Motif ID: Gata2_Gata1

Z-value: 0.516

Transcription factors associated with Gata2_Gata1:

Gene SymbolEntrez IDGene Name
Gata1 ENSMUSG00000031162.8 Gata1
Gata2 ENSMUSG00000015053.8 Gata2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gata2mm10_v2_chr6_+_88198656_881986750.173.0e-01Click!
Gata1mm10_v2_chrX_-_7967817_7967910-0.086.4e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Gata2_Gata1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_150547375 2.824 ENSMUST00000066337.6
ENSMUST00000112715.1
Alas2

aminolevulinic acid synthase 2, erythroid

chr11_+_32276400 2.664 ENSMUST00000020531.2
Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr7_+_119900099 2.354 ENSMUST00000106516.1
Lyrm1
LYR motif containing 1
chr13_-_91388079 2.320 ENSMUST00000181054.1
A830009L08Rik
RIKEN cDNA A830009L08 gene
chr10_-_62342674 2.308 ENSMUST00000143179.1
ENSMUST00000130422.1
Hk1

hexokinase 1

chr4_-_14621805 2.230 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr9_-_77251829 2.130 ENSMUST00000184322.1
ENSMUST00000184316.1
Mlip

muscular LMNA-interacting protein

chr11_+_32276893 2.101 ENSMUST00000145569.1
Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr16_+_45093611 1.942 ENSMUST00000099498.2
Ccdc80
coiled-coil domain containing 80
chr8_+_84701430 1.722 ENSMUST00000037165.4
Lyl1
lymphoblastomic leukemia 1
chr1_+_45311538 1.704 ENSMUST00000087883.6
Col3a1
collagen, type III, alpha 1
chr16_+_45094036 1.690 ENSMUST00000061050.5
Ccdc80
coiled-coil domain containing 80
chr9_-_77251871 1.640 ENSMUST00000183955.1
Mlip
muscular LMNA-interacting protein
chr4_+_13751297 1.539 ENSMUST00000105566.2
Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr6_+_30541582 1.463 ENSMUST00000096066.4
Cpa2
carboxypeptidase A2, pancreatic
chr7_-_139582790 1.453 ENSMUST00000106095.2
Nkx6-2
NK6 homeobox 2
chr4_-_14621669 1.363 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr3_-_84479418 1.250 ENSMUST00000091002.1
Fhdc1
FH2 domain containing 1
chr1_-_162866502 1.177 ENSMUST00000046049.7
Fmo1
flavin containing monooxygenase 1
chr6_+_17306335 1.157 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
Cav1



caveolin 1, caveolae protein



chr3_-_20242173 1.143 ENSMUST00000001921.1
Cpa3
carboxypeptidase A3, mast cell
chr4_-_14621494 1.109 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr10_+_116177351 1.102 ENSMUST00000155606.1
ENSMUST00000128399.1
Ptprr

protein tyrosine phosphatase, receptor type, R

chr6_+_125552948 1.094 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
Vwf


Von Willebrand factor homolog


chr11_+_90030295 1.092 ENSMUST00000092788.3
Tmem100
transmembrane protein 100
chr6_-_122856151 1.012 ENSMUST00000042081.8
C3ar1
complement component 3a receptor 1
chr17_-_45593626 0.981 ENSMUST00000163905.1
ENSMUST00000167692.1
Slc29a1

solute carrier family 29 (nucleoside transporters), member 1

chr6_+_17463927 0.967 ENSMUST00000115442.1
Met
met proto-oncogene
chr11_+_67586520 0.922 ENSMUST00000108682.2
Gas7
growth arrest specific 7
chr9_-_32541589 0.881 ENSMUST00000016231.7
Fli1
Friend leukemia integration 1
chr2_+_32621750 0.856 ENSMUST00000113278.2
Ak1
adenylate kinase 1
chr2_-_36104060 0.854 ENSMUST00000112961.3
ENSMUST00000112966.3
Lhx6

LIM homeobox protein 6

chr19_+_38264761 0.834 ENSMUST00000087252.5
Lgi1
leucine-rich repeat LGI family, member 1
chr13_+_42681513 0.818 ENSMUST00000149235.1
Phactr1
phosphatase and actin regulator 1
chr2_-_33086366 0.804 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr5_-_125294107 0.794 ENSMUST00000127148.1
Scarb1
scavenger receptor class B, member 1
chr1_+_75507077 0.788 ENSMUST00000037330.4
Inha
inhibin alpha
chr13_+_42709482 0.782 ENSMUST00000066928.5
ENSMUST00000148891.1
Phactr1

phosphatase and actin regulator 1

chr6_-_136941887 0.771 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr2_-_33087169 0.764 ENSMUST00000102810.3
Garnl3
GTPase activating RANGAP domain-like 3
chr3_+_7366598 0.750 ENSMUST00000028999.6
Pkia
protein kinase inhibitor, alpha
chr13_+_38345716 0.744 ENSMUST00000171970.1
Bmp6
bone morphogenetic protein 6
chr14_-_64455903 0.740 ENSMUST00000067927.7
Msra
methionine sulfoxide reductase A
chr11_+_5009515 0.738 ENSMUST00000101613.2
Ap1b1
adaptor protein complex AP-1, beta 1 subunit
chr19_-_7019423 0.685 ENSMUST00000040772.8
Fermt3
fermitin family homolog 3 (Drosophila)
chr7_-_80403315 0.684 ENSMUST00000147150.1
Furin
furin (paired basic amino acid cleaving enzyme)
chr16_-_95459245 0.679 ENSMUST00000176345.1
ENSMUST00000121809.2
ENSMUST00000118113.1
ENSMUST00000122199.1
Erg



avian erythroblastosis virus E-26 (v-ets) oncogene related



chr3_-_59262825 0.656 ENSMUST00000050360.7
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr6_-_136941494 0.647 ENSMUST00000111892.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr3_+_135825788 0.636 ENSMUST00000167390.1
Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr6_-_136941694 0.627 ENSMUST00000032344.5
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr6_+_86078070 0.622 ENSMUST00000032069.5
Add2
adducin 2 (beta)
chr12_-_25096080 0.621 ENSMUST00000020974.6
Id2
inhibitor of DNA binding 2
chr3_-_154330543 0.606 ENSMUST00000184966.1
ENSMUST00000177846.2
Lhx8

LIM homeobox protein 8

chr1_-_132367879 0.604 ENSMUST00000142609.1
Tmcc2
transmembrane and coiled-coil domains 2
chr14_-_52279238 0.600 ENSMUST00000167116.1
ENSMUST00000100631.4
Rab2b

RAB2B, member RAS oncogene family

chr18_+_76059458 0.599 ENSMUST00000167921.1
Zbtb7c
zinc finger and BTB domain containing 7C
chr2_+_169633517 0.569 ENSMUST00000109157.1
Tshz2
teashirt zinc finger family member 2
chrX_+_99975570 0.568 ENSMUST00000113779.1
ENSMUST00000113776.1
ENSMUST00000113775.1
ENSMUST00000113780.1
ENSMUST00000113778.1
ENSMUST00000113781.1
ENSMUST00000113783.1
ENSMUST00000071453.2
ENSMUST00000113777.1
Eda








ectodysplasin-A








chr13_-_18031616 0.563 ENSMUST00000099736.2
Vdac3-ps1
voltage-dependent anion channel 3, pseudogene 1
chr10_+_61648552 0.558 ENSMUST00000020286.6
Ppa1
pyrophosphatase (inorganic) 1
chr10_-_62327757 0.523 ENSMUST00000139228.1
Hk1
hexokinase 1
chrX_-_107403295 0.523 ENSMUST00000033591.5
Itm2a
integral membrane protein 2A
chr2_+_70474923 0.496 ENSMUST00000100043.2
Sp5
trans-acting transcription factor 5
chr10_+_80019621 0.490 ENSMUST00000043311.6
Hmha1
histocompatibility (minor) HA-1
chr19_-_37176055 0.477 ENSMUST00000142973.1
ENSMUST00000154376.1
Cpeb3

cytoplasmic polyadenylation element binding protein 3

chr8_+_46490968 0.461 ENSMUST00000110372.1
ENSMUST00000130563.1
Acsl1

acyl-CoA synthetase long-chain family member 1

chr10_-_115185015 0.455 ENSMUST00000006949.8
Tph2
tryptophan hydroxylase 2
chr13_-_116309639 0.446 ENSMUST00000036060.6
Isl1
ISL1 transcription factor, LIM/homeodomain
chr5_-_121836810 0.437 ENSMUST00000118580.1
ENSMUST00000040308.7
Sh2b3

SH2B adaptor protein 3

chr9_-_21963568 0.419 ENSMUST00000006397.5
Epor
erythropoietin receptor
chr2_+_97467657 0.407 ENSMUST00000059049.7
Lrrc4c
leucine rich repeat containing 4C
chr2_+_169632996 0.406 ENSMUST00000109159.2
Tshz2
teashirt zinc finger family member 2
chr11_-_61453992 0.403 ENSMUST00000060255.7
ENSMUST00000054927.7
ENSMUST00000102661.3
Rnf112


ring finger protein 112


chr11_+_4986824 0.402 ENSMUST00000009234.9
ENSMUST00000109897.1
Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr4_-_138326234 0.396 ENSMUST00000105817.3
ENSMUST00000030536.6
Pink1

PTEN induced putative kinase 1

chr2_+_26583858 0.395 ENSMUST00000100290.5
ENSMUST00000102907.5
Egfl7

EGF-like domain 7

chr2_-_25224653 0.390 ENSMUST00000043584.4
Tubb4b
tubulin, beta 4B class IVB
chr3_+_135826075 0.381 ENSMUST00000029810.5
Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr3_+_90080442 0.379 ENSMUST00000127955.1
Tpm3
tropomyosin 3, gamma
chr11_+_87760533 0.372 ENSMUST00000039627.5
ENSMUST00000100644.3
Bzrap1

benzodiazepine receptor associated protein 1

chr7_-_4522427 0.366 ENSMUST00000098859.3
Tnni3
troponin I, cardiac 3
chr10_+_90576252 0.345 ENSMUST00000182427.1
ENSMUST00000182053.1
ENSMUST00000182113.1
Anks1b


ankyrin repeat and sterile alpha motif domain containing 1B


chr10_+_90576570 0.341 ENSMUST00000182786.1
ENSMUST00000182600.1
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr6_+_15185203 0.337 ENSMUST00000154448.1
Foxp2
forkhead box P2
chr18_-_78123324 0.333 ENSMUST00000160292.1
ENSMUST00000091813.5
Slc14a1

solute carrier family 14 (urea transporter), member 1

chr6_+_17743582 0.332 ENSMUST00000000674.6
ENSMUST00000077080.2
St7

suppression of tumorigenicity 7

chr6_+_17306415 0.323 ENSMUST00000150901.1
Cav1
caveolin 1, caveolae protein
chr10_+_90576777 0.311 ENSMUST00000183136.1
ENSMUST00000182595.1
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr19_-_42202150 0.306 ENSMUST00000018966.7
Sfrp5
secreted frizzled-related sequence protein 5
chr10_+_90576708 0.304 ENSMUST00000182430.1
ENSMUST00000182960.1
ENSMUST00000182045.1
ENSMUST00000182083.1
Anks1b



ankyrin repeat and sterile alpha motif domain containing 1B



chr2_+_103957976 0.301 ENSMUST00000156813.1
ENSMUST00000170926.1
Lmo2

LIM domain only 2

chrX_+_93675088 0.299 ENSMUST00000045898.3
Pcyt1b
phosphate cytidylyltransferase 1, choline, beta isoform
chr1_+_75450699 0.290 ENSMUST00000037708.9
Asic4
acid-sensing (proton-gated) ion channel family member 4
chr14_+_55560904 0.289 ENSMUST00000072530.4
ENSMUST00000128490.1
Dcaf11

DDB1 and CUL4 associated factor 11

chr7_-_4522794 0.288 ENSMUST00000140424.1
Tnni3
troponin I, cardiac 3
chr17_+_36869567 0.284 ENSMUST00000060524.9
Trim10
tripartite motif-containing 10
chr11_+_118428493 0.284 ENSMUST00000017590.2
C1qtnf1
C1q and tumor necrosis factor related protein 1
chr10_+_90576678 0.279 ENSMUST00000182284.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr3_-_88000350 0.260 ENSMUST00000090971.5
Bcan
brevican
chr7_+_110627650 0.255 ENSMUST00000033054.8
Adm
adrenomedullin
chr14_-_55560340 0.251 ENSMUST00000066106.3
A730061H03Rik
RIKEN cDNA A730061H03 gene
chr3_+_106113229 0.249 ENSMUST00000079132.5
ENSMUST00000139086.1
Chia

chitinase, acidic

chr3_+_96596628 0.246 ENSMUST00000058943.7
Ankrd34a
ankyrin repeat domain 34A
chr17_+_71204647 0.244 ENSMUST00000126681.1
Lpin2
lipin 2
chr5_+_24364804 0.232 ENSMUST00000030834.4
ENSMUST00000115090.1
Nos3

nitric oxide synthase 3, endothelial cell

chr7_+_110773658 0.228 ENSMUST00000143786.1
Ampd3
adenosine monophosphate deaminase 3
chr3_-_94886945 0.227 ENSMUST00000005923.6
Psmb4
proteasome (prosome, macropain) subunit, beta type 4
chr12_-_10900296 0.225 ENSMUST00000085735.2
Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr1_+_75450436 0.223 ENSMUST00000113577.1
Asic4
acid-sensing (proton-gated) ion channel family member 4
chr7_-_44892358 0.219 ENSMUST00000003049.6
Med25
mediator of RNA polymerase II transcription, subunit 25 homolog (yeast)
chr14_+_55560480 0.218 ENSMUST00000121622.1
ENSMUST00000143431.1
ENSMUST00000150481.1
Dcaf11


DDB1 and CUL4 associated factor 11


chr15_-_77153772 0.217 ENSMUST00000166610.1
ENSMUST00000111581.2
Rbfox2

RNA binding protein, fox-1 homolog (C. elegans) 2

chr10_+_5593718 0.198 ENSMUST00000051809.8
Myct1
myc target 1
chr16_-_23520579 0.189 ENSMUST00000089883.5
Masp1
mannan-binding lectin serine peptidase 1
chr4_+_43493345 0.185 ENSMUST00000030181.5
ENSMUST00000107922.2
Ccdc107

coiled-coil domain containing 107

chrX_+_10485121 0.178 ENSMUST00000076354.6
ENSMUST00000115526.1
Tspan7

tetraspanin 7

chr10_+_90576872 0.177 ENSMUST00000182550.1
ENSMUST00000099364.5
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr5_-_121836852 0.162 ENSMUST00000086310.1
Sh2b3
SH2B adaptor protein 3
chr3_+_133338936 0.162 ENSMUST00000150386.1
ENSMUST00000125858.1
Ppa2

pyrophosphatase (inorganic) 2

chr14_+_55561060 0.161 ENSMUST00000117701.1
Dcaf11
DDB1 and CUL4 associated factor 11
chr17_-_33713372 0.149 ENSMUST00000173392.1
March2
membrane-associated ring finger (C3HC4) 2
chr15_-_83170498 0.149 ENSMUST00000162178.1
Cyb5r3
cytochrome b5 reductase 3
chr1_+_75549581 0.145 ENSMUST00000154101.1
Slc4a3
solute carrier family 4 (anion exchanger), member 3
chr1_+_172341197 0.142 ENSMUST00000056136.3
Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr11_+_110399115 0.129 ENSMUST00000020949.5
ENSMUST00000100260.1
Map2k6

mitogen-activated protein kinase kinase 6

chr3_+_79884496 0.126 ENSMUST00000118853.1
Fam198b
family with sequence similarity 198, member B
chr11_+_97801917 0.122 ENSMUST00000127033.2
Lasp1
LIM and SH3 protein 1
chr4_+_134864536 0.120 ENSMUST00000030627.7
Rhd
Rh blood group, D antigen
chr2_-_52558539 0.111 ENSMUST00000102760.3
ENSMUST00000102761.2
Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr3_+_89136572 0.107 ENSMUST00000107482.3
ENSMUST00000127058.1
Pklr

pyruvate kinase liver and red blood cell

chr3_+_89136133 0.105 ENSMUST00000047111.6
Pklr
pyruvate kinase liver and red blood cell
chr7_-_100662315 0.098 ENSMUST00000151123.1
ENSMUST00000107047.2
Plekhb1

pleckstrin homology domain containing, family B (evectins) member 1

chr9_+_44069421 0.085 ENSMUST00000114830.2
Usp2
ubiquitin specific peptidase 2
chr19_+_10015016 0.084 ENSMUST00000137637.1
ENSMUST00000149967.1
Rab3il1

RAB3A interacting protein (rabin3)-like 1

chr17_+_46650328 0.081 ENSMUST00000043464.7
Cul7
cullin 7
chr3_-_146839365 0.076 ENSMUST00000084614.3
Gm10288
predicted gene 10288
chr3_+_79884576 0.075 ENSMUST00000145992.1
Fam198b
family with sequence similarity 198, member B
chr1_+_180851131 0.075 ENSMUST00000038091.6
Sde2
SDE2 telomere maintenance homolog (S. pombe)
chr19_+_24875679 0.073 ENSMUST00000073080.5
Gm10053
predicted gene 10053
chr8_+_34115030 0.073 ENSMUST00000095345.3
Mboat4
membrane bound O-acyltransferase domain containing 4
chr4_+_117096049 0.072 ENSMUST00000030443.5
Ptch2
patched homolog 2
chrX_-_73869804 0.070 ENSMUST00000066576.5
ENSMUST00000114430.1
L1cam

L1 cell adhesion molecule

chr13_+_98263242 0.066 ENSMUST00000022164.8
ENSMUST00000150352.1
Ankra2

ankyrin repeat, family A (RFXANK-like), 2

chr10_+_53337686 0.066 ENSMUST00000046221.6
ENSMUST00000163319.1
Pln

phospholamban

chr3_+_90072641 0.065 ENSMUST00000121503.1
ENSMUST00000119570.1
ENSMUST00000062193.9
Tpm3


tropomyosin 3, gamma


chr5_-_13121766 0.063 ENSMUST00000078246.4
Gm10108
predicted pseudogene 10108
chr2_-_77170592 0.063 ENSMUST00000164114.2
ENSMUST00000049544.7
Ccdc141

coiled-coil domain containing 141

chrX_-_7572843 0.060 ENSMUST00000132788.1
Ppp1r3f
protein phosphatase 1, regulatory (inhibitor) subunit 3F
chr8_+_107436355 0.052 ENSMUST00000166615.1
Wwp2
WW domain containing E3 ubiquitin protein ligase 2
chr4_-_46404224 0.051 ENSMUST00000107764.2
Hemgn
hemogen
chr9_+_109832998 0.049 ENSMUST00000119376.1
ENSMUST00000122343.1
Nme6

NME/NM23 nucleoside diphosphate kinase 6

chr19_+_58670358 0.047 ENSMUST00000057270.7
Pnlip
pancreatic lipase
chr15_-_83170168 0.042 ENSMUST00000162834.1
Cyb5r3
cytochrome b5 reductase 3
chr17_-_85688252 0.039 ENSMUST00000024947.7
ENSMUST00000163568.2
Six2

sine oculis-related homeobox 2

chr6_-_55681257 0.039 ENSMUST00000044767.8
Neurod6
neurogenic differentiation 6
chr3_+_79885930 0.037 ENSMUST00000029567.8
Fam198b
family with sequence similarity 198, member B
chr11_-_102469839 0.030 ENSMUST00000103086.3
Itga2b
integrin alpha 2b
chr10_-_13388830 0.021 ENSMUST00000079698.5
Phactr2
phosphatase and actin regulator 2
chr4_-_59438633 0.018 ENSMUST00000040166.7
ENSMUST00000107544.1
Susd1

sushi domain containing 1

chr5_+_42067960 0.018 ENSMUST00000087332.4
Gm16223
predicted gene 16223
chr15_+_76904070 0.017 ENSMUST00000004072.8
Rpl8
ribosomal protein L8
chr2_+_112284561 0.013 ENSMUST00000053666.7
Slc12a6
solute carrier family 12, member 6
chrX_-_134111852 0.012 ENSMUST00000033610.6
Nox1
NADPH oxidase 1
chr11_+_118428203 0.007 ENSMUST00000124861.1
C1qtnf1
C1q and tumor necrosis factor related protein 1
chr8_+_105636509 0.005 ENSMUST00000005841.9
Ctcf
CCCTC-binding factor
chr15_+_80623499 0.004 ENSMUST00000043149.7
Grap2
GRB2-related adaptor protein 2

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.8 GO:0015671 oxygen transport(GO:0015671)
0.7 4.7 GO:0019532 oxalate transport(GO:0019532)
0.4 2.8 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.3 1.7 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.3 2.0 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.3 1.0 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.3 1.5 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.3 1.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.3 0.8 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
0.2 1.7 GO:0001955 blood vessel maturation(GO:0001955)
0.2 0.7 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.2 0.7 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.2 1.5 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.2 0.6 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.2 3.6 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.2 0.6 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.2 0.7 GO:0090472 dibasic protein processing(GO:0090472)
0.2 1.1 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.2 0.5 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1 0.4 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.1 1.8 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 0.9 GO:0006172 ADP biosynthetic process(GO:0006172)
0.1 0.9 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 1.0 GO:0015862 uridine transport(GO:0015862)
0.1 1.0 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 1.1 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.1 1.0 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.1 0.2 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.1 0.7 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.1 0.3 GO:0071918 urea transmembrane transport(GO:0071918)
0.1 0.7 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.1 0.3 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.1 1.0 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 0.4 GO:0036482 neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384)
0.1 1.2 GO:0070995 toxin metabolic process(GO:0009404) NADPH oxidation(GO:0070995)
0.1 3.8 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.1 0.5 GO:0002317 plasma cell differentiation(GO:0002317) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.1 0.6 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.1 0.5 GO:0006586 tryptophan metabolic process(GO:0006568) indolalkylamine metabolic process(GO:0006586)
0.1 0.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 1.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.2 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.3 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.4 GO:0061032 visceral serous pericardium development(GO:0061032)
0.0 0.1 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.0 0.6 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.0 0.5 GO:0044539 long-chain fatty acid import(GO:0044539)
0.0 0.9 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.1 GO:0009957 epidermal cell fate specification(GO:0009957)
0.0 0.1 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.0 0.2 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.2 GO:0032261 purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264)
0.0 3.7 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.3 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.2 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 1.5 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.5 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 0.0 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.1 GO:0032308 positive regulation of prostaglandin secretion(GO:0032308)
0.0 0.6 GO:0071158 positive regulation of cell cycle arrest(GO:0071158)
0.0 1.1 GO:0030168 platelet activation(GO:0030168)
0.0 0.0 GO:0045852 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.0 0.1 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.4 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.6 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 1.1 GO:0031532 actin cytoskeleton reorganization(GO:0031532)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.8 GO:0005833 hemoglobin complex(GO:0005833)
0.3 0.8 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
0.2 1.1 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 0.7 GO:1990584 cardiac Troponin complex(GO:1990584)
0.2 2.6 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.7 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 2.8 GO:0097228 sperm principal piece(GO:0097228)
0.1 1.5 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.9 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.6 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 0.6 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.4 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.7 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.4 GO:0045298 tubulin complex(GO:0045298)
0.0 3.8 GO:0016605 PML body(GO:0016605)
0.0 0.4 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 1.1 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.1 GO:1990393 3M complex(GO:1990393)
0.0 6.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.4 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.7 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.7 GO:0002102 podosome(GO:0002102)
0.0 2.4 GO:0030496 midbody(GO:0030496)
0.0 1.5 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.0 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.2 GO:0005839 proteasome core complex(GO:0005839)
0.0 2.8 GO:0005759 mitochondrial matrix(GO:0005759)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.8 GO:0005344 oxygen transporter activity(GO:0005344)
0.9 2.8 GO:0016748 succinyltransferase activity(GO:0016748)
0.6 2.8 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.4 4.7 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.3 1.0 GO:0004875 complement receptor activity(GO:0004875)
0.3 1.5 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.3 2.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.3 0.8 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.2 0.7 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.2 1.0 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.2 1.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 0.7 GO:0030172 troponin C binding(GO:0030172)
0.2 0.7 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.2 0.5 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.2 0.5 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 2.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 3.6 GO:0001968 fibronectin binding(GO:0001968)
0.1 1.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 1.1 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 0.7 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.8 GO:0034711 inhibin binding(GO:0034711)
0.1 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 0.7 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.2 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.3 GO:0015265 urea channel activity(GO:0015265)
0.1 0.7 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.3 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 1.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.7 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.4 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.9 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 1.0 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 1.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 1.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.0 GO:0070051 fibrinogen binding(GO:0070051)
0.0 0.1 GO:0005119 smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.9 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.5 GO:0005272 sodium channel activity(GO:0005272)
0.0 0.1 GO:2001069 glycogen binding(GO:2001069)
0.0 1.9 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 0.1 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.2 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 4.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.5 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 2.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.6 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 1.0 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.1 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.1 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 2.2 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.1 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.1 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 0.7 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 2.8 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.1 1.5 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 0.8 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 1.0 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 4.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.7 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.2 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.1 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.5 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.9 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.4 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.2 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 1.4 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.6 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.3 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.4 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 1.0 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 1.0 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.5 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 0.5 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.3 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.6 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.2 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.2 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.1 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.2 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation