Motif ID: Hoxb4

Z-value: 0.470


Transcription factors associated with Hoxb4:

Gene SymbolEntrez IDGene Name
Hoxb4 ENSMUSG00000038692.7 Hoxb4



Activity profile for motif Hoxb4.

activity profile for motif Hoxb4


Sorted Z-values histogram for motif Hoxb4

Sorted Z-values for motif Hoxb4



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_84775388 5.413 ENSMUST00000023994.3
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr2_-_84775420 5.120 ENSMUST00000111641.1
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr8_-_105471481 2.102 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr1_-_45503282 2.072 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr10_-_92162753 1.841 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr13_+_94083490 1.459 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr18_-_15063560 1.293 ENSMUST00000168989.1
 Kctd1
potassium channel tetramerisation domain containing 1
chr17_+_43952999 1.200 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr6_+_116650674 1.021 ENSMUST00000067354.5
ENSMUST00000178241.1
 8430408G22Rik

RIKEN cDNA 8430408G22 gene

chr1_+_10993452 0.931 ENSMUST00000027056.5
 Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr17_+_86963279 0.872 ENSMUST00000139344.1
 Rhoq
ras homolog gene family, member Q
chrX_-_49797700 0.671 ENSMUST00000033442.7
ENSMUST00000114891.1
 Igsf1

immunoglobulin superfamily, member 1

chr3_-_39359128 0.588 ENSMUST00000056409.2
 Gm9845
predicted pseudogene 9845
chr3_-_51277470 0.537 ENSMUST00000108053.2
ENSMUST00000108051.1
 Elf2

E74-like factor 2

chr15_-_50889691 0.473 ENSMUST00000165201.2
ENSMUST00000184458.1
 Trps1

trichorhinophalangeal syndrome I (human)

chr18_-_56562261 0.459 ENSMUST00000066208.6
ENSMUST00000172734.1
 Aldh7a1

aldehyde dehydrogenase family 7, member A1

chr10_-_89621253 0.442 ENSMUST00000020102.7
 Slc17a8
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
chrX_-_8193387 0.417 ENSMUST00000143223.1
ENSMUST00000033509.8
 Ebp

phenylalkylamine Ca2+ antagonist (emopamil) binding protein

chr3_-_37125943 0.413 ENSMUST00000029275.5
 Il2
interleukin 2
chr18_-_56562215 0.385 ENSMUST00000170309.1
 Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr18_-_56562187 0.371 ENSMUST00000171844.2
 Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr1_-_78968079 0.370 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chrX_+_166344692 0.347 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
 Gpm6b





glycoprotein m6b





chr17_+_25951472 0.346 ENSMUST00000181174.1
 D630044L22Rik
RIKEN cDNA gene D630044L22 gene
chr3_-_54714353 0.314 ENSMUST00000178832.1
 Gm21958
predicted gene, 21958
chr16_-_37384940 0.312 ENSMUST00000114781.1
ENSMUST00000114780.1
 Stxbp5l

syntaxin binding protein 5-like

chr16_+_78930940 0.305 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
 Chodl


chondrolectin


chr10_-_59616667 0.305 ENSMUST00000020312.6
 Mcu
mitochondrial calcium uniporter
chr10_-_88605017 0.223 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chr5_+_143363890 0.215 ENSMUST00000010969.8
 Grid2ip
glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1
chr16_-_37384915 0.182 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
 Stxbp5l



syntaxin binding protein 5-like



chr1_+_146497614 0.173 ENSMUST00000132847.1
ENSMUST00000166814.1
 Brinp3

bone morphogenetic protein/retinoic acid inducible neural specific 3

chr16_-_94370450 0.132 ENSMUST00000138514.1
 Pigp
phosphatidylinositol glycan anchor biosynthesis, class P
chr2_-_119156824 0.111 ENSMUST00000135419.1
ENSMUST00000129351.1
ENSMUST00000139519.1
ENSMUST00000094695.5
 Rmdn3



regulator of microtubule dynamics 3



chr7_+_30232310 0.055 ENSMUST00000108193.1
ENSMUST00000108192.1
 Polr2i

polymerase (RNA) II (DNA directed) polypeptide I


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.5 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.7 2.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.4 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013) negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.1 1.2 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 0.3 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.2 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.3 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.9 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 2.1 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.9 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.5 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.4 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.2 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.5 GO:0046676 negative regulation of insulin secretion(GO:0046676)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0005588 collagen type V trimer(GO:0005588)
0.2 2.1 GO:0097427 microtubule bundle(GO:0097427)
0.1 0.4 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 10.5 GO:0072562 blood microparticle(GO:0072562)
0.1 0.3 GO:1990246 uniplex complex(GO:1990246)
0.0 0.2 GO:0005859 muscle myosin complex(GO:0005859)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 10.5 GO:0001848 complement binding(GO:0001848)
0.3 1.2 GO:0008802 betaine-aldehyde dehydrogenase activity(GO:0008802)
0.2 1.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.4 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 0.4 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 0.7 GO:0034711 inhibin binding(GO:0034711)
0.1 0.9 GO:0005522 profilin binding(GO:0005522)
0.1 2.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.2 GO:0097493 muscle alpha-actinin binding(GO:0051371) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.4 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 10.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.1 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.6 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.9 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.9 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 10.5 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 2.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling