Motif ID: Fosl2_Bach2

Z-value: 0.868

Transcription factors associated with Fosl2_Bach2:

Gene SymbolEntrez IDGene Name
Bach2 ENSMUSG00000040270.10 Bach2
Fosl2 ENSMUSG00000029135.9 Fosl2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosl2mm10_v2_chr5_+_32136458_321365050.721.9e-07Click!
Bach2mm10_v2_chr4_+_32238713_32238804-0.153.7e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Fosl2_Bach2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_17463927 10.381 ENSMUST00000115442.1
Met
met proto-oncogene
chr1_-_33907721 7.449 ENSMUST00000115161.1
ENSMUST00000062289.8
Bend6

BEN domain containing 6

chr14_+_65968483 7.311 ENSMUST00000022616.6
Clu
clusterin
chr7_-_105482197 5.507 ENSMUST00000047040.2
Prkcdbp
protein kinase C, delta binding protein
chr17_-_24644933 4.638 ENSMUST00000019684.5
Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr16_-_22439719 4.452 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr3_-_88503331 4.235 ENSMUST00000029699.6
Lmna
lamin A
chr3_-_88503187 4.059 ENSMUST00000120377.1
Lmna
lamin A
chr14_+_101840602 4.050 ENSMUST00000159314.1
Lmo7
LIM domain only 7
chr6_+_17463749 3.926 ENSMUST00000115443.1
Met
met proto-oncogene
chr6_-_124769548 3.844 ENSMUST00000149652.1
ENSMUST00000112476.1
ENSMUST00000004378.8
Eno2


enolase 2, gamma neuronal


chr10_-_76725978 3.843 ENSMUST00000001147.4
Col6a1
collagen, type VI, alpha 1
chr14_+_101840501 3.766 ENSMUST00000159026.1
Lmo7
LIM domain only 7
chr9_+_60712989 3.709 ENSMUST00000038407.5
Larp6
La ribonucleoprotein domain family, member 6
chr13_-_54611274 3.421 ENSMUST00000049575.7
Cltb
clathrin, light polypeptide (Lcb)
chrY_-_1286563 3.403 ENSMUST00000091190.5
Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr9_-_20728219 3.393 ENSMUST00000034692.7
Olfm2
olfactomedin 2
chr13_-_54611332 3.388 ENSMUST00000091609.4
Cltb
clathrin, light polypeptide (Lcb)
chr6_+_124996681 3.143 ENSMUST00000032479.4
Pianp
PILR alpha associated neural protein
chr6_+_17463826 2.967 ENSMUST00000140070.1
Met
met proto-oncogene
chr2_+_91257323 2.957 ENSMUST00000111349.2
ENSMUST00000131711.1
Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr2_+_156475803 2.950 ENSMUST00000029155.8
Epb4.1l1
erythrocyte protein band 4.1-like 1
chr10_+_21993890 2.948 ENSMUST00000092673.4
Sgk1
serum/glucocorticoid regulated kinase 1
chr10_+_116143881 2.948 ENSMUST00000105271.2
Ptprr
protein tyrosine phosphatase, receptor type, R
chr2_+_156475844 2.902 ENSMUST00000103135.1
Epb4.1l1
erythrocyte protein band 4.1-like 1
chr10_+_97482350 2.782 ENSMUST00000163448.2
Dcn
decorin
chr18_+_37955544 2.763 ENSMUST00000070709.2
ENSMUST00000177058.1
ENSMUST00000169360.2
ENSMUST00000163591.2
ENSMUST00000091932.5
Rell2




RELT-like 2




chr8_+_95703037 2.643 ENSMUST00000073139.7
ENSMUST00000080666.7
Ndrg4

N-myc downstream regulated gene 4

chr3_+_55461758 2.619 ENSMUST00000070418.4
Dclk1
doublecortin-like kinase 1
chr10_-_64090265 2.567 ENSMUST00000105439.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr13_-_113663670 2.555 ENSMUST00000054650.4
Hspb3
heat shock protein 3
chr10_-_64090241 2.508 ENSMUST00000133588.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr3_-_10208569 2.482 ENSMUST00000029041.4
Fabp4
fatty acid binding protein 4, adipocyte
chr18_+_37955685 2.481 ENSMUST00000169498.2
Rell2
RELT-like 2
chr2_-_36105271 2.480 ENSMUST00000112960.1
ENSMUST00000112967.5
ENSMUST00000112963.1
Lhx6


