Motif ID: Gata6

Z-value: 0.341


Transcription factors associated with Gata6:

Gene SymbolEntrez IDGene Name
Gata6 ENSMUSG00000005836.8 Gata6



Activity profile for motif Gata6.

activity profile for motif Gata6


Sorted Z-values histogram for motif Gata6

Sorted Z-values for motif Gata6



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 1.492 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr8_+_45627709 1.386 ENSMUST00000134321.1
ENSMUST00000135336.1
 Sorbs2

sorbin and SH3 domain containing 2

chr8_+_45627946 1.340 ENSMUST00000145458.1
 Sorbs2
sorbin and SH3 domain containing 2
chr8_+_45628176 1.317 ENSMUST00000130850.1
 Sorbs2
sorbin and SH3 domain containing 2
chr7_-_103853199 1.062 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr12_+_95692212 0.864 ENSMUST00000057324.3
 Flrt2
fibronectin leucine rich transmembrane protein 2
chr16_-_46010212 0.542 ENSMUST00000130481.1
 Plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr3_-_154330543 0.533 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chr9_+_66350465 0.464 ENSMUST00000042824.6
 Herc1
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr1_+_179803376 0.448 ENSMUST00000097454.2
 Gm10518
predicted gene 10518
chr16_-_64786321 0.422 ENSMUST00000052588.4
 Zfp654
zinc finger protein 654
chr4_-_110287479 0.404 ENSMUST00000106598.1
ENSMUST00000102723.4
ENSMUST00000153906.1
 Elavl4


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)


chr2_+_71786923 0.374 ENSMUST00000112101.1
ENSMUST00000028522.3
 Itga6

integrin alpha 6

chr2_-_59948155 0.373 ENSMUST00000153136.1
 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr2_-_125859139 0.371 ENSMUST00000110463.1
ENSMUST00000028635.5
 Cops2

COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)

chr1_-_14310198 0.344 ENSMUST00000168081.2
ENSMUST00000027066.6
 Eya1

eyes absent 1 homolog (Drosophila)

chrX_-_37110257 0.307 ENSMUST00000076265.6
 Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr11_-_53707269 0.304 ENSMUST00000124352.1
ENSMUST00000020649.7
 Rad50

RAD50 homolog (S. cerevisiae)

chr18_-_43477764 0.289 ENSMUST00000057110.9
 Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr8_-_122699066 0.287 ENSMUST00000127984.1
 Cbfa2t3
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
chr6_-_136875794 0.277 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr2_+_68104671 0.265 ENSMUST00000042456.3
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr2_-_7081256 0.254 ENSMUST00000183209.1
 Celf2
CUGBP, Elav-like family member 2
chr1_-_144177259 0.233 ENSMUST00000111941.1
ENSMUST00000052375.1
 Rgs13

regulator of G-protein signaling 13

chr10_-_40883073 0.224 ENSMUST00000044166.7
 Cdc40
cell division cycle 40
chr16_-_34262945 0.213 ENSMUST00000114953.1
 Kalrn
kalirin, RhoGEF kinase
chr2_-_7081207 0.212 ENSMUST00000114923.2
ENSMUST00000182706.1
 Celf2

CUGBP, Elav-like family member 2

chr1_-_25829511 0.198 ENSMUST00000135518.1
ENSMUST00000151309.1
 Bai3

brain-specific angiogenesis inhibitor 3

chr2_-_7395968 0.190 ENSMUST00000002176.6
 Celf2
CUGBP, Elav-like family member 2
chr5_-_73191848 0.188 ENSMUST00000176910.1
 Fryl
furry homolog-like (Drosophila)
chr9_+_65032413 0.178 ENSMUST00000034960.6
 Dpp8
dipeptidylpeptidase 8
chr4_+_13751297 0.177 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr17_+_71204647 0.164 ENSMUST00000126681.1
 Lpin2
lipin 2
chr10_+_52417532 0.162 ENSMUST00000023830.8
 Nus1
nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)
chr11_+_95712673 0.135 ENSMUST00000107717.1
 Zfp652
zinc finger protein 652
chr9_+_62342449 0.119 ENSMUST00000156461.1
 Anp32a
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr2_-_7396192 0.116 ENSMUST00000137733.2
 Celf2
CUGBP, Elav-like family member 2
chr9_-_95815389 0.110 ENSMUST00000119760.1
 Pls1
plastin 1 (I-isoform)
chr2_-_172370506 0.101 ENSMUST00000109139.1
ENSMUST00000028997.7
ENSMUST00000109140.3
 Aurka


aurora kinase A


chr16_+_91647859 0.100 ENSMUST00000119368.1
ENSMUST00000114037.2
ENSMUST00000114036.2
ENSMUST00000122302.1
 Son



Son DNA binding protein



chr8_-_64205970 0.100 ENSMUST00000066166.4
 Tll1
tolloid-like
chr6_-_127109517 0.091 ENSMUST00000039913.8
 9630033F20Rik
RIKEN cDNA 9630033F20 gene
chr2_-_7395879 0.090 ENSMUST00000182404.1
 Celf2
CUGBP, Elav-like family member 2
chr6_-_38124568 0.088 ENSMUST00000040259.4
 Atp6v0a4
ATPase, H+ transporting, lysosomal V0 subunit A4
chr16_+_36041184 0.084 ENSMUST00000042203.8
 Wdr5b
WD repeat domain 5B
chr3_-_20242173 0.084 ENSMUST00000001921.1
 Cpa3
carboxypeptidase A3, mast cell
chr7_+_88278085 0.081 ENSMUST00000032779.5
ENSMUST00000128791.1
 Ctsc

cathepsin C

chr2_+_65930117 0.080 ENSMUST00000176109.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr17_+_57249450 0.065 ENSMUST00000019631.9
 Trip10
thyroid hormone receptor interactor 10
chr9_+_44379490 0.064 ENSMUST00000066601.6
 Hyou1
hypoxia up-regulated 1
chr2_+_80617045 0.056 ENSMUST00000028384.4
 Dusp19
dual specificity phosphatase 19
chr7_-_99238564 0.056 ENSMUST00000064231.7
 Mogat2
monoacylglycerol O-acyltransferase 2
chr2_-_77170592 0.056 ENSMUST00000164114.2
ENSMUST00000049544.7
 Ccdc141

coiled-coil domain containing 141

chr2_+_125859134 0.054 ENSMUST00000028636.6
ENSMUST00000125084.1
 Galk2

galactokinase 2

chr5_-_30461902 0.046 ENSMUST00000133509.1
ENSMUST00000074171.6
ENSMUST00000114747.2
ENSMUST00000144125.1
 Otof



otoferlin



chr2_+_143915273 0.039 ENSMUST00000103172.3
 Dstn
destrin
chr7_+_110627650 0.031 ENSMUST00000033054.8
 Adm
adrenomedullin
chr10_-_34207551 0.030 ENSMUST00000048010.7
 Dse
dermatan sulfate epimerase
chr5_+_121777929 0.028 ENSMUST00000160821.1
 Atxn2
ataxin 2
chr2_+_72476225 0.019 ENSMUST00000157019.1
 Cdca7
cell division cycle associated 7
chr7_+_28833975 0.018 ENSMUST00000066723.8
 Lgals4
lectin, galactose binding, soluble 4
chr13_+_24802020 0.014 ENSMUST00000155575.1
 BC005537
cDNA sequence BC005537
chr5_+_76840597 0.012 ENSMUST00000120639.2
ENSMUST00000163347.1
ENSMUST00000121851.1
 C530008M17Rik


RIKEN cDNA C530008M17 gene


chr3_+_135826075 0.007 ENSMUST00000029810.5
 Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr1_-_173333503 0.004 ENSMUST00000038227.4
 Darc
Duffy blood group, chemokine receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 1.1 GO:0015671 oxygen transport(GO:0015671)
0.1 0.9 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 4.1 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.4 GO:0035878 nail development(GO:0035878)
0.1 0.3 GO:0000019 regulation of mitotic recombination(GO:0000019) telomeric 3' overhang formation(GO:0031860)
0.1 0.3 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 0.3 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.0 0.1 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
0.0 0.3 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.2 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0 0.1 GO:0007056 spindle assembly involved in female meiosis(GO:0007056) positive regulation of oocyte development(GO:0060282)
0.0 0.2 GO:0032380 dolichol metabolic process(GO:0019348) regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 0.4 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.9 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.5 GO:0021702 cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.2 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.1 GO:0046462 monoacylglycerol metabolic process(GO:0046462)
0.0 0.1 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0005833 hemoglobin complex(GO:0005833)
0.1 0.6 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 0.3 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.4 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.1 GO:1990357 terminal web(GO:1990357)
0.0 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 0.4 GO:0038132 neuregulin binding(GO:0038132)
0.1 0.3 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.9 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.3 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.1 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.1 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 0.1 GO:0004335 galactokinase activity(GO:0004335)
0.0 0.9 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.4 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.2 GO:0004659 prenyltransferase activity(GO:0004659)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.2 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE