Motif ID: Fosb

Z-value: 0.386


Transcription factors associated with Fosb:

Gene SymbolEntrez IDGene Name
Fosb ENSMUSG00000003545.2 Fosb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosbmm10_v2_chr7_-_19310035_193100500.019.6e-01Click!


Activity profile for motif Fosb.

activity profile for motif Fosb


Sorted Z-values histogram for motif Fosb

Sorted Z-values for motif Fosb



Network of associatons between targets according to the STRING database.



First level regulatory network of Fosb

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_113663670 2.794 ENSMUST00000054650.4
 Hspb3
heat shock protein 3
chr2_+_118663235 1.761 ENSMUST00000099557.3
 Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
chr6_+_17463927 1.725 ENSMUST00000115442.1
 Met
met proto-oncogene
chr7_+_30413744 1.721 ENSMUST00000032800.9
 Tyrobp
TYRO protein tyrosine kinase binding protein
chr9_+_104566677 1.440 ENSMUST00000157006.1
 Cpne4
copine IV
chr8_+_36489191 1.352 ENSMUST00000171777.1
 6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr16_+_17561885 1.155 ENSMUST00000171002.1
ENSMUST00000023441.4
 P2rx6

purinergic receptor P2X, ligand-gated ion channel, 6

chr14_+_27622433 1.034 ENSMUST00000090302.5
 Erc2
ELKS/RAB6-interacting/CAST family member 2
chr18_-_31317043 1.032 ENSMUST00000139924.1
ENSMUST00000153060.1
 Rit2

Ras-like without CAAX 2

chr10_-_64090265 0.926 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr2_-_151632471 0.912 ENSMUST00000137936.1
ENSMUST00000146172.1
ENSMUST00000094456.3
ENSMUST00000148755.1
ENSMUST00000109875.1
ENSMUST00000028951.7
ENSMUST00000109877.3
 Snph






syntaphilin






chr3_+_55461758 0.909 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr9_+_114978507 0.881 ENSMUST00000183104.1
 Osbpl10
oxysterol binding protein-like 10
chr2_-_45110241 0.868 ENSMUST00000177302.1
 Zeb2
zinc finger E-box binding homeobox 2
chr16_+_78930940 0.863 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
 Chodl


chondrolectin


chr3_+_123267445 0.854 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr2_+_156475844 0.781 ENSMUST00000103135.1
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr6_-_124769548 0.704 ENSMUST00000149652.1
ENSMUST00000112476.1
ENSMUST00000004378.8
 Eno2


enolase 2, gamma neuronal


chr14_+_79426454 0.663 ENSMUST00000061222.7
 Kbtbd7
kelch repeat and BTB (POZ) domain containing 7
chr6_+_86849488 0.649 ENSMUST00000089519.6
ENSMUST00000113668.1
 Aak1

AP2 associated kinase 1

chr2_+_156475803 0.646 ENSMUST00000029155.8
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr10_+_116143881 0.645 ENSMUST00000105271.2
 Ptprr
protein tyrosine phosphatase, receptor type, R
chr5_-_21785115 0.635 ENSMUST00000115193.1
ENSMUST00000115192.1
ENSMUST00000115195.1
ENSMUST00000030771.5
 Dnajc2



DnaJ (Hsp40) homolog, subfamily C, member 2



chr3_+_109573907 0.601 ENSMUST00000106576.2
 Vav3
vav 3 oncogene
chr16_-_4880284 0.587 ENSMUST00000037843.6
 Ubald1
UBA-like domain containing 1
chr11_-_3914664 0.586 ENSMUST00000109995.1
ENSMUST00000051207.1
 Slc35e4

solute carrier family 35, member E4

chr10_+_26078255 0.583 ENSMUST00000041011.3
 Gm9767
predicted gene 9767
chr11_-_69666062 0.573 ENSMUST00000108654.2
ENSMUST00000018918.5
 Cd68

CD68 antigen

chr2_-_25224653 0.571 ENSMUST00000043584.4
 Tubb4b
tubulin, beta 4B class IVB
chr18_-_43477764 0.567 ENSMUST00000057110.9
 Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr10_-_64090241 0.529 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr13_-_54611274 0.528 ENSMUST00000049575.7
 Cltb
clathrin, light polypeptide (Lcb)
chr5_-_86676346 0.477 ENSMUST00000038448.6
 Tmprss11bnl
transmembrane protease, serine 11b N terminal like
chr13_-_54611332 0.442 ENSMUST00000091609.4
 Cltb
clathrin, light polypeptide (Lcb)
chr13_+_30659999 0.441 ENSMUST00000091672.6
ENSMUST00000110310.1
ENSMUST00000095914.5
 Dusp22


dual specificity phosphatase 22


chr5_-_5265224 0.432 ENSMUST00000115450.1
 Cdk14
cyclin-dependent kinase 14
chr2_+_164948219 0.423 ENSMUST00000017881.2
 Mmp9
matrix metallopeptidase 9
chr9_+_44240668 0.412 ENSMUST00000092426.3
 Ccdc153
coiled-coil domain containing 153
chr7_-_100547620 0.408 ENSMUST00000064334.2
 D630004N19Rik
RIKEN cDNA D630004N19 gene
chr11_+_78188737 0.396 ENSMUST00000108322.2
 Rab34
RAB34, member of RAS oncogene family
chr17_+_35841491 0.391 ENSMUST00000082337.6
 Mdc1
mediator of DNA damage checkpoint 1
chr8_+_107293500 0.387 ENSMUST00000151114.1
ENSMUST00000075922.4
ENSMUST00000125721.1
 Nfat5


nuclear factor of activated T cells 5


chr3_-_88177671 0.348 ENSMUST00000181837.1
 1700113A16Rik
RIKEN cDNA 1700113A16 gene
chr15_-_102257306 0.339 ENSMUST00000135466.1
 Rarg
retinoic acid receptor, gamma
chr14_+_80000292 0.337 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr15_-_102257449 0.333 ENSMUST00000043172.8
 Rarg
retinoic acid receptor, gamma
chr12_+_83632208 0.330 ENSMUST00000048155.9
ENSMUST00000182618.1
ENSMUST00000183154.1
ENSMUST00000182036.1
ENSMUST00000182347.1
 Rbm25




RNA binding motif protein 25




chr19_+_5447692 0.308 ENSMUST00000025850.5
 Fosl1
fos-like antigen 1
chr11_-_96075655 0.305 ENSMUST00000090541.5
 Atp5g1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)
chr19_-_32210969 0.293 ENSMUST00000151289.1
 Sgms1
sphingomyelin synthase 1
chr11_+_78188806 0.280 ENSMUST00000056241.5
 Rab34
RAB34, member of RAS oncogene family
chr11_+_78188422 0.277 ENSMUST00000002128.7
ENSMUST00000150941.1
 Rab34

RAB34, member of RAS oncogene family

chrX_-_75578188 0.276 ENSMUST00000033545.5
 Rab39b
RAB39B, member RAS oncogene family
chr8_+_4226827 0.272 ENSMUST00000053035.6
 Lrrc8e
leucine rich repeat containing 8 family, member E
chr11_-_96075581 0.247 ENSMUST00000107686.1
ENSMUST00000107684.1
 Atp5g1

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)

chr7_-_4778141 0.241 ENSMUST00000094892.5
 Il11
interleukin 11
chr7_-_29505447 0.231 ENSMUST00000183096.1
ENSMUST00000085809.4
 Sipa1l3

signal-induced proliferation-associated 1 like 3

chr6_-_129533267 0.231 ENSMUST00000181594.1
 1700101I11Rik
RIKEN cDNA 1700101I11 gene
chr17_-_45592485 0.208 ENSMUST00000166119.1
 Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr4_+_42158092 0.184 ENSMUST00000098122.2
 Gm13306
predicted gene 13306
chr11_-_120630516 0.175 ENSMUST00000106181.1
 Mafg
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
chr8_-_8639363 0.175 ENSMUST00000152698.1
 Efnb2
ephrin B2
chr17_-_45592262 0.136 ENSMUST00000164769.1
 Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr2_+_30441831 0.100 ENSMUST00000131476.1
 Ppp2r4
protein phosphatase 2A, regulatory subunit B (PR 53)
chr14_-_55758458 0.097 ENSMUST00000001497.7
 Cideb
cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
chr1_+_120602405 0.093 ENSMUST00000079721.7
 En1
engrailed 1
chr17_+_35841668 0.091 ENSMUST00000174124.1
 Mdc1
mediator of DNA damage checkpoint 1
chr2_+_167777467 0.085 ENSMUST00000139927.1
ENSMUST00000127441.1
 Gm14321

predicted gene 14321

chr17_+_46161021 0.075 ENSMUST00000024748.7
ENSMUST00000172170.1
 Gtpbp2

GTP binding protein 2

chr2_-_29253001 0.061 ENSMUST00000071201.4
 Ntng2
netrin G2
chr5_-_107875035 0.059 ENSMUST00000138111.1
ENSMUST00000112642.1
 Evi5

ecotropic viral integration site 5

chr17_-_30612613 0.057 ENSMUST00000167624.1
ENSMUST00000024823.6
 Glo1

glyoxalase 1

chr15_+_102503722 0.049 ENSMUST00000096145.4
 Gm10337
predicted gene 10337
chr18_+_40258361 0.046 ENSMUST00000091927.4
 Kctd16
potassium channel tetramerisation domain containing 16
chr1_+_86064619 0.034 ENSMUST00000027432.8
 Psmd1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr1_-_182517447 0.024 ENSMUST00000068505.8
 Capn2
calpain 2
chr7_-_45920830 0.018 ENSMUST00000164119.1
 Emp3
epithelial membrane protein 3
chr7_-_127946725 0.016 ENSMUST00000118755.1
ENSMUST00000094026.3
 Prss36

protease, serine, 36

chr11_-_109473598 0.007 ENSMUST00000070152.5
 Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr12_-_85288419 0.007 ENSMUST00000121930.1
 Acyp1
acylphosphatase 1, erythrocyte (common) type

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:2001204 regulation of osteoclast development(GO:2001204)
0.2 1.7 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.2 1.0 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
0.2 1.0 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.2 0.7 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.2 0.6 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.9 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 1.4 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 1.5 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 0.4 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.1 0.4 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.1 0.9 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.3 GO:0015862 uridine transport(GO:0015862)
0.0 1.2 GO:0033198 response to ATP(GO:0033198)
0.0 0.3 GO:0007296 vitellogenesis(GO:0007296)
0.0 0.3 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.6 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.1 GO:0061743 motor learning(GO:0061743)
0.0 0.9 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.2 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.0 0.6 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 0.6 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.1 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.0 1.0 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.0 0.4 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 0.6 GO:2000279 negative regulation of DNA biosynthetic process(GO:2000279)
0.0 0.9 GO:0045806 negative regulation of endocytosis(GO:0045806)
0.0 1.8 GO:0007613 memory(GO:0007613)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0097447 dendritic tree(GO:0097447)
0.1 0.6 GO:0071439 clathrin complex(GO:0071439)
0.1 1.0 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 0.4 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 1.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 0.6 GO:0045298 tubulin complex(GO:0045298)
0.1 0.9 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.6 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.3 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 2.3 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.3 GO:0042581 specific granule(GO:0042581)
0.0 1.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.0 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 1.8 GO:0001650 fibrillar center(GO:0001650)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.2 1.4 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.2 1.2 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.6 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 1.0 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.3 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 1.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.6 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.7 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.8 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.9 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.3 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.9 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.4 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.3 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 1.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 0.4 GO:0030332 cyclin binding(GO:0030332)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.1 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 1.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.0 PID_ARF_3PATHWAY Arf1 pathway
0.0 1.0 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.6 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.7 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.4 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.5 PID_ATM_PATHWAY ATM pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 1.7 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 1.0 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 1.0 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.9 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.7 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.6 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.6 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.5 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.6 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.2 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix