Motif ID: Gmeb1

Z-value: 0.430


Transcription factors associated with Gmeb1:

Gene SymbolEntrez IDGene Name
Gmeb1 ENSMUSG00000028901.7 Gmeb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gmeb1mm10_v2_chr4_-_132261596_1322616220.681.5e-06Click!


Activity profile for motif Gmeb1.

activity profile for motif Gmeb1


Sorted Z-values histogram for motif Gmeb1

Sorted Z-values for motif Gmeb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gmeb1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_127553462 2.215 ENSMUST00000043108.4
 4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr6_+_113531675 1.724 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr3_+_40800054 1.675 ENSMUST00000168287.1
 Plk4
polo-like kinase 4
chr3_+_40800013 1.522 ENSMUST00000026858.5
ENSMUST00000170825.1
 Plk4

polo-like kinase 4

chr11_-_40733373 1.512 ENSMUST00000020579.8
 Hmmr
hyaluronan mediated motility receptor (RHAMM)
chr15_+_99074968 1.244 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr1_+_175880775 1.215 ENSMUST00000039725.6
 Exo1
exonuclease 1
chr15_-_58135047 1.172 ENSMUST00000038194.3
 Atad2
ATPase family, AAA domain containing 2
chr2_-_157007039 1.132 ENSMUST00000103129.2
ENSMUST00000103130.1
 Dsn1

DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)

chr18_+_36559972 0.958 ENSMUST00000134146.1
 Ankhd1
ankyrin repeat and KH domain containing 1
chr2_+_75659253 0.954 ENSMUST00000111964.1
ENSMUST00000111962.1
ENSMUST00000111961.1
ENSMUST00000164947.2
ENSMUST00000090792.4
 Hnrnpa3




heterogeneous nuclear ribonucleoprotein A3




chr11_+_51263114 0.952 ENSMUST00000093132.6
ENSMUST00000109113.1
 Clk4

CDC like kinase 4

chr2_+_69723071 0.923 ENSMUST00000040915.8
 Ppig
peptidyl-prolyl isomerase G (cyclophilin G)
chr2_+_69722797 0.913 ENSMUST00000090858.3
 Ppig
peptidyl-prolyl isomerase G (cyclophilin G)
chr2_-_157007015 0.893 ENSMUST00000146413.1
 Dsn1
DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)
chr12_+_4917376 0.886 ENSMUST00000045664.5
 Atad2b
ATPase family, AAA domain containing 2B
chr4_-_40269778 0.820 ENSMUST00000042575.6
 Topors
topoisomerase I binding, arginine/serine-rich
chr11_-_86544754 0.810 ENSMUST00000138810.1
ENSMUST00000058286.2
ENSMUST00000154617.1
 Rps6kb1


ribosomal protein S6 kinase, polypeptide 1


chr18_+_23954668 0.738 ENSMUST00000060762.4
 Zfp397
zinc finger protein 397
chr3_+_138143483 0.705 ENSMUST00000162864.1
 Trmt10a
tRNA methyltransferase 10A
chr8_+_26119361 0.662 ENSMUST00000014022.8
ENSMUST00000153528.1
ENSMUST00000131138.1
ENSMUST00000110575.1
 Rnf170



ring finger protein 170



chr3_+_138143429 0.619 ENSMUST00000040321.6
 Trmt10a
tRNA methyltransferase 10A
chr8_-_25016743 0.595 ENSMUST00000084032.5
 Adam9
a disintegrin and metallopeptidase domain 9 (meltrin gamma)
chr8_-_25016901 0.591 ENSMUST00000084035.5
 Adam9
a disintegrin and metallopeptidase domain 9 (meltrin gamma)
chr13_+_49653297 0.572 ENSMUST00000021824.7
 Nol8
nucleolar protein 8
chrX_+_112311334 0.508 ENSMUST00000026599.3
ENSMUST00000113415.1
 Apool

apolipoprotein O-like

chr8_+_26119611 0.485 ENSMUST00000140819.1
 Rnf170
ring finger protein 170
chr3_-_127553233 0.471 ENSMUST00000029588.5
 Larp7
La ribonucleoprotein domain family, member 7
chr17_+_84511832 0.450 ENSMUST00000047206.5
 Plekhh2
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr9_-_45906837 0.436 ENSMUST00000161203.1
ENSMUST00000058720.5
ENSMUST00000160699.1
 Rnf214


ring finger protein 214


chr9_-_48495321 0.407 ENSMUST00000170000.2
 Rbm7
RNA binding motif protein 7
chr3_-_138143352 0.386 ENSMUST00000098580.2
 Mttp
microsomal triglyceride transfer protein
chr18_-_53744509 0.356 ENSMUST00000049811.6
 Cep120
centrosomal protein 120
chr4_-_72200833 0.347 ENSMUST00000102848.2
ENSMUST00000072695.6
ENSMUST00000107337.1
ENSMUST00000074216.7
 Tle1



transducin-like enhancer of split 1, homolog of Drosophila E(spl)



chr11_-_74724670 0.327 ENSMUST00000021091.8
 Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr11_-_100822525 0.323 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chr7_+_5020561 0.308 ENSMUST00000085427.3
 Zfp865
zinc finger protein 865
chr17_+_83350925 0.303 ENSMUST00000096766.4
ENSMUST00000112363.2
ENSMUST00000049503.8
 Eml4


echinoderm microtubule associated protein like 4


chr1_-_160212864 0.293 ENSMUST00000014370.5
 Cacybp
calcyclin binding protein
chr11_+_40733639 0.263 ENSMUST00000020578.4
 Nudcd2
NudC domain containing 2
chr16_-_87432597 0.254 ENSMUST00000039449.7
 Ltn1
listerin E3 ubiquitin protein ligase 1
chr4_-_135353164 0.245 ENSMUST00000084846.5
ENSMUST00000136342.2
ENSMUST00000105861.1
 Srrm1


serine/arginine repetitive matrix 1


chr4_-_135353126 0.243 ENSMUST00000030613.4
ENSMUST00000131373.1
 Srrm1

serine/arginine repetitive matrix 1

chr3_-_108086590 0.227 ENSMUST00000102638.1
ENSMUST00000102637.1
 Ampd2

adenosine monophosphate deaminase 2

chr17_+_23679363 0.226 ENSMUST00000024699.2
 Cldn6
claudin 6
chr1_+_82316452 0.218 ENSMUST00000027322.7
 Rhbdd1
rhomboid domain containing 1
chr3_-_19311269 0.211 ENSMUST00000099195.3
 Pde7a
phosphodiesterase 7A
chr7_+_5020376 0.190 ENSMUST00000076251.4
 Zfp865
zinc finger protein 865
chr17_-_46327949 0.177 ENSMUST00000047970.7
 Abcc10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr15_-_81399594 0.168 ENSMUST00000023039.8
 St13
suppression of tumorigenicity 13
chr7_+_35397046 0.155 ENSMUST00000079414.5
 Cep89
centrosomal protein 89
chr17_-_46327990 0.149 ENSMUST00000167360.1
 Abcc10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr4_-_126202757 0.133 ENSMUST00000080919.5
 Thrap3
thyroid hormone receptor associated protein 3
chr7_-_111082997 0.130 ENSMUST00000161051.1
ENSMUST00000160132.1
ENSMUST00000106666.3
ENSMUST00000162415.1
 Eif4g2



eukaryotic translation initiation factor 4, gamma 2



chr4_+_128727585 0.123 ENSMUST00000106079.3
ENSMUST00000133439.1
 Phc2

polyhomeotic-like 2 (Drosophila)

chr11_+_69095217 0.117 ENSMUST00000101004.2
 Per1
period circadian clock 1
chr4_-_126202583 0.115 ENSMUST00000106142.1
ENSMUST00000169403.1
ENSMUST00000130334.1
 Thrap3


thyroid hormone receptor associated protein 3


chr14_+_20694956 0.114 ENSMUST00000048016.1
 Fut11
fucosyltransferase 11
chr4_+_40970906 0.111 ENSMUST00000098143.4
ENSMUST00000030133.8
ENSMUST00000091614.6
 Nfx1


nuclear transcription factor, X-box binding 1


chr11_-_113751309 0.111 ENSMUST00000106616.1
 Cdc42ep4
CDC42 effector protein (Rho GTPase binding) 4
chr5_-_31291026 0.108 ENSMUST00000041565.7
 Ift172
intraflagellar transport 172
chr12_-_31654767 0.100 ENSMUST00000020977.2
 Dus4l
dihydrouridine synthase 4-like (S. cerevisiae)
chr11_+_69914179 0.087 ENSMUST00000057884.5
 Gps2
G protein pathway suppressor 2
chr15_-_83724979 0.075 ENSMUST00000171496.1
ENSMUST00000043634.5
ENSMUST00000076060.5
ENSMUST00000016907.7
 Scube1



signal peptide, CUB domain, EGF-like 1



chr16_+_49699198 0.074 ENSMUST00000046777.4
ENSMUST00000142682.1
 Ift57

intraflagellar transport 57

chr3_+_95434386 0.073 ENSMUST00000102749.4
ENSMUST00000090804.5
ENSMUST00000107161.1
ENSMUST00000107160.1
ENSMUST00000015666.10
 Arnt




aryl hydrocarbon receptor nuclear translocator




chr4_+_55350043 0.073 ENSMUST00000030134.8
 Rad23b
RAD23b homolog (S. cerevisiae)
chr15_-_81400043 0.065 ENSMUST00000172107.1
ENSMUST00000169204.1
ENSMUST00000163382.1
 St13


suppression of tumorigenicity 13


chr6_-_87672142 0.061 ENSMUST00000032130.2
ENSMUST00000065997.2
 Aplf

aprataxin and PNKP like factor

chr15_-_79546741 0.041 ENSMUST00000054014.7
 Ddx17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr7_+_100607410 0.039 ENSMUST00000107048.1
ENSMUST00000032946.3
 Rab6a

RAB6A, member RAS oncogene family

chr13_-_53473074 0.021 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr6_+_29348069 0.018 ENSMUST00000173216.1
ENSMUST00000031779.10
ENSMUST00000090481.7
 Calu


calumenin


chr8_-_45333189 0.011 ENSMUST00000095328.4
 Cyp4v3
cytochrome P450, family 4, subfamily v, polypeptide 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0051316 attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316)
0.5 3.2 GO:0098535 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
0.4 1.2 GO:0034241 positive regulation of macrophage fusion(GO:0034241)
0.2 1.7 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.2 0.8 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.2 2.1 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.1 1.2 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.1 0.3 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.1 0.4 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.1 0.4 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 0.2 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 0.3 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.6 GO:1902570 protein localization to nucleolus(GO:1902570)
0.1 1.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.3 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 0.5 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 0.8 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.2 GO:0032264 IMP salvage(GO:0032264)
0.0 0.5 GO:0042407 cristae formation(GO:0042407)
0.0 0.2 GO:0061084 negative regulation of protein refolding(GO:0061084)
0.0 0.1 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0 0.1 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0 0.1 GO:0051105 regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)
0.0 0.1 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0 0.7 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.3 GO:2000811 negative regulation of anoikis(GO:2000811)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.2 GO:0098536 deuterosome(GO:0098536)
0.5 2.0 GO:0000939 nuclear MIS12/MIND complex(GO:0000818) condensed chromosome inner kinetochore(GO:0000939)
0.1 1.2 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.1 0.5 GO:0061617 MICOS complex(GO:0061617)
0.1 0.3 GO:0000235 astral microtubule(GO:0000235)
0.0 1.0 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.4 GO:0031528 microvillus membrane(GO:0031528)
0.0 2.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.2 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.2 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.2 GO:0016327 apicolateral plasma membrane(GO:0016327)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.3 0.8 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.2 1.0 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.2 1.3 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.1 0.8 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.1 1.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.2 GO:0032564 dATP binding(GO:0032564)
0.1 1.6 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 1.8 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 1.2 GO:0043236 laminin binding(GO:0043236)
0.0 0.9 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.2 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.2 GO:0001618 virus receptor activity(GO:0001618)
0.0 1.0 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.4 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.3 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.3 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.8 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.2 1.5 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 3.1 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.5 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.3 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.4 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.6 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.2 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 1.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase