Motif ID: Creb3l2
Z-value: 0.563
Transcription factors associated with Creb3l2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Creb3l2 | ENSMUSG00000038648.5 | Creb3l2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Creb3l2 | mm10_v2_chr6_-_37442095_37442154 | -0.19 | 2.4e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.9 | GO:0008295 | spermidine biosynthetic process(GO:0008295) |
| 0.7 | 2.2 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 0.5 | 1.5 | GO:1990523 | bone regeneration(GO:1990523) |
| 0.3 | 0.8 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
| 0.2 | 2.6 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.2 | 1.4 | GO:0006265 | DNA topological change(GO:0006265) |
| 0.2 | 0.7 | GO:0006244 | pyrimidine nucleotide catabolic process(GO:0006244) pyrimidine deoxyribonucleotide catabolic process(GO:0009223) |
| 0.2 | 0.5 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
| 0.2 | 0.8 | GO:0010668 | ectodermal cell differentiation(GO:0010668) |
| 0.2 | 2.1 | GO:0007141 | male meiosis I(GO:0007141) |
| 0.2 | 4.7 | GO:2000310 | regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310) |
| 0.1 | 0.6 | GO:0071638 | negative regulation of monocyte chemotactic protein-1 production(GO:0071638) |
| 0.1 | 0.4 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
| 0.1 | 1.0 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.1 | 3.1 | GO:0043496 | regulation of protein homodimerization activity(GO:0043496) |
| 0.1 | 0.4 | GO:0070625 | zymogen granule exocytosis(GO:0070625) |
| 0.1 | 0.7 | GO:0032815 | negative regulation of natural killer cell activation(GO:0032815) |
| 0.1 | 1.1 | GO:1990253 | cellular response to leucine starvation(GO:1990253) |
| 0.1 | 1.5 | GO:0015816 | glycine transport(GO:0015816) |
| 0.1 | 0.5 | GO:0006041 | glucosamine metabolic process(GO:0006041) |
| 0.1 | 0.9 | GO:0051103 | DNA ligation involved in DNA repair(GO:0051103) |
| 0.1 | 0.3 | GO:1901857 | positive regulation of cellular respiration(GO:1901857) |
| 0.1 | 0.5 | GO:0051013 | microtubule severing(GO:0051013) |
| 0.1 | 0.3 | GO:0072531 | pyrimidine-containing compound transmembrane transport(GO:0072531) |
| 0.1 | 0.8 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879) |
| 0.1 | 0.4 | GO:0072717 | cellular response to actinomycin D(GO:0072717) |
| 0.1 | 0.3 | GO:1904451 | regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453) |
| 0.1 | 0.4 | GO:0046598 | positive regulation of viral entry into host cell(GO:0046598) |
| 0.1 | 0.4 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
| 0.1 | 1.6 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.1 | 1.6 | GO:0051560 | mitochondrial calcium ion homeostasis(GO:0051560) |
| 0.1 | 0.6 | GO:0014029 | neural crest formation(GO:0014029) |
| 0.0 | 0.8 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.0 | 1.3 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 0.7 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 0.8 | GO:0005980 | polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247) |
| 0.0 | 0.5 | GO:0051683 | establishment of Golgi localization(GO:0051683) |
| 0.0 | 0.7 | GO:0006103 | 2-oxoglutarate metabolic process(GO:0006103) |
| 0.0 | 0.8 | GO:1901032 | negative regulation of response to reactive oxygen species(GO:1901032) negative regulation of hydrogen peroxide-induced cell death(GO:1903206) |
| 0.0 | 0.4 | GO:0044819 | mitotic G1 DNA damage checkpoint(GO:0031571) mitotic G1/S transition checkpoint(GO:0044819) |
| 0.0 | 0.1 | GO:0043686 | co-translational protein modification(GO:0043686) |
| 0.0 | 1.1 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 0.2 | GO:0032049 | cardiolipin biosynthetic process(GO:0032049) |
| 0.0 | 0.9 | GO:0032292 | myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292) |
| 0.0 | 0.1 | GO:0002725 | negative regulation of T cell cytokine production(GO:0002725) |
| 0.0 | 1.1 | GO:0005978 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.0 | 0.2 | GO:0060510 | Type II pneumocyte differentiation(GO:0060510) |
| 0.0 | 0.2 | GO:0045794 | negative regulation of cell volume(GO:0045794) |
| 0.0 | 0.1 | GO:0006526 | arginine biosynthetic process(GO:0006526) |
| 0.0 | 0.9 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.0 | 0.2 | GO:0051503 | adenine nucleotide transport(GO:0051503) |
| 0.0 | 0.5 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.0 | 0.1 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.0 | 2.2 | GO:0007030 | Golgi organization(GO:0007030) |
| 0.0 | 1.2 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 0.0 | 2.7 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.0 | 0.5 | GO:0019432 | triglyceride biosynthetic process(GO:0019432) |
| 0.0 | 0.8 | GO:0060612 | adipose tissue development(GO:0060612) |
| 0.0 | 0.1 | GO:1904715 | negative regulation of chaperone-mediated autophagy(GO:1904715) |
| 0.0 | 0.7 | GO:0045214 | sarcomere organization(GO:0045214) |
| 0.0 | 0.3 | GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315) |
| 0.0 | 0.0 | GO:1903960 | negative regulation of anion channel activity(GO:0010360) negative regulation of anion transmembrane transport(GO:1903960) |
| 0.0 | 0.2 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 0.0 | 0.1 | GO:0009098 | branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099) |
| 0.0 | 0.6 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
| 0.0 | 0.0 | GO:0032241 | positive regulation of nucleobase-containing compound transport(GO:0032241) |
| 0.0 | 0.3 | GO:0001921 | positive regulation of receptor recycling(GO:0001921) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.1 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.2 | 0.7 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.2 | 1.3 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807) |
| 0.2 | 2.6 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.1 | 1.6 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 0.8 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.1 | 0.4 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
| 0.1 | 0.3 | GO:0097574 | lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795) |
| 0.1 | 1.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 1.5 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.1 | 0.4 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 0.3 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.0 | 1.1 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 0.4 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.0 | 3.1 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.0 | 0.2 | GO:0034715 | pICln-Sm protein complex(GO:0034715) |
| 0.0 | 0.5 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 0.2 | GO:0035032 | phosphatidylinositol 3-kinase complex, class III(GO:0035032) |
| 0.0 | 1.4 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 0.4 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.0 | 0.4 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.0 | 0.6 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.9 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.0 | 0.1 | GO:0033263 | CORVET complex(GO:0033263) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.4 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
| 0.2 | 0.7 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
| 0.2 | 1.3 | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599) |
| 0.2 | 0.6 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.2 | 0.8 | GO:0008184 | glycogen phosphorylase activity(GO:0008184) |
| 0.2 | 0.8 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 0.2 | 0.5 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
| 0.2 | 1.5 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.1 | 2.5 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 1.1 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 0.1 | 0.8 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.1 | 0.4 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
| 0.1 | 0.5 | GO:1904288 | BAT3 complex binding(GO:1904288) |
| 0.1 | 0.3 | GO:1990050 | phosphatidic acid transporter activity(GO:1990050) |
| 0.1 | 1.6 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.1 | 0.5 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.1 | 0.7 | GO:0047429 | nucleoside-triphosphate diphosphatase activity(GO:0047429) |
| 0.1 | 2.1 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.1 | 0.4 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798) |
| 0.1 | 0.3 | GO:0004096 | catalase activity(GO:0004096) |
| 0.1 | 0.6 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 0.1 | 1.5 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 0.4 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
| 0.1 | 0.9 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 0.2 | GO:0046964 | 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964) |
| 0.1 | 3.9 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.1 | 1.1 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.0 | 1.0 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.0 | 5.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 1.5 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 1.1 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.0 | 1.6 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.1 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.0 | 0.3 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 3.5 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.0 | 0.5 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.0 | 1.0 | GO:0008378 | galactosyltransferase activity(GO:0008378) |
| 0.0 | 0.1 | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812) |
| 0.0 | 2.2 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
| 0.0 | 0.2 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.0 | 0.5 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.8 | GO:0016790 | thiolester hydrolase activity(GO:0016790) |
| 0.0 | 0.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 0.3 | GO:0015215 | nucleotide transmembrane transporter activity(GO:0015215) |
| 0.0 | 0.4 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.3 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.1 | GO:0052654 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
| 0.0 | 0.1 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.0 | 0.3 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.0 | 0.6 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.6 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 1.5 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.0 | 1.3 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 2.2 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.3 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.3 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 0.9 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.6 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
| 0.0 | 1.3 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.0 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.8 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.2 | 4.7 | REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.2 | 3.2 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.1 | 0.8 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 1.6 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.1 | 1.3 | REACTOME_INTEGRATION_OF_PROVIRUS | Genes involved in Integration of provirus |
| 0.1 | 0.8 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 0.8 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.1 | 0.8 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.1 | 1.1 | REACTOME_RNA_POL_III_CHAIN_ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.0 | 0.7 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 2.2 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 0.5 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
| 0.0 | 0.9 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 1.3 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.4 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 1.5 | REACTOME_G_ALPHA_S_SIGNALLING_EVENTS | Genes involved in G alpha (s) signalling events |
| 0.0 | 1.0 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.2 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PG | Genes involved in Acyl chain remodelling of PG |
| 0.0 | 0.3 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.0 | 1.5 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.7 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.4 | REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 0.4 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
