Motif ID: Hoxa9_Hoxb9
Z-value: 0.637
Transcription factors associated with Hoxa9_Hoxb9:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hoxa9 | ENSMUSG00000038227.9 | Hoxa9 |
| Hoxb9 | ENSMUSG00000020875.8 | Hoxb9 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.3 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
| 0.8 | 3.9 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
| 0.6 | 8.6 | GO:0032098 | regulation of appetite(GO:0032098) |
| 0.5 | 2.0 | GO:0090126 | protein complex assembly involved in synapse maturation(GO:0090126) |
| 0.5 | 2.5 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
| 0.4 | 1.9 | GO:0032489 | regulation of Cdc42 protein signal transduction(GO:0032489) |
| 0.4 | 1.1 | GO:0070366 | regulation of hepatocyte differentiation(GO:0070366) |
| 0.3 | 2.1 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.2 | 1.8 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.2 | 20.1 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.2 | 1.0 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.2 | 0.5 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.1 | 0.4 | GO:0001193 | maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193) |
| 0.1 | 0.8 | GO:1903056 | melanocyte migration(GO:0097324) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.1 | 5.9 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.1 | 0.9 | GO:0031848 | protection from non-homologous end joining at telomere(GO:0031848) |
| 0.1 | 0.4 | GO:0010891 | negative regulation of sequestering of triglyceride(GO:0010891) positive regulation of triglyceride catabolic process(GO:0010898) |
| 0.1 | 0.6 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
| 0.1 | 0.6 | GO:0032264 | IMP salvage(GO:0032264) |
| 0.1 | 1.9 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 0.0 | 0.9 | GO:0001516 | prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457) |
| 0.0 | 1.0 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 0.6 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.0 | 0.2 | GO:0015822 | ornithine transport(GO:0015822) |
| 0.0 | 0.4 | GO:2000821 | regulation of grooming behavior(GO:2000821) |
| 0.0 | 1.1 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.0 | 0.1 | GO:1990414 | replication-born double-strand break repair via sister chromatid exchange(GO:1990414) |
| 0.0 | 0.3 | GO:0051001 | negative regulation of nitric-oxide synthase activity(GO:0051001) |
| 0.0 | 0.9 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.0 | 0.1 | GO:0043415 | positive regulation of skeletal muscle tissue regeneration(GO:0043415) |
| 0.0 | 0.7 | GO:0008299 | isoprenoid biosynthetic process(GO:0008299) |
| 0.0 | 0.8 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.0 | 0.8 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
| 0.0 | 0.7 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 0.0 | 0.9 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.0 | 0.1 | GO:1903966 | monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966) |
| 0.0 | 3.9 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.0 | 1.2 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.9 | GO:0043512 | inhibin A complex(GO:0043512) |
| 0.5 | 1.9 | GO:0097447 | dendritic tree(GO:0097447) |
| 0.3 | 1.0 | GO:0099631 | postsynaptic endocytic zone cytoplasmic component(GO:0099631) |
| 0.3 | 1.0 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.2 | 2.0 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.2 | 17.5 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 1.2 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.1 | 1.1 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.1 | 1.8 | GO:0097449 | dense core granule(GO:0031045) astrocyte projection(GO:0097449) |
| 0.1 | 5.3 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 0.7 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 0.6 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.1 | 8.6 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 0.9 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.0 | 0.6 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 2.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 0.5 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.4 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 0.6 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 0.2 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 1.1 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.6 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.9 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.5 | 11.0 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.5 | 2.5 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.4 | 1.8 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.3 | 0.8 | GO:0016160 | alpha-amylase activity(GO:0004556) amylase activity(GO:0016160) |
| 0.3 | 0.8 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
| 0.2 | 0.9 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
| 0.2 | 1.0 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.2 | 2.0 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.1 | 0.7 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.1 | 0.9 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.1 | 0.4 | GO:0004609 | phosphatidylserine decarboxylase activity(GO:0004609) |
| 0.1 | 0.7 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.1 | 1.9 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 2.1 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.1 | 1.0 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.1 | 0.6 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.1 | 1.1 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 1.1 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 0.2 | GO:0000064 | L-ornithine transmembrane transporter activity(GO:0000064) |
| 0.0 | 0.6 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 0.6 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.0 | 0.4 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 1.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 1.0 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 12.6 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 3.2 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 6.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 0.1 | GO:0009378 | four-way junction helicase activity(GO:0009378) |
| 0.0 | 0.2 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.0 | 0.6 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.1 | GO:0032896 | palmitoyl-CoA 9-desaturase activity(GO:0032896) |
| 0.0 | 1.2 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 0.3 | GO:0032183 | SUMO binding(GO:0032183) |
| 0.0 | 0.0 | GO:0051870 | methotrexate binding(GO:0051870) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.5 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.1 | 2.4 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
| 0.1 | 3.9 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.0 | 1.4 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 1.9 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 2.1 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 1.0 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 0.9 | PID_IFNG_PATHWAY | IFN-gamma pathway |
| 0.0 | 1.0 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.0 | 1.4 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 1.4 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.9 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 0.8 | 20.8 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 2.1 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 8.6 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 1.9 | REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN | Genes involved in Signalling to p38 via RIT and RIN |
| 0.1 | 3.0 | REACTOME_G_PROTEIN_ACTIVATION | Genes involved in G-protein activation |
| 0.1 | 1.0 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 2.5 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 0.4 | REACTOME_COPI_MEDIATED_TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.0 | 0.6 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.0 | 0.5 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 0.6 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 1.0 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 0.4 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 1.0 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.4 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.3 | REACTOME_ENOS_ACTIVATION_AND_REGULATION | Genes involved in eNOS activation and regulation |
| 0.0 | 1.9 | REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.0 | 1.5 | REACTOME_L1CAM_INTERACTIONS | Genes involved in L1CAM interactions |
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