Motif ID: Hivep1
Z-value: 0.731
Transcription factors associated with Hivep1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hivep1 | ENSMUSG00000021366.7 | Hivep1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hivep1 | mm10_v2_chr13_+_42052015_42052072 | 0.10 | 5.5e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.9 | GO:0072382 | minus-end-directed vesicle transport along microtubule(GO:0072382) |
| 0.9 | 4.6 | GO:0002158 | osteoclast proliferation(GO:0002158) |
| 0.8 | 3.8 | GO:0032224 | positive regulation of synaptic transmission, cholinergic(GO:0032224) |
| 0.7 | 1.4 | GO:0046878 | positive regulation of saliva secretion(GO:0046878) |
| 0.7 | 2.0 | GO:1990046 | positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046) |
| 0.5 | 3.4 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 0.5 | 5.7 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.4 | 1.6 | GO:0002484 | antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485) |
| 0.4 | 2.2 | GO:0097473 | cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) |
| 0.3 | 1.0 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) |
| 0.3 | 2.9 | GO:0042487 | regulation of odontogenesis of dentin-containing tooth(GO:0042487) |
| 0.3 | 0.9 | GO:0021998 | neural plate mediolateral regionalization(GO:0021998) mesoderm structural organization(GO:0048338) paraxial mesoderm structural organization(GO:0048352) positive regulation of cardiac ventricle development(GO:1904414) |
| 0.2 | 0.7 | GO:0032916 | positive regulation of transforming growth factor beta3 production(GO:0032916) |
| 0.2 | 0.7 | GO:0032918 | polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918) |
| 0.2 | 1.0 | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427) |
| 0.2 | 1.6 | GO:1902373 | negative regulation of mRNA catabolic process(GO:1902373) |
| 0.2 | 0.9 | GO:0032329 | serine transport(GO:0032329) |
| 0.1 | 0.6 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.1 | 0.6 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
| 0.1 | 0.6 | GO:1904659 | glucose transmembrane transport(GO:1904659) |
| 0.1 | 1.1 | GO:0001842 | neural fold formation(GO:0001842) |
| 0.1 | 3.3 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
| 0.1 | 0.4 | GO:0006545 | glycine biosynthetic process(GO:0006545) |
| 0.1 | 3.6 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.1 | 0.4 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.1 | 0.4 | GO:0034729 | histone H3-K79 methylation(GO:0034729) |
| 0.1 | 0.7 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 0.1 | 0.9 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.1 | 0.3 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.1 | 0.2 | GO:0070944 | neutrophil mediated killing of bacterium(GO:0070944) |
| 0.1 | 0.8 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 0.3 | GO:2000319 | negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320) |
| 0.1 | 1.1 | GO:0035090 | maintenance of apical/basal cell polarity(GO:0035090) |
| 0.1 | 0.8 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.1 | 0.2 | GO:0001827 | inner cell mass cell fate commitment(GO:0001827) |
| 0.1 | 3.1 | GO:1901998 | toxin transport(GO:1901998) |
| 0.1 | 1.6 | GO:1900027 | regulation of ruffle assembly(GO:1900027) |
| 0.1 | 0.2 | GO:1901509 | regulation of endothelial tube morphogenesis(GO:1901509) |
| 0.1 | 0.7 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.1 | 0.3 | GO:0070345 | negative regulation of fat cell proliferation(GO:0070345) |
| 0.0 | 0.1 | GO:2000016 | negative regulation of determination of dorsal identity(GO:2000016) |
| 0.0 | 2.0 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
| 0.0 | 1.0 | GO:0030575 | nuclear body organization(GO:0030575) |
| 0.0 | 6.6 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 0.5 | GO:0043084 | penile erection(GO:0043084) |
| 0.0 | 0.1 | GO:1902220 | positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902220) |
| 0.0 | 0.6 | GO:0060219 | camera-type eye photoreceptor cell differentiation(GO:0060219) |
| 0.0 | 0.2 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
| 0.0 | 0.5 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 0.0 | 0.5 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.0 | 0.2 | GO:0048852 | diencephalon morphogenesis(GO:0048852) |
| 0.0 | 1.7 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.0 | 0.9 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.0 | 0.1 | GO:1904884 | telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884) |
| 0.0 | 0.6 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.0 | 0.3 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.0 | 1.8 | GO:0021766 | hippocampus development(GO:0021766) |
| 0.0 | 0.1 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.0 | 0.1 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
| 0.0 | 0.1 | GO:0060217 | positive regulation of chromatin assembly or disassembly(GO:0045799) hemangioblast cell differentiation(GO:0060217) regulation of mast cell differentiation(GO:0060375) |
| 0.0 | 0.7 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.0 | 0.2 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.0 | 0.0 | GO:1902623 | negative regulation of neutrophil migration(GO:1902623) regulation of dendritic cell chemotaxis(GO:2000508) |
| 0.0 | 0.2 | GO:0060749 | mammary gland alveolus development(GO:0060749) mammary gland lobule development(GO:0061377) |
| 0.0 | 1.7 | GO:0030833 | regulation of actin filament polymerization(GO:0030833) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.6 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.7 | 2.2 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.4 | 5.2 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.4 | 1.4 | GO:0032127 | dense core granule membrane(GO:0032127) |
| 0.3 | 1.1 | GO:0090537 | CERF complex(GO:0090537) |
| 0.2 | 3.9 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.2 | 2.0 | GO:0042581 | specific granule(GO:0042581) |
| 0.2 | 1.4 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 0.8 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
| 0.1 | 2.2 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.1 | 0.7 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.1 | 0.4 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.1 | 0.8 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.1 | 1.1 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.1 | 1.6 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.1 | 1.4 | GO:0005605 | basal lamina(GO:0005605) |
| 0.1 | 0.6 | GO:0034464 | BBSome(GO:0034464) |
| 0.1 | 0.9 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 0.3 | GO:0070776 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.1 | 0.8 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 0.5 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.0 | 2.0 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 5.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 0.8 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 0.6 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 1.4 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 5.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 0.2 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.0 | 1.9 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 0.1 | GO:0033193 | Lsd1/2 complex(GO:0033193) |
| 0.0 | 0.7 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 0.6 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 0.3 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 2.1 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.9 | GO:0005901 | caveola(GO:0005901) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.1 | GO:0036132 | 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522) |
| 0.6 | 5.7 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.4 | 5.2 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.3 | 2.0 | GO:1901612 | phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612) |
| 0.3 | 3.9 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.3 | 1.4 | GO:0015166 | polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168) |
| 0.2 | 4.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 2.2 | GO:0036122 | BMP binding(GO:0036122) |
| 0.2 | 0.7 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 0.2 | 0.7 | GO:0004145 | diamine N-acetyltransferase activity(GO:0004145) |
| 0.2 | 0.9 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.2 | 1.4 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.1 | 0.4 | GO:0008732 | threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.1 | 0.8 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.1 | 0.5 | GO:0004096 | catalase activity(GO:0004096) |
| 0.1 | 0.4 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.1 | 0.7 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.1 | 0.9 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.1 | 0.3 | GO:0010484 | H3 histone acetyltransferase activity(GO:0010484) |
| 0.1 | 2.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 0.5 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.1 | 0.3 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.1 | 2.9 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 0.9 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.1 | 0.2 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
| 0.1 | 1.9 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 4.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.2 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.0 | 0.5 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 0.3 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
| 0.0 | 1.9 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.0 | 2.6 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 2.2 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.0 | 0.9 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 1.4 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.6 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.0 | 0.8 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 0.6 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.0 | 0.3 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.0 | 0.1 | GO:0032405 | MutLalpha complex binding(GO:0032405) |
| 0.0 | 0.4 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 0.6 | GO:0015370 | solute:sodium symporter activity(GO:0015370) |
| 0.0 | 0.1 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.0 | 0.2 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.0 | 0.2 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.8 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.3 | 2.6 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 3.1 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 4.4 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 2.2 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.1 | 0.7 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 2.1 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.0 | 0.7 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.0 | 1.9 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.0 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 1.6 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 3.4 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 0.7 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.6 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 2.4 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.8 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 0.7 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.0 | 0.1 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.8 | PID_NFAT_3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.0 | 0.6 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.8 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 0.3 | PID_CXCR3_PATHWAY | CXCR3-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.4 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 1.4 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.2 | 2.2 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.1 | 3.9 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.1 | 0.9 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.1 | 0.7 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 1.6 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 1.5 | REACTOME_PIP3_ACTIVATES_AKT_SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.0 | 0.8 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.8 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.7 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 1.4 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.4 | REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.0 | 0.8 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.3 | REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 1.9 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.6 | REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 0.5 | REACTOME_NOD1_2_SIGNALING_PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 0.5 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.4 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 0.6 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.2 | REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.0 | 0.2 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 0.1 | REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
