Motif ID: Dbp
Z-value: 1.159
Transcription factors associated with Dbp:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Dbp | ENSMUSG00000059824.4 | Dbp |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Dbp | mm10_v2_chr7_+_45705518_45705624 | -0.56 | 1.7e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 8.9 | GO:0098923 | retrograde trans-synaptic signaling by soluble gas(GO:0098923) |
| 2.5 | 7.4 | GO:0001928 | regulation of exocyst assembly(GO:0001928) |
| 2.0 | 12.0 | GO:0051964 | negative regulation of synapse assembly(GO:0051964) |
| 1.9 | 7.7 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 1.7 | 20.5 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 1.4 | 4.1 | GO:0042663 | regulation of endodermal cell fate specification(GO:0042663) |
| 1.1 | 4.4 | GO:2000182 | regulation of progesterone biosynthetic process(GO:2000182) |
| 0.9 | 7.7 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.8 | 4.9 | GO:0060012 | synaptic transmission, glycinergic(GO:0060012) |
| 0.8 | 8.2 | GO:0014824 | artery smooth muscle contraction(GO:0014824) |
| 0.8 | 4.1 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.7 | 6.6 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.7 | 2.1 | GO:1902630 | regulation of membrane hyperpolarization(GO:1902630) |
| 0.6 | 3.9 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
| 0.6 | 5.8 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.6 | 1.9 | GO:0003345 | proepicardium cell migration involved in pericardium morphogenesis(GO:0003345) |
| 0.6 | 1.8 | GO:0032241 | positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) |
| 0.6 | 2.4 | GO:2000211 | regulation of glutamate metabolic process(GO:2000211) |
| 0.6 | 5.9 | GO:0061470 | interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619) |
| 0.6 | 1.8 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
| 0.6 | 4.7 | GO:0061368 | maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
| 0.6 | 5.1 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
| 0.5 | 1.6 | GO:0086046 | membrane depolarization during SA node cell action potential(GO:0086046) |
| 0.5 | 9.2 | GO:1902993 | positive regulation of amyloid precursor protein catabolic process(GO:1902993) |
| 0.5 | 1.5 | GO:0061075 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871) |
| 0.4 | 1.2 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
| 0.4 | 1.2 | GO:2000224 | regulation of testosterone biosynthetic process(GO:2000224) |
| 0.4 | 7.6 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.4 | 1.9 | GO:0010993 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) |
| 0.4 | 1.8 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.4 | 1.8 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.3 | 2.0 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.3 | 5.9 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 0.3 | 6.0 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
| 0.3 | 2.3 | GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) |
| 0.3 | 2.0 | GO:1900042 | positive regulation of interleukin-2 secretion(GO:1900042) |
| 0.3 | 0.9 | GO:0070366 | regulation of hepatocyte differentiation(GO:0070366) |
| 0.3 | 1.7 | GO:0098909 | regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909) |
| 0.3 | 0.8 | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) |
| 0.2 | 2.0 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.2 | 1.3 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.2 | 1.1 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
| 0.2 | 1.1 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.2 | 2.8 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
| 0.2 | 0.8 | GO:0097105 | presynaptic membrane assembly(GO:0097105) |
| 0.2 | 1.0 | GO:0036324 | negative regulation of toll-like receptor 4 signaling pathway(GO:0034144) vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) |
| 0.2 | 0.9 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 0.2 | 1.1 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
| 0.2 | 1.8 | GO:0019065 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
| 0.2 | 4.3 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.2 | 0.8 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.2 | 1.1 | GO:0030718 | germ-line stem cell population maintenance(GO:0030718) |
| 0.2 | 3.6 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.1 | 10.9 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.1 | 0.8 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368) |
| 0.1 | 7.0 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.1 | 4.9 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 0.1 | 0.6 | GO:0060050 | positive regulation of protein glycosylation(GO:0060050) |
| 0.1 | 0.5 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.1 | 8.3 | GO:0060395 | SMAD protein signal transduction(GO:0060395) |
| 0.1 | 5.1 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.1 | 1.5 | GO:0043982 | histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982) |
| 0.1 | 2.9 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.1 | 0.8 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.1 | 2.1 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552) |
| 0.1 | 2.0 | GO:0050884 | neuromuscular process controlling posture(GO:0050884) |
| 0.1 | 0.8 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
| 0.1 | 2.7 | GO:0051968 | positive regulation of synaptic transmission, glutamatergic(GO:0051968) |
| 0.1 | 1.0 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.1 | 0.9 | GO:0021960 | anterior commissure morphogenesis(GO:0021960) |
| 0.1 | 0.8 | GO:0070072 | vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072) |
| 0.1 | 3.6 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.1 | 6.8 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
| 0.1 | 0.3 | GO:0006553 | lysine metabolic process(GO:0006553) |
| 0.1 | 0.9 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 0.1 | 0.4 | GO:0090070 | positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234) |
| 0.1 | 0.9 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.1 | 2.1 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.1 | 0.1 | GO:2000170 | positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170) |
| 0.1 | 0.8 | GO:0033089 | positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400) |
| 0.1 | 6.0 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.1 | 0.6 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.1 | 0.2 | GO:1904020 | regulation of G-protein coupled receptor internalization(GO:1904020) |
| 0.1 | 8.7 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.1 | 1.0 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.1 | 0.6 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 0.1 | 1.4 | GO:0007097 | nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) |
| 0.1 | 0.6 | GO:0043312 | neutrophil degranulation(GO:0043312) |
| 0.1 | 0.9 | GO:0021702 | cerebellar Purkinje cell differentiation(GO:0021702) |
| 0.1 | 0.4 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 0.0 | 0.2 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 0.0 | 0.2 | GO:0071313 | cellular response to caffeine(GO:0071313) |
| 0.0 | 1.3 | GO:0070306 | lens fiber cell differentiation(GO:0070306) |
| 0.0 | 0.8 | GO:0071625 | vocalization behavior(GO:0071625) |
| 0.0 | 1.8 | GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200) |
| 0.0 | 2.1 | GO:0050775 | positive regulation of dendrite morphogenesis(GO:0050775) |
| 0.0 | 0.3 | GO:0035826 | rubidium ion transport(GO:0035826) cellular hypotonic response(GO:0071476) |
| 0.0 | 0.7 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.0 | 0.3 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.0 | 0.1 | GO:0051001 | negative regulation of nitric-oxide synthase activity(GO:0051001) |
| 0.0 | 2.0 | GO:0030968 | endoplasmic reticulum unfolded protein response(GO:0030968) |
| 0.0 | 0.4 | GO:0010155 | regulation of proton transport(GO:0010155) |
| 0.0 | 0.4 | GO:0060837 | blood vessel endothelial cell differentiation(GO:0060837) |
| 0.0 | 1.9 | GO:0007173 | epidermal growth factor receptor signaling pathway(GO:0007173) |
| 0.0 | 0.2 | GO:1902969 | mitotic DNA replication(GO:1902969) |
| 0.0 | 0.7 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.0 | 2.2 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
| 0.0 | 2.0 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.0 | 1.2 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.0 | 1.2 | GO:0021766 | hippocampus development(GO:0021766) |
| 0.0 | 3.4 | GO:0071805 | potassium ion transmembrane transport(GO:0071805) |
| 0.0 | 0.0 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
| 0.0 | 0.2 | GO:1900364 | negative regulation of mRNA polyadenylation(GO:1900364) |
| 0.0 | 1.1 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.0 | 1.6 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.0 | 0.2 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.0 | 0.1 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.0 | 0.4 | GO:0006813 | potassium ion transport(GO:0006813) |
| 0.0 | 0.1 | GO:0021527 | spinal cord association neuron differentiation(GO:0021527) |
| 0.0 | 0.1 | GO:0042473 | outer ear morphogenesis(GO:0042473) |
| 0.0 | 0.6 | GO:0042439 | ethanolamine-containing compound metabolic process(GO:0042439) |
| 0.0 | 1.0 | GO:0031398 | positive regulation of protein ubiquitination(GO:0031398) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.5 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 1.1 | 7.7 | GO:0042627 | chylomicron(GO:0042627) |
| 0.9 | 3.6 | GO:0031673 | H zone(GO:0031673) |
| 0.9 | 12.8 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.7 | 2.1 | GO:0098855 | HCN channel complex(GO:0098855) |
| 0.6 | 5.1 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.5 | 9.8 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.5 | 1.8 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.4 | 8.9 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.4 | 2.0 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.3 | 2.0 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
| 0.3 | 7.7 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.3 | 2.4 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.3 | 3.3 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.2 | 1.0 | GO:1990032 | parallel fiber(GO:1990032) |
| 0.2 | 1.7 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.2 | 4.9 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.2 | 53.9 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.2 | 0.7 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.2 | 1.0 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.2 | 5.3 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.2 | 1.8 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.1 | 3.3 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.1 | 3.3 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.1 | 1.1 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.1 | 0.8 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.1 | 22.9 | GO:0030427 | site of polarized growth(GO:0030427) |
| 0.1 | 2.2 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 6.6 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 2.5 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.1 | 0.5 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.1 | 1.0 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 0.6 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.1 | 0.2 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.1 | 1.1 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.1 | 0.9 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.1 | 2.3 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 0.3 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.0 | 0.8 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.0 | 1.5 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 0.6 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.0 | 0.4 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.0 | 0.4 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 0.3 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.0 | 1.2 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 1.2 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 6.0 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 0.4 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 0.7 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 0.9 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.6 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 0.8 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 0.8 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 0.8 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 1.0 | GO:0042641 | actomyosin(GO:0042641) |
| 0.0 | 6.2 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.0 | 1.3 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 0.3 | GO:0031902 | late endosome membrane(GO:0031902) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 6.6 | GO:0047275 | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275) |
| 1.6 | 4.9 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 1.3 | 10.7 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 1.0 | 7.0 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.9 | 5.5 | GO:0022851 | GABA-gated chloride ion channel activity(GO:0022851) |
| 0.7 | 5.9 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.6 | 5.1 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.6 | 7.7 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.6 | 7.2 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.6 | 1.7 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.6 | 2.8 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.5 | 2.2 | GO:0001847 | opsonin receptor activity(GO:0001847) |
| 0.5 | 2.1 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.5 | 3.5 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.5 | 3.5 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.4 | 7.8 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.4 | 22.2 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.4 | 5.5 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.4 | 7.4 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.4 | 1.8 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.4 | 1.1 | GO:0004517 | nitric-oxide synthase activity(GO:0004517) |
| 0.3 | 3.5 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.3 | 1.3 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.3 | 1.2 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
| 0.3 | 10.3 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.3 | 1.1 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 0.3 | 0.8 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
| 0.3 | 1.8 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795) |
| 0.2 | 0.9 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
| 0.2 | 1.5 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.2 | 0.8 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.2 | 1.1 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.2 | 1.5 | GO:0043995 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
| 0.2 | 2.7 | GO:0030955 | potassium ion binding(GO:0030955) |
| 0.2 | 0.8 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 0.1 | 1.9 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.1 | 2.3 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.1 | 0.6 | GO:0031800 | type 3 metabotropic glutamate receptor binding(GO:0031800) |
| 0.1 | 1.0 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.1 | 2.4 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.1 | 1.9 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.1 | 2.6 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
| 0.1 | 1.4 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.1 | 5.7 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.1 | 0.8 | GO:0008556 | sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556) |
| 0.1 | 3.4 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 8.2 | GO:0035254 | glutamate receptor binding(GO:0035254) |
| 0.1 | 5.7 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 1.0 | GO:0004691 | cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 2.9 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 0.7 | GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) |
| 0.1 | 2.0 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.1 | 1.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 0.2 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) |
| 0.1 | 0.4 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
| 0.1 | 0.6 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.1 | 2.3 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.1 | 0.6 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 0.1 | 0.3 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
| 0.1 | 1.1 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.1 | 3.6 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.1 | 1.0 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.1 | 1.1 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.1 | 1.7 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.1 | 2.9 | GO:0008081 | phosphoric diester hydrolase activity(GO:0008081) |
| 0.1 | 0.4 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.0 | 0.7 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.0 | 0.1 | GO:0042284 | sphingolipid delta-4 desaturase activity(GO:0042284) |
| 0.0 | 1.7 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 4.6 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 7.6 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 0.4 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 1.0 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 2.4 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.0 | 0.5 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.0 | 0.7 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 1.2 | GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620) |
| 0.0 | 3.8 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.1 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.0 | 0.5 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 0.3 | GO:0042288 | GTPase activating protein binding(GO:0032794) MHC class I protein binding(GO:0042288) |
| 0.0 | 4.5 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.0 | 1.6 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.8 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 2.8 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
| 0.0 | 0.3 | GO:0016646 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646) |
| 0.0 | 4.7 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 0.0 | 4.9 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.4 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.2 | 4.7 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.1 | 4.4 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 7.4 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.1 | 3.5 | PID_BETA_CATENIN_DEG_PATHWAY | Degradation of beta catenin |
| 0.1 | 4.3 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
| 0.1 | 1.7 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.1 | 3.5 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 1.8 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.1 | 2.1 | ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.1 | 4.8 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.1 | 2.2 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 5.3 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
| 0.1 | 1.0 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.1 | 0.8 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.1 | 2.2 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.0 | 1.0 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.8 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 1.5 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
| 0.0 | 4.1 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.8 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 1.3 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.0 | PID_CDC42_PATHWAY | CDC42 signaling events |
| 0.0 | 0.6 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 0.2 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 0.6 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 0.3 | PID_NFAT_3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 17.7 | REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.6 | 15.2 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.5 | 7.7 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.4 | 6.7 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.3 | 4.1 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
| 0.2 | 2.4 | REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.2 | 7.4 | REACTOME_SIGNAL_TRANSDUCTION_BY_L1 | Genes involved in Signal transduction by L1 |
| 0.1 | 4.0 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 1.7 | REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING | Genes involved in GRB2 events in ERBB2 signaling |
| 0.1 | 2.1 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 2.9 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.1 | 3.3 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 1.3 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 2.9 | REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.1 | 6.7 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 1.1 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.1 | 0.8 | REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.1 | 1.0 | REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.1 | 2.0 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 0.8 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
| 0.1 | 2.7 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 0.8 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.1 | 1.9 | REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 1.2 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 1.8 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 1.1 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 3.8 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 2.1 | REACTOME_POTASSIUM_CHANNELS | Genes involved in Potassium Channels |
| 0.0 | 0.8 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 2.3 | REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES | Genes involved in Transmission across Chemical Synapses |
| 0.0 | 1.1 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 0.1 | REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.0 | 0.2 | REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
