Motif ID: Gsx2_Hoxd3_Vax1

Z-value: 0.685

Transcription factors associated with Gsx2_Hoxd3_Vax1:

Gene SymbolEntrez IDGene Name
Gsx2 ENSMUSG00000035946.6 Gsx2
Hoxd3 ENSMUSG00000079277.3 Hoxd3
Vax1 ENSMUSG00000006270.6 Vax1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gsx2mm10_v2_chr5_+_75075464_750756010.552.5e-04Click!
Vax1mm10_v2_chr19_-_59170978_591709780.517.6e-04Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Gsx2_Hoxd3_Vax1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_14621805 6.990 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr4_-_14621494 4.952 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr4_-_14621669 4.936 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr15_-_8710734 4.894 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710409 4.372 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_-_59220150 3.539 ENSMUST00000170388.1
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr12_+_112760652 2.446 ENSMUST00000063888.3
Pld4
phospholipase D family, member 4
chr15_-_37459327 2.402 ENSMUST00000119730.1
ENSMUST00000120746.1
Ncald

neurocalcin delta

chr8_+_66386292 2.169 ENSMUST00000039540.5
ENSMUST00000110253.2
March1

membrane-associated ring finger (C3HC4) 1

chr5_+_66968559 2.069 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr3_-_116253467 1.878 ENSMUST00000090473.5
Gpr88
G-protein coupled receptor 88
chr2_+_36230426 1.803 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr12_+_38780284 1.774 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chrX_+_150547375 1.738 ENSMUST00000066337.6
ENSMUST00000112715.1
Alas2

aminolevulinic acid synthase 2, erythroid

chr2_-_164171113 1.662 ENSMUST00000045196.3
Kcns1
K+ voltage-gated channel, subfamily S, 1
chr5_+_66968416 1.638 ENSMUST00000038188.7
Limch1
LIM and calponin homology domains 1
chr8_+_94152607 1.538 ENSMUST00000034211.8
Mt3
metallothionein 3
chr3_+_66219909 1.480 ENSMUST00000029421.5
Ptx3
pentraxin related gene
chr12_+_38780817 1.468 ENSMUST00000160856.1
Etv1
ets variant gene 1
chr6_+_145934113 1.430 ENSMUST00000032383.7
Sspn
sarcospan
chr2_+_109917639 1.351 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr3_+_55782500 1.325 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chr8_+_36489191 1.232 ENSMUST00000171777.1
6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr12_+_38781093 1.192 ENSMUST00000161513.1
Etv1
ets variant gene 1
chr9_-_39603635 1.125 ENSMUST00000119722.1
AW551984
expressed sequence AW551984
chr16_-_92400067 1.121 ENSMUST00000023672.8
Rcan1
regulator of calcineurin 1
chr9_-_90255927 1.096 ENSMUST00000144646.1
Tbc1d2b
TBC1 domain family, member 2B
chr10_+_116018213 1.069 ENSMUST00000063470.4
Ptprr
protein tyrosine phosphatase, receptor type, R
chr18_+_12741324 1.007 ENSMUST00000115857.2
ENSMUST00000121018.1
ENSMUST00000119108.1
Cabyr


calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)


chr15_+_92597104 1.006 ENSMUST00000035399.8
Pdzrn4
PDZ domain containing RING finger 4
chr9_+_94669876 0.998 ENSMUST00000033463.9
Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr14_-_64455903 0.995 ENSMUST00000067927.7
Msra
methionine sulfoxide reductase A
chr15_+_82256023 0.986 ENSMUST00000143238.1
1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr19_+_55895508 0.966 ENSMUST00000111646.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr2_-_28916412 0.953 ENSMUST00000050776.2
ENSMUST00000113849.1
Barhl1

BarH-like 1 (Drosophila)

chr19_-_57360668 0.936 ENSMUST00000181921.1
B230217O12Rik
RIKEN cDNA B230217O12 gene
chr2_+_125136692 0.895 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr14_-_48662740 0.887 ENSMUST00000122009.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr2_-_28916668 0.864 ENSMUST00000113847.1
Barhl1
BarH-like 1 (Drosophila)
chr6_-_34317442 0.844 ENSMUST00000154655.1
ENSMUST00000102980.4
Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)

chr4_+_102589687 0.818 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b

phosphodiesterase 4B, cAMP specific

chr1_-_152625212 0.750 ENSMUST00000027760.7
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr3_+_159839729 0.716 ENSMUST00000068952.5
Wls
wntless homolog (Drosophila)
chr18_+_59062462 0.708 ENSMUST00000058633.2
ENSMUST00000175897.1
ENSMUST00000118510.1
ENSMUST00000175830.1
A730017C20Rik



RIKEN cDNA A730017C20 gene



chr8_-_106573461 0.706 ENSMUST00000073722.5
Gm10073
predicted pseudogene 10073
chr18_+_59062282 0.697 ENSMUST00000165666.2
A730017C20Rik
RIKEN cDNA A730017C20 gene
chr4_+_154964117 0.691 ENSMUST00000030931.4
ENSMUST00000070953.4
Pank4

pantothenate kinase 4

chr6_-_136875794 0.691 ENSMUST00000032342.1
Mgp
matrix Gla protein
chr13_+_51408618 0.673 ENSMUST00000087978.3
S1pr3
sphingosine-1-phosphate receptor 3
chr13_-_102906046 0.671 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr18_-_75697639 0.661 ENSMUST00000165559.1
Ctif
CBP80/20-dependent translation initiation factor
chr5_+_26817357 0.646 ENSMUST00000071500.6
Dpp6
dipeptidylpeptidase 6
chr10_+_116143881 0.641 ENSMUST00000105271.2
Ptprr
protein tyrosine phosphatase, receptor type, R
chr3_+_68584154 0.594 ENSMUST00000182997.1
Schip1
schwannomin interacting protein 1
chr9_-_103222063 0.590 ENSMUST00000170904.1
Trf
transferrin
chr2_+_91650169 0.588 ENSMUST00000090614.4
Arhgap1
Rho GTPase activating protein 1
chr18_+_33464163 0.572 ENSMUST00000097634.3
Gm10549
predicted gene 10549
chr11_+_116843278 0.571 ENSMUST00000106370.3
Mettl23
methyltransferase like 23
chr5_-_136986829 0.556 ENSMUST00000034953.7
ENSMUST00000085941.5
Znhit1

zinc finger, HIT domain containing 1

chr3_-_130730375 0.547 ENSMUST00000079085.6
Rpl34
ribosomal protein L34
chr3_-_33082004 0.528 ENSMUST00000108225.3
Pex5l
peroxisomal biogenesis factor 5-like
chr4_+_105789869 0.524 ENSMUST00000184254.1
Gm12728
predicted gene 12728
chr2_-_33087169 0.518 ENSMUST00000102810.3
Garnl3
GTPase activating RANGAP domain-like 3
chr5_-_62765618 0.515 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr12_-_80643799 0.505 ENSMUST00000166931.1
Erh
enhancer of rudimentary homolog (Drosophila)
chr14_+_69347587 0.487 ENSMUST00000064831.5
Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr4_-_15149755 0.486 ENSMUST00000108273.1
Necab1
N-terminal EF-hand calcium binding protein 1
chr2_-_120154600 0.484 ENSMUST00000028755.7
Ehd4
EH-domain containing 4
chr13_-_102905740 0.476 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr6_+_125552948 0.475 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
Vwf


Von Willebrand factor homolog


chr5_-_62766153 0.474 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr9_+_32116040 0.474 ENSMUST00000174641.1
Arhgap32
Rho GTPase activating protein 32
chr1_+_75436002 0.463 ENSMUST00000131545.1
ENSMUST00000141124.1
Gmppa

GDP-mannose pyrophosphorylase A

chr2_+_91650116 0.462 ENSMUST00000111331.2
Arhgap1
Rho GTPase activating protein 1
chr17_+_66111605 0.446 ENSMUST00000116556.2
Wash
WAS protein family homolog
chr18_+_37355271 0.443 ENSMUST00000051163.1
Pcdhb8
protocadherin beta 8
chr8_+_107031218 0.440 ENSMUST00000034388.9
Vps4a
vacuolar protein sorting 4a (yeast)
chr8_-_13890233 0.400 ENSMUST00000033839.7
Coprs
coordinator of PRMT5, differentiation stimulator
chr9_-_112187898 0.378 ENSMUST00000178410.1
ENSMUST00000172380.3
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr17_+_66111529 0.371 ENSMUST00000072383.6
Wash
WAS protein family homolog
chr4_-_150914401 0.353 ENSMUST00000105675.1
Park7
Parkinson disease (autosomal recessive, early onset) 7
chr4_+_59035088 0.337 ENSMUST00000041160.6
Gng10
guanine nucleotide binding protein (G protein), gamma 10
chr18_+_56432116 0.335 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr7_+_100159241 0.331 ENSMUST00000032967.3
Lipt2
lipoyl(octanoyl) transferase 2 (putative)
chr9_-_112187766 0.306 ENSMUST00000111872.2
ENSMUST00000164754.2
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr2_-_160619971 0.297 ENSMUST00000109473.1
Gm14221
predicted gene 14221
chr8_-_112011266 0.297 ENSMUST00000164470.1
ENSMUST00000093120.5
Kars

lysyl-tRNA synthetase

chr3_+_53488677 0.294 ENSMUST00000029307.3
Stoml3
stomatin (Epb7.2)-like 3
chr8_-_112011320 0.292 ENSMUST00000034426.6
Kars
lysyl-tRNA synthetase
chr19_-_32196393 0.281 ENSMUST00000151822.1
Sgms1
sphingomyelin synthase 1
chr9_-_110476637 0.277 ENSMUST00000111934.1
ENSMUST00000068025.6
Klhl18

kelch-like 18

chr6_+_63255971 0.274 ENSMUST00000159561.1
ENSMUST00000095852.3
Grid2

glutamate receptor, ionotropic, delta 2

chr4_-_117682233 0.270 ENSMUST00000102687.3
Dmap1
DNA methyltransferase 1-associated protein 1
chr5_+_136987019 0.259 ENSMUST00000004968.4
Plod3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr9_+_110052016 0.253 ENSMUST00000164930.1
ENSMUST00000163979.1
Map4

microtubule-associated protein 4

chr1_+_75435930 0.251 ENSMUST00000037796.7
ENSMUST00000113584.1
ENSMUST00000145166.1
ENSMUST00000143730.1
ENSMUST00000133418.1
ENSMUST00000144874.1
ENSMUST00000140287.1
Gmppa






GDP-mannose pyrophosphorylase A






chr16_-_89818338 0.249 ENSMUST00000164263.2
Tiam1
T cell lymphoma invasion and metastasis 1
chr1_-_36557517 0.248 ENSMUST00000114990.1
ENSMUST00000128104.1
ENSMUST00000027295.4
Sema4c


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C


chr2_-_164389095 0.241 ENSMUST00000167427.1
Slpi
secretory leukocyte peptidase inhibitor
chr6_+_8948608 0.234 ENSMUST00000160300.1
Nxph1
neurexophilin 1
chr10_+_128337761 0.229 ENSMUST00000005826.7
Cs
citrate synthase
chr3_+_88297115 0.211 ENSMUST00000001452.7
Cct3
chaperonin containing Tcp1, subunit 3 (gamma)
chr7_+_38183217 0.207 ENSMUST00000165308.1
1600014C10Rik
RIKEN cDNA 1600014C10 gene
chr17_+_85028347 0.199 ENSMUST00000024944.7
Slc3a1
solute carrier family 3, member 1
chr6_-_54566484 0.198 ENSMUST00000019268.4
Scrn1
secernin 1
chr2_-_29787622 0.197 ENSMUST00000177467.1
ENSMUST00000113807.3
Trub2

TruB pseudouridine (psi) synthase homolog 2 (E. coli)

chr12_+_80644212 0.194 ENSMUST00000085245.5
Slc39a9
solute carrier family 39 (zinc transporter), member 9
chr3_+_88297147 0.191 ENSMUST00000164166.1
ENSMUST00000168062.1
Cct3

chaperonin containing Tcp1, subunit 3 (gamma)

chrM_+_8600 0.191 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chrX_-_101086020 0.178 ENSMUST00000113710.1
Slc7a3
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3
chr2_+_120476911 0.170 ENSMUST00000110716.1
ENSMUST00000028748.6
ENSMUST00000090028.5
ENSMUST00000110719.2
Capn3



calpain 3



chr12_+_108605757 0.170 ENSMUST00000109854.2
Evl
Ena-vasodilator stimulated phosphoprotein
chr5_-_3647806 0.159 ENSMUST00000119783.1
ENSMUST00000007559.8
Gatad1

GATA zinc finger domain containing 1

chr6_+_134640940 0.156 ENSMUST00000062755.8
Loh12cr1
loss of heterozygosity, 12, chromosomal region 1 homolog (human)
chr17_-_47502276 0.154 ENSMUST00000067103.2
Taf8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factorq
chr12_+_111814170 0.152 ENSMUST00000021714.7
Zfyve21
zinc finger, FYVE domain containing 21
chr10_-_8886033 0.147 ENSMUST00000015449.5
Sash1
SAM and SH3 domain containing 1
chr2_-_73625731 0.146 ENSMUST00000070579.6
Chn1
chimerin (chimaerin) 1
chr7_+_126950687 0.142 ENSMUST00000106333.1
Sez6l2
seizure related 6 homolog like 2
chr14_-_52104015 0.142 ENSMUST00000111610.4
ENSMUST00000164655.1
Hnrnpc

heterogeneous nuclear ribonucleoprotein C

chrX_+_169685191 0.134 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1

midline 1

chrX_-_99470672 0.128 ENSMUST00000113797.3
ENSMUST00000113790.1
ENSMUST00000036354.6
ENSMUST00000167246.1
Pja1



praja1, RING-H2 motif containing



chr9_+_37208291 0.117 ENSMUST00000034632.8
Tmem218
transmembrane protein 218
chrX_+_93675088 0.107 ENSMUST00000045898.3
Pcyt1b
phosphate cytidylyltransferase 1, choline, beta isoform
chr2_+_19371636 0.106 ENSMUST00000023856.8
Msrb2
methionine sulfoxide reductase B2
chr16_-_32877723 0.103 ENSMUST00000119810.1
1700021K19Rik
RIKEN cDNA 1700021K19 gene
chr11_+_59306920 0.099 ENSMUST00000000128.3
ENSMUST00000108783.3
Wnt9a

wingless-type MMTV integration site 9A

chr1_+_93421682 0.096 ENSMUST00000096427.4
Gm17415
predicted gene, 17415
chr11_+_101087277 0.086 ENSMUST00000107302.1
ENSMUST00000107303.3
ENSMUST00000017945.8
ENSMUST00000149597.1
Mlx



MAX-like protein X



chr10_+_90071095 0.083 ENSMUST00000183109.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr1_+_110099295 0.079 ENSMUST00000134301.1
Cdh7
cadherin 7, type 2
chr14_+_58893465 0.077 ENSMUST00000079960.1
Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr5_-_100416115 0.076 ENSMUST00000182886.1
ENSMUST00000094578.4
Sec31a

Sec31 homolog A (S. cerevisiae)

chr1_-_161070613 0.074 ENSMUST00000035430.3
Dars2
aspartyl-tRNA synthetase 2 (mitochondrial)
chr12_-_98577940 0.073 ENSMUST00000110113.1
Kcnk10
potassium channel, subfamily K, member 10
chr5_-_137072254 0.073 ENSMUST00000077523.3
ENSMUST00000041388.4
Serpine1

serine (or cysteine) peptidase inhibitor, clade E, member 1

chr7_+_101896817 0.071 ENSMUST00000143835.1
Anapc15
anaphase prompoting complex C subunit 15
chr11_-_109611417 0.071 ENSMUST00000103060.3
ENSMUST00000047186.3
ENSMUST00000106689.1
Wipi1


WD repeat domain, phosphoinositide interacting 1


chr8_-_54724474 0.066 ENSMUST00000175915.1
Wdr17
WD repeat domain 17
chr11_+_58171648 0.061 ENSMUST00000020820.1
Mrpl22
mitochondrial ribosomal protein L22
chr14_-_104522615 0.058 ENSMUST00000022716.2
Rnf219
ring finger protein 219
chr14_+_64589802 0.057 ENSMUST00000180610.1
A930011O12Rik
RIKEN cDNA A930011O12 gene
chr4_+_95557494 0.056 ENSMUST00000079223.4
ENSMUST00000177394.1
Fggy

FGGY carbohydrate kinase domain containing

chr12_+_102128718 0.054 ENSMUST00000159329.1
Slc24a4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr1_-_163725123 0.049 ENSMUST00000159679.1
Mettl11b
methyltransferase like 11B
chr4_-_115133977 0.032 ENSMUST00000051400.7
Cyp4x1
cytochrome P450, family 4, subfamily x, polypeptide 1
chr15_-_63997969 0.031 ENSMUST00000164532.1
Fam49b
family with sequence similarity 49, member B
chr2_+_106693185 0.030 ENSMUST00000111063.1
Mpped2
metallophosphoesterase domain containing 2
chr2_+_91257323 0.003 ENSMUST00000111349.2
ENSMUST00000131711.1
Pacsin3

protein kinase C and casein kinase substrate in neurons 3


Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 16.9 GO:0019532 oxalate transport(GO:0019532)
2.3 9.3 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.3 5.3 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.5 1.5 GO:0097212 lysosomal membrane organization(GO:0097212)
0.5 1.9 GO:0061743 motor learning(GO:0061743)
0.5 1.4 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.4 1.7 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.4 4.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.3 1.5 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.3 0.8 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.2 0.7 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.2 0.9 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.2 1.1 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) negative regulation of vacuolar transport(GO:1903336)
0.2 0.6 GO:0045575 basophil activation involved in immune response(GO:0002276) basophil activation(GO:0045575)
0.2 1.1 GO:0060923 cardiac muscle cell fate commitment(GO:0060923)
0.1 0.4 GO:0061738 abscission(GO:0009838) late endosomal microautophagy(GO:0061738) positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.1 1.0 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 0.4 GO:0050787 glycolate metabolic process(GO:0009441) enzyme active site formation via L-cysteine sulfinic acid(GO:0018323) primary alcohol biosynthetic process(GO:0034309) cellular response to glyoxal(GO:0036471) glycolate biosynthetic process(GO:0046295) detoxification of mercury ion(GO:0050787) negative regulation of TRAIL-activated apoptotic signaling pathway(GO:1903122) regulation of pyrroline-5-carboxylate reductase activity(GO:1903167) positive regulation of pyrroline-5-carboxylate reductase activity(GO:1903168) regulation of tyrosine 3-monooxygenase activity(GO:1903176) positive regulation of tyrosine 3-monooxygenase activity(GO:1903178) regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181) L-dopa metabolic process(GO:1903184) L-dopa biosynthetic process(GO:1903185) glyoxal metabolic process(GO:1903189) regulation of L-dopa biosynthetic process(GO:1903195) positive regulation of L-dopa biosynthetic process(GO:1903197) regulation of L-dopa decarboxylase activity(GO:1903198) positive regulation of L-dopa decarboxylase activity(GO:1903200) positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.1 2.2 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1 1.2 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 0.3 GO:0009106 lipoate metabolic process(GO:0009106)
0.1 1.7 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.1 0.4 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.1 1.0 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 0.6 GO:0070447 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
0.1 0.2 GO:1900149 positive regulation of Schwann cell migration(GO:1900149)
0.1 0.5 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 0.6 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.1 0.3 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1 1.0 GO:0048240 sperm capacitation(GO:0048240)
0.1 0.8 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.1 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.1 0.2 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.1 0.7 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.1 0.3 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.1 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.0 0.7 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.6 GO:0001553 luteinization(GO:0001553)
0.0 0.2 GO:0015822 ornithine transport(GO:0015822)
0.0 0.1 GO:0090365 regulation of mRNA modification(GO:0090365)
0.0 0.4 GO:1990173 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.0 1.7 GO:0030901 midbrain development(GO:0030901)
0.0 0.3 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.7 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 2.4 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 0.2 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:2000097 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.5 GO:0006907 pinocytosis(GO:0006907)
0.0 0.2 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 0.1 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 0.3 GO:1904861 prepulse inhibition(GO:0060134) excitatory synapse assembly(GO:1904861)
0.0 0.1 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.7 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.6 GO:0019228 neuronal action potential(GO:0019228) positive regulation of potassium ion transmembrane transport(GO:1901381)
0.0 3.0 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 2.4 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 1.1 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.3 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.7 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.2 GO:0019731 antibacterial humoral response(GO:0019731)
0.0 0.2 GO:0021535 cell migration in hindbrain(GO:0021535)
0.0 0.7 GO:0030500 regulation of bone mineralization(GO:0030500)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0097454 Schwann cell microvillus(GO:0097454)
0.2 1.1 GO:0097443 sorting endosome(GO:0097443)
0.2 0.5 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.1 4.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.5 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 1.0 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 28.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 1.4 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.5 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.5 GO:0034709 methylosome(GO:0034709)
0.1 0.6 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.4 GO:0090543 ESCRT III complex(GO:0000815) Flemming body(GO:0090543)
0.0 0.6 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.3 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.2 GO:0060091 kinocilium(GO:0060091)
0.0 1.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 2.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.7 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.3 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.1 GO:0042583 chromaffin granule(GO:0042583)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 9.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.5 16.9 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.6 1.7 GO:0016748 succinyltransferase activity(GO:0016748)
0.5 3.5 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.3 1.0 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.3 2.4 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.2 1.2 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.2 1.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.2 1.5 GO:0046790 virion binding(GO:0046790)
0.2 0.8 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.7 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.7 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 1.0 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 0.4 GO:0036470 tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478)
0.1 1.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 0.5 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 1.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.6 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 0.7 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 2.0 GO:0042287 MHC protein binding(GO:0042287)
0.1 2.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 0.7 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 0.5 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.1 0.3 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1 0.3 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.5 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 1.0 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 1.8 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.1 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.6 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.2 GO:0031432 titin binding(GO:0031432)
0.0 0.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 1.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 2.0 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 6.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 1.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.2 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.3 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 3.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.1 GO:0022821 potassium ion antiporter activity(GO:0022821)
0.0 0.6 GO:0015459 potassium channel regulator activity(GO:0015459)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.4 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.5 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.7 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.1 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.0 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.1 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.5 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.2 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 26.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3 2.3 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 2.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.7 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.5 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.7 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.5 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.7 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 1.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.7 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 2.6 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.4 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.4 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.3 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.2 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases