tceal6
transcription elongation factor A (SII)-like 6
chrX_-_136203637 0.775 ENSMUST00000151592.1
ENSMUST00000131510.1
ENSMUST00000066819.4
 Tceal5


transcription elongation factor A (SII)-like 5


chr5_+_65199691 0.695 ENSMUST00000041892.8
 Wdr19
WD repeat domain 19
chr3_-_10440054 0.687 ENSMUST00000099223.4
ENSMUST00000029047.6
 Snx16

sorting nexin 16

chrX_+_136138996 0.680 ENSMUST00000116527.1
 Bex4
brain expressed gene 4
chrX_+_153832225 0.670 ENSMUST00000148708.1
ENSMUST00000123264.1
ENSMUST00000049999.8
 Spin2c


spindlin family, member 2C


chr17_+_70561739 0.589 ENSMUST00000097288.2
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr5_-_123572976 0.458 ENSMUST00000031388.8
 Vps33a
vacuolar protein sorting 33A (yeast)
chr16_-_92466081 0.438 ENSMUST00000060005.8
 Rcan1
regulator of calcineurin 1
chr7_+_121707189 0.430 ENSMUST00000065310.2
 1700069B07Rik
RIKEN cDNA 1700069B07 gene
chr10_+_78574492 0.430 ENSMUST00000105384.3
 Ilvbl
ilvB (bacterial acetolactate synthase)-like
chr16_-_44139003 0.411 ENSMUST00000124102.1
 Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A
chr1_+_5083105 0.407 ENSMUST00000044369.7
 Atp6v1h
ATPase, H+ transporting, lysosomal V1 subunit H
chr8_+_85036906 0.404 ENSMUST00000093360.4
 Tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chr11_+_75348433 0.396 ENSMUST00000044530.2
 Smyd4
SET and MYND domain containing 4
chr10_-_80139347 0.393 ENSMUST00000105369.1
 Dos
downstream of Stk11
chr5_-_137533212 0.371 ENSMUST00000111038.1
ENSMUST00000143495.1
 Epo
Gnb2
erythropoietin
guanine nucleotide binding protein (G protein), beta 2
chr4_-_48473403 0.368 ENSMUST00000164866.1
ENSMUST00000030030.8
 Tex10

testis expressed gene 10

chr5_-_137533170 0.364 ENSMUST00000168746.1
ENSMUST00000170293.1
 Gnb2

guanine nucleotide binding protein (G protein), beta 2

chr4_+_134468320 0.363 ENSMUST00000030636.4
ENSMUST00000127279.1
ENSMUST00000105867.1
 Stmn1


stathmin 1


chr12_+_86947343 0.352 ENSMUST00000038369.4
 2310044G17Rik
RIKEN cDNA 2310044G17 gene
chr8_+_85037151 0.340 ENSMUST00000166592.1
 Tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chrX_+_136270253 0.339 ENSMUST00000178632.1
ENSMUST00000053540.4
 Ngfrap1

nerve growth factor receptor (TNFRSF16) associated protein 1

chrX_-_136068236 0.338 ENSMUST00000049130.7
 Bex2
brain expressed X-linked 2
chr3_-_95882031 0.327 ENSMUST00000161994.1
 Gm129
predicted gene 129
chr15_+_80255184 0.318 ENSMUST00000109605.3
 Atf4
activating transcription factor 4
chr2_+_166805506 0.318 ENSMUST00000099078.3
 Arfgef2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr5_+_123252087 0.313 ENSMUST00000121964.1
 Wdr66
WD repeat domain 66
chrX_+_68678624 0.295 ENSMUST00000114656.1
 Fmr1
fragile X mental retardation syndrome 1
chr8_+_84689308 0.291 ENSMUST00000125370.3
ENSMUST00000175784.1
 Trmt1

tRNA methyltransferase 1

chr8_+_84689247 0.273 ENSMUST00000109767.2
ENSMUST00000177084.1
ENSMUST00000109768.2
ENSMUST00000152301.2
ENSMUST00000177423.1
 Trmt1




tRNA methyltransferase 1




chr19_-_33392255 0.263 ENSMUST00000096114.5
ENSMUST00000163093.1
 Rnls

renalase, FAD-dependent amine oxidase

chr2_-_37422869 0.261 ENSMUST00000112936.1
ENSMUST00000112934.1
 Rc3h2

ring finger and CCCH-type zinc finger domains 2

chrX_+_68678541 0.257 ENSMUST00000088546.5
 Fmr1
fragile X mental retardation syndrome 1
chr4_-_141790891 0.255 ENSMUST00000038014.4
ENSMUST00000153880.1
 Dnajc16

DnaJ (Hsp40) homolog, subfamily C, member 16

chr16_-_44139196 0.249 ENSMUST00000063661.6
ENSMUST00000114666.2
 Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr8_-_84846860 0.244 ENSMUST00000003912.6
 Calr
calreticulin
chrX_+_136270302 0.243 ENSMUST00000113112.1
 Ngfrap1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr3_+_85574109 0.241 ENSMUST00000127348.1
ENSMUST00000107672.1
ENSMUST00000107674.1
 Pet112


PET112 homolog (S. cerevisiae)


chr5_+_104046869 0.233 ENSMUST00000031250.7
 Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr12_-_3426700 0.212 ENSMUST00000180149.1
 1110002L01Rik
RIKEN cDNA 1110002L01 gene
chr12_-_84450944 0.205 ENSMUST00000085192.5
 Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr19_-_4201591 0.183 ENSMUST00000025740.6
 Rad9a
RAD9 homolog A
chr16_-_44139630 0.181 ENSMUST00000137557.1
ENSMUST00000147025.1
 Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr1_-_152766323 0.176 ENSMUST00000111857.1
 Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr16_+_8830093 0.176 ENSMUST00000023150.5
 1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr1_-_152766281 0.175 ENSMUST00000111859.1
ENSMUST00000148865.1
 Rgl1

ral guanine nucleotide dissociation stimulator,-like 1

chr16_+_5233615 0.167 ENSMUST00000100196.2
ENSMUST00000049207.8
 Alg1

asparagine-linked glycosylation 1 (beta-1,4-mannosyltransferase)

chr18_+_31609512 0.166 ENSMUST00000164667.1
 B930094E09Rik
RIKEN cDNA B930094E09 gene
chrX_+_68678712 0.165 ENSMUST00000114654.1
ENSMUST00000114655.1
ENSMUST00000114657.2
ENSMUST00000114653.1
 Fmr1



fragile X mental retardation syndrome 1



chr8_+_3500451 0.158 ENSMUST00000004683.6
ENSMUST00000160338.1
 Mcoln1

mucolipin 1

chr5_+_104046980 0.158 ENSMUST00000134313.1
 Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr8_+_111033890 0.153 ENSMUST00000034441.7
 Aars
alanyl-tRNA synthetase
chr17_+_33824591 0.153 ENSMUST00000048249.6
 Ndufa7
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a)
chrX_+_134601271 0.153 ENSMUST00000050331.6
ENSMUST00000059297.5
 Hnrnph2

heterogeneous nuclear ribonucleoprotein H2

chr11_+_3649494 0.151 ENSMUST00000093389.2
 Morc2a
microrchidia 2A
chr3_-_95106779 0.146 ENSMUST00000005768.7
ENSMUST00000107232.2
ENSMUST00000107236.2
 Pip5k1a


phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha


chr4_-_137048695 0.143 ENSMUST00000049583.7
 Zbtb40
zinc finger and BTB domain containing 40
chr16_-_5049882 0.127 ENSMUST00000023189.7
ENSMUST00000115844.1
 Glyr1

glyoxylate reductase 1 homolog (Arabidopsis)

chr11_+_95666957 0.113 ENSMUST00000125172.1
ENSMUST00000036374.5
 Phb

prohibitin

chrX_+_134601179 0.112 ENSMUST00000074950.4
ENSMUST00000113203.1
ENSMUST00000113202.1
 Hnrnph2


heterogeneous nuclear ribonucleoprotein H2


chr6_+_17693965 0.109 ENSMUST00000115419.1
 St7
suppression of tumorigenicity 7
chr7_+_35802593 0.102 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene
chr5_+_104046526 0.101 ENSMUST00000150226.1
 Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr2_-_30286312 0.097 ENSMUST00000100219.3
 Dolk
dolichol kinase
chr3_-_95106907 0.093 ENSMUST00000107233.2
 Pip5k1a
phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
chr17_-_33824346 0.092 ENSMUST00000173879.1
ENSMUST00000166693.2
ENSMUST00000173019.1
ENSMUST00000087342.6
ENSMUST00000173844.1
 Rps28




ribosomal protein S28




chr3_-_95882193 0.086 ENSMUST00000159863.1
ENSMUST00000159739.1
ENSMUST00000036418.3
 Gm129


predicted gene 129


chr3_-_107333289 0.085 ENSMUST00000061772.9
 Rbm15
RNA binding motif protein 15
chr11_-_70239794 0.081 ENSMUST00000040428.3
 Rnasek
ribonuclease, RNase K
chr12_-_91590009 0.074 ENSMUST00000021345.6
 Gtf2a1
general transcription factor II A, 1
chr2_+_30286406 0.071 ENSMUST00000138666.1
ENSMUST00000113634.2
 Nup188

nucleoporin 188

chr3_-_90052463 0.062 ENSMUST00000029553.9
ENSMUST00000064639.8
ENSMUST00000090908.6
 Ubap2l


ubiquitin associated protein 2-like


chr11_+_55204319 0.059 ENSMUST00000108872.2
ENSMUST00000147506.1
ENSMUST00000020499.7
 Slc36a1


solute carrier family 36 (proton/amino acid symporter), member 1


chr7_-_27166413 0.056 ENSMUST00000108382.1
 Egln2
EGL nine homolog 2 (C. elegans)
chr19_+_29522263 0.054 ENSMUST00000043610.6
ENSMUST00000162184.1
 C030046E11Rik

RIKEN cDNA C030046E11 gene

chr18_-_20896078 0.053 ENSMUST00000025177.6
ENSMUST00000097658.1
 Trappc8

trafficking protein particle complex 8

chr9_-_13827029 0.050 ENSMUST00000148086.1
ENSMUST00000034398.5
 Cep57

centrosomal protein 57

chr3_-_95882232 0.046 ENSMUST00000161866.1
 Gm129
predicted gene 129
chr7_-_90475971 0.043 ENSMUST00000032843.7
 Tmem126b
transmembrane protein 126B
chr1_+_152766540 0.041 ENSMUST00000077755.5
ENSMUST00000097536.4
 Arpc5

actin related protein 2/3 complex, subunit 5

chr6_+_17693905 0.033 ENSMUST00000115420.1
 St7
suppression of tumorigenicity 7
chr9_+_108002501 0.032 ENSMUST00000035214.4
ENSMUST00000175874.1
 Ip6k1

inositol hexaphosphate kinase 1

chr9_-_44361625 0.029 ENSMUST00000034644.8
 Vps11
vacuolar protein sorting 11 (yeast)
chr8_+_25601591 0.027 ENSMUST00000155861.1
 Whsc1l1
Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
chr18_+_53176345 0.021 ENSMUST00000037850.5
 Snx2
sorting nexin 2
chr4_-_119422355 0.019 ENSMUST00000106316.1
ENSMUST00000030385.6
 Ppcs

phosphopantothenoylcysteine synthetase

chr3_+_89202916 0.013 ENSMUST00000077367.4
ENSMUST00000167998.1
 Gba

glucosidase, beta, acid

chr11_-_75348261 0.011 ENSMUST00000000767.5
ENSMUST00000092907.5
 Rpa1

replication protein A1

chr9_-_97111117 0.008 ENSMUST00000085206.4
 Slc25a36
solute carrier family 25, member 36
chr6_+_17694005 0.003 ENSMUST00000081635.6
ENSMUST00000052113.5
 St7

suppression of tumorigenicity 7

chr3_+_96727611 0.002 ENSMUST00000029740.9
 Rnf115
ring finger protein 115

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0099547 regulation of translation at synapse, modulating synaptic transmission(GO:0099547) regulation of translation at postsynapse, modulating synaptic transmission(GO:0099578) positive regulation of intracellular transport of viral material(GO:1901254)
0.2 0.6 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.2 0.7 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) myotome development(GO:0061055)
0.2 0.5 GO:0046032 ADP catabolic process(GO:0046032)
0.1 0.4 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.1 0.3 GO:0071873 response to norepinephrine(GO:0071873)
0.1 0.2 GO:2000510 positive regulation of dendritic cell chemotaxis(GO:2000510)
0.1 0.3 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.1 0.2 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 0.7 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 0.4 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 0.2 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 1.2 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 0.6 GO:0070842 aggresome assembly(GO:0070842)
0.0 0.7 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 0.3 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.0 0.4 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 0.5 GO:0048070 regulation of developmental pigmentation(GO:0048070)
0.0 0.1 GO:0002922 positive regulation of humoral immune response(GO:0002922) progesterone receptor signaling pathway(GO:0050847)
0.0 0.9 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.0 0.2 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:1902737 viral replication complex(GO:0019034) dendritic filopodium(GO:1902737)
0.1 1.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.7 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 0.3 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.1 0.3 GO:0032280 symmetric synapse(GO:0032280)
0.1 0.7 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 0.5 GO:0033263 CORVET complex(GO:0033263)
0.0 0.2 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.2 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.4 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.1 0.6 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 0.7 GO:0033592 RNA strand annealing activity(GO:0033592)
0.1 0.4 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.5 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.1 0.4 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 1.2 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 0.2 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.4 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.2 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 1.6 GO:0050699 WW domain binding(GO:0050699)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.2 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 0.1 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.0 0.2 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 2.8 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0015173 hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.3 GO:0050811 GABA receptor binding(GO:0050811)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.4 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 1.4 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 0.7 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta