Motif ID: Hoxb1
Z-value: 0.618
Transcription factors associated with Hoxb1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hoxb1 | ENSMUSG00000018973.2 | Hoxb1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 17.1 | GO:0060032 | notochord regression(GO:0060032) |
| 0.4 | 3.2 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 0.3 | 1.0 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.3 | 8.3 | GO:0014912 | negative regulation of smooth muscle cell migration(GO:0014912) |
| 0.2 | 0.5 | GO:0072038 | mesenchymal stem cell maintenance involved in nephron morphogenesis(GO:0072038) |
| 0.2 | 0.9 | GO:0033563 | dorsal/ventral axon guidance(GO:0033563) |
| 0.2 | 0.5 | GO:0007181 | transforming growth factor beta receptor complex assembly(GO:0007181) |
| 0.2 | 0.7 | GO:0097374 | sensory neuron axon guidance(GO:0097374) |
| 0.2 | 1.5 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.1 | 1.0 | GO:0030718 | germ-line stem cell population maintenance(GO:0030718) |
| 0.1 | 0.4 | GO:1990927 | negative regulation of membrane invagination(GO:1905154) calcium ion regulated lysosome exocytosis(GO:1990927) |
| 0.1 | 0.6 | GO:0051890 | regulation of cardioblast differentiation(GO:0051890) |
| 0.1 | 1.2 | GO:2001054 | negative regulation of mesenchymal cell apoptotic process(GO:2001054) |
| 0.1 | 1.3 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.1 | 0.4 | GO:0070859 | positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253) |
| 0.1 | 0.5 | GO:2000138 | positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138) |
| 0.1 | 1.4 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.1 | 1.0 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.1 | 3.9 | GO:0007628 | adult walking behavior(GO:0007628) |
| 0.1 | 0.4 | GO:1990928 | response to amino acid starvation(GO:1990928) |
| 0.1 | 6.0 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.1 | 7.9 | GO:0021954 | central nervous system neuron development(GO:0021954) |
| 0.1 | 0.7 | GO:0060124 | positive regulation of growth hormone secretion(GO:0060124) |
| 0.1 | 1.9 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
| 0.1 | 0.4 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.1 | 0.8 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) regulation of dopamine receptor signaling pathway(GO:0060159) |
| 0.1 | 1.8 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.1 | 0.3 | GO:1903847 | regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849) |
| 0.0 | 0.1 | GO:0045014 | detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594) |
| 0.0 | 1.5 | GO:0006826 | iron ion transport(GO:0006826) |
| 0.0 | 0.3 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
| 0.0 | 0.2 | GO:0034393 | positive regulation of smooth muscle cell apoptotic process(GO:0034393) |
| 0.0 | 0.3 | GO:0032693 | negative regulation of interleukin-10 production(GO:0032693) |
| 0.0 | 3.4 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.0 | 0.1 | GO:0032782 | bile acid secretion(GO:0032782) positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360) |
| 0.0 | 0.6 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.0 | 0.3 | GO:0003341 | cilium movement(GO:0003341) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 17.1 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.3 | 1.0 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.2 | 0.5 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.2 | 1.5 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.1 | 4.4 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 0.4 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
| 0.0 | 0.4 | GO:0032009 | early phagosome(GO:0032009) |
| 0.0 | 1.5 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 0.4 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.0 | 0.3 | GO:0005858 | axonemal dynein complex(GO:0005858) |
| 0.0 | 0.8 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.0 | 1.3 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 0.1 | GO:0046581 | intercellular canaliculus(GO:0046581) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 16.3 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.4 | 8.3 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.2 | 0.9 | GO:0008802 | betaine-aldehyde dehydrogenase activity(GO:0008802) |
| 0.2 | 7.9 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 1.5 | GO:0015093 | ferrous iron transmembrane transporter activity(GO:0015093) |
| 0.1 | 0.9 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.1 | 1.3 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.1 | 0.3 | GO:0003996 | acyl-CoA ligase activity(GO:0003996) |
| 0.1 | 1.2 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.1 | 0.5 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
| 0.0 | 1.5 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 1.8 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.0 | 0.5 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.0 | 1.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.1 | GO:0004534 | transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160) 5'-3' exoribonuclease activity(GO:0004534) |
| 0.0 | 0.1 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
| 0.0 | 0.4 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
| 0.0 | 7.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 0.6 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.0 | 0.3 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 0.8 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 0.3 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
| 0.0 | 0.3 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 1.0 | GO:0051213 | dioxygenase activity(GO:0051213) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 17.1 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 8.3 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.5 | PID_IL5_PATHWAY | IL5-mediated signaling events |
| 0.0 | 1.0 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.0 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.9 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 1.0 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.3 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.3 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 1.8 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 1.3 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 0.4 | REACTOME_STEROID_HORMONES | Genes involved in Steroid hormones |
| 0.0 | 0.6 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.6 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 1.0 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.7 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
