Motif ID: Ddit3
Z-value: 0.892
Transcription factors associated with Ddit3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Ddit3 | ENSMUSG00000025408.9 | Ddit3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ddit3 | mm10_v2_chr10_+_127290774_127290803 | -0.35 | 2.6e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.5 | GO:0021577 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
| 1.1 | 3.2 | GO:0051892 | negative regulation of cardioblast differentiation(GO:0051892) |
| 1.0 | 8.9 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.7 | 4.1 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.6 | 1.2 | GO:0034334 | adherens junction maintenance(GO:0034334) |
| 0.6 | 6.7 | GO:0090232 | positive regulation of spindle checkpoint(GO:0090232) |
| 0.5 | 3.2 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.5 | 1.4 | GO:0042275 | error-free postreplication DNA repair(GO:0042275) |
| 0.4 | 1.7 | GO:0086042 | cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) |
| 0.4 | 1.1 | GO:0014826 | vein smooth muscle contraction(GO:0014826) |
| 0.3 | 2.5 | GO:0006004 | fucose metabolic process(GO:0006004) |
| 0.3 | 1.2 | GO:0099527 | postsynapse to nucleus signaling pathway(GO:0099527) |
| 0.3 | 0.9 | GO:0051715 | cytolysis in other organism(GO:0051715) |
| 0.3 | 1.6 | GO:0019695 | choline metabolic process(GO:0019695) |
| 0.3 | 1.1 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) calcium-dependent cell-matrix adhesion(GO:0016340) |
| 0.3 | 1.0 | GO:0006751 | glutathione catabolic process(GO:0006751) |
| 0.2 | 1.5 | GO:0072318 | clathrin coat disassembly(GO:0072318) |
| 0.2 | 0.7 | GO:0070649 | meiotic chromosome movement towards spindle pole(GO:0016344) formin-nucleated actin cable assembly(GO:0070649) |
| 0.2 | 4.8 | GO:0014049 | positive regulation of glutamate secretion(GO:0014049) |
| 0.2 | 2.2 | GO:0061470 | interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619) |
| 0.2 | 0.9 | GO:0071680 | response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681) |
| 0.2 | 1.3 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.2 | 0.5 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
| 0.2 | 1.0 | GO:1990928 | response to amino acid starvation(GO:1990928) |
| 0.2 | 0.5 | GO:0001951 | intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896) |
| 0.1 | 0.6 | GO:0006409 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.1 | 3.0 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.1 | 0.9 | GO:0006561 | proline biosynthetic process(GO:0006561) |
| 0.1 | 0.6 | GO:0018364 | peptidyl-glutamine methylation(GO:0018364) |
| 0.1 | 3.2 | GO:0031571 | mitotic G1 DNA damage checkpoint(GO:0031571) |
| 0.1 | 0.8 | GO:0030242 | pexophagy(GO:0030242) |
| 0.1 | 0.8 | GO:2000973 | regulation of pro-B cell differentiation(GO:2000973) |
| 0.1 | 1.0 | GO:0031125 | rRNA 3'-end processing(GO:0031125) |
| 0.1 | 0.6 | GO:0010747 | positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) |
| 0.1 | 0.3 | GO:1901475 | pyruvate transmembrane transport(GO:1901475) |
| 0.1 | 0.6 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.1 | 0.7 | GO:2000258 | negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258) |
| 0.1 | 0.7 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.1 | 0.9 | GO:1990403 | embryonic brain development(GO:1990403) |
| 0.1 | 0.4 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
| 0.1 | 1.4 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.1 | 1.8 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.1 | 0.4 | GO:0032308 | positive regulation of prostaglandin secretion(GO:0032308) |
| 0.1 | 2.4 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 0.1 | 0.8 | GO:0015809 | arginine transport(GO:0015809) |
| 0.1 | 1.4 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
| 0.1 | 1.5 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 0.2 | GO:0036089 | cleavage furrow formation(GO:0036089) |
| 0.0 | 0.2 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
| 0.0 | 0.8 | GO:0050901 | leukocyte tethering or rolling(GO:0050901) |
| 0.0 | 0.4 | GO:0071816 | tail-anchored membrane protein insertion into ER membrane(GO:0071816) |
| 0.0 | 0.3 | GO:0051004 | regulation of lipoprotein lipase activity(GO:0051004) |
| 0.0 | 0.2 | GO:0042138 | meiotic DNA double-strand break formation(GO:0042138) |
| 0.0 | 1.0 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 2.1 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.0 | 0.3 | GO:0051103 | DNA ligation involved in DNA repair(GO:0051103) |
| 0.0 | 0.3 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
| 0.0 | 4.5 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.0 | 0.4 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 0.6 | GO:0035067 | negative regulation of histone acetylation(GO:0035067) |
| 0.0 | 0.1 | GO:0010845 | positive regulation of reciprocal meiotic recombination(GO:0010845) |
| 0.0 | 0.2 | GO:0033184 | positive regulation of histone ubiquitination(GO:0033184) |
| 0.0 | 0.8 | GO:0009409 | response to cold(GO:0009409) |
| 0.0 | 0.1 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.0 | 0.4 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.0 | 0.4 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.0 | 1.7 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
| 0.0 | 0.2 | GO:0042407 | cristae formation(GO:0042407) |
| 0.0 | 0.3 | GO:0033194 | response to hydroperoxide(GO:0033194) |
| 0.0 | 2.2 | GO:0048839 | inner ear development(GO:0048839) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.5 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.5 | 1.4 | GO:0031372 | UBC13-MMS2 complex(GO:0031372) |
| 0.4 | 1.4 | GO:0031673 | H zone(GO:0031673) |
| 0.3 | 8.9 | GO:0031430 | M band(GO:0031430) |
| 0.2 | 0.7 | GO:0097057 | TRAF2-GSTP1 complex(GO:0097057) |
| 0.2 | 3.2 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.2 | 6.7 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.2 | 4.0 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.2 | 2.4 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.1 | 2.4 | GO:0043196 | varicosity(GO:0043196) |
| 0.1 | 1.0 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.1 | 1.0 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
| 0.1 | 1.8 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.1 | 1.4 | GO:0043203 | axon hillock(GO:0043203) |
| 0.1 | 0.5 | GO:1990357 | terminal web(GO:1990357) |
| 0.1 | 0.6 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.1 | 1.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 0.8 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.1 | 0.9 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.1 | 1.4 | GO:0016514 | SWI/SNF complex(GO:0016514) |
| 0.1 | 2.4 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.1 | 0.4 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.1 | 0.6 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.0 | 3.3 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.4 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 0.2 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.0 | 3.4 | GO:0005903 | brush border(GO:0005903) |
| 0.0 | 0.4 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 0.9 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 1.0 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 1.8 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 0.9 | GO:0035869 | ciliary transition zone(GO:0035869) |
| 0.0 | 0.1 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.0 | 7.6 | GO:0005635 | nuclear envelope(GO:0005635) |
| 0.0 | 3.6 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 0.9 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 0.3 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.0 | 0.3 | GO:0031305 | integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 0.2 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.0 | 0.2 | GO:0031045 | dense core granule(GO:0031045) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.5 | GO:0015928 | alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928) |
| 0.7 | 3.6 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.4 | 1.6 | GO:0004104 | cholinesterase activity(GO:0004104) choline binding(GO:0033265) |
| 0.4 | 1.1 | GO:0004962 | endothelin receptor activity(GO:0004962) |
| 0.3 | 1.7 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.3 | 1.0 | GO:0071207 | histone pre-mRNA stem-loop binding(GO:0071207) |
| 0.2 | 0.9 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 0.2 | 0.9 | GO:0042834 | peptidoglycan binding(GO:0042834) |
| 0.2 | 1.0 | GO:0003839 | gamma-glutamylcyclotransferase activity(GO:0003839) |
| 0.2 | 1.0 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 0.2 | 4.1 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.2 | 9.7 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.2 | 6.7 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.2 | 0.6 | GO:0061628 | H3K27me3 modified histone binding(GO:0061628) |
| 0.1 | 2.4 | GO:0005003 | ephrin receptor activity(GO:0005003) |
| 0.1 | 3.2 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 0.8 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
| 0.1 | 1.3 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 0.3 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 0.1 | 3.2 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 3.5 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.1 | 1.4 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 0.9 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 0.7 | GO:0008106 | alcohol dehydrogenase (NADP+) activity(GO:0008106) |
| 0.1 | 1.7 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 0.3 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
| 0.0 | 1.2 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 1.2 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 0.6 | GO:0008649 | rRNA methyltransferase activity(GO:0008649) |
| 0.0 | 0.9 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.0 | 1.5 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.0 | 1.0 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 1.4 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.0 | 0.6 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.0 | 1.4 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 0.7 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 0.2 | GO:0045322 | unmethylated CpG binding(GO:0045322) |
| 0.0 | 1.7 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.0 | 0.2 | GO:0000990 | transcription factor activity, core RNA polymerase binding(GO:0000990) |
| 0.0 | 3.4 | GO:0016810 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810) |
| 0.0 | 0.8 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.0 | 0.1 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.0 | 0.4 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 0.4 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 2.2 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 1.1 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 0.8 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.0 | 0.9 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 1.5 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 2.9 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.0 | 0.4 | GO:0015485 | cholesterol binding(GO:0015485) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.8 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 3.5 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 2.4 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.0 | 1.2 | PID_PI3KCI_AKT_PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.0 | 1.7 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 1.9 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 1.6 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.4 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.8 | ST_INTERLEUKIN_4_PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 1.4 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.1 | PID_ENDOTHELIN_PATHWAY | Endothelins |
| 0.0 | 1.0 | PID_TCPTP_PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 1.2 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 1.3 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.4 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 0.9 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 1.2 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.1 | 1.7 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 3.4 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 1.8 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 1.6 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
| 0.1 | 2.9 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.1 | 0.8 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.0 | 4.1 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 1.5 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 0.8 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.8 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.4 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 0.6 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 0.4 | REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.0 | 0.5 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 2.4 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
