Motif ID: Evx2
Z-value: 0.953
Transcription factors associated with Evx2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Evx2 | ENSMUSG00000001815.9 | Evx2 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 7.5 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 0.6 | 1.9 | GO:1902498 | regulation of protein autoubiquitination(GO:1902498) |
| 0.6 | 2.5 | GO:0035553 | oxidative single-stranded RNA demethylation(GO:0035553) |
| 0.5 | 7.9 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.5 | 1.5 | GO:2000564 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
| 0.4 | 6.5 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.4 | 1.4 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 0.3 | 6.6 | GO:0007530 | sex determination(GO:0007530) |
| 0.3 | 1.7 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) |
| 0.2 | 4.2 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.1 | 0.4 | GO:0021523 | somatic motor neuron differentiation(GO:0021523) |
| 0.1 | 0.8 | GO:0070100 | negative regulation of chemokine-mediated signaling pathway(GO:0070100) |
| 0.1 | 0.9 | GO:0046292 | formaldehyde metabolic process(GO:0046292) |
| 0.1 | 5.7 | GO:1901998 | toxin transport(GO:1901998) |
| 0.1 | 1.0 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.1 | 4.6 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.1 | 0.8 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.1 | 0.9 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
| 0.1 | 1.5 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.1 | 0.7 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
| 0.1 | 0.4 | GO:1902746 | regulation of lens fiber cell differentiation(GO:1902746) |
| 0.1 | 0.8 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.0 | 1.2 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.0 | 0.5 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.0 | 2.5 | GO:0051290 | protein heterotetramerization(GO:0051290) |
| 0.0 | 0.8 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.0 | 3.1 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.0 | 4.6 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.0 | 0.8 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.0 | 0.3 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
| 0.0 | 0.7 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.0 | 0.3 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 1.8 | GO:0048489 | synaptic vesicle transport(GO:0048489) establishment of synaptic vesicle localization(GO:0097480) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 4.0 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.2 | 0.9 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.1 | 1.7 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.1 | 1.5 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 7.5 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 0.7 | GO:0033503 | HULC complex(GO:0033503) |
| 0.1 | 1.4 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.1 | 3.1 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.1 | 7.2 | GO:0000792 | heterochromatin(GO:0000792) |
| 0.0 | 2.5 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.0 | 0.6 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.0 | 6.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.9 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.0 | 0.2 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.0 | 1.5 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 1.5 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.5 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 0.2 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 1.8 | GO:0055037 | recycling endosome(GO:0055037) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 4.6 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.6 | 2.5 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
| 0.6 | 4.0 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.4 | 2.5 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
| 0.2 | 0.9 | GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
| 0.2 | 0.8 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.2 | 1.5 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.2 | 6.6 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 1.0 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.1 | 0.8 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.1 | 0.8 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.1 | 1.4 | GO:0043495 | protein anchor(GO:0043495) |
| 0.1 | 1.2 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.1 | 1.5 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.1 | 1.9 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.0 | 0.5 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.0 | 3.5 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 0.7 | GO:0008373 | sialyltransferase activity(GO:0008373) |
| 0.0 | 1.7 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 7.4 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 4.6 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 14.3 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.0 | 3.6 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 0.6 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.7 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 4.6 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 6.5 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.0 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.0 | 2.5 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.8 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.8 | PID_BCR_5PATHWAY | BCR signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.6 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.2 | 9.6 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 3.1 | REACTOME_REGULATION_OF_KIT_SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.1 | 0.5 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.0 | 3.0 | REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE | Genes involved in Late Phase of HIV Life Cycle |
| 0.0 | 1.7 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 0.9 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 0.8 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.9 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.8 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
