Motif ID: Gata2_Gata1
Z-value: 0.516
![logo of Gata2](../logos/Gata2.png)
![logo of Gata1](../logos/Gata1.png)
Transcription factors associated with Gata2_Gata1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Gata1 | ENSMUSG00000031162.8 | Gata1 |
Gata2 | ENSMUSG00000015053.8 | Gata2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Gata2 | mm10_v2_chr6_+_88198656_88198675 | 0.17 | 3.0e-01 | Click! |
Gata1 | mm10_v2_chrX_-_7967817_7967910 | -0.08 | 6.4e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 4.8 | GO:0015671 | oxygen transport(GO:0015671) |
0.7 | 4.7 | GO:0019532 | oxalate transport(GO:0019532) |
0.4 | 2.8 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
0.3 | 1.7 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
0.3 | 2.0 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
0.3 | 1.0 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) |
0.3 | 1.5 | GO:1903609 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
0.3 | 1.1 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
0.3 | 0.8 | GO:0015920 | regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920) |
0.2 | 1.7 | GO:0001955 | blood vessel maturation(GO:0001955) |
0.2 | 0.7 | GO:0003199 | endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) |
0.2 | 0.7 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
0.2 | 1.5 | GO:0021913 | regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) |
0.2 | 0.6 | GO:0061030 | epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) |
0.2 | 3.6 | GO:0042541 | hemoglobin biosynthetic process(GO:0042541) |
0.2 | 0.6 | GO:0061153 | trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) |
0.2 | 0.7 | GO:0090472 | dibasic protein processing(GO:0090472) |
0.2 | 1.1 | GO:0002002 | regulation of angiotensin levels in blood(GO:0002002) |
0.2 | 0.5 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
0.1 | 0.4 | GO:0032650 | regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913) |
0.1 | 1.8 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
0.1 | 0.9 | GO:0006172 | ADP biosynthetic process(GO:0006172) |
0.1 | 0.9 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
0.1 | 1.0 | GO:0015862 | uridine transport(GO:0015862) |
0.1 | 1.0 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
0.1 | 1.1 | GO:0060842 | arterial endothelial cell differentiation(GO:0060842) |
0.1 | 1.0 | GO:2000857 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
0.1 | 0.2 | GO:0014738 | regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900) |
0.1 | 0.7 | GO:0033632 | regulation of cell-cell adhesion mediated by integrin(GO:0033632) |
0.1 | 0.3 | GO:0071918 | urea transmembrane transport(GO:0071918) |
0.1 | 0.7 | GO:0001980 | regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980) |
0.1 | 0.3 | GO:0044333 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
0.1 | 1.0 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
0.1 | 0.4 | GO:0036482 | neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384) |
0.1 | 1.2 | GO:0070995 | toxin metabolic process(GO:0009404) NADPH oxidation(GO:0070995) |
0.1 | 3.8 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
0.1 | 0.5 | GO:0002317 | plasma cell differentiation(GO:0002317) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
0.1 | 0.6 | GO:1903025 | regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025) |
0.1 | 0.5 | GO:0006586 | tryptophan metabolic process(GO:0006568) indolalkylamine metabolic process(GO:0006586) |
0.1 | 0.7 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
0.0 | 1.1 | GO:0048268 | clathrin coat assembly(GO:0048268) |
0.0 | 0.2 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
0.0 | 0.3 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
0.0 | 0.4 | GO:0061032 | visceral serous pericardium development(GO:0061032) |
0.0 | 0.1 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
0.0 | 0.6 | GO:0050901 | leukocyte tethering or rolling(GO:0050901) |
0.0 | 0.5 | GO:0044539 | long-chain fatty acid import(GO:0044539) |
0.0 | 0.9 | GO:0035855 | megakaryocyte development(GO:0035855) |
0.0 | 0.1 | GO:0009957 | epidermal cell fate specification(GO:0009957) |
0.0 | 0.1 | GO:0051933 | amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935) |
0.0 | 0.2 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
0.0 | 0.2 | GO:0032261 | purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264) |
0.0 | 3.7 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
0.0 | 0.3 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
0.0 | 0.2 | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus(GO:0002862) |
0.0 | 1.5 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
0.0 | 0.2 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
0.0 | 0.5 | GO:0036342 | post-anal tail morphogenesis(GO:0036342) |
0.0 | 0.0 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
0.0 | 0.1 | GO:0032308 | positive regulation of prostaglandin secretion(GO:0032308) |
0.0 | 0.6 | GO:0071158 | positive regulation of cell cycle arrest(GO:0071158) |
0.0 | 1.1 | GO:0030168 | platelet activation(GO:0030168) |
0.0 | 0.0 | GO:0045852 | pH elevation(GO:0045852) intracellular pH elevation(GO:0051454) |
0.0 | 0.1 | GO:0050908 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) |
0.0 | 0.4 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
0.0 | 0.6 | GO:0042982 | amyloid precursor protein metabolic process(GO:0042982) |
0.0 | 1.1 | GO:0031532 | actin cytoskeleton reorganization(GO:0031532) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 4.8 | GO:0005833 | hemoglobin complex(GO:0005833) |
0.3 | 0.8 | GO:0043512 | inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512) |
0.2 | 1.1 | GO:0033093 | Weibel-Palade body(GO:0033093) |
0.2 | 0.7 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
0.2 | 2.6 | GO:0005614 | interstitial matrix(GO:0005614) |
0.1 | 1.7 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
0.1 | 2.8 | GO:0097228 | sperm principal piece(GO:0097228) |
0.1 | 1.5 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
0.1 | 0.9 | GO:0001520 | outer dense fiber(GO:0001520) |
0.1 | 0.6 | GO:0001674 | female germ cell nucleus(GO:0001674) |
0.1 | 0.6 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
0.0 | 0.4 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
0.0 | 0.7 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
0.0 | 0.4 | GO:0045298 | tubulin complex(GO:0045298) |
0.0 | 3.8 | GO:0016605 | PML body(GO:0016605) |
0.0 | 0.4 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
0.0 | 1.1 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
0.0 | 0.1 | GO:1990393 | 3M complex(GO:1990393) |
0.0 | 6.2 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
0.0 | 0.5 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
0.0 | 0.4 | GO:0031528 | microvillus membrane(GO:0031528) |
0.0 | 0.7 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
0.0 | 0.7 | GO:0002102 | podosome(GO:0002102) |
0.0 | 2.4 | GO:0030496 | midbody(GO:0030496) |
0.0 | 1.5 | GO:0016363 | nuclear matrix(GO:0016363) |
0.0 | 0.0 | GO:0071438 | invadopodium membrane(GO:0071438) |
0.0 | 0.2 | GO:0005839 | proteasome core complex(GO:0005839) |
0.0 | 2.8 | GO:0005759 | mitochondrial matrix(GO:0005759) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 4.8 | GO:0005344 | oxygen transporter activity(GO:0005344) |
0.9 | 2.8 | GO:0016748 | succinyltransferase activity(GO:0016748) |
0.6 | 2.8 | GO:0008865 | fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
0.4 | 4.7 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
0.3 | 1.0 | GO:0004875 | complement receptor activity(GO:0004875) |
0.3 | 1.5 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
0.3 | 2.0 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
0.3 | 0.8 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
0.2 | 0.7 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
0.2 | 1.0 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
0.2 | 1.2 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
0.2 | 0.7 | GO:0030172 | troponin C binding(GO:0030172) |
0.2 | 0.7 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
0.2 | 0.5 | GO:0043758 | acetate-CoA ligase (ADP-forming) activity(GO:0043758) |
0.2 | 0.5 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
0.1 | 2.6 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
0.1 | 3.6 | GO:0001968 | fibronectin binding(GO:0001968) |
0.1 | 1.7 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
0.1 | 1.1 | GO:0019865 | immunoglobulin binding(GO:0019865) |
0.1 | 0.7 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
0.1 | 0.8 | GO:0034711 | inhibin binding(GO:0034711) |
0.1 | 0.2 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
0.1 | 0.2 | GO:0004517 | nitric-oxide synthase activity(GO:0004517) |
0.1 | 0.7 | GO:0070700 | BMP receptor binding(GO:0070700) |
0.1 | 0.2 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
0.1 | 0.3 | GO:0015265 | urea channel activity(GO:0015265) |
0.1 | 0.7 | GO:0048406 | nerve growth factor binding(GO:0048406) |
0.1 | 0.3 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
0.1 | 1.6 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
0.0 | 0.7 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
0.0 | 0.4 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
0.0 | 0.1 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
0.0 | 0.9 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
0.0 | 1.0 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
0.0 | 1.0 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.0 | 0.2 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
0.0 | 0.4 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
0.0 | 1.8 | GO:0046875 | ephrin receptor binding(GO:0046875) |
0.0 | 0.0 | GO:0070051 | fibrinogen binding(GO:0070051) |
0.0 | 0.1 | GO:0005119 | smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158) |
0.0 | 0.6 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
0.0 | 0.2 | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) |
0.0 | 0.9 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
0.0 | 0.3 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.0 | 0.2 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
0.0 | 0.5 | GO:0005272 | sodium channel activity(GO:0005272) |
0.0 | 0.1 | GO:2001069 | glycogen binding(GO:2001069) |
0.0 | 1.9 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
0.0 | 0.1 | GO:0033691 | sialic acid binding(GO:0033691) |
0.0 | 0.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.0 | 0.4 | GO:0008307 | structural constituent of muscle(GO:0008307) |
0.0 | 0.2 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
0.0 | 0.1 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 4.4 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
0.0 | 1.5 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
0.0 | 2.0 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
0.0 | 1.6 | PID_ENDOTHELIN_PATHWAY | Endothelins |
0.0 | 1.0 | PID_ARF6_PATHWAY | Arf6 signaling events |
0.0 | 1.1 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
0.0 | 1.9 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.0 | 0.1 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 0.8 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
0.1 | 2.2 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
0.1 | 1.1 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
0.1 | 1.1 | REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
0.1 | 0.7 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
0.1 | 2.8 | REACTOME_GLUCOSE_TRANSPORT | Genes involved in Glucose transport |
0.1 | 1.5 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
0.1 | 0.8 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
0.1 | 1.0 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
0.0 | 4.9 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
0.0 | 0.7 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
0.0 | 1.2 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
0.0 | 1.1 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
0.0 | 0.5 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
0.0 | 0.9 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
0.0 | 0.4 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
0.0 | 0.2 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
0.0 | 1.4 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
0.0 | 0.6 | REACTOME_REGULATION_OF_KIT_SIGNALING | Genes involved in Regulation of KIT signaling |
0.0 | 0.3 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
0.0 | 0.4 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
0.0 | 1.0 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
0.0 | 1.0 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
0.0 | 0.5 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
0.0 | 0.5 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
0.0 | 0.3 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
0.0 | 0.6 | REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
0.0 | 0.2 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
0.0 | 0.2 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
0.0 | 0.1 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
0.0 | 0.2 | REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |