Motif ID: Hoxb6

Z-value: 0.309


Transcription factors associated with Hoxb6:

Gene SymbolEntrez IDGene Name
Hoxb6 ENSMUSG00000000690.4 Hoxb6



Activity profile for motif Hoxb6.

activity profile for motif Hoxb6


Sorted Z-values histogram for motif Hoxb6

Sorted Z-values for motif Hoxb6



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 2.158 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr2_+_164769892 1.012 ENSMUST00000088248.6
ENSMUST00000001439.6
 Ube2c

ubiquitin-conjugating enzyme E2C

chr2_-_125859139 0.890 ENSMUST00000110463.1
ENSMUST00000028635.5
 Cops2

COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)

chr13_-_85127514 0.629 ENSMUST00000179230.1
 Gm4076
predicted gene 4076
chr8_-_77610597 0.623 ENSMUST00000034030.8
 Tmem184c
transmembrane protein 184C
chr8_-_77610668 0.610 ENSMUST00000141202.1
ENSMUST00000152168.1
 Tmem184c

transmembrane protein 184C

chrX_-_143933204 0.598 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr7_+_51880312 0.546 ENSMUST00000145049.1
 Gas2
growth arrest specific 2
chrX_-_143933089 0.530 ENSMUST00000087313.3
 Dcx
doublecortin
chr6_-_3494587 0.525 ENSMUST00000049985.8
 Hepacam2
HEPACAM family member 2
chr9_-_35570393 0.504 ENSMUST00000115110.4
 Hyls1
hydrolethalus syndrome 1
chr2_+_125859134 0.471 ENSMUST00000028636.6
ENSMUST00000125084.1
 Galk2

galactokinase 2

chr3_-_100969644 0.458 ENSMUST00000076941.5
 Ttf2
transcription termination factor, RNA polymerase II
chr9_+_92309362 0.453 ENSMUST00000098477.1
ENSMUST00000150594.1
 1700057G04Rik

RIKEN cDNA 1700057G04 gene

chr19_+_25406661 0.416 ENSMUST00000146647.1
 Kank1
KN motif and ankyrin repeat domains 1
chr11_-_74724670 0.401 ENSMUST00000021091.8
 Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr16_+_44347121 0.369 ENSMUST00000050897.6
 Spice1
spindle and centriole associated protein 1
chr8_-_105471481 0.360 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr3_+_94413244 0.332 ENSMUST00000166032.1
ENSMUST00000045245.5
 Tdrkh

tudor and KH domain containing protein

chr4_+_15881255 0.305 ENSMUST00000029876.1
 Calb1
calbindin 1
chr9_-_70141484 0.273 ENSMUST00000034749.8
 Fam81a
family with sequence similarity 81, member A
chr13_+_93304066 0.266 ENSMUST00000109493.1
 Homer1
homer homolog 1 (Drosophila)
chr10_-_64090265 0.261 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr13_+_93304799 0.260 ENSMUST00000080127.5
 Homer1
homer homolog 1 (Drosophila)
chr9_+_96258697 0.242 ENSMUST00000179416.1
 Tfdp2
transcription factor Dp 2
chr3_-_119783262 0.241 ENSMUST00000029780.7
 Ptbp2
polypyrimidine tract binding protein 2
chr6_+_142413441 0.229 ENSMUST00000088263.4
 B230216G23Rik
RIKEN cDNA B230216G23 gene
chr3_-_79145875 0.229 ENSMUST00000118340.1
 Rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
chr5_+_88583527 0.225 ENSMUST00000031229.6
 Rufy3
RUN and FYVE domain containing 3
chr4_-_134853294 0.160 ENSMUST00000030628.8
 Tmem57
transmembrane protein 57
chr2_+_29346803 0.137 ENSMUST00000028139.4
ENSMUST00000113830.4
 Med27

mediator complex subunit 27

chr10_+_72309225 0.131 ENSMUST00000061324.4
 Gm9923
predicted pseudogene 9923
chr11_-_72215592 0.130 ENSMUST00000021157.8
 Med31
mediator of RNA polymerase II transcription, subunit 31 homolog (yeast)
chr14_+_32599922 0.120 ENSMUST00000068938.5
 Prrxl1
paired related homeobox protein-like 1
chr11_-_69795930 0.119 ENSMUST00000045971.8
 Chrnb1
cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)
chr19_+_24875679 0.119 ENSMUST00000073080.5
 Gm10053
predicted gene 10053
chr6_-_12109583 0.111 ENSMUST00000080891.5
 Gm6578
predicted gene 6578
chr13_+_58281183 0.106 ENSMUST00000180882.1
ENSMUST00000180452.1
 Gm26555

predicted gene, 26555

chr13_-_21810190 0.074 ENSMUST00000110469.1
ENSMUST00000091749.2
 Hist1h2bq

histone cluster 1, H2bq

chrX_-_101222426 0.060 ENSMUST00000120389.1
ENSMUST00000156473.1
ENSMUST00000077876.3
 Snx12


sorting nexin 12


chr8_+_31111816 0.056 ENSMUST00000046941.7
 Rnf122
ring finger protein 122
chr8_-_54724474 0.053 ENSMUST00000175915.1
 Wdr17
WD repeat domain 17
chr19_-_6925367 0.049 ENSMUST00000057716.4
 Tex40
testis expressed 40
chr9_+_21955747 0.022 ENSMUST00000053583.5
 Swsap1
SWIM type zinc finger 7 associated protein 1
chr5_+_31526989 0.021 ENSMUST00000114533.2
ENSMUST00000117262.1
ENSMUST00000117319.1
 Slc4a1ap


solute carrier family 4 (anion exchanger), member 1, adaptor protein


chr12_+_103388656 0.002 ENSMUST00000101094.2
ENSMUST00000021620.6
 Otub2

OTU domain, ubiquitin aldehyde binding 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 1.0 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.1 0.4 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.1 0.4 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.2 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.1 1.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.5 GO:0017121 phospholipid scrambling(GO:0017121)
0.1 0.3 GO:0072235 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235)
0.1 0.3 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 0.9 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.5 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.5 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.5 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.0 0.1 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.0 0.4 GO:0046599 regulation of centriole replication(GO:0046599)
0.0 0.3 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.0 0.1 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.2 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.1 GO:0021559 trigeminal nerve development(GO:0021559)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0000235 astral microtubule(GO:0000235)
0.0 0.4 GO:0097427 microtubule bundle(GO:0097427)
0.0 1.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.3 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)
0.0 0.9 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.2 GO:0071437 invadopodium(GO:0071437)
0.0 0.5 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0004335 galactokinase activity(GO:0004335)
0.0 0.5 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.5 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 1.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.4 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.1 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 2.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins