Motif ID: Bsx

Z-value: 0.401


Transcription factors associated with Bsx:

Gene SymbolEntrez IDGene Name
Bsx ENSMUSG00000054360.3 Bsx

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bsxmm10_v2_chr9_+_40873981_40874127-0.251.2e-01Click!


Activity profile for motif Bsx.

activity profile for motif Bsx


Sorted Z-values histogram for motif Bsx

Sorted Z-values for motif Bsx



Network of associatons between targets according to the STRING database.



First level regulatory network of Bsx

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_8710734 3.277 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710409 3.011 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_-_14621805 2.669 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr13_-_105054895 1.654 ENSMUST00000063551.5
 Rgs7bp
regulator of G-protein signalling 7 binding protein
chr15_+_92597104 1.516 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr4_-_14621494 1.514 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr3_-_121263314 1.327 ENSMUST00000029777.7
 Tmem56
transmembrane protein 56
chr2_-_110362985 1.287 ENSMUST00000099626.3
 Fibin
fin bud initiation factor homolog (zebrafish)
chr4_-_14621669 1.198 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr3_+_54361103 1.197 ENSMUST00000107985.3
ENSMUST00000117373.1
ENSMUST00000073012.6
ENSMUST00000081564.6
 Postn



periostin, osteoblast specific factor



chr15_+_78926720 1.091 ENSMUST00000089377.5
 Lgals1
lectin, galactose binding, soluble 1
chrX_+_13632769 0.967 ENSMUST00000096492.3
 Gpr34
G protein-coupled receptor 34
chr11_-_109611417 0.944 ENSMUST00000103060.3
ENSMUST00000047186.3
ENSMUST00000106689.1
 Wipi1


WD repeat domain, phosphoinositide interacting 1


chr11_-_98053415 0.939 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr2_+_125136692 0.897 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr2_+_36230426 0.819 ENSMUST00000062069.5
 Ptgs1
prostaglandin-endoperoxide synthase 1
chr9_+_111271832 0.774 ENSMUST00000060711.5
 Epm2aip1
EPM2A (laforin) interacting protein 1
chr18_+_69346143 0.765 ENSMUST00000114980.1
 Tcf4
transcription factor 4
chr17_-_47833169 0.715 ENSMUST00000131971.1
ENSMUST00000129360.1
ENSMUST00000113280.1
ENSMUST00000132125.1
 Mdfi



MyoD family inhibitor



chr4_+_136310991 0.706 ENSMUST00000084219.5
 Hnrnpr
heterogeneous nuclear ribonucleoprotein R
chr9_-_95750335 0.700 ENSMUST00000053785.3
 Trpc1
transient receptor potential cation channel, subfamily C, member 1
chr17_-_47833256 0.694 ENSMUST00000152455.1
ENSMUST00000035375.7
 Mdfi

MyoD family inhibitor

chr5_+_144100387 0.640 ENSMUST00000041804.7
 Lmtk2
lemur tyrosine kinase 2
chr4_+_136310936 0.628 ENSMUST00000131671.1
 Hnrnpr
heterogeneous nuclear ribonucleoprotein R
chr2_-_113829069 0.614 ENSMUST00000024005.7
 Scg5
secretogranin V
chr15_+_98092569 0.577 ENSMUST00000163507.1
 Pfkm
phosphofructokinase, muscle
chr4_+_136310952 0.565 ENSMUST00000105850.1
ENSMUST00000148843.3
 Hnrnpr

heterogeneous nuclear ribonucleoprotein R

chr7_+_79273201 0.563 ENSMUST00000037315.6
 Abhd2
abhydrolase domain containing 2
chr11_+_120098910 0.546 ENSMUST00000106223.2
 1810043H04Rik
RIKEN cDNA 1810043H04 gene
chr5_-_62766153 0.539 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_-_45112890 0.515 ENSMUST00000076836.6
 Zeb2
zinc finger E-box binding homeobox 2
chr12_-_84450944 0.485 ENSMUST00000085192.5
 Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr13_+_83732438 0.442 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr2_-_120154600 0.424 ENSMUST00000028755.7
 Ehd4
EH-domain containing 4
chr19_+_11965817 0.407 ENSMUST00000025590.9
 Osbp
oxysterol binding protein
chr5_-_137072254 0.405 ENSMUST00000077523.3
ENSMUST00000041388.4
 Serpine1

serine (or cysteine) peptidase inhibitor, clade E, member 1

chr6_+_63255971 0.394 ENSMUST00000159561.1
ENSMUST00000095852.3
 Grid2

glutamate receptor, ionotropic, delta 2

chr7_+_103550368 0.391 ENSMUST00000106888.1
 Olfr613
olfactory receptor 613
chr2_-_67194695 0.379 ENSMUST00000147939.1
 Gm13598
predicted gene 13598
chr2_+_92375306 0.375 ENSMUST00000028650.8
 Pex16
peroxisomal biogenesis factor 16
chr2_+_30364227 0.364 ENSMUST00000077977.7
ENSMUST00000140075.2
 Fam73b

family with sequence similarity 73, member B

chr2_+_30364262 0.358 ENSMUST00000142801.1
ENSMUST00000100214.3
 Fam73b

family with sequence similarity 73, member B

chr6_+_29694204 0.358 ENSMUST00000046750.7
ENSMUST00000115250.3
 Tspan33

tetraspanin 33

chr17_+_24886643 0.354 ENSMUST00000117890.1
ENSMUST00000168265.1
ENSMUST00000120943.1
ENSMUST00000068508.6
ENSMUST00000119829.1
 Spsb3




splA/ryanodine receptor domain and SOCS box containing 3




chr9_-_110476637 0.341 ENSMUST00000111934.1
ENSMUST00000068025.6
 Klhl18

kelch-like 18

chr7_+_3645267 0.338 ENSMUST00000038913.9
 Cnot3
CCR4-NOT transcription complex, subunit 3
chr2_+_116067213 0.336 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr5_+_134932351 0.335 ENSMUST00000047196.7
ENSMUST00000111221.2
ENSMUST00000111219.1
ENSMUST00000068617.5
ENSMUST00000111218.1
ENSMUST00000136246.1
 Wbscr27





Williams Beuren syndrome chromosome region 27 (human)





chr16_+_22857845 0.323 ENSMUST00000004574.7
ENSMUST00000178320.1
ENSMUST00000166487.2
 Dnajb11


DnaJ (Hsp40) homolog, subfamily B, member 11


chr5_-_103977360 0.319 ENSMUST00000048118.8
 Hsd17b13
hydroxysteroid (17-beta) dehydrogenase 13
chr11_+_116843278 0.298 ENSMUST00000106370.3
 Mettl23
methyltransferase like 23
chr16_-_22857514 0.295 ENSMUST00000004576.6
 Tbccd1
TBCC domain containing 1
chr7_+_44384803 0.291 ENSMUST00000120262.1
 Syt3
synaptotagmin III
chr17_-_24886304 0.257 ENSMUST00000044252.5
 Nubp2
nucleotide binding protein 2
chr17_+_71781947 0.256 ENSMUST00000024854.7
 Clip4
CAP-GLY domain containing linker protein family, member 4
chr11_-_70646972 0.240 ENSMUST00000014750.8
 Slc25a11
solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11
chr5_-_74531619 0.228 ENSMUST00000113542.2
ENSMUST00000072857.6
ENSMUST00000121330.1
ENSMUST00000151474.1
 Scfd2



Sec1 family domain containing 2



chr6_-_124779686 0.226 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
 Lrrc23



leucine rich repeat containing 23



chrX_+_56786527 0.221 ENSMUST00000144600.1
 Fhl1
four and a half LIM domains 1
chr4_+_28813125 0.218 ENSMUST00000029964.5
ENSMUST00000080934.4
 Epha7

Eph receptor A7

chr4_+_28813152 0.204 ENSMUST00000108194.2
ENSMUST00000108191.1
 Epha7

Eph receptor A7

chr8_-_67818218 0.196 ENSMUST00000059374.4
 Psd3
pleckstrin and Sec7 domain containing 3
chr3_-_113577743 0.193 ENSMUST00000067980.5
 Amy1
amylase 1, salivary
chr2_+_110597298 0.193 ENSMUST00000045972.6
ENSMUST00000111026.2
 Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr9_-_55919605 0.179 ENSMUST00000037408.8
 Scaper
S phase cyclin A-associated protein in the ER
chr6_-_34317442 0.176 ENSMUST00000154655.1
ENSMUST00000102980.4
 Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)

chr18_-_67245818 0.168 ENSMUST00000073054.3
 Mppe1
metallophosphoesterase 1
chr18_-_36744518 0.165 ENSMUST00000014438.4
 Ndufa2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2
chr6_+_72097561 0.164 ENSMUST00000069994.4
ENSMUST00000114112.1
 St3gal5

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

chr2_-_116067391 0.154 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr5_-_122989260 0.151 ENSMUST00000118027.1
 Kdm2b
lysine (K)-specific demethylase 2B
chr8_-_67818284 0.141 ENSMUST00000120071.1
 Psd3
pleckstrin and Sec7 domain containing 3
chr12_+_84451485 0.093 ENSMUST00000137170.1
 Lin52
lin-52 homolog (C. elegans)
chr8_-_77517898 0.091 ENSMUST00000076316.4
 Arhgap10
Rho GTPase activating protein 10
chr5_+_136987019 0.081 ENSMUST00000004968.4
 Plod3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr5_+_33335540 0.065 ENSMUST00000114449.3
 Maea
macrophage erythroblast attacher
chr15_+_9436028 0.059 ENSMUST00000042360.3
 Capsl
calcyphosine-like
chr7_-_98656530 0.059 ENSMUST00000038359.4
 2210018M11Rik
RIKEN cDNA 2210018M11 gene
chr8_-_78821136 0.049 ENSMUST00000130325.1
ENSMUST00000051867.6
 Lsm6

LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)

chr1_+_171213969 0.046 ENSMUST00000005820.4
ENSMUST00000075469.5
ENSMUST00000155126.1
 Nr1i3


nuclear receptor subfamily 1, group I, member 3


chr8_-_70139197 0.031 ENSMUST00000075724.7
 Rfxank
regulatory factor X-associated ankyrin-containing protein
chr3_+_89245952 0.028 ENSMUST00000040888.5
 Krtcap2
keratinocyte associated protein 2
chr1_-_163725123 0.026 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.3 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.8 5.4 GO:0019532 oxalate transport(GO:0019532)
0.4 1.2 GO:1904207 chemokine (C-C motif) ligand 2 secretion(GO:0035926) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.3 0.8 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.2 1.0 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.2 1.1 GO:0002317 plasma cell differentiation(GO:0002317) positive regulation of viral entry into host cell(GO:0046598)
0.2 0.5 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 0.4 GO:2000097 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.6 GO:0061622 glycolytic process through glucose-1-phosphate(GO:0061622)
0.1 0.2 GO:0006059 hexitol metabolic process(GO:0006059)
0.1 0.8 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.1 0.5 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 1.4 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.1 0.4 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.1 0.7 GO:0046541 saliva secretion(GO:0046541)
0.1 0.8 GO:0042118 endothelial cell activation(GO:0042118)
0.1 0.9 GO:0048199 protein localization to pre-autophagosomal structure(GO:0034497) vesicle targeting, to, from or within Golgi(GO:0048199)
0.1 0.4 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.1 1.9 GO:0061157 mRNA destabilization(GO:0061157)
0.1 0.3 GO:0051661 maintenance of centrosome location(GO:0051661) maintenance of Golgi location(GO:0051684)
0.0 0.6 GO:0033572 transferrin transport(GO:0033572)
0.0 0.6 GO:0032570 response to progesterone(GO:0032570)
0.0 0.6 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.2 GO:0021993 initiation of neural tube closure(GO:0021993)
0.0 0.4 GO:0044144 regulation of growth of symbiont in host(GO:0044126) modulation of growth of symbiont involved in interaction with host(GO:0044144)
0.0 0.4 GO:1904861 excitatory synapse assembly(GO:1904861)
0.0 0.4 GO:0006907 pinocytosis(GO:0006907)
0.0 0.1 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 0.3 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.3 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.3 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.4 GO:0007608 sensory perception of smell(GO:0007608)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 0.4 GO:0042583 chromaffin granule(GO:0042583)
0.1 0.6 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 0.9 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 0.4 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.2 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 12.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.1 GO:0034657 GID complex(GO:0034657)
0.0 1.6 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 6.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.5 5.4 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.2 1.1 GO:0005534 galactose binding(GO:0005534)
0.2 0.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.6 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.1 1.0 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.2 GO:0015140 malate transmembrane transporter activity(GO:0015140)
0.1 0.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 0.2 GO:0016160 alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.1 0.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.4 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.9 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.4 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.8 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.4 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 0.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.4 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 11.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.8 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.5 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.8 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.6 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 1.9 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 0.3 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription