Motif ID: Foxo6

Z-value: 0.449


Transcription factors associated with Foxo6:

Gene SymbolEntrez IDGene Name
Foxo6 ENSMUSG00000052135.8 Foxo6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo6mm10_v2_chr4_-_120287349_120287349-0.324.1e-02Click!


Activity profile for motif Foxo6.

activity profile for motif Foxo6


Sorted Z-values histogram for motif Foxo6

Sorted Z-values for motif Foxo6



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_75111684 2.663 ENSMUST00000100542.3
 Ly6c2
lymphocyte antigen 6 complex, locus C2
chrY_-_6681243 1.628 ENSMUST00000115940.1
 Gm21719
predicted gene, 21719
chr1_-_184883218 1.385 ENSMUST00000048308.5
 C130074G19Rik
RIKEN cDNA C130074G19 gene
chr15_+_3270767 1.375 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr10_-_93310963 1.230 ENSMUST00000151153.1
 Elk3
ELK3, member of ETS oncogene family
chr2_-_84425258 1.220 ENSMUST00000074262.2
 Calcrl
calcitonin receptor-like
chr6_-_23248264 1.200 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr1_-_162898665 1.195 ENSMUST00000111510.1
ENSMUST00000045902.6
 Fmo2

flavin containing monooxygenase 2

chr12_-_113260217 1.117 ENSMUST00000178282.1
 Igha
immunoglobulin heavy constant alpha
chr11_-_12027958 1.030 ENSMUST00000109654.1
 Grb10
growth factor receptor bound protein 10
chr3_-_106167564 1.004 ENSMUST00000063062.8
 Chi3l3
chitinase 3-like 3
chr10_-_93311073 0.990 ENSMUST00000008542.5
 Elk3
ELK3, member of ETS oncogene family
chr1_+_74391479 0.962 ENSMUST00000027367.7
 Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr4_+_134510999 0.952 ENSMUST00000105866.2
 Aunip
aurora kinase A and ninein interacting protein
chr16_+_10812915 0.951 ENSMUST00000115822.1
 Gm11172
predicted gene 11172
chr2_-_67194695 0.930 ENSMUST00000147939.1
 Gm13598
predicted gene 13598
chr17_-_31277327 0.787 ENSMUST00000024832.7
 Rsph1
radial spoke head 1 homolog (Chlamydomonas)
chrX_-_163761323 0.729 ENSMUST00000059320.2
 Rnf138rt1
ring finger protein 138, retrogene 1
chr9_+_25089422 0.674 ENSMUST00000086238.2
 Gm10181
predicted gene 10181
chr14_-_47418407 0.642 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr3_-_51408925 0.573 ENSMUST00000038108.6
 Ndufc1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1
chr9_+_6168638 0.541 ENSMUST00000058692.7
 Pdgfd
platelet-derived growth factor, D polypeptide
chrX_-_8193387 0.470 ENSMUST00000143223.1
ENSMUST00000033509.8
 Ebp

phenylalkylamine Ca2+ antagonist (emopamil) binding protein

chr13_-_71963713 0.450 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr11_+_46235460 0.426 ENSMUST00000060185.2
 Fndc9
fibronectin type III domain containing 9
chr5_-_65391408 0.404 ENSMUST00000057885.6
 Rpl9
ribosomal protein L9
chr5_-_65391380 0.394 ENSMUST00000120094.1
ENSMUST00000118543.1
ENSMUST00000127874.1
 Rpl9


ribosomal protein L9


chr5_-_117389029 0.388 ENSMUST00000111953.1
ENSMUST00000086461.6
 Rfc5

replication factor C (activator 1) 5

chr5_+_110330697 0.384 ENSMUST00000112481.1
 Pole
polymerase (DNA directed), epsilon
chr17_-_57839233 0.354 ENSMUST00000095218.3
 Rpl7a-ps5
ribosomal protein L7A, pseudogene 5
chr14_-_50924626 0.336 ENSMUST00000160375.1
ENSMUST00000162177.1
ENSMUST00000159292.1
 Osgep


O-sialoglycoprotein endopeptidase


chr17_-_24696147 0.328 ENSMUST00000046839.8
 Gfer
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chr7_-_123369870 0.325 ENSMUST00000106442.2
ENSMUST00000098060.3
ENSMUST00000167309.1
 Arhgap17


Rho GTPase activating protein 17


chr18_+_5593566 0.315 ENSMUST00000160910.1
 Zeb1
zinc finger E-box binding homeobox 1
chr18_+_60212080 0.309 ENSMUST00000031549.5
 Gm4951
predicted gene 4951
chr15_-_81843699 0.304 ENSMUST00000092020.2
 Gm8444
predicted gene 8444
chr5_+_7179299 0.292 ENSMUST00000179460.1
 Tubb4b-ps1
tubulin, beta 4B class IVB, pseudogene 1
chr2_+_4718145 0.282 ENSMUST00000056914.6
 Bend7
BEN domain containing 7
chr2_-_155357392 0.276 ENSMUST00000165234.1
ENSMUST00000077626.6
 Pigu

phosphatidylinositol glycan anchor biosynthesis, class U

chr7_+_28808795 0.269 ENSMUST00000172529.1
 Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chrX_+_134585644 0.246 ENSMUST00000113211.1
 Rpl36a
ribosomal protein L36A
chr11_+_87853207 0.237 ENSMUST00000038196.6
 Mks1
Meckel syndrome, type 1
chr14_+_34170640 0.235 ENSMUST00000104925.3
 Rpl23a-ps3
ribosomal protein L23A, pseudogene 3
chr7_+_140881898 0.231 ENSMUST00000026560.7
 Psmd13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr12_-_102423741 0.220 ENSMUST00000110020.1
 Lgmn
legumain
chr16_+_44943737 0.218 ENSMUST00000114622.3
ENSMUST00000166731.1
 Cd200r3

CD200 receptor 3

chr12_-_84617326 0.214 ENSMUST00000021666.4
 Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr1_-_180245927 0.214 ENSMUST00000010753.7
 Psen2
presenilin 2
chr5_+_21186267 0.201 ENSMUST00000036031.8
 Gsap
gamma-secretase activating protein
chr1_+_51987139 0.201 ENSMUST00000168302.1
 Stat4
signal transducer and activator of transcription 4
chr5_-_99037035 0.183 ENSMUST00000031277.6
 Prkg2
protein kinase, cGMP-dependent, type II
chr7_+_19368498 0.179 ENSMUST00000132655.1
 Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr7_+_143052739 0.174 ENSMUST00000037941.9
 Cd81
CD81 antigen
chr7_+_28440927 0.168 ENSMUST00000078845.6
 Gmfg
glia maturation factor, gamma
chr1_+_110099295 0.166 ENSMUST00000134301.1
 Cdh7
cadherin 7, type 2
chr19_+_8892987 0.147 ENSMUST00000096249.5
 Ints5
integrator complex subunit 5
chr11_-_89639631 0.145 ENSMUST00000128717.1
 Ankfn1
ankyrin-repeat and fibronectin type III domain containing 1
chr5_+_65391497 0.145 ENSMUST00000031101.3
ENSMUST00000122026.1
 Lias

lipoic acid synthetase

chr1_+_171270321 0.145 ENSMUST00000064272.3
ENSMUST00000141999.1
ENSMUST00000111313.3
 B4galt3


UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3


chr10_+_79879614 0.143 ENSMUST00000006679.8
 Prtn3
proteinase 3
chrX_+_106920618 0.143 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr1_-_180245757 0.135 ENSMUST00000111104.1
 Psen2
presenilin 2
chr3_-_34351685 0.130 ENSMUST00000174114.1
 Gm20514
predicted gene 20514
chr17_+_25471564 0.129 ENSMUST00000025002.1
 Tekt4
tektin 4
chr7_+_64287665 0.125 ENSMUST00000032736.4
 Mtmr10
myotubularin related protein 10
chr9_-_22071345 0.114 ENSMUST00000179605.1
ENSMUST00000043922.6
 Zfp653

zinc finger protein 653

chr15_+_103453782 0.110 ENSMUST00000047405.7
 Nckap1l
NCK associated protein 1 like
chr4_-_139131058 0.110 ENSMUST00000143971.1
 Minos1
mitochondrial inner membrane organizing system 1
chr18_-_60648290 0.109 ENSMUST00000143275.2
 Synpo
synaptopodin
chr11_+_85832551 0.109 ENSMUST00000000095.6
 Tbx2
T-box 2
chr7_+_62476306 0.108 ENSMUST00000097132.3
 Atp5l-ps1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g, pseudogene 1
chr4_-_149099802 0.108 ENSMUST00000103217.4
 Pex14
peroxisomal biogenesis factor 14
chr8_+_83566671 0.066 ENSMUST00000036996.5
 Ndufb7
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7
chr2_-_30194112 0.064 ENSMUST00000113659.1
ENSMUST00000113660.1
 Ccbl1

cysteine conjugate-beta lyase 1

chr1_-_160077918 0.053 ENSMUST00000028061.3
 4930562F07Rik
RIKEN cDNA 4930562F07 gene
chr5_+_115605642 0.035 ENSMUST00000094427.3
 Gcn1l1
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
chr2_+_129593195 0.028 ENSMUST00000099113.3
ENSMUST00000103202.3
 Sirpa

signal-regulatory protein alpha

chr8_+_46986913 0.013 ENSMUST00000039840.7
ENSMUST00000119686.1
 Enpp6

ectonucleotide pyrophosphatase/phosphodiesterase 6

chr19_-_46969474 0.002 ENSMUST00000086961.7
 Nt5c2
5'-nucleotidase, cytosolic II

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.3 1.2 GO:0072592 oxygen metabolic process(GO:0072592)
0.2 1.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 0.5 GO:0035696 monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437)
0.1 0.4 GO:0045004 DNA replication proofreading(GO:0045004)
0.1 1.0 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 0.4 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.1 0.3 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1 1.1 GO:0002385 mucosal immune response(GO:0002385)
0.1 0.2 GO:0006624 vacuolar protein processing(GO:0006624)
0.0 0.1 GO:0009106 lipoate metabolic process(GO:0009106)
0.0 0.1 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.0 0.3 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.4 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.1 GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.0 0.1 GO:0098886 modification of dendritic spine(GO:0098886)
0.0 0.1 GO:0007521 muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596)
0.0 0.1 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.0 0.2 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.3 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 0.2 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.3 GO:0097421 liver regeneration(GO:0097421)
0.0 0.3 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 0.3 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.2 GO:0061009 common bile duct development(GO:0061009)
0.0 0.2 GO:2001225 hypotonic response(GO:0006971) cellular hypotonic response(GO:0071476) regulation of chloride transport(GO:2001225)
0.0 0.2 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 0.1 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.0 1.0 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.1 GO:0050957 equilibrioception(GO:0050957)
0.0 0.1 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.6 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.8 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.2 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.0 0.8 GO:0002181 cytoplasmic translation(GO:0002181)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.8 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.4 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 0.3 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 0.4 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.3 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.1 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.0 0.1 GO:0097444 spine apparatus(GO:0097444)
0.0 2.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.3 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 1.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.3 GO:0045120 pronucleus(GO:0045120)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.2 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 1.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 0.5 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.2 1.2 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.1 0.4 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.1 0.3 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.1 1.0 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.3 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 1.1 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 0.3 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.1 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.0 0.2 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.3 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.4 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
0.0 0.5 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.3 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 1.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.2 GO:1990459 virus receptor activity(GO:0001618) transferrin receptor binding(GO:1990459)
0.0 0.8 GO:0019843 rRNA binding(GO:0019843)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.0 PID_IGF1_PATHWAY IGF1 pathway
0.0 0.5 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.6 PID_AURORA_A_PATHWAY Aurora A signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 1.0 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 1.2 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.3 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.2 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.5 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)