LIM homeobox protein 6


chr11_-_51650813 2.443 ENSMUST00000142721.1
ENSMUST00000156835.1
ENSMUST00000001080.9
N4bp3


NEDD4 binding protein 3


chr18_+_32938955 2.380 ENSMUST00000042868.4
Camk4
calcium/calmodulin-dependent protein kinase IV
chr9_-_116175318 2.296 ENSMUST00000061101.4
ENSMUST00000035014.6
Tgfbr2

transforming growth factor, beta receptor II

chr11_+_103103051 2.289 ENSMUST00000152971.1
Acbd4
acyl-Coenzyme A binding domain containing 4
chr6_-_122856151 2.267 ENSMUST00000042081.8
C3ar1
complement component 3a receptor 1
chrX_+_99975570 2.267 ENSMUST00000113779.1
ENSMUST00000113776.1
ENSMUST00000113775.1
ENSMUST00000113780.1
ENSMUST00000113778.1
ENSMUST00000113781.1
ENSMUST00000113783.1
ENSMUST00000071453.2
ENSMUST00000113777.1
Eda








ectodysplasin-A








chr4_-_42034726 2.244 ENSMUST00000084677.2
Gm21093
predicted gene, 21093
chr1_-_134235420 2.223 ENSMUST00000038191.6
ENSMUST00000086465.4
Adora1

adenosine A1 receptor

chr10_-_128498676 2.213 ENSMUST00000026428.3
Myl6b
myosin, light polypeptide 6B
chr15_-_97767798 2.211 ENSMUST00000129223.2
ENSMUST00000126854.2
ENSMUST00000135080.1
Rapgef3


Rap guanine nucleotide exchange factor (GEF) 3


chr16_+_90220742 2.039 ENSMUST00000023707.9
Sod1
superoxide dismutase 1, soluble
chr14_-_79301623 1.990 ENSMUST00000022595.7
Rgcc
regulator of cell cycle
chr2_-_151632471 1.951 ENSMUST00000137936.1
ENSMUST00000146172.1
ENSMUST00000094456.3
ENSMUST00000148755.1
ENSMUST00000109875.1
ENSMUST00000028951.7
ENSMUST00000109877.3
Snph






syntaphilin






chr11_-_32222233 1.933 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
Rhbdf1


rhomboid family 1 (Drosophila)


chr11_+_78188422 1.908 ENSMUST00000002128.7
ENSMUST00000150941.1
Rab34

RAB34, member of RAS oncogene family

chr1_-_180193475 1.871 ENSMUST00000160482.1
ENSMUST00000170472.1
Adck3

aarF domain containing kinase 3

chr5_+_37050854 1.862 ENSMUST00000043794.4
Jakmip1
janus kinase and microtubule interacting protein 1
chr5_-_124187150 1.842 ENSMUST00000161938.1
Pitpnm2
phosphatidylinositol transfer protein, membrane-associated 2
chr13_+_54949388 1.838 ENSMUST00000026994.7
ENSMUST00000109994.2
Unc5a

unc-5 homolog A (C. elegans)

chr17_-_45592485 1.837 ENSMUST00000166119.1
Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr4_+_126148457 1.825 ENSMUST00000106150.2
Eva1b
eva-1 homolog B (C. elegans)
chr17_-_56133817 1.822 ENSMUST00000167545.1
Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chrX_-_8132770 1.811 ENSMUST00000130832.1
ENSMUST00000033506.6
ENSMUST00000115623.1
ENSMUST00000153839.1
Wdr13



WD repeat domain 13



chr9_+_69454066 1.807 ENSMUST00000134907.1
Anxa2
annexin A2
chr17_-_45592262 1.773 ENSMUST00000164769.1
Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr15_-_102257306 1.771 ENSMUST00000135466.1
Rarg
retinoic acid receptor, gamma
chr10_+_128933782 1.756 ENSMUST00000099112.2
Itga7
integrin alpha 7
chr2_-_45110241 1.745 ENSMUST00000177302.1
Zeb2
zinc finger E-box binding homeobox 2
chr19_-_6840590 1.739 ENSMUST00000170516.2
ENSMUST00000025903.5
Rps6ka4

ribosomal protein S6 kinase, polypeptide 4

chr7_+_126776939 1.714 ENSMUST00000038614.5
ENSMUST00000170882.1
ENSMUST00000106359.1
ENSMUST00000106357.1
ENSMUST00000145762.1
ENSMUST00000132643.1
ENSMUST00000106356.1
Ypel3






yippee-like 3 (Drosophila)






chrX_+_7722214 1.711 ENSMUST00000043045.2
ENSMUST00000116634.1
ENSMUST00000115689.3
ENSMUST00000131077.1
ENSMUST00000115688.1
ENSMUST00000116633.1
Wdr45





WD repeat domain 45





chr15_-_102257449 1.672 ENSMUST00000043172.8
Rarg
retinoic acid receptor, gamma
chr18_+_61045139 1.640 ENSMUST00000025522.4
ENSMUST00000115274.1
Pdgfrb

platelet derived growth factor receptor, beta polypeptide

chr2_+_164948219 1.625 ENSMUST00000017881.2
Mmp9
matrix metallopeptidase 9
chr7_-_127946725 1.606 ENSMUST00000118755.1
ENSMUST00000094026.3
Prss36

protease, serine, 36

chr9_+_50752758 1.586 ENSMUST00000034562.7
Cryab
crystallin, alpha B
chr7_+_4460687 1.581 ENSMUST00000167298.1
ENSMUST00000171445.1
Eps8l1

EPS8-like 1

chr18_-_37969742 1.579 ENSMUST00000166148.1
ENSMUST00000163131.1
ENSMUST00000043437.7
Fchsd1


FCH and double SH3 domains 1


chr9_+_69453620 1.568 ENSMUST00000034756.8
ENSMUST00000123470.1
Anxa2

annexin A2

chr9_-_109059711 1.520 ENSMUST00000061973.4
Trex1
three prime repair exonuclease 1
chr7_+_110772604 1.519 ENSMUST00000005829.6
Ampd3
adenosine monophosphate deaminase 3
chr1_+_171437535 1.488 ENSMUST00000043839.4
F11r
F11 receptor
chr4_+_42158092 1.483 ENSMUST00000098122.2
Gm13306
predicted gene 13306
chr3_+_103576081 1.480 ENSMUST00000183637.1
ENSMUST00000117221.2
ENSMUST00000118117.1
ENSMUST00000118563.2
Syt6



synaptotagmin VI



chr5_+_35278566 1.474 ENSMUST00000049545.5
Adra2c
adrenergic receptor, alpha 2c
chr17_-_47834682 1.460 ENSMUST00000066368.6
Mdfi
MyoD family inhibitor
chr1_+_164115264 1.448 ENSMUST00000162746.1
Selp
selectin, platelet
chr11_+_78188737 1.442 ENSMUST00000108322.2
Rab34
RAB34, member of RAS oncogene family
chr6_+_135362931 1.414 ENSMUST00000032330.9
Emp1
epithelial membrane protein 1
chr11_+_78188806 1.411 ENSMUST00000056241.5
Rab34
RAB34, member of RAS oncogene family
chr7_-_31126945 1.405 ENSMUST00000098548.4
Scn1b
sodium channel, voltage-gated, type I, beta
chr5_-_92348871 1.402 ENSMUST00000038816.6
ENSMUST00000118006.1
Cxcl10

chemokine (C-X-C motif) ligand 10

chr7_+_128523576 1.379 ENSMUST00000033136.7
Bag3
BCL2-associated athanogene 3
chr2_+_32628390 1.351 ENSMUST00000156578.1
Ak1
adenylate kinase 1
chr1_+_75549581 1.332 ENSMUST00000154101.1
Slc4a3
solute carrier family 4 (anion exchanger), member 3
chr15_+_54571358 1.318 ENSMUST00000025356.2
Mal2
mal, T cell differentiation protein 2
chr4_+_42459563 1.314 ENSMUST00000098119.2
Gm3883
predicted gene 3883
chr9_+_114978507 1.295 ENSMUST00000183104.1
Osbpl10
oxysterol binding protein-like 10
chrX_+_159840463 1.282 ENSMUST00000112451.1
ENSMUST00000112453.2
Sh3kbp1

SH3-domain kinase binding protein 1

chr5_+_30013141 1.278 ENSMUST00000026845.7
Il6
interleukin 6
chr9_-_86695897 1.272 ENSMUST00000034989.8
Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr15_-_103366763 1.239 ENSMUST00000023128.6
Itga5
integrin alpha 5 (fibronectin receptor alpha)
chr4_-_6454262 1.222 ENSMUST00000029910.5
Nsmaf
neutral sphingomyelinase (N-SMase) activation associated factor
chr18_+_40258361 1.203 ENSMUST00000091927.4
Kctd16
potassium channel tetramerisation domain containing 16
chr11_-_120041774 1.189 ENSMUST00000103019.1
Aatk
apoptosis-associated tyrosine kinase
chr3_+_142620596 1.148 ENSMUST00000165774.1
Gbp2
guanylate binding protein 2
chr14_+_76476913 1.130 ENSMUST00000140251.2
Tsc22d1
TSC22 domain family, member 1
chr1_-_182517447 1.127 ENSMUST00000068505.8
Capn2
calpain 2
chr1_-_132390301 1.127 ENSMUST00000132435.1
Tmcc2
transmembrane and coiled-coil domains 2
chr19_+_8664005 1.124 ENSMUST00000035444.3
ENSMUST00000163785.1
Chrm1

cholinergic receptor, muscarinic 1, CNS

chr7_-_113347273 1.114 ENSMUST00000117577.1
Btbd10
BTB (POZ) domain containing 10
chr10_+_86779000 1.108 ENSMUST00000099396.2
Nt5dc3
5'-nucleotidase domain containing 3
chrX_+_71962971 1.108 ENSMUST00000048790.6
Prrg3
proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
chr7_-_100547620 1.102 ENSMUST00000064334.2
D630004N19Rik
RIKEN cDNA D630004N19 gene
chr2_+_131909928 1.102 ENSMUST00000091288.6
Prnp
prion protein
chrX_-_7740206 1.097 ENSMUST00000128289.1
Ccdc120
coiled-coil domain containing 120
chr11_+_75655873 1.089 ENSMUST00000108431.2
Myo1c
myosin IC
chr13_+_30659999 1.087 ENSMUST00000091672.6
ENSMUST00000110310.1
ENSMUST00000095914.5
Dusp22


dual specificity phosphatase 22


chr16_-_4880284 1.084 ENSMUST00000037843.6
Ubald1
UBA-like domain containing 1
chr7_-_44670820 1.080 ENSMUST00000048102.7
Myh14
myosin, heavy polypeptide 14
chr3_-_121283096 1.066 ENSMUST00000135818.1
ENSMUST00000137234.1
Tmem56

transmembrane protein 56

chr3_+_62338344 1.066 ENSMUST00000079300.6
Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr4_+_138972885 1.050 ENSMUST00000123636.1
ENSMUST00000043042.3
ENSMUST00000050949.2
Tmco4


transmembrane and coiled-coil domains 4


chr4_-_140648736 1.025 ENSMUST00000039204.3
ENSMUST00000105799.1
ENSMUST00000097820.2
Arhgef10l


Rho guanine nucleotide exchange factor (GEF) 10-like


chr2_-_25224653 1.018 ENSMUST00000043584.4
Tubb4b
tubulin, beta 4B class IVB
chr12_+_80518990 1.010 ENSMUST00000021558.6
Galnt16
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
chrX_-_167209149 0.991 ENSMUST00000112176.1
Tmsb4x
thymosin, beta 4, X chromosome
chr14_+_27622433 0.989 ENSMUST00000090302.5
Erc2
ELKS/RAB6-interacting/CAST family member 2
chr13_-_60897439 0.988 ENSMUST00000171347.1
ENSMUST00000021884.8
Ctla2b

cytotoxic T lymphocyte-associated protein 2 beta

chr2_-_45110336 0.982 ENSMUST00000028229.6
ENSMUST00000152232.1
Zeb2

zinc finger E-box binding homeobox 2

chr9_+_78615501 0.975 ENSMUST00000093812.4
Cd109
CD109 antigen
chr1_-_30949756 0.970 ENSMUST00000076587.3
ENSMUST00000027232.7
Ptp4a1

protein tyrosine phosphatase 4a1

chr15_-_97767644 0.968 ENSMUST00000128775.2
ENSMUST00000134885.2
Rapgef3

Rap guanine nucleotide exchange factor (GEF) 3

chr3_+_79885930 0.962 ENSMUST00000029567.8
Fam198b
family with sequence similarity 198, member B
chr10_+_80930071 0.955 ENSMUST00000015456.8
Gadd45b
growth arrest and DNA-damage-inducible 45 beta
chr16_+_17561885 0.946 ENSMUST00000171002.1
ENSMUST00000023441.4
P2rx6

purinergic receptor P2X, ligand-gated ion channel, 6

chr2_+_136713444 0.945 ENSMUST00000028727.4
ENSMUST00000110098.3
Snap25

synaptosomal-associated protein 25

chr7_+_19181159 0.935 ENSMUST00000120595.1
ENSMUST00000048502.8
Eml2

echinoderm microtubule associated protein like 2

chr7_-_45920830 0.932 ENSMUST00000164119.1
Emp3
epithelial membrane protein 3
chr9_-_32541589 0.925 ENSMUST00000016231.7
Fli1
Friend leukemia integration 1
chr11_-_120467414 0.910 ENSMUST00000076921.6
Arl16
ADP-ribosylation factor-like 16
chr2_+_131909951 0.907 ENSMUST00000124100.1
ENSMUST00000136783.1
PRND

prion protein gene complex (Prn), transcript variant 1, mRNA

chr1_+_165461037 0.903 ENSMUST00000027853.5
Mpc2
mitochondrial pyruvate carrier 2
chr8_-_11008458 0.898 ENSMUST00000040514.6
Irs2
insulin receptor substrate 2
chr8_-_105966038 0.887 ENSMUST00000116429.2
ENSMUST00000034370.9
Slc12a4

solute carrier family 12, member 4

chr6_-_99044414 0.884 ENSMUST00000177507.1
ENSMUST00000123992.1
Foxp1

forkhead box P1

chr11_+_120467635 0.875 ENSMUST00000140862.1
ENSMUST00000106205.1
ENSMUST00000106203.1
ENSMUST00000026900.7
Hgs



HGF-regulated tyrosine kinase substrate



chr5_+_117363513 0.875 ENSMUST00000111959.1
Wsb2
WD repeat and SOCS box-containing 2
chr3_-_57294880 0.874 ENSMUST00000171384.1
Tm4sf1
transmembrane 4 superfamily member 1
chr13_+_93304799 0.849 ENSMUST00000080127.5
Homer1
homer homolog 1 (Drosophila)
chr19_+_8989277 0.820 ENSMUST00000092955.3
ENSMUST00000092956.2
Ahnak

AHNAK nucleoprotein (desmoyokin)

chrX_-_48454152 0.801 ENSMUST00000114958.1
Elf4
E74-like factor 4 (ets domain transcription factor)
chr19_-_32210969 0.794 ENSMUST00000151289.1
Sgms1
sphingomyelin synthase 1
chr7_-_80401707 0.791 ENSMUST00000120753.1
Furin
furin (paired basic amino acid cleaving enzyme)
chr4_-_6454068 0.788 ENSMUST00000124344.1
Nsmaf
neutral sphingomyelinase (N-SMase) activation associated factor
chr9_-_78480736 0.787 ENSMUST00000156988.1
Eef1a1
eukaryotic translation elongation factor 1 alpha 1
chr10_-_83337440 0.779 ENSMUST00000126617.1
Slc41a2
solute carrier family 41, member 2
chr4_+_123183456 0.774 ENSMUST00000126995.1
Hpcal4
hippocalcin-like 4
chr7_+_120917744 0.769 ENSMUST00000033173.7
ENSMUST00000106483.2
Polr3e

polymerase (RNA) III (DNA directed) polypeptide E

chr3_-_85722474 0.761 ENSMUST00000119077.1
Fam160a1
family with sequence similarity 160, member A1
chr14_-_31417666 0.750 ENSMUST00000100730.3
Sh3bp5
SH3-domain binding protein 5 (BTK-associated)
chr19_+_5447692 0.748 ENSMUST00000025850.5
Fosl1
fos-like antigen 1
chr2_+_25428699 0.738 ENSMUST00000102919.3
Abca2
ATP-binding cassette, sub-family A (ABC1), member 2
chr11_-_116024489 0.733 ENSMUST00000016703.7
H3f3b
H3 histone, family 3B
chr4_-_126321669 0.726 ENSMUST00000102617.4
Adprhl2
ADP-ribosylhydrolase like 2
chr18_-_31317043 0.685 ENSMUST00000139924.1
ENSMUST00000153060.1
Rit2

Ras-like without CAAX 2

chr2_-_25461021 0.681 ENSMUST00000151239.1
BC029214
cDNA sequence BC029214
chr11_+_9118070 0.677 ENSMUST00000020677.1
ENSMUST00000101525.2
ENSMUST00000170444.1
Upp1


uridine phosphorylase 1


chr19_+_8929628 0.673 ENSMUST00000096241.4
Eml3
echinoderm microtubule associated protein like 3
chr6_-_56901870 0.665 ENSMUST00000101367.2
Nt5c3
5'-nucleotidase, cytosolic III
chrX_+_6415736 0.649 ENSMUST00000143641.3
Shroom4
shroom family member 4
chr4_-_149126688 0.644 ENSMUST00000030815.2
Cort
cortistatin
chr8_-_60954726 0.631 ENSMUST00000110302.1
Clcn3
chloride channel 3
chr4_+_152008803 0.631 ENSMUST00000097773.3
Klhl21
kelch-like 21
chr7_+_127244511 0.605 ENSMUST00000052509.4
Zfp771
zinc finger protein 771
chr9_-_109059216 0.602 ENSMUST00000112053.1
Trex1
three prime repair exonuclease 1
chr17_+_78508063 0.599 ENSMUST00000024880.9
Vit
vitrin
chr7_-_30195046 0.594 ENSMUST00000001845.5
Capns1
calpain, small subunit 1
chr9_+_86695542 0.581 ENSMUST00000150367.2
A330041J22Rik
RIKEN cDNA A330041J22 gene
chr11_-_115708538 0.578 ENSMUST00000106495.1
ENSMUST00000021090.7
Grb2

growth factor receptor bound protein 2

chr5_+_25247344 0.577 ENSMUST00000114950.1
Galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr17_-_27513341 0.573 ENSMUST00000118161.1
Grm4
glutamate receptor, metabotropic 4
chr13_+_93303757 0.564 ENSMUST00000109494.1
Homer1
homer homolog 1 (Drosophila)
chr18_-_82406777 0.562 ENSMUST00000065224.6
Galr1
galanin receptor 1
chr7_+_110774240 0.553 ENSMUST00000147587.1
Ampd3
adenosine monophosphate deaminase 3
chr19_-_46338632 0.541 ENSMUST00000051234.8
ENSMUST00000167861.1
Cuedc2

CUE domain containing 2

chr6_-_97459279 0.538 ENSMUST00000113359.1
Frmd4b
FERM domain containing 4B
chr1_+_75546258 0.535 ENSMUST00000124341.1
Slc4a3
solute carrier family 4 (anion exchanger), member 3
chr13_-_56296551 0.530 ENSMUST00000021970.9
Cxcl14
chemokine (C-X-C motif) ligand 14
chr10_+_60277627 0.526 ENSMUST00000105465.1
ENSMUST00000177779.1
ENSMUST00000179238.1
ENSMUST00000004316.8
Psap



prosaposin



chr10_+_61695503 0.525 ENSMUST00000020284.4
Tysnd1
trypsin domain containing 1
chr10_-_81427114 0.524 ENSMUST00000078185.7
ENSMUST00000020461.8
ENSMUST00000105321.3
Nfic


nuclear factor I/C


chr13_-_58128542 0.514 ENSMUST00000007980.6
Hnrnpa0
heterogeneous nuclear ribonucleoprotein A0
chr7_-_80403315 0.502 ENSMUST00000147150.1
Furin
furin (paired basic amino acid cleaving enzyme)
chr9_-_96752822 0.499 ENSMUST00000152594.1
Zbtb38
zinc finger and BTB domain containing 38
chr17_-_30612613 0.493 ENSMUST00000167624.1
ENSMUST00000024823.6
Glo1

glyoxalase 1

chrX_+_7722267 0.489 ENSMUST00000125991.1
ENSMUST00000148624.1
Wdr45

WD repeat domain 45

chr15_+_84669565 0.483 ENSMUST00000171460.1
Prr5
proline rich 5 (renal)
chr18_-_35498856 0.477 ENSMUST00000025215.8
Sil1
endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae)
chr11_-_93968293 0.471 ENSMUST00000170303.1
Gm20390
predicted gene 20390
chr2_-_29253001 0.459 ENSMUST00000071201.4
Ntng2
netrin G2
chr3_+_109573907 0.448 ENSMUST00000106576.2
Vav3
vav 3 oncogene
chr2_+_30441831 0.440 ENSMUST00000131476.1
Ppp2r4
protein phosphatase 2A, regulatory subunit B (PR 53)
chr6_+_17281185 0.434 ENSMUST00000000058.6
Cav2
caveolin 2
chr15_+_82275197 0.429 ENSMUST00000116423.1
Sept3
septin 3

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 17.3 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
1.7 8.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.4 5.7 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
1.2 7.3 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
1.0 4.8 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.9 4.5 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.8 3.2 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.8 4.7 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
0.8 2.3 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.8 2.3 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.7 2.2 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.7 2.9 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.6 1.7 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.6 5.1 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.5 1.6 GO:0035441 cell migration involved in vasculogenesis(GO:0035441) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.5 3.6 GO:0015862 uridine transport(GO:0015862)
0.5 2.0 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.5 1.5 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.5 1.4 GO:0086047 membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
0.5 1.4 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.5 3.2 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) negative regulation of cellular response to vascular endothelial growth factor stimulus(GO:1902548)
0.5 2.7 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.4 1.7 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.4 1.3 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.4 2.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.4 1.5 GO:0035624 receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625)
0.4 1.1 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938)
0.4 4.4 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.4 2.5 GO:0032261 purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264)
0.3 0.7 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
0.3 1.6 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.3 0.9 GO:0046032 ADP catabolic process(GO:0046032)
0.3 2.0 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.3 2.5 GO:0071285 cellular response to lithium ion(GO:0071285)
0.3 1.6 GO:0007021 tubulin complex assembly(GO:0007021)
0.3 1.3 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.3 1.3 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.2 0.2 GO:0030862 positive regulation of polarized epithelial cell differentiation(GO:0030862)
0.2 0.7 GO:0071544 diphosphoinositol polyphosphate catabolic process(GO:0071544)
0.2 4.6 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.2 1.8 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.2 0.9 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.2 0.7 GO:0046133 pyrimidine ribonucleoside catabolic process(GO:0046133)
0.2 1.4 GO:0046103 ADP biosynthetic process(GO:0006172) inosine biosynthetic process(GO:0046103)
0.2 1.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.2 2.2 GO:0030049 muscle filament sliding(GO:0030049)
0.2 1.1 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.2 2.9 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.2 0.6 GO:0097401 synaptic vesicle lumen acidification(GO:0097401)
0.2 2.6 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.2 0.8 GO:0001787 natural killer cell proliferation(GO:0001787)
0.2 1.0 GO:0072675 osteoclast fusion(GO:0072675)
0.2 1.1 GO:0016540 protein autoprocessing(GO:0016540)
0.2 0.6 GO:0051464 positive regulation of cortisol secretion(GO:0051464)
0.2 7.4 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.2 0.7 GO:1902340 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.2 0.5 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.2 0.5 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.2 3.8 GO:0070208 protein heterotrimerization(GO:0070208)
0.2 1.0 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 1.1 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.1 1.2 GO:0098967 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.1 1.4 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.1 0.6 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.1 3.0 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 1.7 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.1 1.2 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.1 0.9 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 1.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.9 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.1 1.8 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.1 0.8 GO:0060161 positive regulation of dopamine receptor signaling pathway(GO:0060161)
0.1 0.4 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.1 1.5 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 3.8 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.1 2.3 GO:0032060 bleb assembly(GO:0032060)
0.1 0.9 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.1 2.4 GO:0044804 nucleophagy(GO:0044804)
0.1 1.2 GO:0032482 Rab protein signal transduction(GO:0032482)
0.1 0.4 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.1 0.7 GO:0007296 vitellogenesis(GO:0007296)
0.1 0.7 GO:0032380 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.1 0.4 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.1 3.3 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.1 0.7 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 0.9 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 0.9 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 0.5 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.1 7.1 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.1 0.6 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.1 1.5 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.1 1.6 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.1 1.1 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.1 1.8 GO:0034113 heterotypic cell-cell adhesion(GO:0034113)
0.1 2.6 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 1.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 0.4 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.3 GO:0035617 stress granule disassembly(GO:0035617)
0.1 0.2 GO:0042275 error-free postreplication DNA repair(GO:0042275)
0.1 1.5 GO:0071625 vocalization behavior(GO:0071625)
0.1 0.3 GO:1901525 negative regulation of macromitophagy(GO:1901525)
0.1 0.8 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 1.1 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.3 GO:0090170 regulation of Golgi inheritance(GO:0090170)
0.0 0.9 GO:0033198 response to ATP(GO:0033198)
0.0 1.2 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 0.9 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 2.0 GO:0045806 negative regulation of endocytosis(GO:0045806)
0.0 0.2 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.0 0.6 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 1.9 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.0 0.2 GO:0006538 glutamate catabolic process(GO:0006538)
0.0 0.3 GO:0019532 oxalate transport(GO:0019532)
0.0 0.2 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313) negative regulation of neutrophil activation(GO:1902564)
0.0 0.7 GO:0071451 cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451)
0.0 0.5 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 4.0 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.1 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) negative regulation of determination of dorsal identity(GO:2000016)
0.0 0.4 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.3 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 1.7 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.2 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.1 GO:1903527 regulation of membrane tubulation(GO:1903525) positive regulation of membrane tubulation(GO:1903527)
0.0 0.8 GO:0071364 response to epidermal growth factor(GO:0070849) cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.3 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 0.6 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.4 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.8 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.4 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.0 0.8 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 0.2 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.3 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 1.5 GO:0051453 regulation of intracellular pH(GO:0051453)
0.0 0.1 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.1 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.1 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.0 1.2 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 0.1 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.6 GO:0032465 regulation of cytokinesis(GO:0032465)
0.0 0.1 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.0 0.0 GO:0030397 membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 8.3 GO:0005638 lamin filament(GO:0005638)
1.1 3.4 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
1.0 7.3 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.8 3.2 GO:0097574 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.6 6.8 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.6 1.8 GO:0005927 muscle tendon junction(GO:0005927)
0.4 3.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.4 1.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.4 1.1 GO:0045160 myosin I complex(GO:0045160)
0.4 1.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.3 16.7 GO:0009925 basal plasma membrane(GO:0009925)
0.3 1.6 GO:0097512 cardiac myofibril(GO:0097512)
0.3 1.3 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.2 2.2 GO:0016461 unconventional myosin complex(GO:0016461)
0.2 0.2 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
0.2 0.9 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.2 0.8 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.2 1.1 GO:0097513 myosin II filament(GO:0097513)
0.2 0.7 GO:0097447 dendritic tree(GO:0097447)
0.2 1.4 GO:0001520 outer dense fiber(GO:0001520)
0.2 1.5 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 3.3 GO:0032279 asymmetric synapse(GO:0032279)
0.1 2.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 2.8 GO:0098644 complex of collagen trimers(GO:0098644)
0.1 0.6 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.1 2.0 GO:0031045 dense core granule(GO:0031045)
0.1 1.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 6.1 GO:0005581 collagen trimer(GO:0005581)
0.1 4.6 GO:0032420 stereocilium(GO:0032420)
0.1 1.1 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.1 1.0 GO:0045298 tubulin complex(GO:0045298)
0.1 0.6 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 1.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.6 GO:0005827 polar microtubule(GO:0005827)
0.1 3.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 5.3 GO:0042734 presynaptic membrane(GO:0042734)
0.1 4.6 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 1.1 GO:0031143 pseudopodium(GO:0031143)
0.1 0.2 GO:0097487 multivesicular body membrane(GO:0032585) multivesicular body, internal vesicle(GO:0097487)
0.1 1.2 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 2.5 GO:0043034 costamere(GO:0043034)
0.1 1.3 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 1.1 GO:0043235 receptor complex(GO:0043235)
0.1 0.9 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 4.0 GO:0005604 basement membrane(GO:0005604)
0.1 13.4 GO:0016324 apical plasma membrane(GO:0016324)
0.1 1.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 0.8 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.3 GO:0071439 clathrin complex(GO:0071439)
0.0 0.1 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.0 0.8 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.4 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.4 GO:0044754 secondary lysosome(GO:0005767) autolysosome(GO:0044754)
0.0 1.3 GO:0030018 Z disc(GO:0030018)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 2.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.4 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 4.5 GO:0001650 fibrillar center(GO:0001650)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.9 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 2.6 GO:0055037 recycling endosome(GO:0055037)
0.0 3.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.7 GO:0031253 cell projection membrane(GO:0031253)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.1 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)
0.0 0.2 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.0 0.5 GO:0072562 blood microparticle(GO:0072562)
0.0 0.3 GO:0035253 ciliary rootlet(GO:0035253)
0.0 1.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.3 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.2 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 1.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 17.3 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.8 3.4 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.8 2.3 GO:0004875 complement receptor activity(GO:0004875)
0.6 2.3 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.6 6.8 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.5 2.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.5 2.0 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.5 2.0 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.5 1.5 GO:0051379 epinephrine binding(GO:0051379)
0.4 3.8 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.4 1.3 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.4 0.8 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.4 3.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.4 2.9 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.4 5.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.4 1.4 GO:0042806 fucose binding(GO:0042806)
0.4 2.5 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.4 11.9 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.3 2.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.3 1.8 GO:0005042 netrin receptor activity(GO:0005042)
0.3 1.4 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.3 8.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 2.8 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.3 6.2 GO:0017160 Ral GTPase binding(GO:0017160)
0.2 1.2 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.2 7.8 GO:0042805 actinin binding(GO:0042805)
0.2 3.0 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.2 0.9 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.2 1.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.2 3.4 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.2 7.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 1.4 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.2 2.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 1.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 1.3 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.2 0.6 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.2 0.9 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.2 1.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.6 GO:0004966 galanin receptor activity(GO:0004966)
0.1 3.6 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 0.9 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 2.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.4 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 4.7 GO:0070412 R-SMAD binding(GO:0070412)
0.1 1.3 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.9 GO:0047631 adenosine-diphosphatase activity(GO:0043262) ADP-ribose diphosphatase activity(GO:0047631)
0.1 0.6 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 2.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.8 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 0.5 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 1.9 GO:0050811 GABA receptor binding(GO:0050811)
0.1 1.6 GO:0001968 fibronectin binding(GO:0001968)
0.1 1.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.4 GO:0043546 molybdenum ion binding(GO:0030151) molybdopterin cofactor binding(GO:0043546)
0.1 1.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 1.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 2.2 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 1.6 GO:0042608 T cell receptor binding(GO:0042608)
0.1 0.3 GO:0031800 type 3 metabotropic glutamate receptor binding(GO:0031800)
0.1 2.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 4.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 1.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.4 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.1 2.7 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.8 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 2.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 0.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 2.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 1.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 4.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.3 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 1.0 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 5.8 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 2.0 GO:0005518 collagen binding(GO:0005518)
0.0 0.4 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.3 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.3 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 1.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.8 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.8 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.0 1.0 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.2 GO:0070728 leucine binding(GO:0070728)
0.0 0.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.4 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.9 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 0.4 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0008176 tRNA (guanine-N7-)-methyltransferase activity(GO:0008176)
0.0 0.3 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.0 1.7 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.3 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.5 GO:0008009 chemokine activity(GO:0008009)
0.0 2.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.2 GO:0019956 chemokine binding(GO:0019956)
0.0 1.7 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.7 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 0.5 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.3 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 0.4 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 0.4 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 1.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 22.7 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.2 6.9 PID_ARF_3PATHWAY Arf1 pathway
0.2 4.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.2 3.0 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.2 4.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 3.2 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 4.4 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 7.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.4 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 1.1 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 1.2 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.1 3.0 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 0.8 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 4.3 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 2.3 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 4.3 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 2.2 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 0.4 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 1.4 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.1 3.0 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 2.5 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 1.1 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 1.0 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.4 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.7 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 5.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.7 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.4 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.3 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 0.6 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 1.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.3 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 1.3 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 0.3 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.2 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 0.2 PID_IL12_2PATHWAY IL12-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 16.2 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.4 6.8 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.2 2.8 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.2 2.9 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.2 2.2 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.2 3.8 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 1.3 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.1 2.5 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.1 1.8 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 0.7 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 7.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 10.0 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 3.8 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 3.2 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 2.5 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.8 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling
0.1 1.3 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 4.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 0.9 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 3.0 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1
0.1 3.6 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 2.4 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.1 2.2 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.2 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.1 1.0 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 0.3 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 1.5 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 3.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 0.4 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.6 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.8 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 1.1 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.0 1.2 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 2.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.2 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.5 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.9 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.6 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.7 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.4 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 0.3 REACTOME_KINESINS Genes involved in Kinesins