Motif ID: Hes5_Hes7
Z-value: 1.464
Transcription factors associated with Hes5_Hes7:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Hes5 | ENSMUSG00000048001.7 | Hes5 |
Hes7 | ENSMUSG00000023781.2 | Hes7 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Hes7 | mm10_v2_chr11_+_69120404_69120404 | -0.34 | 2.9e-02 | Click! |
Hes5 | mm10_v2_chr4_+_154960915_154960930 | -0.12 | 4.8e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
12.8 | 114.8 | GO:0070874 | negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874) |
2.8 | 8.4 | GO:0003349 | epicardium-derived cardiac endothelial cell differentiation(GO:0003349) |
1.4 | 13.6 | GO:0042095 | interferon-gamma biosynthetic process(GO:0042095) |
0.9 | 7.1 | GO:0090091 | positive regulation of axon extension involved in axon guidance(GO:0048842) positive regulation of extracellular matrix disassembly(GO:0090091) |
0.9 | 3.4 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
0.8 | 2.4 | GO:0051771 | negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) |
0.8 | 5.6 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
0.6 | 1.9 | GO:0021759 | globus pallidus development(GO:0021759) |
0.6 | 3.7 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
0.5 | 1.5 | GO:0060167 | regulation of adenosine receptor signaling pathway(GO:0060167) regulation of G-protein coupled receptor internalization(GO:1904020) |
0.5 | 4.4 | GO:0006975 | DNA damage induced protein phosphorylation(GO:0006975) |
0.5 | 2.9 | GO:1903755 | regulation of SUMO transferase activity(GO:1903182) positive regulation of SUMO transferase activity(GO:1903755) |
0.4 | 1.6 | GO:0015744 | succinate transport(GO:0015744) |
0.3 | 0.9 | GO:1903334 | positive regulation of protein folding(GO:1903334) |
0.3 | 3.0 | GO:0033690 | positive regulation of osteoblast proliferation(GO:0033690) |
0.3 | 5.8 | GO:0045780 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
0.2 | 0.7 | GO:0010814 | substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959) |
0.2 | 1.1 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
0.2 | 0.6 | GO:0035526 | retrograde transport, plasma membrane to Golgi(GO:0035526) |
0.2 | 0.6 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166) |
0.2 | 1.5 | GO:0060046 | regulation of acrosome reaction(GO:0060046) |
0.2 | 3.4 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
0.2 | 2.0 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
0.2 | 0.8 | GO:0090063 | positive regulation of microtubule nucleation(GO:0090063) |
0.1 | 0.9 | GO:0000707 | meiotic DNA recombinase assembly(GO:0000707) |
0.1 | 5.6 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
0.1 | 1.6 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
0.1 | 0.6 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
0.1 | 1.6 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
0.1 | 1.1 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
0.1 | 1.5 | GO:0046850 | regulation of bone remodeling(GO:0046850) |
0.1 | 11.4 | GO:0030177 | positive regulation of Wnt signaling pathway(GO:0030177) |
0.1 | 4.4 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) |
0.1 | 0.6 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
0.1 | 0.5 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
0.1 | 1.7 | GO:0007129 | synapsis(GO:0007129) |
0.1 | 0.5 | GO:0090286 | cytoskeletal anchoring at nuclear membrane(GO:0090286) |
0.0 | 0.2 | GO:0038030 | non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031) |
0.0 | 0.2 | GO:0006361 | transcription initiation from RNA polymerase I promoter(GO:0006361) termination of RNA polymerase I transcription(GO:0006363) |
0.0 | 0.5 | GO:0051292 | nuclear pore complex assembly(GO:0051292) |
0.0 | 0.6 | GO:0008340 | determination of adult lifespan(GO:0008340) |
0.0 | 0.2 | GO:1902951 | negative regulation of dendritic spine maintenance(GO:1902951) |
0.0 | 1.1 | GO:0045214 | sarcomere organization(GO:0045214) |
0.0 | 0.4 | GO:0006878 | cellular copper ion homeostasis(GO:0006878) response to activity(GO:0014823) |
0.0 | 0.3 | GO:0034143 | regulation of toll-like receptor 4 signaling pathway(GO:0034143) |
0.0 | 0.7 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
0.0 | 0.1 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
0.0 | 0.2 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
0.0 | 0.6 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
0.0 | 0.7 | GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 3.4 | GO:0005967 | mitochondrial pyruvate dehydrogenase complex(GO:0005967) |
0.6 | 1.7 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
0.5 | 2.9 | GO:1990356 | sumoylated E2 ligase complex(GO:1990356) |
0.4 | 3.3 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
0.3 | 10.7 | GO:0090544 | BAF-type complex(GO:0090544) |
0.3 | 2.0 | GO:0046581 | intercellular canaliculus(GO:0046581) |
0.2 | 1.0 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
0.1 | 0.7 | GO:0033093 | Weibel-Palade body(GO:0033093) |
0.1 | 0.5 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
0.1 | 1.5 | GO:0097225 | sperm midpiece(GO:0097225) |
0.1 | 1.2 | GO:0005652 | nuclear lamina(GO:0005652) |
0.1 | 0.9 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
0.1 | 1.6 | GO:0046540 | U4/U6 x U5 tri-snRNP complex(GO:0046540) |
0.1 | 4.4 | GO:0005657 | replication fork(GO:0005657) |
0.1 | 0.8 | GO:0005869 | dynactin complex(GO:0005869) |
0.0 | 1.1 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
0.0 | 3.0 | GO:0005581 | collagen trimer(GO:0005581) |
0.0 | 0.3 | GO:0090543 | Flemming body(GO:0090543) |
0.0 | 0.4 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
0.0 | 3.6 | GO:0005903 | brush border(GO:0005903) |
0.0 | 5.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
0.0 | 1.1 | GO:0043034 | costamere(GO:0043034) |
0.0 | 84.3 | GO:0005829 | cytosol(GO:0005829) |
0.0 | 0.5 | GO:0097440 | apical dendrite(GO:0097440) |
0.0 | 1.0 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
0.0 | 4.9 | GO:0005874 | microtubule(GO:0005874) |
0.0 | 1.6 | GO:0005923 | bicellular tight junction(GO:0005923) |
0.0 | 0.7 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
0.0 | 0.7 | GO:0043198 | dendritic shaft(GO:0043198) |
0.0 | 9.0 | GO:0005615 | extracellular space(GO:0005615) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.9 | 114.8 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
2.4 | 7.1 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
1.5 | 4.4 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
0.9 | 3.6 | GO:0008422 | beta-glucosidase activity(GO:0008422) |
0.9 | 3.4 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
0.8 | 3.3 | GO:0035851 | histone deacetylase activity (H4-K16 specific)(GO:0034739) Krueppel-associated box domain binding(GO:0035851) |
0.5 | 1.6 | GO:0015140 | malate transmembrane transporter activity(GO:0015140) |
0.5 | 2.4 | GO:0004661 | protein geranylgeranyltransferase activity(GO:0004661) |
0.5 | 2.9 | GO:0061656 | SUMO conjugating enzyme activity(GO:0061656) |
0.4 | 3.4 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
0.4 | 1.5 | GO:0031687 | A2A adenosine receptor binding(GO:0031687) |
0.2 | 2.0 | GO:0071253 | connexin binding(GO:0071253) |
0.2 | 1.9 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
0.2 | 1.9 | GO:0031996 | thioesterase binding(GO:0031996) |
0.1 | 0.6 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
0.1 | 1.1 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
0.1 | 3.2 | GO:0017147 | Wnt-protein binding(GO:0017147) |
0.1 | 0.9 | GO:0015037 | peptide disulfide oxidoreductase activity(GO:0015037) |
0.1 | 3.7 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
0.1 | 6.1 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.1 | 1.1 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
0.1 | 2.4 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
0.0 | 1.7 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
0.0 | 0.5 | GO:0043495 | protein anchor(GO:0043495) |
0.0 | 2.1 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
0.0 | 0.2 | GO:0042610 | CD8 receptor binding(GO:0042610) |
0.0 | 10.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
0.0 | 0.2 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
0.0 | 0.7 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
0.0 | 2.1 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
0.0 | 0.8 | GO:0070840 | dynein complex binding(GO:0070840) |
0.0 | 0.5 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
0.0 | 0.4 | GO:0005507 | copper ion binding(GO:0005507) |
0.0 | 1.7 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.0 | 0.6 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
0.0 | 0.2 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
0.0 | 0.5 | GO:0045182 | translation regulator activity(GO:0045182) |
0.0 | 0.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.0 | 6.0 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
0.0 | 0.2 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.2 | 114.8 | PID_IGF1_PATHWAY | IGF1 pathway |
0.5 | 4.4 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
0.4 | 13.6 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
0.2 | 7.7 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.2 | 2.9 | PID_RANBP2_PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
0.1 | 1.7 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
0.1 | 3.2 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
0.1 | 1.8 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
0.1 | 3.3 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
0.0 | 2.1 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.0 | 4.3 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
0.0 | 0.6 | PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY | EGF receptor (ErbB1) signaling pathway |
0.0 | 1.1 | PID_AURORA_A_PATHWAY | Aurora A signaling |
0.0 | 0.6 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
0.0 | 1.1 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
0.0 | 0.8 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
0.0 | 3.1 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 3.4 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.0 | 0.3 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
0.0 | 0.6 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
0.0 | 0.7 | PID_LKB1_PATHWAY | LKB1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
5.5 | 114.8 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
0.4 | 4.4 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
0.3 | 4.4 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
0.3 | 7.1 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
0.3 | 3.4 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
0.2 | 1.7 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
0.2 | 3.4 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.2 | 5.8 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
0.1 | 12.6 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
0.1 | 2.9 | REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
0.1 | 1.7 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
0.1 | 1.6 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
0.1 | 0.8 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
0.0 | 1.1 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
0.0 | 2.9 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
0.0 | 0.6 | REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
0.0 | 1.8 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
0.0 | 3.7 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
0.0 | 0.5 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |