Motif ID: Hdx
Z-value: 6.333
Transcription factors associated with Hdx:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hdx | ENSMUSG00000034551.6 | Hdx |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hdx | mm10_v2_chrX_-_111697069_111697127 | -0.12 | 4.5e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 19.5 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 2.0 | 8.0 | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) |
| 1.8 | 5.5 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 1.7 | 5.1 | GO:0070488 | neutrophil aggregation(GO:0070488) |
| 0.8 | 3.3 | GO:0001692 | histamine metabolic process(GO:0001692) histidine metabolic process(GO:0006547) imidazole-containing compound catabolic process(GO:0052805) |
| 0.6 | 1.9 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.4 | 1.2 | GO:0061526 | acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) regulation of sulfur amino acid metabolic process(GO:0031335) musculoskeletal movement, spinal reflex action(GO:0050883) acetylcholine secretion(GO:0061526) |
| 0.3 | 1.8 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
| 0.3 | 6.4 | GO:0007413 | axonal fasciculation(GO:0007413) |
| 0.3 | 4.0 | GO:0010818 | T cell chemotaxis(GO:0010818) |
| 0.2 | 1.8 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.2 | 0.5 | GO:0046381 | CMP-N-acetylneuraminate metabolic process(GO:0046381) |
| 0.2 | 1.2 | GO:0002002 | regulation of angiotensin levels in blood(GO:0002002) |
| 0.2 | 0.8 | GO:0021905 | pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937) |
| 0.1 | 1856.2 | GO:0008150 | biological_process(GO:0008150) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.9 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.1 | 1903.0 | GO:0005575 | cellular_component(GO:0005575) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 5.1 | GO:0050786 | arachidonic acid binding(GO:0050544) RAGE receptor binding(GO:0050786) |
| 0.8 | 4.0 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.4 | 2.3 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.3 | 8.0 | GO:0017046 | peptide hormone binding(GO:0017046) |
| 0.2 | 0.9 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.2 | 0.5 | GO:0016716 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716) |
| 0.2 | 6.4 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.1 | 2.5 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 0.9 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.1 | 23.3 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 1874.5 | GO:0003674 | molecular_function(GO:0003674) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.1 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.1 | 8.0 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.1 | 5.5 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 2.8 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 8.0 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 3.0 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 1.2 | REACTOME_REGULATION_OF_INSULIN_SECRETION | Genes involved in Regulation of Insulin Secretion |
| 0.1 | 0.8 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 1.2 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
