Motif ID: Hoxa1
Z-value: 1.143
Transcription factors associated with Hoxa1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hoxa1 | ENSMUSG00000029844.9 | Hoxa1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 6.4 | GO:1901731 | positive regulation of platelet aggregation(GO:1901731) |
| 1.0 | 3.1 | GO:0014826 | vein smooth muscle contraction(GO:0014826) |
| 0.9 | 2.6 | GO:2000418 | positive regulation of eosinophil migration(GO:2000418) |
| 0.7 | 2.1 | GO:0044339 | canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339) |
| 0.7 | 8.0 | GO:1900121 | negative regulation of receptor binding(GO:1900121) |
| 0.6 | 1.9 | GO:1902256 | apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) |
| 0.6 | 6.5 | GO:0046543 | development of secondary female sexual characteristics(GO:0046543) |
| 0.6 | 7.3 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.5 | 5.5 | GO:0033089 | positive regulation of T cell differentiation in thymus(GO:0033089) regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643) positive regulation of thymocyte aggregation(GO:2000400) |
| 0.4 | 2.8 | GO:0061304 | retinal blood vessel morphogenesis(GO:0061304) |
| 0.4 | 1.5 | GO:0072272 | proximal/distal pattern formation involved in metanephric nephron development(GO:0072272) |
| 0.3 | 2.0 | GO:0072318 | clathrin coat disassembly(GO:0072318) |
| 0.3 | 0.9 | GO:0010700 | negative regulation of norepinephrine secretion(GO:0010700) |
| 0.3 | 0.8 | GO:0051030 | snRNA transport(GO:0051030) |
| 0.3 | 1.0 | GO:0015825 | L-serine transport(GO:0015825) |
| 0.3 | 2.3 | GO:0043084 | penile erection(GO:0043084) |
| 0.2 | 0.9 | GO:0090126 | protein complex assembly involved in synapse maturation(GO:0090126) |
| 0.2 | 1.6 | GO:0033563 | dorsal/ventral axon guidance(GO:0033563) |
| 0.2 | 1.2 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.2 | 0.8 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.1 | 0.7 | GO:0000454 | snoRNA guided rRNA pseudouridine synthesis(GO:0000454) |
| 0.1 | 1.9 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
| 0.1 | 2.4 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.1 | 1.5 | GO:0042473 | outer ear morphogenesis(GO:0042473) |
| 0.1 | 1.6 | GO:0001553 | luteinization(GO:0001553) |
| 0.1 | 0.6 | GO:0030916 | otic vesicle formation(GO:0030916) |
| 0.1 | 6.1 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.1 | 1.8 | GO:0050765 | negative regulation of phagocytosis(GO:0050765) |
| 0.1 | 2.5 | GO:0051968 | positive regulation of synaptic transmission, glutamatergic(GO:0051968) |
| 0.1 | 6.5 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.1 | 1.8 | GO:0071625 | vocalization behavior(GO:0071625) |
| 0.1 | 0.5 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.1 | 1.5 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.1 | 3.3 | GO:1901381 | positive regulation of potassium ion transmembrane transport(GO:1901381) |
| 0.1 | 1.8 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.1 | 1.1 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
| 0.0 | 0.3 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.0 | 0.6 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 0.0 | 0.2 | GO:1904800 | regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) |
| 0.0 | 2.9 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 1.2 | GO:0009409 | response to cold(GO:0009409) |
| 0.0 | 1.7 | GO:0030500 | regulation of bone mineralization(GO:0030500) |
| 0.0 | 3.3 | GO:0006694 | steroid biosynthetic process(GO:0006694) |
| 0.0 | 1.0 | GO:0048713 | regulation of oligodendrocyte differentiation(GO:0048713) |
| 0.0 | 0.1 | GO:2001054 | negative regulation of mesenchymal cell apoptotic process(GO:2001054) |
| 0.0 | 0.2 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.0 | 0.7 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 1.0 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.0 | 1.2 | GO:0000086 | G2/M transition of mitotic cell cycle(GO:0000086) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 6.4 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.6 | 2.8 | GO:0005587 | collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651) |
| 0.4 | 2.5 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
| 0.2 | 0.7 | GO:0090661 | box H/ACA telomerase RNP complex(GO:0090661) |
| 0.1 | 0.9 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.1 | 1.8 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.1 | 1.1 | GO:0071437 | invadopodium(GO:0071437) |
| 0.1 | 10.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 1.9 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.1 | 4.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 2.1 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 6.5 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 0.1 | GO:0032127 | dense core granule membrane(GO:0032127) |
| 0.0 | 2.3 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.0 | 0.6 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 2.7 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 8.1 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 1.0 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 1.0 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 0.9 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 0.8 | GO:0036477 | somatodendritic compartment(GO:0036477) |
| 0.0 | 3.1 | GO:0031965 | nuclear membrane(GO:0031965) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.1 | GO:0004962 | endothelin receptor activity(GO:0004962) |
| 0.6 | 8.0 | GO:1990459 | transferrin receptor binding(GO:1990459) |
| 0.6 | 6.4 | GO:0015250 | water channel activity(GO:0015250) |
| 0.5 | 3.0 | GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) |
| 0.5 | 2.4 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.4 | 2.5 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.3 | 1.2 | GO:0031800 | type 3 metabotropic glutamate receptor binding(GO:0031800) |
| 0.3 | 4.7 | GO:0048018 | receptor agonist activity(GO:0048018) |
| 0.2 | 1.6 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.2 | 2.8 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.1 | 1.9 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.1 | 1.0 | GO:0015180 | L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858) |
| 0.1 | 2.3 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 0.7 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 0.1 | 0.3 | GO:0004096 | catalase activity(GO:0004096) |
| 0.1 | 6.5 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.1 | 0.9 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.1 | 0.8 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.1 | 1.2 | GO:0047617 | acyl-CoA hydrolase activity(GO:0047617) |
| 0.1 | 3.3 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.0 | 1.9 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 1.6 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 4.1 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 1.9 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 4.1 | GO:0016779 | nucleotidyltransferase activity(GO:0016779) |
| 0.0 | 2.9 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 4.9 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 0.6 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 1.7 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 0.9 | GO:0004601 | peroxidase activity(GO:0004601) |
| 0.0 | 1.2 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.3 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 2.7 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 5.1 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.0 | 0.2 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.0 | 3.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.0 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.1 | 5.5 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 3.6 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 2.1 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.1 | 1.7 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 3.1 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
| 0.0 | 5.2 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.5 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.9 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 1.5 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.0 | 3.2 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.3 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.6 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.2 | 2.1 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 1.6 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 2.5 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.1 | 2.0 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.1 | 1.2 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.6 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.0 | 3.1 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 1.2 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.9 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 2.8 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 1.9 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 0.7 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 2.1 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.8 | REACTOME_METABOLISM_OF_NON_CODING_RNA | Genes involved in Metabolism of non-coding RNA |
