Motif ID: Hmx3

Z-value: 0.439


Transcription factors associated with Hmx3:

Gene SymbolEntrez IDGene Name
Hmx3 ENSMUSG00000040148.5 Hmx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmx3mm10_v2_chr7_+_131542867_1315428670.086.2e-01Click!


Activity profile for motif Hmx3.

activity profile for motif Hmx3


Sorted Z-values histogram for motif Hmx3

Sorted Z-values for motif Hmx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_144893127 1.846 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr10_+_99263224 1.504 ENSMUST00000020118.4
 Dusp6
dual specificity phosphatase 6
chr4_+_154960915 0.904 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr13_+_118714678 0.901 ENSMUST00000022246.8
 Fgf10
fibroblast growth factor 10
chr5_+_15516489 0.851 ENSMUST00000178227.1
 Gm21847
predicted gene, 21847
chr11_+_103133303 0.846 ENSMUST00000107037.1
 Hexim2
hexamethylene bis-acetamide inducible 2
chr3_+_62419668 0.845 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr12_-_83487708 0.807 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr11_+_103133333 0.662 ENSMUST00000124928.1
ENSMUST00000062530.4
 Hexim2

hexamethylene bis-acetamide inducible 2

chr19_-_41933276 0.619 ENSMUST00000075280.4
ENSMUST00000112123.2
 Exosc1

exosome component 1

chr11_+_114668524 0.618 ENSMUST00000106602.3
ENSMUST00000077915.3
ENSMUST00000106599.1
ENSMUST00000082092.4
 Rpl38



ribosomal protein L38



chr2_-_153015331 0.599 ENSMUST00000028972.8
 Pdrg1
p53 and DNA damage regulated 1
chr7_-_126897424 0.595 ENSMUST00000120007.1
 Tmem219
transmembrane protein 219
chr19_+_41933464 0.540 ENSMUST00000026154.7
 Zdhhc16
zinc finger, DHHC domain containing 16
chr11_+_69838514 0.522 ENSMUST00000133967.1
ENSMUST00000094065.4
 Tmem256

transmembrane protein 256

chr7_+_3645267 0.520 ENSMUST00000038913.9
 Cnot3
CCR4-NOT transcription complex, subunit 3
chr15_+_9436028 0.517 ENSMUST00000042360.3
 Capsl
calcyphosine-like
chr3_+_96629919 0.512 ENSMUST00000048915.6
 Rbm8a
RNA binding motif protein 8a
chr7_-_30559600 0.506 ENSMUST00000043975.4
ENSMUST00000156241.1
 Lin37

lin-37 homolog (C. elegans)

chr5_-_137684665 0.505 ENSMUST00000100544.4
ENSMUST00000031736.9
ENSMUST00000151839.1
 Agfg2


ArfGAP with FG repeats 2


chr14_+_54464141 0.476 ENSMUST00000022782.8
 Lrp10
low-density lipoprotein receptor-related protein 10
chr13_+_23746734 0.458 ENSMUST00000099703.2
 Hist1h2bb
histone cluster 1, H2bb
chr13_-_92131494 0.440 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr7_-_127208423 0.427 ENSMUST00000120705.1
 Tbc1d10b
TBC1 domain family, member 10b
chr6_+_86371489 0.419 ENSMUST00000089558.5
 Snrpg
small nuclear ribonucleoprotein polypeptide G
chr19_+_8802486 0.410 ENSMUST00000172175.1
 Zbtb3
zinc finger and BTB domain containing 3
chr7_-_121035096 0.404 ENSMUST00000065740.2
 Gm9905
predicted gene 9905
chr3_-_49757257 0.401 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr14_-_55560340 0.391 ENSMUST00000066106.3
 A730061H03Rik
RIKEN cDNA A730061H03 gene
chr7_+_25267669 0.379 ENSMUST00000169266.1
 Cic
capicua homolog (Drosophila)
chrM_+_9452 0.368 ENSMUST00000082411.1
 mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr7_-_45510400 0.343 ENSMUST00000033096.7
 Nucb1
nucleobindin 1
chr9_-_123678782 0.340 ENSMUST00000170591.1
ENSMUST00000171647.1
 Slc6a20a

solute carrier family 6 (neurotransmitter transporter), member 20A

chr7_-_30559828 0.340 ENSMUST00000108164.1
 Lin37
lin-37 homolog (C. elegans)
chr4_+_65604984 0.339 ENSMUST00000050850.7
ENSMUST00000107366.1
 Trim32

tripartite motif-containing 32

chr7_+_25681158 0.330 ENSMUST00000108403.3
 B9d2
B9 protein domain 2
chr1_-_78968079 0.317 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr17_-_57247632 0.302 ENSMUST00000005975.6
 Gpr108
G protein-coupled receptor 108
chr2_+_3114220 0.298 ENSMUST00000072955.5
 Fam171a1
family with sequence similarity 171, member A1
chr9_+_21955747 0.260 ENSMUST00000053583.5
 Swsap1
SWIM type zinc finger 7 associated protein 1
chr8_-_23237623 0.242 ENSMUST00000033950.5
 Gins4
GINS complex subunit 4 (Sld5 homolog)
chr1_-_175979114 0.215 ENSMUST00000104983.1
 B020018G12Rik
RIKEN cDNA B020018G12 gene
chr5_-_87482258 0.204 ENSMUST00000079811.6
ENSMUST00000144144.1
 Ugt2a1

UDP glucuronosyltransferase 2 family, polypeptide A1

chrX_+_150594420 0.197 ENSMUST00000112713.2
 Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr7_+_79273201 0.196 ENSMUST00000037315.6
 Abhd2
abhydrolase domain containing 2
chr2_-_130424242 0.195 ENSMUST00000089581.4
 Pced1a
PC-esterase domain containing 1A
chr4_-_62470868 0.182 ENSMUST00000135811.1
ENSMUST00000120095.1
ENSMUST00000030087.7
ENSMUST00000107452.1
ENSMUST00000155522.1
 Wdr31




WD repeat domain 31




chrX_+_159708593 0.168 ENSMUST00000080394.6
 Sh3kbp1
SH3-domain kinase binding protein 1
chr10_+_115569986 0.162 ENSMUST00000173620.1
 A930009A15Rik
RIKEN cDNA A930009A15 gene
chr12_-_108179237 0.145 ENSMUST00000071095.7
 Setd3
SET domain containing 3
chr19_+_11965817 0.144 ENSMUST00000025590.9
 Osbp
oxysterol binding protein
chr2_-_130424673 0.122 ENSMUST00000110277.1
 Pced1a
PC-esterase domain containing 1A
chr2_-_72986716 0.118 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr3_-_142169311 0.118 ENSMUST00000106230.1
 Bmpr1b
bone morphogenetic protein receptor, type 1B
chr3_-_154328634 0.108 ENSMUST00000167744.1
 Lhx8
LIM homeobox protein 8
chr2_+_130424321 0.106 ENSMUST00000128994.1
ENSMUST00000028900.9
 Vps16

vacuolar protein sorting 16 (yeast)

chr9_-_123678873 0.104 ENSMUST00000040960.6
 Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr4_+_134397380 0.101 ENSMUST00000105870.1
 Pafah2
platelet-activating factor acetylhydrolase 2
chr4_-_45532470 0.069 ENSMUST00000147448.1
 Shb
src homology 2 domain-containing transforming protein B
chr4_-_129261394 0.046 ENSMUST00000145261.1
 C77080
expressed sequence C77080
chr2_-_84715160 0.035 ENSMUST00000035840.5
 Zdhhc5
zinc finger, DHHC domain containing 5
chr3_+_66985947 0.010 ENSMUST00000161726.1
ENSMUST00000160504.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr7_+_24370255 0.006 ENSMUST00000171904.1
 Kcnn4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.3 0.9 GO:0071336 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.2 0.9 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.2 1.8 GO:0042572 retinol metabolic process(GO:0042572)
0.1 0.6 GO:0048318 axial mesoderm development(GO:0048318)
0.1 0.3 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 1.5 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.4 GO:0015838 proline transport(GO:0015824) amino-acid betaine transport(GO:0015838)
0.0 0.2 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.2 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.8 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.1 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.6 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.4 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 0.5 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.2 GO:0032570 response to progesterone(GO:0032570)
0.0 0.1 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.5 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0000811 GINS complex(GO:0000811)
0.1 0.3 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.1 0.2 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 0.5 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.4 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 0.6 GO:0016272 prefoldin complex(GO:0016272)
0.1 0.3 GO:0005859 muscle myosin complex(GO:0005859)
0.1 0.6 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.8 GO:0071565 nBAF complex(GO:0071565)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 0.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.1 GO:0033263 CORVET complex(GO:0033263)
0.0 0.5 GO:0035145 exon-exon junction complex(GO:0035145)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 0.9 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.2 1.5 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 1.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.4 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.5 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.4 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.1 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.5 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.6 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 0.9 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 0.6 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.4 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.8 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.2 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.5 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.2 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.5 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.5 REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_ Genes involved in Cleavage of Growing Transcript in the Termination Region
0.0 0.9 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription