Motif ID: Egr4
Z-value: 0.732
Transcription factors associated with Egr4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Egr4 | ENSMUSG00000071341.3 | Egr4 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.7 | GO:0003365 | establishment of cell polarity involved in ameboidal cell migration(GO:0003365) |
| 0.6 | 2.8 | GO:2000325 | regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327) |
| 0.5 | 1.4 | GO:1904975 | response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976) |
| 0.4 | 1.7 | GO:0044340 | canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340) |
| 0.4 | 1.3 | GO:0003100 | angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) regulation of systemic arterial blood pressure by endothelin(GO:0003100) beta selection(GO:0043366) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) |
| 0.3 | 5.9 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 0.3 | 1.0 | GO:0045819 | plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819) |
| 0.3 | 7.0 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.3 | 7.2 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
| 0.3 | 1.3 | GO:0002572 | pro-T cell differentiation(GO:0002572) |
| 0.3 | 1.3 | GO:0060741 | prostate gland stromal morphogenesis(GO:0060741) |
| 0.3 | 0.9 | GO:0006931 | substrate-dependent cell migration, cell attachment to substrate(GO:0006931) |
| 0.2 | 1.0 | GO:2000383 | regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384) |
| 0.2 | 0.9 | GO:1905077 | negative regulation of interleukin-17 secretion(GO:1905077) |
| 0.2 | 0.9 | GO:0048319 | axial mesoderm morphogenesis(GO:0048319) |
| 0.2 | 0.7 | GO:0060399 | positive regulation of growth hormone receptor signaling pathway(GO:0060399) |
| 0.2 | 0.8 | GO:0045358 | negative regulation of interferon-beta biosynthetic process(GO:0045358) |
| 0.2 | 6.4 | GO:0014912 | negative regulation of smooth muscle cell migration(GO:0014912) |
| 0.2 | 1.5 | GO:0000050 | urea cycle(GO:0000050) urea metabolic process(GO:0019627) |
| 0.2 | 1.4 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 0.2 | 0.5 | GO:0045014 | detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594) |
| 0.1 | 2.6 | GO:0032897 | negative regulation of viral transcription(GO:0032897) |
| 0.1 | 1.4 | GO:2000807 | regulation of synaptic vesicle clustering(GO:2000807) |
| 0.1 | 1.5 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.1 | 0.7 | GO:1902510 | regulation of apoptotic DNA fragmentation(GO:1902510) |
| 0.1 | 0.4 | GO:0032237 | activation of store-operated calcium channel activity(GO:0032237) |
| 0.1 | 0.5 | GO:0045200 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) |
| 0.1 | 1.7 | GO:0001967 | suckling behavior(GO:0001967) |
| 0.1 | 0.7 | GO:0010571 | positive regulation of nuclear cell cycle DNA replication(GO:0010571) |
| 0.1 | 0.3 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
| 0.1 | 0.5 | GO:0051151 | negative regulation of smooth muscle cell differentiation(GO:0051151) |
| 0.1 | 1.7 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.0 | 0.7 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 0.0 | 0.5 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.0 | 0.7 | GO:0045292 | mRNA cis splicing, via spliceosome(GO:0045292) |
| 0.0 | 0.8 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) |
| 0.0 | 0.4 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 0.0 | 0.5 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.0 | 1.7 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
| 0.0 | 2.0 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) |
| 0.0 | 2.0 | GO:0070613 | regulation of protein processing(GO:0070613) |
| 0.0 | 0.4 | GO:0030238 | male sex determination(GO:0030238) |
| 0.0 | 0.9 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.0 | 0.2 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.0 | 0.2 | GO:0090267 | positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) |
| 0.0 | 3.8 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123) |
| 0.0 | 0.8 | GO:0003170 | heart valve development(GO:0003170) |
| 0.0 | 0.6 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.0 | 1.2 | GO:0045669 | positive regulation of osteoblast differentiation(GO:0045669) |
| 0.0 | 0.5 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.0 | 1.4 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 0.0 | GO:0098501 | polynucleotide dephosphorylation(GO:0098501) |
| 0.0 | 2.4 | GO:0032869 | cellular response to insulin stimulus(GO:0032869) |
| 0.0 | 0.3 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.0 | 1.8 | GO:0051607 | defense response to virus(GO:0051607) |
| 0.0 | 1.3 | GO:0031532 | actin cytoskeleton reorganization(GO:0031532) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 5.9 | GO:0002111 | BRCA2-BRAF35 complex(GO:0002111) |
| 0.5 | 1.5 | GO:0036488 | CHOP-C/EBP complex(GO:0036488) |
| 0.2 | 0.5 | GO:0033186 | CAF-1 complex(GO:0033186) |
| 0.2 | 2.6 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.1 | 1.0 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.1 | 0.9 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 0.1 | 3.2 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.1 | 0.8 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 1.4 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.1 | 0.5 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.1 | 2.5 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 0.7 | GO:0031011 | Ino80 complex(GO:0031011) |
| 0.0 | 0.3 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.0 | 0.4 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.0 | 1.7 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.0 | 0.7 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 7.7 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.1 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 3.3 | GO:0001726 | ruffle(GO:0001726) |
| 0.0 | 0.1 | GO:0089701 | U2AF(GO:0089701) |
| 0.0 | 0.3 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.0 | 0.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 3.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 0.1 | GO:0030914 | STAGA complex(GO:0030914) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.7 | GO:0043532 | angiostatin binding(GO:0043532) |
| 0.5 | 1.4 | GO:0005118 | sevenless binding(GO:0005118) |
| 0.3 | 1.0 | GO:0000402 | open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402) |
| 0.3 | 6.4 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.3 | 5.9 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 0.2 | 0.7 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.2 | 5.1 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.1 | 0.8 | GO:0043426 | MRF binding(GO:0043426) |
| 0.1 | 1.3 | GO:0051022 | Rho GDP-dissociation inhibitor binding(GO:0051022) |
| 0.1 | 2.8 | GO:0032183 | SUMO binding(GO:0032183) |
| 0.1 | 1.5 | GO:0001013 | RNA polymerase I regulatory region DNA binding(GO:0001013) |
| 0.1 | 0.4 | GO:0045131 | pre-mRNA branch point binding(GO:0045131) |
| 0.1 | 0.5 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.1 | 1.4 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.1 | 0.9 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.1 | 7.7 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.1 | 0.3 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 0.1 | 2.6 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 0.4 | GO:0031685 | adenosine receptor binding(GO:0031685) |
| 0.1 | 1.3 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 0.7 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.0 | 0.2 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.0 | 1.7 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 1.8 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.0 | 0.4 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 0.2 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 0.7 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 0.5 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.0 | 1.3 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 0.9 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 0.7 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 0.7 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 0.0 | 0.1 | GO:0050733 | RS domain binding(GO:0050733) |
| 0.0 | 0.2 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 6.0 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159) |
| 0.0 | 2.2 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 6.7 | GO:0008134 | transcription factor binding(GO:0008134) |
| 0.0 | 0.1 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 2.3 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 0.8 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.8 | ST_INTERFERON_GAMMA_PATHWAY | Interferon gamma pathway. |
| 0.1 | 3.1 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 1.3 | PID_THROMBIN_PAR4_PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 1.4 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.1 | 6.9 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 2.0 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 6.4 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.0 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.5 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 0.9 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 2.8 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 2.0 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.5 | PID_ERBB2_ERBB3_PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 1.0 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 0.7 | PID_CERAMIDE_PATHWAY | Ceramide signaling pathway |
| 0.0 | 0.9 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.4 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.2 | 6.1 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 1.8 | REACTOME_REGULATION_OF_IFNG_SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.1 | 4.4 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 1.1 | REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 0.4 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.1 | 1.3 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 6.9 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.9 | REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.8 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.3 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 0.1 | REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
