Motif ID: Foxc1

Z-value: 0.710


Transcription factors associated with Foxc1:

Gene SymbolEntrez IDGene Name
Foxc1 ENSMUSG00000050295.2 Foxc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxc1mm10_v2_chr13_+_31806627_31806650-0.115.1e-01Click!


Activity profile for motif Foxc1.

activity profile for motif Foxc1


Sorted Z-values histogram for motif Foxc1

Sorted Z-values for motif Foxc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxc1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_+_1010543 4.597 ENSMUST00000091197.3
Eif2s3y
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr12_-_113422730 2.989 ENSMUST00000177715.1
ENSMUST00000103426.1
Ighm

immunoglobulin heavy constant mu

chr3_-_87263518 2.642 ENSMUST00000090986.4
Fcrls
Fc receptor-like S, scavenger receptor
chr3_-_87263703 2.487 ENSMUST00000146512.1
Fcrls
Fc receptor-like S, scavenger receptor
chr15_+_78597047 1.828 ENSMUST00000043069.5
Cyth4
cytohesin 4
chr15_-_66948419 1.457 ENSMUST00000167817.1
Ndrg1
N-myc downstream regulated gene 1
chr6_+_68161415 1.143 ENSMUST00000168090.1
Igkv1-115
immunoglobulin kappa variable 1-115
chr13_+_53525703 1.056 ENSMUST00000081132.4
Gm5449
predicted pseudogene 5449
chr13_-_49320219 0.989 ENSMUST00000110086.1
Fgd3
FYVE, RhoGEF and PH domain containing 3
chr1_+_72824482 0.983 ENSMUST00000047328.4
Igfbp2
insulin-like growth factor binding protein 2
chr6_-_42324554 0.948 ENSMUST00000095974.3
Fam131b
family with sequence similarity 131, member B
chr2_+_4976113 0.921 ENSMUST00000167607.1
ENSMUST00000115010.2
Ucma

upper zone of growth plate and cartilage matrix associated

chr6_-_42324640 0.872 ENSMUST00000031891.8
ENSMUST00000143278.1
Fam131b

family with sequence similarity 131, member B

chr18_-_33463615 0.844 ENSMUST00000051087.8
Nrep
neuronal regeneration related protein
chr1_+_107511416 0.785 ENSMUST00000009356.4
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr8_-_13494479 0.783 ENSMUST00000033828.5
Gas6
growth arrest specific 6
chr11_-_102296618 0.781 ENSMUST00000107132.2
ENSMUST00000073234.2
Atxn7l3

ataxin 7-like 3

chr1_-_87394721 0.765 ENSMUST00000113212.3
Kcnj13
potassium inwardly-rectifying channel, subfamily J, member 13
chr16_-_46155077 0.765 ENSMUST00000059524.5
Gm4737
predicted gene 4737
chr15_-_58034289 0.760 ENSMUST00000100655.3
9130401M01Rik
RIKEN cDNA 9130401M01 gene
chr17_+_46254017 0.741 ENSMUST00000095262.4
Lrrc73
leucine rich repeat containing 73
chr1_+_107511489 0.713 ENSMUST00000064916.2
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr15_+_6422240 0.706 ENSMUST00000163082.1
Dab2
disabled 2, mitogen-responsive phosphoprotein
chr15_-_76656905 0.693 ENSMUST00000176274.1
Cyhr1
cysteine and histidine rich 1
chr11_-_78550777 0.683 ENSMUST00000103242.4
Tmem97
transmembrane protein 97
chr16_-_21947536 0.665 ENSMUST00000023562.7
Tmem41a
transmembrane protein 41a
chr11_+_32300069 0.664 ENSMUST00000020535.1
Hbq1a
hemoglobin, theta 1A
chr12_+_105336922 0.652 ENSMUST00000180503.1
2810011L19Rik
RIKEN cDNA 2810011L19 gene
chr15_-_102667749 0.640 ENSMUST00000075630.3
Atp5g2
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9)
chr7_+_16309577 0.632 ENSMUST00000002152.6
Bbc3
BCL2 binding component 3
chr1_-_71653162 0.621 ENSMUST00000055226.6
Fn1
fibronectin 1
chr15_-_102257306 0.614 ENSMUST00000135466.1
Rarg
retinoic acid receptor, gamma
chr6_+_86371489 0.575 ENSMUST00000089558.5
Snrpg
small nuclear ribonucleoprotein polypeptide G
chr2_+_30807826 0.574 ENSMUST00000041830.3
ENSMUST00000152374.1
Ntmt1

N-terminal Xaa-Pro-Lys N-methyltransferase 1

chr2_-_126709567 0.574 ENSMUST00000099423.2
Gm10774
predicted pseudogene 10774
chr4_+_117550326 0.549 ENSMUST00000037127.8
Eri3
exoribonuclease 3
chr9_-_103222063 0.541 ENSMUST00000170904.1
Trf
transferrin
chr4_-_43030440 0.527 ENSMUST00000135660.1
Stoml2
stomatin (Epb7.2)-like 2
chr18_+_78349754 0.522 ENSMUST00000164064.1
Gm6133
predicted gene 6133
chr9_-_106891401 0.522 ENSMUST00000069036.7
Manf
mesencephalic astrocyte-derived neurotrophic factor
chr13_+_42680565 0.505 ENSMUST00000128646.1
Phactr1
phosphatase and actin regulator 1
chr17_+_45686322 0.498 ENSMUST00000024734.7
Mrpl14
mitochondrial ribosomal protein L14
chr11_+_70017199 0.495 ENSMUST00000133140.1
Dlg4
discs, large homolog 4 (Drosophila)
chr9_-_21037775 0.495 ENSMUST00000180870.1
Gm26592
predicted gene, 26592
chr14_-_31128924 0.494 ENSMUST00000064032.4
ENSMUST00000049732.5
ENSMUST00000090205.3
Smim4


small itegral membrane protein 4


chr3_-_95282076 0.489 ENSMUST00000015855.7
Prune
prune homolog (Drosophila)
chr3_-_141982224 0.487 ENSMUST00000029948.8
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr18_+_33464163 0.487 ENSMUST00000097634.3
Gm10549
predicted gene 10549
chr3_-_96197580 0.477 ENSMUST00000016087.3
Bola1
bolA-like 1 (E. coli)
chr1_+_84839833 0.470 ENSMUST00000097672.3
Fbxo36
F-box protein 36
chr14_-_48662740 0.465 ENSMUST00000122009.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr7_+_129257027 0.461 ENSMUST00000094018.4
Ppapdc1a
phosphatidic acid phosphatase type 2 domain containing 1A
chr9_+_110419750 0.455 ENSMUST00000035061.6
Ngp
neutrophilic granule protein
chr17_-_36951338 0.449 ENSMUST00000173540.1
Ppp1r11
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr11_+_73160403 0.447 ENSMUST00000006104.3
P2rx5
purinergic receptor P2X, ligand-gated ion channel, 5
chr4_-_40948196 0.439 ENSMUST00000030125.4
ENSMUST00000108089.1
Bag1

BCL2-associated athanogene 1

chr7_-_127026479 0.438 ENSMUST00000032916.4
Maz
MYC-associated zinc finger protein (purine-binding transcription factor)
chr1_+_120602405 0.437 ENSMUST00000079721.7
En1
engrailed 1
chr11_+_6415443 0.433 ENSMUST00000132846.1
Ppia
peptidylprolyl isomerase A
chr17_-_36951636 0.431 ENSMUST00000040402.7
ENSMUST00000174711.1
Ppp1r11

protein phosphatase 1, regulatory (inhibitor) subunit 11

chr6_-_29212240 0.428 ENSMUST00000160878.1
ENSMUST00000078155.5
Impdh1

inosine 5'-phosphate dehydrogenase 1

chr15_-_102257449 0.425 ENSMUST00000043172.8
Rarg
retinoic acid receptor, gamma
chr3_-_89998656 0.421 ENSMUST00000079724.4
Hax1
HCLS1 associated X-1
chr8_+_106870827 0.411 ENSMUST00000176144.1
ENSMUST00000175987.1
Has3

hyaluronan synthase 3

chr13_-_107414742 0.407 ENSMUST00000061241.6
Apoo-ps
apolipoprotein O, pseudogene
chr17_+_3397189 0.406 ENSMUST00000072156.6
Tiam2
T cell lymphoma invasion and metastasis 2
chr13_-_34077992 0.406 ENSMUST00000056427.8
Tubb2a
tubulin, beta 2A class IIA
chr8_-_25840440 0.403 ENSMUST00000110609.1
Ash2l
ash2 (absent, small, or homeotic)-like (Drosophila)
chr3_+_95160449 0.396 ENSMUST00000090823.1
ENSMUST00000090821.3
Sema6c

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C

chr2_+_151542483 0.396 ENSMUST00000044011.5
Fkbp1a
FK506 binding protein 1a
chr15_+_102503722 0.387 ENSMUST00000096145.4
Gm10337
predicted gene 10337
chr10_+_77864623 0.381 ENSMUST00000092366.2
Tspear
thrombospondin type laminin G domain and EAR repeats
chr2_+_172370658 0.379 ENSMUST00000151511.1
ENSMUST00000116375.1
Cstf1

cleavage stimulation factor, 3' pre-RNA, subunit 1

chr5_-_135573036 0.378 ENSMUST00000004936.6
Ccl24
chemokine (C-C motif) ligand 24
chr14_+_113314602 0.376 ENSMUST00000072359.6
Tpm3-rs7
tropomyosin 3, related sequence 7
chr2_+_163994960 0.374 ENSMUST00000018470.3
Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr13_-_18382041 0.372 ENSMUST00000139064.2
ENSMUST00000175703.2
Pou6f2

POU domain, class 6, transcription factor 2

chr5_+_8046077 0.371 ENSMUST00000088786.4
Sri
sorcin
chr15_+_80255184 0.370 ENSMUST00000109605.3
Atf4
activating transcription factor 4
chr11_+_70017085 0.366 ENSMUST00000108589.2
Dlg4
discs, large homolog 4 (Drosophila)
chr12_-_69198419 0.364 ENSMUST00000021356.5
Dnaaf2
dynein, axonemal assembly factor 2
chr7_-_89941084 0.362 ENSMUST00000075010.4
ENSMUST00000153470.1
l7Rn6

lethal, Chr 7, Rinchik 6

chrY_+_90843934 0.356 ENSMUST00000178550.1
Gm21742
predicted gene, 21742
chr7_+_44816088 0.347 ENSMUST00000057195.9
ENSMUST00000107891.1
Nup62

nucleoporin 62

chr15_-_100599864 0.345 ENSMUST00000177247.2
ENSMUST00000177505.2
Pou6f1

POU domain, class 6, transcription factor 1

chr17_+_37045980 0.344 ENSMUST00000174456.1
Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr17_-_70851710 0.339 ENSMUST00000166395.2
Tgif1
TGFB-induced factor homeobox 1
chr9_-_86880414 0.327 ENSMUST00000074501.5
ENSMUST00000098495.3
ENSMUST00000074468.6
ENSMUST00000036347.6
Snap91



synaptosomal-associated protein 91



chr3_+_90079540 0.323 ENSMUST00000029549.9
ENSMUST00000118566.1
ENSMUST00000119158.1
Tpm3


tropomyosin 3, gamma


chr12_-_73047179 0.318 ENSMUST00000050029.7
Six1
sine oculis-related homeobox 1
chr3_+_94377432 0.317 ENSMUST00000107292.1
Rorc
RAR-related orphan receptor gamma
chr1_+_74284930 0.316 ENSMUST00000113805.1
ENSMUST00000027370.6
ENSMUST00000087226.4
Pnkd


paroxysmal nonkinesiogenic dyskinesia


chr3_+_94377505 0.308 ENSMUST00000098877.2
Rorc
RAR-related orphan receptor gamma
chr9_-_86880647 0.307 ENSMUST00000167014.1
Snap91
synaptosomal-associated protein 91
chr3_+_124321031 0.304 ENSMUST00000058994.4
Tram1l1
translocation associated membrane protein 1-like 1
chr18_-_78123324 0.299 ENSMUST00000160292.1
ENSMUST00000091813.5
Slc14a1

solute carrier family 14 (urea transporter), member 1

chr11_-_4594750 0.298 ENSMUST00000109943.3
Mtmr3
myotubularin related protein 3
chr7_+_19228334 0.295 ENSMUST00000063976.8
Opa3
optic atrophy 3
chr6_+_47244359 0.291 ENSMUST00000060839.6
Cntnap2
contactin associated protein-like 2
chr3_+_154597352 0.286 ENSMUST00000140644.1
ENSMUST00000144764.1
ENSMUST00000155232.1
Cryz


crystallin, zeta


chr9_+_72806874 0.283 ENSMUST00000055535.8
Prtg
protogenin homolog (Gallus gallus)
chr16_-_97170707 0.283 ENSMUST00000056102.7
Dscam
Down syndrome cell adhesion molecule
chr13_-_54611332 0.279 ENSMUST00000091609.4
Cltb
clathrin, light polypeptide (Lcb)
chr6_-_88045190 0.278 ENSMUST00000113596.1
ENSMUST00000113600.3
Rab7

RAB7, member RAS oncogene family

chr13_-_54766553 0.272 ENSMUST00000036825.7
Sncb
synuclein, beta
chr9_-_60838200 0.271 ENSMUST00000063858.7
Gm9869
predicted gene 9869
chr15_-_97814830 0.267 ENSMUST00000121514.1
Hdac7
histone deacetylase 7
chr3_+_61364507 0.267 ENSMUST00000049064.2
Rap2b
RAP2B, member of RAS oncogene family
chr15_-_100599983 0.265 ENSMUST00000073837.6
Pou6f1
POU domain, class 6, transcription factor 1
chr1_+_134182404 0.264 ENSMUST00000153856.1
ENSMUST00000082060.3
ENSMUST00000133701.1
ENSMUST00000132873.1
Chi3l1



chitinase 3-like 1



chr1_+_34439851 0.264 ENSMUST00000027303.7
Imp4
IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr2_-_103485068 0.263 ENSMUST00000111168.3
Cat
catalase
chr17_-_45685973 0.261 ENSMUST00000145873.1
Tmem63b
transmembrane protein 63b
chr6_+_55203381 0.259 ENSMUST00000053094.7
Fam188b
family with sequence similarity 188, member B
chr11_-_98625661 0.257 ENSMUST00000104933.1
Gm12355
predicted gene 12355
chr5_-_34187670 0.256 ENSMUST00000042701.6
ENSMUST00000119171.1
Mxd4

Max dimerization protein 4

chr1_+_75236439 0.249 ENSMUST00000082158.6
ENSMUST00000055223.7
Dnajb2

DnaJ (Hsp40) homolog, subfamily B, member 2

chr13_-_54611274 0.247 ENSMUST00000049575.7
Cltb
clathrin, light polypeptide (Lcb)
chr7_-_51862216 0.247 ENSMUST00000169357.1
Fancf
Fanconi anemia, complementation group F
chr16_-_59632520 0.243 ENSMUST00000118438.1
Arl6
ADP-ribosylation factor-like 6
chr1_-_74284636 0.242 ENSMUST00000178235.1
ENSMUST00000006462.7
Aamp

angio-associated migratory protein

chr7_-_44816586 0.239 ENSMUST00000047356.8
Atf5
activating transcription factor 5
chr7_-_44892358 0.234 ENSMUST00000003049.6
Med25
mediator of RNA polymerase II transcription, subunit 25 homolog (yeast)
chr15_+_88819584 0.227 ENSMUST00000024042.3
Creld2
cysteine-rich with EGF-like domains 2
chr10_-_14705459 0.219 ENSMUST00000149485.1
ENSMUST00000154132.1
Vta1

Vps20-associated 1 homolog (S. cerevisiae)

chr6_-_99096196 0.218 ENSMUST00000175886.1
Foxp1
forkhead box P1
chr2_-_181365306 0.212 ENSMUST00000108808.1
ENSMUST00000170190.1
ENSMUST00000127988.1
Arfrp1


ADP-ribosylation factor related protein 1


chr7_+_44816364 0.211 ENSMUST00000118125.1
Il4i1
interleukin 4 induced 1
chr16_+_18248866 0.201 ENSMUST00000115640.1
ENSMUST00000140206.1
Trmt2a

TRM2 tRNA methyltransferase 2A

chr17_-_57011271 0.201 ENSMUST00000002733.6
Gtf2f1
general transcription factor IIF, polypeptide 1
chrX_-_101222426 0.196 ENSMUST00000120389.1
ENSMUST00000156473.1
ENSMUST00000077876.3
Snx12


sorting nexin 12


chr8_-_41417042 0.188 ENSMUST00000033999.6
Frg1
FSHD region gene 1
chr11_-_45944910 0.178 ENSMUST00000129820.1
Lsm11
U7 snRNP-specific Sm-like protein LSM11
chr5_-_149636164 0.176 ENSMUST00000076410.4
Hsph1
heat shock 105kDa/110kDa protein 1
chr8_+_69088646 0.175 ENSMUST00000006435.7
Atp6v1b2
ATPase, H+ transporting, lysosomal V1 subunit B2
chr12_+_4234023 0.174 ENSMUST00000179139.1
Ptrhd1
peptidyl-tRNA hydrolase domain containing 1
chrX_-_102252154 0.173 ENSMUST00000050551.3
Cited1
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chr15_+_80623499 0.171 ENSMUST00000043149.7
Grap2
GRB2-related adaptor protein 2
chr3_+_154597197 0.165 ENSMUST00000155385.1
ENSMUST00000029850.8
Cryz

crystallin, zeta

chr17_-_45686214 0.151 ENSMUST00000113523.2
Tmem63b
transmembrane protein 63b
chr9_-_71592265 0.150 ENSMUST00000169573.1
ENSMUST00000166843.1
ENSMUST00000163998.1
Myzap
Gcom1

myocardial zonula adherens protein
GRINL1A complex locus

chr9_+_38718263 0.144 ENSMUST00000001544.5
ENSMUST00000118144.1
Vwa5a

von Willebrand factor A domain containing 5A

chr16_+_18248961 0.140 ENSMUST00000100099.3
Trmt2a
TRM2 tRNA methyltransferase 2A
chr16_-_94370450 0.140 ENSMUST00000138514.1
Pigp
phosphatidylinositol glycan anchor biosynthesis, class P
chr4_+_40948401 0.139 ENSMUST00000030128.5
Chmp5
charged multivesicular body protein 5
chr5_-_139484420 0.137 ENSMUST00000150992.1
Zfand2a
zinc finger, AN1-type domain 2A
chr10_+_115569986 0.137 ENSMUST00000173620.1
A930009A15Rik
RIKEN cDNA A930009A15 gene
chr11_+_101082565 0.134 ENSMUST00000001806.3
ENSMUST00000107308.3
Coasy

Coenzyme A synthase

chr9_-_67049143 0.132 ENSMUST00000113687.1
ENSMUST00000113693.1
ENSMUST00000113701.1
ENSMUST00000034928.5
ENSMUST00000113685.3
ENSMUST00000030185.4
ENSMUST00000050905.9
ENSMUST00000113705.1
ENSMUST00000113697.1
ENSMUST00000113707.2
Tpm1









tropomyosin 1, alpha









chr4_+_100478806 0.131 ENSMUST00000133493.2
ENSMUST00000092730.3
ENSMUST00000106979.3
Ube2u


ubiquitin-conjugating enzyme E2U (putative)


chr16_+_20674111 0.127 ENSMUST00000151679.1
Eif4g1
eukaryotic translation initiation factor 4, gamma 1
chr15_-_78405824 0.125 ENSMUST00000058659.7
Tst
thiosulfate sulfurtransferase, mitochondrial
chr5_-_77115145 0.122 ENSMUST00000081964.5
Hopx
HOP homeobox
chr4_-_59783800 0.119 ENSMUST00000107526.1
ENSMUST00000095063.4
Inip

INTS3 and NABP interacting protein

chr2_-_172370506 0.117 ENSMUST00000109139.1
ENSMUST00000028997.7
ENSMUST00000109140.3
Aurka


aurora kinase A


chr11_-_96829959 0.116 ENSMUST00000081775.5
Nfe2l1
nuclear factor, erythroid derived 2,-like 1
chr1_-_131097535 0.115 ENSMUST00000016672.4
Mapkapk2
MAP kinase-activated protein kinase 2
chr13_+_23934434 0.114 ENSMUST00000072391.1
Hist1h2aa
histone cluster 1, H2aa
chr13_+_65512678 0.103 ENSMUST00000081471.2
Gm10139
predicted gene 10139
chr17_+_55959146 0.098 ENSMUST00000086869.4
Ccdc94
coiled-coil domain containing 94
chr17_-_83631892 0.098 ENSMUST00000051482.1
Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr2_-_26140468 0.088 ENSMUST00000133808.1
C330006A16Rik
RIKEN cDNA C330006A16 gene
chr5_+_98854434 0.086 ENSMUST00000031278.4
Bmp3
bone morphogenetic protein 3
chr17_-_45686120 0.071 ENSMUST00000143907.1
ENSMUST00000127065.1
Tmem63b

transmembrane protein 63b

chr18_+_53245618 0.068 ENSMUST00000165032.1
Snx24
sorting nexing 24
chr11_+_68968107 0.068 ENSMUST00000102606.3
ENSMUST00000018884.5
Slc25a35

solute carrier family 25, member 35

chr6_-_55175019 0.064 ENSMUST00000003569.5
Inmt
indolethylamine N-methyltransferase
chr7_+_83584910 0.059 ENSMUST00000039317.7
ENSMUST00000164944.1
Tmc3

transmembrane channel-like gene family 3

chr11_+_85353156 0.057 ENSMUST00000108061.1
ENSMUST00000108062.1
ENSMUST00000108056.1
ENSMUST00000138423.1
ENSMUST00000074875.4
ENSMUST00000092821.3
Bcas3





breast carcinoma amplified sequence 3





chr2_-_155514796 0.055 ENSMUST00000029131.4
Ggt7
gamma-glutamyltransferase 7
chr11_+_3202612 0.048 ENSMUST00000110049.1
Eif4enif1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr1_+_189728264 0.039 ENSMUST00000097442.2
Ptpn14
protein tyrosine phosphatase, non-receptor type 14
chr2_+_35622010 0.029 ENSMUST00000091010.5
Dab2ip
disabled 2 interacting protein
chr15_+_79108911 0.029 ENSMUST00000040320.8
Micall1
microtubule associated monooxygenase, calponin and LIM domain containing -like 1
chrX_-_57338598 0.019 ENSMUST00000033468.4
ENSMUST00000114736.1
Arhgef6

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

chr16_+_35983424 0.015 ENSMUST00000173555.1
Kpna1
karyopherin (importin) alpha 1
chr14_+_31641051 0.015 ENSMUST00000090147.6
Btd
biotinidase
chr9_-_83146601 0.014 ENSMUST00000162246.2
ENSMUST00000161796.2
Hmgn3

high mobility group nucleosomal binding domain 3

chr11_-_96829904 0.013 ENSMUST00000107657.1
Nfe2l1
nuclear factor, erythroid derived 2,-like 1
chr12_-_87443800 0.013 ENSMUST00000162961.1
Alkbh1
alkB, alkylation repair homolog 1 (E. coli)
chr10_-_14718191 0.010 ENSMUST00000020016.4
Gje1
gap junction protein, epsilon 1
chr9_-_110476637 0.006 ENSMUST00000111934.1
ENSMUST00000068025.6
Klhl18

kelch-like 18

chr1_+_163994866 0.002 ENSMUST00000111490.1
ENSMUST00000045694.7
Mettl18

methyltransferase like 18


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.0 GO:0002339 B cell selection(GO:0002339)
0.3 0.8 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of protein import into nucleus, translocation(GO:0033159) regulation of oligodendrocyte apoptotic process(GO:1900141) negative regulation of oligodendrocyte apoptotic process(GO:1900142) positive regulation of dendritic cell chemotaxis(GO:2000510)
0.3 1.0 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.2 0.6 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044)
0.2 0.5 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.2 0.5 GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.2 0.6 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 0.6 GO:0018201 peptidyl-glycine modification(GO:0018201)
0.1 0.4 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.1 1.5 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.1 0.4 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.1 0.5 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 0.7 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026) regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.1 0.5 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1 0.3 GO:1903490 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.1 0.5 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.1 0.4 GO:0061743 motor learning(GO:0061743)
0.1 0.3 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.1 0.3 GO:0071918 urea transmembrane transport(GO:0071918)
0.1 0.3 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.1 0.4 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.1 0.6 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.1 0.4 GO:0006177 GMP biosynthetic process(GO:0006177)
0.1 0.2 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.1 0.6 GO:0043416 regulation of skeletal muscle tissue regeneration(GO:0043416)
0.1 0.6 GO:0072615 interleukin-17 secretion(GO:0072615)
0.1 0.4 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 0.4 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.1 1.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.3 GO:1903542 negative regulation of exosomal secretion(GO:1903542)
0.1 0.5 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.1 1.3 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 0.2 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.1 0.4 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 0.4 GO:0055118 negative regulation of cardiac muscle contraction(GO:0055118) negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.1 0.2 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.1 0.4 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.3 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 1.0 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 0.9 GO:2000821 regulation of grooming behavior(GO:2000821)
0.0 0.3 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.0 0.2 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345) positive regulation of NK T cell activation(GO:0051135)
0.0 0.2 GO:0071105 response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
0.0 0.1 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.0 0.1 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 4.6 GO:0006413 translational initiation(GO:0006413)
0.0 0.5 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.0 0.3 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.8 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 0.8 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.2 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.8 GO:0010107 potassium ion import(GO:0010107)
0.0 0.3 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.4 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.4 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.2 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.1 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.0 0.3 GO:0009650 UV protection(GO:0009650)
0.0 0.9 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 0.1 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) macropinocytosis(GO:0044351)
0.0 0.3 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.2 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.0 0.4 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.0 0.2 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 0.1 GO:0006751 glutathione catabolic process(GO:0006751)
0.0 0.1 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.2 GO:0009072 aromatic amino acid family metabolic process(GO:0009072)
0.0 0.3 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.7 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 0.3 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.2 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.0 GO:0019815 B cell receptor complex(GO:0019815)
0.2 0.6 GO:0098835 presynaptic endosome(GO:0098830) presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.2 0.6 GO:0005577 fibrinogen complex(GO:0005577)
0.2 0.7 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.4 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.4 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.1 0.3 GO:0034457 Mpp10 complex(GO:0034457)
0.1 0.6 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 0.3 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 0.5 GO:0097433 dense body(GO:0097433)
0.1 1.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.5 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.8 GO:0000124 SAGA complex(GO:0000124)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.3 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.5 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.2 GO:0005683 U7 snRNP(GO:0005683)
0.0 0.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.3 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.4 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.4 GO:0032420 stereocilium(GO:0032420)
0.0 0.1 GO:0033503 HULC complex(GO:0033503)
0.0 0.9 GO:0016235 aggresome(GO:0016235)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.2 0.6 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.4 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 0.4 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 1.0 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 0.9 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.9 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 0.4 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 0.6 GO:0045340 mercury ion binding(GO:0045340)
0.1 1.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 0.4 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.2 GO:0071209 U7 snRNA binding(GO:0071209)
0.1 0.3 GO:0030519 snoRNP binding(GO:0030519)
0.1 0.3 GO:0051425 PTB domain binding(GO:0051425)
0.1 0.4 GO:1990188 euchromatin binding(GO:1990188)
0.1 0.5 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 0.5 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.1 4.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 0.2 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 0.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 1.2 GO:0048018 receptor agonist activity(GO:0048018)
0.1 0.3 GO:0004096 aminoacylase activity(GO:0004046) catalase activity(GO:0004096)
0.1 0.6 GO:1990446 U1 snRNP binding(GO:1990446)
0.1 0.4 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 1.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.3 GO:0015265 urea channel activity(GO:0015265)
0.1 0.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.3 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 0.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 1.0 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.1 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.0 0.4 GO:0048185 activin binding(GO:0048185)
0.0 0.2 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.3 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.3 GO:1903136 cuprous ion binding(GO:1903136)
0.0 0.8 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.3 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 1.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.2 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.0 0.5 GO:0070402 NADPH binding(GO:0070402)
0.0 0.1 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.5 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.9 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.0 0.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.8 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.6 GO:0042054 histone methyltransferase activity(GO:0042054)
0.0 0.2 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 0.3 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.3 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.2 GO:0070628 proteasome binding(GO:0070628)
0.0 0.1 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.6 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.9 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.5 PID_ARF_3PATHWAY Arf1 pathway
0.0 2.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.0 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.2 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.7 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 0.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.4 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.2 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.5 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.4 PID_AP1_PATHWAY AP-1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 0.8 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 0.4 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 0.9 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.0 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.4 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.4 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.3 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.4 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.4 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 1.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.3 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 1.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.5 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.3 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.4 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.3 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.2 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.1 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 0.3 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein