Motif ID: Hoxc10

Z-value: 0.449


Transcription factors associated with Hoxc10:

Gene SymbolEntrez IDGene Name
Hoxc10 ENSMUSG00000022484.7 Hoxc10



Activity profile for motif Hoxc10.

activity profile for motif Hoxc10


Sorted Z-values histogram for motif Hoxc10

Sorted Z-values for motif Hoxc10



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc10

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_13454010 2.709 ENSMUST00000112656.2
 Synpr
synaptoporin
chr3_-_63851251 2.393 ENSMUST00000162269.2
ENSMUST00000159676.2
ENSMUST00000175947.1
 Plch1


phospholipase C, eta 1


chr14_+_13453937 2.249 ENSMUST00000153954.1
 Synpr
synaptoporin
chr11_-_84067063 1.499 ENSMUST00000108101.1
 Dusp14
dual specificity phosphatase 14
chr15_+_25773985 1.402 ENSMUST00000125667.1
 Myo10
myosin X
chr10_-_49783259 1.324 ENSMUST00000105484.3
ENSMUST00000105486.1
ENSMUST00000079751.2
ENSMUST00000105485.1
 Grik2



glutamate receptor, ionotropic, kainate 2 (beta 2)



chr2_-_25469742 1.176 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr4_+_144893127 0.977 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr2_-_25470031 0.956 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr13_+_104287855 0.952 ENSMUST00000065766.6
 Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr14_+_124005355 0.904 ENSMUST00000166105.1
 Gm17615
predicted gene, 17615
chr11_+_94211431 0.887 ENSMUST00000041589.5
 Tob1
transducer of ErbB-2.1
chr5_-_111761697 0.877 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr3_-_88410295 0.780 ENSMUST00000056370.7
 Pmf1
polyamine-modulated factor 1
chr5_-_62766153 0.683 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_-_123672321 0.670 ENSMUST00000172537.1
ENSMUST00000029602.6
 Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

chr4_-_133967296 0.641 ENSMUST00000105893.1
 Hmgn2
high mobility group nucleosomal binding domain 2
chr2_+_130576170 0.623 ENSMUST00000028764.5
 Oxt
oxytocin
chr1_-_45503282 0.610 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr3_-_49757257 0.599 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr6_-_136875794 0.595 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr18_-_15063560 0.583 ENSMUST00000168989.1
 Kctd1
potassium channel tetramerisation domain containing 1
chr1_-_163289214 0.579 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr19_-_50678642 0.531 ENSMUST00000072685.6
ENSMUST00000164039.2
 Sorcs1

VPS10 domain receptor protein SORCS 1

chr4_-_42661893 0.527 ENSMUST00000108006.3
 Il11ra2
interleukin 11 receptor, alpha chain 2
chr8_-_41016295 0.519 ENSMUST00000131965.1
 Mtus1
mitochondrial tumor suppressor 1
chr10_+_88091070 0.513 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr3_+_76074270 0.497 ENSMUST00000038364.8
 Fstl5
follistatin-like 5
chr8_-_47352348 0.486 ENSMUST00000110367.2
 Stox2
storkhead box 2
chr5_+_92809372 0.484 ENSMUST00000113054.2
 Shroom3
shroom family member 3
chr13_+_24943144 0.460 ENSMUST00000021773.5
 Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr19_+_56548254 0.440 ENSMUST00000071423.5
 Nhlrc2
NHL repeat containing 2
chr4_-_110290884 0.437 ENSMUST00000142722.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chrM_+_3906 0.381 ENSMUST00000082396.1
 mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr7_-_30612731 0.378 ENSMUST00000006476.4
 Upk1a
uroplakin 1A
chr19_+_55894508 0.373 ENSMUST00000142291.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr1_+_17601893 0.370 ENSMUST00000088476.2
 Pi15
peptidase inhibitor 15
chr15_+_81936911 0.356 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr1_+_194619815 0.351 ENSMUST00000027952.5
 Plxna2
plexin A2
chr8_-_18741542 0.346 ENSMUST00000033846.6
 Angpt2
angiopoietin 2
chr1_-_97761538 0.344 ENSMUST00000171129.1
 Ppip5k2
diphosphoinositol pentakisphosphate kinase 2
chr7_+_103550368 0.333 ENSMUST00000106888.1
 Olfr613
olfactory receptor 613
chr14_-_54686060 0.332 ENSMUST00000125265.1
 Acin1
apoptotic chromatin condensation inducer 1
chr4_+_128759258 0.319 ENSMUST00000030585.7
 A3galt2
alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase)
chrX_+_169685191 0.314 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr4_+_11758147 0.306 ENSMUST00000029871.5
ENSMUST00000108303.1
 Cdh17

cadherin 17

chr19_+_33822908 0.304 ENSMUST00000042061.6
 Gm5519
predicted pseudogene 5519
chr2_+_80315461 0.300 ENSMUST00000028392.7
 Dnajc10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr2_-_26122769 0.300 ENSMUST00000140993.1
ENSMUST00000028300.5
 Nacc2

nucleus accumbens associated 2, BEN and BTB (POZ) domain containing

chr9_+_75775355 0.283 ENSMUST00000012281.7
 Bmp5
bone morphogenetic protein 5
chr10_+_37139558 0.280 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr11_-_109472611 0.278 ENSMUST00000168740.1
 Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr3_+_32436151 0.269 ENSMUST00000029201.7
 Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr11_-_100146120 0.260 ENSMUST00000007317.7
 Krt19
keratin 19
chr1_+_58646608 0.254 ENSMUST00000081455.4
 Gm10068
predicted gene 10068
chr9_+_37208291 0.244 ENSMUST00000034632.8
 Tmem218
transmembrane protein 218
chr1_+_189728264 0.241 ENSMUST00000097442.2
 Ptpn14
protein tyrosine phosphatase, non-receptor type 14
chr9_+_50575273 0.229 ENSMUST00000059081.6
ENSMUST00000180021.1
 Il18

interleukin 18

chr18_-_6490808 0.220 ENSMUST00000028100.6
ENSMUST00000050542.5
 Epc1

enhancer of polycomb homolog 1 (Drosophila)

chr15_+_85510812 0.220 ENSMUST00000079690.2
 Gm4825
predicted pseudogene 4825
chr1_-_69108039 0.201 ENSMUST00000121473.1
 Erbb4
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
chr13_-_106847267 0.195 ENSMUST00000057427.4
 Lrrc70
leucine rich repeat containing 70
chr1_-_63114255 0.191 ENSMUST00000153992.1
ENSMUST00000165066.1
ENSMUST00000172416.1
ENSMUST00000137511.1
 Ino80d



INO80 complex subunit D



chr9_-_44799179 0.173 ENSMUST00000114705.1
ENSMUST00000002100.7
 Tmem25

transmembrane protein 25

chr7_+_43690418 0.158 ENSMUST00000056329.6
 Klk14
kallikrein related-peptidase 14
chr1_+_137928100 0.157 ENSMUST00000054333.2
 A130050O07Rik
RIKEN cDNA A130050O07 gene
chr1_-_63114516 0.137 ENSMUST00000097718.2
 Ino80d
INO80 complex subunit D
chr13_-_41273977 0.124 ENSMUST00000163881.1
 Gm17364
predicted gene, 17364
chr17_-_78684262 0.118 ENSMUST00000145480.1
 Strn
striatin, calmodulin binding protein
chr17_-_25844417 0.112 ENSMUST00000176591.1
 Rhot2
ras homolog gene family, member T2
chr5_-_62765618 0.110 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr11_-_97700327 0.109 ENSMUST00000018681.7
 Pcgf2
polycomb group ring finger 2
chr6_-_125165576 0.108 ENSMUST00000183272.1
ENSMUST00000182052.1
ENSMUST00000182277.1
 Gapdh


glyceraldehyde-3-phosphate dehydrogenase


chr7_-_73537621 0.108 ENSMUST00000172704.1
 Chd2
chromodomain helicase DNA binding protein 2
chr1_+_179960472 0.097 ENSMUST00000097453.2
ENSMUST00000111117.1
 Cdc42bpa

CDC42 binding protein kinase alpha

chr8_-_111992258 0.078 ENSMUST00000034427.5
ENSMUST00000139820.1
 Adat1

adenosine deaminase, tRNA-specific 1

chr1_-_63176653 0.072 ENSMUST00000027111.8
ENSMUST00000168099.2
 Ndufs1

NADH dehydrogenase (ubiquinone) Fe-S protein 1

chr2_-_27463994 0.071 ENSMUST00000164296.1
 Brd3
bromodomain containing 3
chr2_-_144527341 0.070 ENSMUST00000163701.1
ENSMUST00000081982.5
 Dzank1

double zinc ribbon and ankyrin repeat domains 1

chr6_-_124965485 0.064 ENSMUST00000112439.2
 Cops7a
COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)
chr15_+_81936753 0.055 ENSMUST00000038757.7
 Csdc2
cold shock domain containing C2, RNA binding
chr6_-_124965403 0.053 ENSMUST00000129446.1
ENSMUST00000032220.8
 Cops7a

COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)

chr3_+_31902666 0.051 ENSMUST00000119970.1
ENSMUST00000178668.1
 Kcnmb2

potassium large conductance calcium-activated channel, subfamily M, beta member 2

chr1_+_109993982 0.033 ENSMUST00000027542.6
 Cdh7
cadherin 7, type 2
chr1_+_180111339 0.032 ENSMUST00000145181.1
 Cdc42bpa
CDC42 binding protein kinase alpha
chr13_-_107890059 0.030 ENSMUST00000105097.2
 Zswim6
zinc finger SWIM-type containing 6
chrX_+_96455359 0.029 ENSMUST00000033553.7
 Heph
hephaestin
chr1_+_191025350 0.026 ENSMUST00000181050.1
 A230020J21Rik
RIKEN cDNA A230020J21 gene
chr3_+_108591279 0.018 ENSMUST00000051145.8
ENSMUST00000139626.1
 Wdr47

WD repeat domain 47

chr5_+_71699918 0.010 ENSMUST00000031122.7
 Gabrb1
gamma-aminobutyric acid (GABA) A receptor, subunit beta 1
chr6_-_124965248 0.007 ENSMUST00000129976.1
 Cops7a
COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)
chr9_-_116175318 0.002 ENSMUST00000061101.4
ENSMUST00000035014.6
 Tgfbr2

transforming growth factor, beta receptor II


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.1 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.2 0.6 GO:0042713 sperm ejaculation(GO:0042713) negative regulation of gastric acid secretion(GO:0060455)
0.2 0.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.2 0.5 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.2 0.5 GO:0002430 complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507)
0.1 1.3 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 0.3 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.7 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 0.3 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.9 GO:1902373 negative regulation of mRNA catabolic process(GO:1902373)
0.1 0.3 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 1.0 GO:0042572 retinol metabolic process(GO:0042572)
0.1 0.2 GO:0032817 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819)
0.1 0.3 GO:0021502 neural fold elevation formation(GO:0021502)
0.1 0.2 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.0 0.3 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.4 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.6 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.2 GO:0007320 insemination(GO:0007320)
0.0 0.4 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.0 0.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.3 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.3 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.3 GO:0006020 inositol metabolic process(GO:0006020)
0.0 1.0 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.6 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.0 0.3 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.5 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 2.4 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015) inositol lipid-mediated signaling(GO:0048017)
0.0 1.0 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 1.0 GO:0035904 aorta development(GO:0035904)
0.0 0.1 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.0 0.2 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.2 GO:0001946 lymphangiogenesis(GO:0001946)
0.0 0.3 GO:0007608 sensory perception of smell(GO:0007608)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.2 5.0 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 0.6 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.8 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.1 0.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 0.3 GO:1990357 terminal web(GO:1990357)
0.0 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.4 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.9 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.3 GO:0061574 ASAP complex(GO:0061574)
0.0 0.4 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 1.4 GO:0016459 myosin complex(GO:0016459)
0.0 1.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.1 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.2 1.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 0.7 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.1 1.0 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 2.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 0.3 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.3 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.1 0.8 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 1.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 0.3 GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
0.1 0.5 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.2 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 1.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.3 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.3 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 1.4 GO:0030507 spectrin binding(GO:0030507)
0.0 0.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.3 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 1.1 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.6 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.1 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
0.0 0.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.4 GO:0017091 AU-rich element binding(GO:0017091)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.5 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.6 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.6 NABA_COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.4 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.6 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 1.4 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.2 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling