Motif ID: E2f4

Z-value: 2.545


Transcription factors associated with E2f4:

Gene SymbolEntrez IDGene Name
E2f4 ENSMUSG00000014859.8 E2f4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f4mm10_v2_chr8_+_105297663_1052977420.721.8e-07Click!


Activity profile for motif E2f4.

activity profile for motif E2f4


Sorted Z-values histogram for motif E2f4

Sorted Z-values for motif E2f4



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_-_34751502 24.869 ENSMUST00000060710.7
Cdc25c
cell division cycle 25C
chr11_-_101551837 23.109 ENSMUST00000017290.4
Brca1
breast cancer 1
chr8_-_53638945 23.027 ENSMUST00000047768.4
Neil3
nei like 3 (E. coli)
chr19_+_6084983 22.719 ENSMUST00000025704.2
Cdca5
cell division cycle associated 5
chr14_-_47418407 21.586 ENSMUST00000043296.3
Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr1_-_189688074 20.059 ENSMUST00000171929.1
ENSMUST00000165962.1
Cenpf

centromere protein F

chr6_+_124830217 18.434 ENSMUST00000131847.1
ENSMUST00000151674.1
Cdca3

cell division cycle associated 3

chr1_-_169531343 17.876 ENSMUST00000028000.7
Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr4_+_134510999 17.206 ENSMUST00000105866.2
Aunip
aurora kinase A and ninein interacting protein
chr9_+_72438534 16.121 ENSMUST00000034746.8
Mns1
meiosis-specific nuclear structural protein 1
chr1_-_169531447 15.625 ENSMUST00000111368.1
Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr9_+_72438519 14.807 ENSMUST00000184604.1
Mns1
meiosis-specific nuclear structural protein 1
chr4_-_116123618 14.205 ENSMUST00000102704.3
ENSMUST00000102705.3
Rad54l

RAD54 like (S. cerevisiae)

chr15_+_57912199 13.809 ENSMUST00000022992.6
Tbc1d31
TBC1 domain family, member 31
chr2_+_163054682 13.308 ENSMUST00000018005.3
Mybl2
myeloblastosis oncogene-like 2
chr18_+_34751803 12.785 ENSMUST00000181453.1
ENSMUST00000181641.1
2010110K18Rik

RIKEN cDNA 2010110K18 gene

chr4_-_133967235 12.600 ENSMUST00000123234.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr4_-_133967296 12.550 ENSMUST00000105893.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr10_-_88146867 12.437 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
Parpbp



PARP1 binding protein



chr2_-_26503814 12.307 ENSMUST00000028288.4
Notch1
notch 1
chr10_+_79997463 12.185 ENSMUST00000171637.1
ENSMUST00000043866.7
Abca7

ATP-binding cassette, sub-family A (ABC1), member 7

chr4_+_11558914 10.628 ENSMUST00000178703.1
ENSMUST00000095145.5
ENSMUST00000108306.2
ENSMUST00000070755.6
Rad54b



RAD54 homolog B (S. cerevisiae)



chr17_-_25727364 10.258 ENSMUST00000170070.1
ENSMUST00000048054.7
Chtf18

CTF18, chromosome transmission fidelity factor 18

chr17_-_24251382 10.146 ENSMUST00000115390.3
Ccnf
cyclin F
chr5_-_112228934 9.884 ENSMUST00000181535.2
Miat
myocardial infarction associated transcript (non-protein coding)
chr9_-_82975475 9.469 ENSMUST00000034787.5
Phip
pleckstrin homology domain interacting protein
chr5_-_112228900 9.293 ENSMUST00000182509.1
Miat
myocardial infarction associated transcript (non-protein coding)
chr17_+_50698525 8.883 ENSMUST00000061681.7
Gm7334
predicted gene 7334
chr6_+_113531675 8.854 ENSMUST00000036340.5
ENSMUST00000101051.2
Fancd2

Fanconi anemia, complementation group D2

chr4_-_133967893 8.557 ENSMUST00000100472.3
ENSMUST00000136327.1
Hmgn2

high mobility group nucleosomal binding domain 2

chr17_-_28350747 8.537 ENSMUST00000080572.7
ENSMUST00000156862.1
Tead3

TEA domain family member 3

chr13_-_23745511 8.026 ENSMUST00000091752.2
Hist1h3c
histone cluster 1, H3c
chr1_+_157412352 7.937 ENSMUST00000061537.5
2810025M15Rik
RIKEN cDNA 2810025M15 gene
chr11_+_98907801 7.923 ENSMUST00000092706.6
Cdc6
cell division cycle 6
chr9_-_32344237 7.826 ENSMUST00000034533.5
Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr17_-_28350600 7.316 ENSMUST00000114799.1
Tead3
TEA domain family member 3
chr4_-_132345686 7.060 ENSMUST00000030726.6
Rcc1
regulator of chromosome condensation 1
chr10_+_17723220 6.841 ENSMUST00000038107.7
Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr4_-_58553553 6.529 ENSMUST00000107575.2
ENSMUST00000107574.1
ENSMUST00000147354.1
Lpar1


lysophosphatidic acid receptor 1


chrX_-_164980310 6.420 ENSMUST00000004715.1
ENSMUST00000112248.2
Mospd2

motile sperm domain containing 2

chr15_+_55307743 6.353 ENSMUST00000023053.5
ENSMUST00000110221.2
ENSMUST00000110217.3
Col14a1


collagen, type XIV, alpha 1


chr1_-_77515048 6.306 ENSMUST00000027451.6
Epha4
Eph receptor A4
chr4_-_132345715 6.298 ENSMUST00000084250.4
Rcc1
regulator of chromosome condensation 1
chr7_-_38107490 6.204 ENSMUST00000108023.3
Ccne1
cyclin E1
chr4_-_133967953 6.135 ENSMUST00000102553.4
Hmgn2
high mobility group nucleosomal binding domain 2
chr2_-_172940299 5.964 ENSMUST00000009143.7
Bmp7
bone morphogenetic protein 7
chr9_+_92250039 5.921 ENSMUST00000093801.3
Plscr1
phospholipid scramblase 1
chr12_+_76533540 5.716 ENSMUST00000075249.4
Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr13_+_23535411 5.678 ENSMUST00000080859.5
Hist1h3g
histone cluster 1, H3g
chr2_+_101678403 5.606 ENSMUST00000004949.7
Traf6
TNF receptor-associated factor 6
chr7_-_109865586 5.551 ENSMUST00000007423.5
ENSMUST00000106728.2
ENSMUST00000106729.1
Scube2


signal peptide, CUB domain, EGF-like 2


chr1_-_57377476 5.547 ENSMUST00000181949.1
4930558J18Rik
RIKEN cDNA 4930558J18 gene
chr4_-_58553311 5.482 ENSMUST00000107571.1
ENSMUST00000055018.4
Lpar1

lysophosphatidic acid receptor 1

chr1_+_74601548 5.448 ENSMUST00000087186.4
Stk36
serine/threonine kinase 36
chrX_-_164980279 5.434 ENSMUST00000112247.2
Mospd2
motile sperm domain containing 2
chr12_-_4233958 5.194 ENSMUST00000111169.3
ENSMUST00000020981.5
Cenpo

centromere protein O

chr1_+_74601441 5.139 ENSMUST00000087183.4
ENSMUST00000148456.1
ENSMUST00000113694.1
Stk36


serine/threonine kinase 36


chr6_+_70726430 5.084 ENSMUST00000103410.1
Igkc
immunoglobulin kappa constant
chr19_+_5366764 5.080 ENSMUST00000025759.7
Eif1ad
eukaryotic translation initiation factor 1A domain containing
chr5_+_33721724 4.996 ENSMUST00000067150.7
ENSMUST00000169212.2
ENSMUST00000114411.2
ENSMUST00000164207.3
Fgfr3



fibroblast growth factor receptor 3



chr17_+_88440711 4.510 ENSMUST00000112238.2
ENSMUST00000155640.1
Foxn2

forkhead box N2

chr3_-_142881942 4.445 ENSMUST00000043812.8
Pkn2
protein kinase N2
chr1_+_52630692 4.370 ENSMUST00000165859.1
Tmem194b
transmembrane protein 194B
chrY_-_90754821 4.309 ENSMUST00000177893.1
Gm21860
predicted gene, 21860
chr17_-_17624458 4.292 ENSMUST00000041047.2
Lnpep
leucyl/cystinyl aminopeptidase
chr4_+_43059028 4.284 ENSMUST00000163653.1
ENSMUST00000107952.2
ENSMUST00000107953.2
Unc13b


unc-13 homolog B (C. elegans)


chr4_+_43058939 4.276 ENSMUST00000079978.6
Unc13b
unc-13 homolog B (C. elegans)
chr15_+_102406143 4.131 ENSMUST00000170884.1
ENSMUST00000165924.1
ENSMUST00000163709.1
ENSMUST00000001326.6
Sp1



trans-acting transcription factor 1



chr8_-_64205970 4.068 ENSMUST00000066166.4
Tll1
tolloid-like
chr13_-_73937761 3.961 ENSMUST00000022053.8
Trip13
thyroid hormone receptor interactor 13
chrX_+_164980592 3.831 ENSMUST00000101082.4
ENSMUST00000167446.1
ENSMUST00000057150.6
Fancb


Fanconi anemia, complementation group B


chr5_-_25705791 3.797 ENSMUST00000030773.7
Xrcc2
X-ray repair complementing defective repair in Chinese hamster cells 2
chr9_-_44134481 3.792 ENSMUST00000180670.1
Gm10687
predicted gene 10687
chr11_+_16951371 3.787 ENSMUST00000109635.1
ENSMUST00000061327.1
Fbxo48

F-box protein 48

chr12_+_106010263 3.736 ENSMUST00000021539.8
ENSMUST00000085026.4
ENSMUST00000072040.5
Vrk1


vaccinia related kinase 1


chr5_+_88764983 3.630 ENSMUST00000031311.9
Dck
deoxycytidine kinase
chr15_-_98831498 3.552 ENSMUST00000168846.1
Prkag1
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
chr14_-_33978751 3.529 ENSMUST00000166737.1
Zfp488
zinc finger protein 488
chr10_+_88147061 3.499 ENSMUST00000169309.1
Nup37
nucleoporin 37
chr11_-_106999482 3.474 ENSMUST00000018506.6
Kpna2
karyopherin (importin) alpha 2
chr11_-_106999369 3.462 ENSMUST00000106768.1
ENSMUST00000144834.1
Kpna2

karyopherin (importin) alpha 2

chr12_+_9029982 3.405 ENSMUST00000085741.1
Ttc32
tetratricopeptide repeat domain 32
chr9_+_119937606 3.392 ENSMUST00000035100.5
Ttc21a
tetratricopeptide repeat domain 21A
chr5_+_9100681 3.279 ENSMUST00000115365.1
Tmem243
transmembrane protein 243, mitochondrial
chr2_-_166713758 3.270 ENSMUST00000036719.5
Prex1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr7_-_92874196 3.266 ENSMUST00000032877.9
4632434I11Rik
RIKEN cDNA 4632434I11 gene
chr7_+_126781483 3.192 ENSMUST00000172352.1
ENSMUST00000094037.4
Tbx6

T-box 6

chr2_-_63184253 3.139 ENSMUST00000075052.3
ENSMUST00000112454.1
Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr17_+_29490812 3.004 ENSMUST00000024811.6
Pim1
proviral integration site 1
chr18_-_39490649 2.986 ENSMUST00000115567.1
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr4_-_58553184 2.950 ENSMUST00000145361.1
Lpar1
lysophosphatidic acid receptor 1
chr7_+_97579868 2.925 ENSMUST00000042399.7
ENSMUST00000107153.1
Rsf1

remodeling and spacing factor 1

chrX_+_105079761 2.923 ENSMUST00000119477.1
Pbdc1
polysaccharide biosynthesis domain containing 1
chr16_-_90727329 2.921 ENSMUST00000099554.4
Mis18a
MIS18 kinetochore protein homolog A (S. pombe)
chr10_-_81427114 2.863 ENSMUST00000078185.7
ENSMUST00000020461.8
ENSMUST00000105321.3
Nfic


nuclear factor I/C


chr2_-_145935014 2.776 ENSMUST00000001818.4
Crnkl1
Crn, crooked neck-like 1 (Drosophila)
chr14_+_31019125 2.748 ENSMUST00000112095.1
ENSMUST00000112098.3
ENSMUST00000112106.1
ENSMUST00000146325.1
Pbrm1



polybromo 1



chr11_+_101552135 2.701 ENSMUST00000103099.1
Nbr1
neighbor of Brca1 gene 1
chr11_+_101552188 2.655 ENSMUST00000147239.1
Nbr1
neighbor of Brca1 gene 1
chr10_+_88146992 2.648 ENSMUST00000052355.7
Nup37
nucleoporin 37
chr6_-_56704673 2.626 ENSMUST00000170382.2
Lsm5
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr2_+_103970221 2.613 ENSMUST00000111140.2
ENSMUST00000111139.2
Lmo2

LIM domain only 2

chr2_+_106695594 2.591 ENSMUST00000016530.7
Mpped2
metallophosphoesterase domain containing 2
chr2_+_181319806 2.576 ENSMUST00000153112.1
Rtel1
regulator of telomere elongation helicase 1
chr2_+_181319714 2.572 ENSMUST00000098971.4
ENSMUST00000054622.8
ENSMUST00000108814.1
ENSMUST00000048608.9
ENSMUST00000108815.1
Rtel1




regulator of telomere elongation helicase 1




chrX_+_105079735 2.527 ENSMUST00000033577.4
Pbdc1
polysaccharide biosynthesis domain containing 1
chr14_-_87141114 2.503 ENSMUST00000168889.1
Diap3
diaphanous homolog 3 (Drosophila)
chr17_-_35046726 2.497 ENSMUST00000097338.4
Msh5
mutS homolog 5 (E. coli)
chr9_-_83441065 2.453 ENSMUST00000034791.8
ENSMUST00000034793.8
Lca5

Leber congenital amaurosis 5 (human)

chr14_+_31019159 2.305 ENSMUST00000112094.1
ENSMUST00000144009.1
Pbrm1

polybromo 1

chr1_-_157412576 2.272 ENSMUST00000078308.6
ENSMUST00000139470.1
Rasal2

RAS protein activator like 2

chr2_+_71786923 2.232 ENSMUST00000112101.1
ENSMUST00000028522.3
Itga6

integrin alpha 6

chr19_-_4397052 2.221 ENSMUST00000075856.4
Kdm2a
lysine (K)-specific demethylase 2A
chr10_+_127677064 2.187 ENSMUST00000118612.1
ENSMUST00000048099.4
Tmem194

transmembrane protein 194

chr1_-_179803625 2.180 ENSMUST00000027768.7
Ahctf1
AT hook containing transcription factor 1
chr2_-_63184170 2.111 ENSMUST00000112452.1
Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr4_-_43562397 2.092 ENSMUST00000030187.7
Tln1
talin 1
chr9_-_65580040 2.072 ENSMUST00000068944.7
Plekho2
pleckstrin homology domain containing, family O member 2
chr15_-_76639840 2.026 ENSMUST00000166974.1
ENSMUST00000168185.1
Tonsl

tonsoku-like, DNA repair protein

chr1_+_132007606 1.882 ENSMUST00000086556.5
Elk4
ELK4, member of ETS oncogene family
chr15_-_38078842 1.860 ENSMUST00000110336.2
Ubr5
ubiquitin protein ligase E3 component n-recognin 5
chr1_+_57377593 1.835 ENSMUST00000042734.2
1700066M21Rik
RIKEN cDNA 1700066M21 gene
chr10_-_19907645 1.680 ENSMUST00000166511.1
ENSMUST00000020182.8
Pex7

peroxisomal biogenesis factor 7

chr5_-_33652296 1.614 ENSMUST00000151081.1
ENSMUST00000101354.3
Slbp

stem-loop binding protein

chr17_-_87025353 1.591 ENSMUST00000024957.6
Pigf
phosphatidylinositol glycan anchor biosynthesis, class F
chr15_-_39943963 1.576 ENSMUST00000110305.2
Lrp12
low density lipoprotein-related protein 12
chr12_+_117843873 1.439 ENSMUST00000176735.1
ENSMUST00000177339.1
Cdca7l

cell division cycle associated 7 like

chr2_+_153649617 1.430 ENSMUST00000109771.1
Dnmt3b
DNA methyltransferase 3B
chr17_-_12507704 1.368 ENSMUST00000024595.2
Slc22a3
solute carrier family 22 (organic cation transporter), member 3
chrX_+_162901567 1.367 ENSMUST00000112303.1
ENSMUST00000033727.7
Ctps2

cytidine 5'-triphosphate synthase 2

chrX_-_12762069 1.324 ENSMUST00000096495.4
ENSMUST00000076016.5
Med14

mediator complex subunit 14

chr12_+_4234023 1.295 ENSMUST00000179139.1
Ptrhd1
peptidyl-tRNA hydrolase domain containing 1
chr2_-_62646146 1.292 ENSMUST00000112459.3
ENSMUST00000028259.5
Ifih1

interferon induced with helicase C domain 1

chr7_+_97371604 1.169 ENSMUST00000098300.4
Alg8
asparagine-linked glycosylation 8 (alpha-1,3-glucosyltransferase)
chr8_-_69974367 1.085 ENSMUST00000116463.2
Gatad2a
GATA zinc finger domain containing 2A
chr6_+_37870786 1.071 ENSMUST00000120428.1
ENSMUST00000031859.7
Trim24

tripartite motif-containing 24

chr6_-_148831395 1.049 ENSMUST00000145960.1
Ipo8
importin 8
chr5_-_33652339 1.041 ENSMUST00000075670.6
Slbp
stem-loop binding protein
chr13_+_73937799 1.036 ENSMUST00000099384.2
Brd9
bromodomain containing 9
chr4_+_84884276 0.969 ENSMUST00000047023.6
Cntln
centlein, centrosomal protein
chr2_+_174076296 0.934 ENSMUST00000155000.1
ENSMUST00000134876.1
ENSMUST00000147038.1
Stx16


syntaxin 16


chr2_+_30286406 0.922 ENSMUST00000138666.1
ENSMUST00000113634.2
Nup188

nucleoporin 188

chr10_-_91123955 0.917 ENSMUST00000164505.1
ENSMUST00000170810.1
ENSMUST00000076694.6
Slc25a3


solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3


chr4_-_132463873 0.852 ENSMUST00000102567.3
Med18
mediator of RNA polymerase II transcription, subunit 18 homolog (yeast)
chr12_+_99884498 0.810 ENSMUST00000153627.1
Tdp1
tyrosyl-DNA phosphodiesterase 1
chr11_-_6606053 0.767 ENSMUST00000045713.3
Nacad
NAC alpha domain containing
chrX_+_162901226 0.717 ENSMUST00000101095.2
Ctps2
cytidine 5'-triphosphate synthase 2
chr9_+_57708534 0.701 ENSMUST00000043990.7
ENSMUST00000142807.1
Edc3

enhancer of mRNA decapping 3 homolog (S. cerevisiae)

chr11_+_108425192 0.694 ENSMUST00000150863.2
ENSMUST00000061287.5
ENSMUST00000149683.2
Cep112


centrosomal protein 112


chr1_+_179803376 0.681 ENSMUST00000097454.2
Gm10518
predicted gene 10518
chrX_+_162901762 0.631 ENSMUST00000112302.1
ENSMUST00000112301.1
Ctps2

cytidine 5'-triphosphate synthase 2

chrX_-_78583782 0.625 ENSMUST00000177904.1
Prrg1
proline rich Gla (G-carboxyglutamic acid) 1
chr4_+_84884418 0.573 ENSMUST00000169371.2
Cntln
centlein, centrosomal protein
chr2_+_3513035 0.472 ENSMUST00000036350.2
Cdnf
cerebral dopamine neurotrophic factor
chrX_-_78583882 0.431 ENSMUST00000114025.1
ENSMUST00000134602.1
ENSMUST00000114024.2
Prrg1


proline rich Gla (G-carboxyglutamic acid) 1


chr1_+_134415414 0.392 ENSMUST00000112237.1
Adipor1
adiponectin receptor 1
chr10_+_19934472 0.360 ENSMUST00000095806.3
ENSMUST00000120259.1
Map3k5

mitogen-activated protein kinase kinase kinase 5

chr17_+_34982099 0.339 ENSMUST00000007266.7
Lsm2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr17_-_84187939 0.320 ENSMUST00000060366.6
Zfp36l2
zinc finger protein 36, C3H type-like 2
chr9_+_44334685 0.298 ENSMUST00000052686.2
H2afx
H2A histone family, member X
chr17_+_34982154 0.298 ENSMUST00000173004.1
Lsm2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr3_-_62506970 0.275 ENSMUST00000029336.4
Dhx36
DEAH (Asp-Glu-Ala-His) box polypeptide 36
chr7_-_127208423 0.206 ENSMUST00000120705.1
Tbc1d10b
TBC1 domain family, member 10b
chr2_+_132686931 0.171 ENSMUST00000061891.4
1110034G24Rik
RIKEN cDNA 1110034G24 gene
chr18_+_56707725 0.143 ENSMUST00000025486.8
Lmnb1
lamin B1
chr10_-_117792663 0.112 ENSMUST00000167943.1
ENSMUST00000064848.5
Nup107

nucleoporin 107

chr1_-_9748376 0.099 ENSMUST00000057438.6
Vcpip1
valosin containing protein (p97)/p47 complex interacting protein 1
chr9_+_118926453 0.087 ENSMUST00000073109.5
Ctdspl
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr17_+_34981847 0.075 ENSMUST00000114011.4
Lsm2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr5_+_113772748 0.074 ENSMUST00000026937.5
ENSMUST00000112311.1
ENSMUST00000112312.1
Iscu


IscU iron-sulfur cluster scaffold homolog (E. coli)


chr4_-_59783800 0.039 ENSMUST00000107526.1
ENSMUST00000095063.4
Inip

INTS3 and NABP interacting protein

chr1_-_151500794 0.030 ENSMUST00000076110.4
Rnf2
ring finger protein 2
chr9_-_60688118 0.028 ENSMUST00000114034.2
ENSMUST00000065603.5
Lrrc49

leucine rich repeat containing 49

chr5_+_130257029 0.026 ENSMUST00000100662.3
ENSMUST00000040213.6
Tyw1

tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)

chr16_-_59632520 0.010 ENSMUST00000118438.1
Arl6
ADP-ribosylation factor-like 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.7 23.1 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
7.6 22.7 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
4.1 12.3 GO:0003219 atrioventricular node development(GO:0003162) cardiac right ventricle formation(GO:0003219)
3.7 15.0 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
3.5 10.6 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
2.7 37.8 GO:0070986 left/right axis specification(GO:0070986)
2.4 12.2 GO:1902995 apolipoprotein A-I-mediated signaling pathway(GO:0038027) regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) positive regulation of apoptotic cell clearance(GO:2000427)
2.1 8.6 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
2.1 6.3 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
2.0 6.0 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
2.0 5.9 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
1.9 5.6 GO:0045410 positive regulation of interleukin-6 biosynthetic process(GO:0045410)
1.8 15.9 GO:0055059 asymmetric neuroblast division(GO:0055059)
1.7 5.1 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
1.7 5.0 GO:0061144 alveolar secondary septum development(GO:0061144)
1.6 39.8 GO:0040034 regulation of development, heterochronic(GO:0040034)
1.6 7.8 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
1.5 19.2 GO:0035881 amacrine cell differentiation(GO:0035881)
1.4 10.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
1.3 5.1 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990) negative regulation of t-circle formation(GO:1904430)
1.3 8.9 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
1.1 10.3 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
1.1 5.6 GO:1902732 positive regulation of chondrocyte proliferation(GO:1902732)
1.1 16.3 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
1.0 3.0 GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
0.9 3.8 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.9 9.5 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.9 3.7 GO:0043987 histone H3-S10 phosphorylation(GO:0043987)
0.9 3.6 GO:0046125 pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.9 33.5 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.9 24.1 GO:0008340 determination of adult lifespan(GO:0008340)
0.9 24.9 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.7 4.0 GO:0007144 female meiosis I(GO:0007144)
0.6 1.9 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.6 3.0 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.6 4.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353) hydrogen sulfide biosynthetic process(GO:0070814)
0.6 20.1 GO:0051310 metaphase plate congression(GO:0051310)
0.5 7.9 GO:0051984 positive regulation of chromosome segregation(GO:0051984)
0.5 23.0 GO:0006284 base-excision repair(GO:0006284)
0.5 2.5 GO:0051026 chiasma assembly(GO:0051026)
0.5 2.9 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.5 1.4 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
0.5 3.2 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.4 2.9 GO:0016584 nucleosome positioning(GO:0016584)
0.4 2.2 GO:0035878 nail development(GO:0035878)
0.3 2.1 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.3 26.7 GO:0051225 spindle assembly(GO:0051225)
0.3 2.7 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.3 5.2 GO:0034508 centromere complex assembly(GO:0034508)
0.3 1.3 GO:0039530 MDA-5 signaling pathway(GO:0039530)
0.3 6.9 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.3 2.2 GO:0033184 positive regulation of histone ubiquitination(GO:0033184)
0.3 1.1 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.3 4.4 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.3 6.4 GO:0061050 regulation of cell growth involved in cardiac muscle cell development(GO:0061050)
0.2 5.1 GO:0006958 complement activation, classical pathway(GO:0006958)
0.2 6.2 GO:0007129 synapsis(GO:0007129)
0.2 2.6 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.2 1.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.2 1.7 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.2 2.7 GO:0046036 CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)
0.2 3.4 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.2 11.9 GO:0007051 spindle organization(GO:0007051)
0.2 2.3 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.2 5.7 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2 0.9 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.1 1.9 GO:0070932 histone H3 deacetylation(GO:0070932)
0.1 4.3 GO:0043171 peptide catabolic process(GO:0043171)
0.1 1.4 GO:0051608 histamine transport(GO:0051608)
0.1 2.0 GO:0031297 replication fork processing(GO:0031297)
0.1 0.9 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 8.0 GO:0006334 nucleosome assembly(GO:0006334)
0.1 5.4 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.1 0.7 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 1.2 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.1 0.3 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.1 3.3 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 3.5 GO:0014003 oligodendrocyte development(GO:0014003)
0.1 0.1 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
0.1 2.5 GO:0042073 intraciliary transport(GO:0042073)
0.1 0.8 GO:0000012 single strand break repair(GO:0000012)
0.1 0.7 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 0.3 GO:0090669 telomerase RNA stabilization(GO:0090669)
0.1 0.6 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 2.9 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 0.4 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628)
0.0 5.7 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 2.3 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 20.2 GO:0051301 cell division(GO:0051301)
0.0 1.6 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 2.6 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 1.3 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.0 0.4 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.0 4.7 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.0 0.1 GO:0090168 Golgi reassembly(GO:0090168)
0.0 2.1 GO:0000956 nuclear-transcribed mRNA catabolic process(GO:0000956)
0.0 14.2 GO:0007049 cell cycle(GO:0007049)
0.0 0.9 GO:0048278 vesicle docking(GO:0048278)
0.0 0.5 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.7 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 1.7 GO:0006413 translational initiation(GO:0006413)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 1.6 GO:0001764 neuron migration(GO:0001764)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 33.5 GO:0031262 Ndc80 complex(GO:0031262)
3.9 23.1 GO:0070531 BRCA1-A complex(GO:0070531)
3.2 22.7 GO:0008278 cohesin complex(GO:0008278)
2.7 13.3 GO:0031523 Myb complex(GO:0031523)
2.5 12.3 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
1.7 20.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
1.4 8.6 GO:0044305 calyx of Held(GO:0044305)
1.1 10.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
1.1 21.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.8 8.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.8 3.8 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.7 2.0 GO:0035101 FACT complex(GO:0035101)
0.5 12.2 GO:0001891 phagocytic cup(GO:0001891)
0.5 3.3 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.5 31.1 GO:0005882 intermediate filament(GO:0005882)
0.5 5.1 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.4 6.4 GO:0005614 interstitial matrix(GO:0005614)
0.4 2.8 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.4 2.7 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.4 3.4 GO:0030991 intraciliary transport particle A(GO:0030991)
0.4 5.6 GO:0035631 CD40 receptor complex(GO:0035631)
0.4 2.2 GO:0030056 hemidesmosome(GO:0030056)
0.4 2.2 GO:0070847 core mediator complex(GO:0070847)
0.4 4.3 GO:0001673 male germ cell nucleus(GO:0001673)
0.3 3.8 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.3 7.9 GO:0051233 spindle midzone(GO:0051233)
0.2 15.9 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.2 3.6 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.2 23.1 GO:0043198 dendritic shaft(GO:0043198)
0.2 13.7 GO:0000786 nucleosome(GO:0000786)
0.2 17.2 GO:0000922 spindle pole(GO:0000922)
0.2 0.9 GO:0044611 nuclear pore inner ring(GO:0044611)
0.2 2.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 5.0 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.2 5.1 GO:0090544 BAF-type complex(GO:0090544)
0.2 1.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 5.4 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 2.9 GO:0031010 ISWI-type complex(GO:0031010)
0.1 10.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 14.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 6.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 6.9 GO:0005643 nuclear pore(GO:0005643)
0.1 4.7 GO:0000793 condensed chromosome(GO:0000793)
0.1 4.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 7.8 GO:0030315 T-tubule(GO:0030315)
0.1 0.4 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 1.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 5.2 GO:0000776 kinetochore(GO:0000776)
0.1 5.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 17.7 GO:0016607 nuclear speck(GO:0016607)
0.0 4.7 GO:0005795 Golgi stack(GO:0005795)
0.0 8.9 GO:0005813 centrosome(GO:0005813)
0.0 8.3 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.9 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 4.6 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 14.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.5 GO:0005930 axoneme(GO:0005930)
0.0 5.6 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 5.9 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 3.0 GO:0043197 dendritic spine(GO:0043197)
0.0 0.7 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.0 GO:0070876 SOSS complex(GO:0070876)
0.0 2.1 GO:0001726 ruffle(GO:0001726)
0.0 31.9 GO:0005654 nucleoplasm(GO:0005654)
0.0 1.7 GO:0001650 fibrillar center(GO:0001650)
0.0 0.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 41.9 GO:0005634 nucleus(GO:0005634)
0.0 2.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 23.0 GO:0000405 bubble DNA binding(GO:0000405)
4.1 12.2 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
2.9 8.6 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
2.2 13.4 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
2.1 15.0 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
1.7 13.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
1.6 7.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
1.5 10.6 GO:0015616 DNA translocase activity(GO:0015616)
1.4 14.2 GO:0036310 annealing helicase activity(GO:0036310)
1.4 5.6 GO:0097108 hedgehog family protein binding(GO:0097108)
1.1 6.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005) PH domain binding(GO:0042731)
0.9 10.3 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.9 3.6 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.9 2.7 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.7 3.7 GO:0035174 nucleosomal histone binding(GO:0031493) histone serine kinase activity(GO:0035174)
0.7 3.0 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.7 24.9 GO:0050699 WW domain binding(GO:0050699)
0.7 2.7 GO:0003883 CTP synthase activity(GO:0003883)
0.7 5.9 GO:0042609 CD4 receptor binding(GO:0042609)
0.6 2.5 GO:0030983 mismatched DNA binding(GO:0030983)
0.6 6.0 GO:0070700 BMP receptor binding(GO:0070700)
0.6 20.1 GO:0070840 dynein complex binding(GO:0070840)
0.6 6.8 GO:0050693 LBD domain binding(GO:0050693)
0.6 5.0 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.5 3.8 GO:0000150 recombinase activity(GO:0000150)
0.5 5.6 GO:0031996 thioesterase binding(GO:0031996)
0.5 11.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.5 14.0 GO:0070182 DNA polymerase binding(GO:0070182)
0.5 1.4 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.4 2.2 GO:0038132 neuregulin binding(GO:0038132)
0.4 2.2 GO:0045322 unmethylated CpG binding(GO:0045322)
0.4 3.6 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.4 1.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.4 22.6 GO:0003684 damaged DNA binding(GO:0003684)
0.3 5.2 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.3 12.3 GO:0005112 Notch binding(GO:0005112)
0.3 1.3 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.3 13.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 5.1 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.3 3.0 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.2 2.1 GO:0030274 LIM domain binding(GO:0030274)
0.2 6.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 4.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 1.7 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.2 4.4 GO:0004697 protein kinase C activity(GO:0004697)
0.2 1.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.2 6.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 24.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 1.9 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 5.4 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 20.2 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.1 3.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.4 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.1 0.9 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.1 0.3 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.1 5.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 1.6 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.1 4.1 GO:0005518 collagen binding(GO:0005518)
0.1 1.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 5.0 GO:0042393 histone binding(GO:0042393)
0.0 0.7 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 20.7 GO:0003682 chromatin binding(GO:0003682)
0.0 2.2 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 1.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 9.6 GO:0008134 transcription factor binding(GO:0008134)
0.0 0.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.3 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.1 GO:0008432 JUN kinase binding(GO:0008432)
0.0 1.7 GO:0030674 protein binding, bridging(GO:0030674)
0.0 6.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.0 GO:0008565 protein transporter activity(GO:0008565)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 57.1 PID_ATM_PATHWAY ATM pathway
0.7 30.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.6 21.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.5 6.0 PID_ALK2_PATHWAY ALK2 signaling events
0.3 11.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 2.2 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.3 18.2 PID_E2F_PATHWAY E2F transcription factor network
0.3 7.0 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 7.8 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.2 6.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.2 10.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.2 5.6 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.2 15.0 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.2 3.0 PID_IL5_PATHWAY IL5-mediated signaling events
0.2 5.9 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.2 4.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 13.4 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 6.4 NABA_COLLAGENS Genes encoding collagen proteins
0.1 3.8 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 2.0 ST_GAQ_PATHWAY G alpha q Pathway
0.1 5.0 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 5.0 PID_FGF_PATHWAY FGF signaling pathway
0.1 0.4 ST_GA13_PATHWAY G alpha 13 Pathway
0.1 3.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 3.5 PID_LKB1_PATHWAY LKB1 signaling events
0.1 3.3 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.9 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 4.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.1 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.1 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 24.9 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
1.7 35.8 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
1.4 4.3 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
1.1 27.4 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.9 5.5 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.6 12.2 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.6 5.0 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.5 5.8 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.5 15.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.4 8.6 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.4 43.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 3.6 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.3 14.0 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 4.0 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.2 1.4 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.2 2.7 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.2 3.6 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.2 7.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 10.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 4.1 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 2.1 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 14.3 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.1 6.7 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 5.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 15.0 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 1.3 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 2.5 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.1 3.0 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 2.7 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 0.9 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.6 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 0.8 REACTOME_DOUBLE_STRAND_BREAK_REPAIR Genes involved in Double-Strand Break Repair
0.0 1.2 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 1.1 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 3.3 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.0 2.2 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation