Motif ID: Gbx2

Z-value: 0.614


Transcription factors associated with Gbx2:

Gene SymbolEntrez IDGene Name
Gbx2 ENSMUSG00000034486.7 Gbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gbx2mm10_v2_chr1_-_89933290_899332900.057.5e-01Click!


Activity profile for motif Gbx2.

activity profile for motif Gbx2


Sorted Z-values histogram for motif Gbx2

Sorted Z-values for motif Gbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_-_36784924 4.924 ENSMUST00000168279.1
ENSMUST00000164579.1
ENSMUST00000023616.2
 Slc15a2


solute carrier family 15 (H+/peptide transporter), member 2


chr13_-_97747373 4.438 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr16_-_36784784 4.212 ENSMUST00000165531.1
 Slc15a2
solute carrier family 15 (H+/peptide transporter), member 2
chr13_-_97747399 4.163 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr3_+_94372794 3.135 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr14_-_48667508 2.790 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr2_-_160619971 2.788 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr12_+_79297345 2.286 ENSMUST00000079533.5
ENSMUST00000171210.1
 Rad51b

RAD51 homolog B

chr17_-_48432723 2.184 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr4_+_110397661 2.057 ENSMUST00000106589.2
ENSMUST00000106587.2
ENSMUST00000106591.1
ENSMUST00000106592.1
 Agbl4



ATP/GTP binding protein-like 4



chr4_+_118961578 1.981 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr5_-_111761697 1.939 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr4_+_110397764 1.909 ENSMUST00000097920.2
ENSMUST00000080744.6
 Agbl4

ATP/GTP binding protein-like 4

chr9_+_96258697 1.815 ENSMUST00000179416.1
 Tfdp2
transcription factor Dp 2
chr3_-_116129615 1.774 ENSMUST00000029574.8
 Vcam1
vascular cell adhesion molecule 1
chr7_+_75455534 1.543 ENSMUST00000147005.1
ENSMUST00000166315.1
 Akap13

A kinase (PRKA) anchor protein 13

chrX_+_106920618 1.540 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr17_-_36032682 1.485 ENSMUST00000102678.4
 H2-T23
histocompatibility 2, T region locus 23
chr3_+_88615367 1.349 ENSMUST00000176539.1
 Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
chr13_+_49544443 1.304 ENSMUST00000177948.1
ENSMUST00000021820.6
 Aspn

asporin

chr13_+_23763660 1.208 ENSMUST00000055770.1
 Hist1h1a
histone cluster 1, H1a
chrM_-_14060 1.042 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr1_-_24005608 1.008 ENSMUST00000027338.3
 1110058L19Rik
RIKEN cDNA 1110058L19 gene
chr4_-_129261394 0.998 ENSMUST00000145261.1
 C77080
expressed sequence C77080
chr3_+_88616133 0.986 ENSMUST00000176500.1
ENSMUST00000177498.1
 Arhgef2

rho/rac guanine nucleotide exchange factor (GEF) 2

chr8_-_41041828 0.961 ENSMUST00000051379.7
 Mtus1
mitochondrial tumor suppressor 1
chr7_-_30664986 0.936 ENSMUST00000019697.8
 Haus5
HAUS augmin-like complex, subunit 5
chr1_+_24005505 0.912 ENSMUST00000181961.1
 Gm26524
predicted gene, 26524
chr18_+_56432116 0.639 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr8_-_21906412 0.598 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr5_+_117781017 0.533 ENSMUST00000138579.2
 Nos1
nitric oxide synthase 1, neuronal
chr12_+_111814170 0.525 ENSMUST00000021714.7
 Zfyve21
zinc finger, FYVE domain containing 21
chr3_-_89998656 0.513 ENSMUST00000079724.4
 Hax1
HCLS1 associated X-1
chr12_-_98259416 0.476 ENSMUST00000021390.7
 Galc
galactosylceramidase
chr3_+_96645579 0.452 ENSMUST00000119365.1
ENSMUST00000029744.5
 Itga10

integrin, alpha 10

chr14_+_58893465 0.439 ENSMUST00000079960.1
 Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr11_+_59306920 0.436 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr10_+_128083273 0.362 ENSMUST00000026459.5
 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr2_+_152754156 0.345 ENSMUST00000010020.5
 Cox4i2
cytochrome c oxidase subunit IV isoform 2
chr11_-_5878207 0.324 ENSMUST00000102922.3
 Pold2
polymerase (DNA directed), delta 2, regulatory subunit
chr11_+_97315716 0.313 ENSMUST00000019026.3
ENSMUST00000132168.1
 Mrpl45

mitochondrial ribosomal protein L45

chr19_-_59170978 0.268 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chrX_-_56598069 0.253 ENSMUST00000059899.2
 Mmgt1
membrane magnesium transporter 1
chr16_+_44394771 0.250 ENSMUST00000099742.2
 Wdr52
WD repeat domain 52
chr3_+_152714094 0.217 ENSMUST00000159899.1
ENSMUST00000045029.8
 Pigk

phosphatidylinositol glycan anchor biosynthesis, class K

chr5_+_115341225 0.211 ENSMUST00000031508.4
 Triap1
TP53 regulated inhibitor of apoptosis 1
chr7_-_141434532 0.195 ENSMUST00000133021.1
ENSMUST00000106007.3
ENSMUST00000150026.1
ENSMUST00000133206.2
 Slc25a22



solute carrier family 25 (mitochondrial carrier, glutamate), member 22



chr7_+_28810886 0.185 ENSMUST00000038572.8
 Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr1_-_4785671 0.165 ENSMUST00000130201.1
ENSMUST00000156816.1
 Mrpl15

mitochondrial ribosomal protein L15

chr3_-_10331358 0.153 ENSMUST00000065938.8
ENSMUST00000118410.1
 Impa1

inositol (myo)-1(or 4)-monophosphatase 1

chr2_-_73580288 0.148 ENSMUST00000028515.3
 Chrna1
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
chr1_-_128102412 0.140 ENSMUST00000112538.1
ENSMUST00000086614.5
 Zranb3

zinc finger, RAN-binding domain containing 3

chr14_-_18893376 0.108 ENSMUST00000151926.1
 Ube2e2
ubiquitin-conjugating enzyme E2E 2
chr7_-_78783026 0.076 ENSMUST00000032841.5
 Mrpl46
mitochondrial ribosomal protein L46
chr1_-_175625580 0.066 ENSMUST00000027810.7
 Fh1
fumarate hydratase 1
chr5_-_115341142 0.056 ENSMUST00000139167.1
 Gatc
glutamyl-tRNA(Gln) amidotransferase, subunit C homolog (bacterial)
chr15_-_83510861 0.045 ENSMUST00000109479.1
ENSMUST00000109480.1
ENSMUST00000016897.4
 Ttll1


tubulin tyrosine ligase-like 1


chr7_-_141434402 0.002 ENSMUST00000136354.1
 Slc25a22
solute carrier family 25 (mitochondrial carrier, glutamate), member 22

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 9.1 GO:0042891 antibiotic transport(GO:0042891) dipeptide transport(GO:0042938)
1.0 4.0 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.7 2.2 GO:0016554 cytidine to uridine editing(GO:0016554)
0.7 2.8 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.5 1.5 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.4 3.1 GO:0072615 interleukin-17 secretion(GO:0072615)
0.4 2.3 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.3 2.3 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.3 1.3 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.3 1.5 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.2 0.5 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
0.2 1.8 GO:0061032 visceral serous pericardium development(GO:0061032)
0.1 0.4 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.1 0.5 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 1.5 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 0.1 GO:0006106 fumarate metabolic process(GO:0006106)
0.1 0.5 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 0.1 GO:0036292 DNA rewinding(GO:0036292)
0.0 0.2 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.3 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.0 2.0 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.0 0.1 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.3 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.0 0.3 GO:0006824 cobalt ion transport(GO:0006824)
0.0 0.2 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.0 0.2 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 0.4 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.2 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 1.2 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 1.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.9 GO:0070652 HAUS complex(GO:0070652)
0.1 0.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 4.1 GO:0002102 podosome(GO:0002102)
0.0 0.5 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.4 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.2 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 4.0 GO:0005814 centriole(GO:0005814)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.5 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.3 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 1.2 GO:0000786 nucleosome(GO:0000786)
0.0 1.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.9 GO:0070469 respiratory chain(GO:0070469)
0.0 1.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.6 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 9.1 GO:0042936 dipeptide transporter activity(GO:0042936)
0.8 3.1 GO:0008142 oxysterol binding(GO:0008142)
0.7 2.0 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.5 2.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.4 1.8 GO:0008131 primary amine oxidase activity(GO:0008131)
0.3 2.3 GO:0000150 recombinase activity(GO:0000150)
0.2 4.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 1.5 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.2 1.5 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.2 0.5 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.2 0.5 GO:0019966 interleukin-1 binding(GO:0019966)
0.2 1.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.5 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 2.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.4 GO:0043532 angiostatin binding(GO:0043532)
0.1 0.2 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.1 0.2 GO:0031403 lithium ion binding(GO:0031403)
0.0 0.2 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 1.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.3 GO:0015087 cobalt ion transmembrane transporter activity(GO:0015087)
0.0 2.8 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 1.3 GO:0005518 collagen binding(GO:0005518)
0.0 0.2 GO:0097157 pre-mRNA intronic binding(GO:0097157) mRNA CDS binding(GO:1990715)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.1 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0036310 annealing helicase activity(GO:0036310)
0.0 0.4 GO:0005109 frizzled binding(GO:0005109)
0.0 1.2 GO:0008201 heparin binding(GO:0008201)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 1.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 3.9 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.5 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.2 9.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.8 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.2 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 3.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 3.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.4 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.5 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.1 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.5 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism