Motif ID: Hoxd12
Z-value: 1.181
Transcription factors associated with Hoxd12:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hoxd12 | ENSMUSG00000001823.4 | Hoxd12 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 20.9 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 2.7 | 29.3 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 1.9 | 7.6 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
| 1.3 | 20.3 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 1.2 | 3.6 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.9 | 7.1 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.7 | 2.8 | GO:0035470 | positive regulation of vascular wound healing(GO:0035470) |
| 0.5 | 1.9 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.5 | 2.3 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
| 0.4 | 1.6 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 0.4 | 3.0 | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
| 0.3 | 1.0 | GO:0090327 | negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
| 0.3 | 2.0 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.3 | 1.0 | GO:0046101 | hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101) |
| 0.3 | 12.6 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
| 0.3 | 2.9 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
| 0.3 | 1.5 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.2 | 1.1 | GO:0061042 | vascular wound healing(GO:0061042) |
| 0.2 | 1.8 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 0.2 | 1.2 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.2 | 2.6 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.2 | 0.7 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.1 | 1.7 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.1 | 5.6 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 1.3 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.1 | 0.8 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
| 0.1 | 1.0 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 0.1 | 0.4 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.1 | 0.5 | GO:0097343 | ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026) |
| 0.1 | 2.0 | GO:0035493 | SNARE complex assembly(GO:0035493) |
| 0.1 | 0.9 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.1 | 3.7 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.1 | 0.7 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
| 0.1 | 0.7 | GO:2000074 | regulation of type B pancreatic cell development(GO:2000074) |
| 0.1 | 0.3 | GO:1903764 | regulation of potassium ion export across plasma membrane(GO:1903764) |
| 0.1 | 2.2 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 0.1 | 0.5 | GO:1901387 | Golgi to lysosome transport(GO:0090160) positive regulation of voltage-gated calcium channel activity(GO:1901387) |
| 0.1 | 1.0 | GO:0007202 | activation of phospholipase C activity(GO:0007202) |
| 0.1 | 0.3 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.1 | 1.3 | GO:0006828 | manganese ion transport(GO:0006828) |
| 0.1 | 1.2 | GO:1900153 | regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153) |
| 0.0 | 0.7 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.0 | 0.7 | GO:0045332 | phospholipid translocation(GO:0045332) |
| 0.0 | 0.1 | GO:0060745 | mammary gland branching involved in pregnancy(GO:0060745) |
| 0.0 | 2.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 2.3 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.0 | 1.0 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
| 0.0 | 0.2 | GO:0098532 | nucleosome positioning(GO:0016584) histone H3-K27 trimethylation(GO:0098532) |
| 0.0 | 0.6 | GO:1901032 | negative regulation of response to reactive oxygen species(GO:1901032) negative regulation of hydrogen peroxide-induced cell death(GO:1903206) |
| 0.0 | 0.6 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 0.0 | 0.6 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.0 | 0.2 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.0 | 0.6 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.0 | 0.4 | GO:0097150 | neuronal stem cell population maintenance(GO:0097150) |
| 0.0 | 3.4 | GO:0043524 | negative regulation of neuron apoptotic process(GO:0043524) |
| 0.0 | 2.3 | GO:0015718 | monocarboxylic acid transport(GO:0015718) |
| 0.0 | 0.8 | GO:0006414 | translational elongation(GO:0006414) |
| 0.0 | 1.1 | GO:0016575 | histone deacetylation(GO:0016575) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 7.6 | GO:0072534 | perineuronal net(GO:0072534) |
| 1.2 | 3.6 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.4 | 2.0 | GO:0070820 | tertiary granule(GO:0070820) |
| 0.3 | 3.0 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.2 | 1.0 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
| 0.2 | 22.0 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.2 | 0.5 | GO:0020018 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
| 0.2 | 2.1 | GO:0030057 | desmosome(GO:0030057) |
| 0.2 | 7.1 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 0.8 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.1 | 1.2 | GO:0071664 | beta-catenin-TCF7L2 complex(GO:0070369) catenin-TCF7L2 complex(GO:0071664) |
| 0.1 | 13.4 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 2.9 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.1 | 2.0 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 20.9 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.1 | 2.6 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 0.3 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 0.9 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 0.4 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 0.8 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 2.3 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 1.3 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 1.3 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 1.5 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.1 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.0 | 0.7 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 0.7 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 1.0 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 2.7 | GO:0045211 | postsynaptic membrane(GO:0045211) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 29.3 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 3.5 | 20.9 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.9 | 2.8 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.7 | 2.9 | GO:0043125 | ErbB-3 class receptor binding(GO:0043125) |
| 0.5 | 3.1 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.5 | 2.3 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.4 | 7.6 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.3 | 1.2 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.3 | 1.8 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.3 | 1.1 | GO:0097003 | adipokinetic hormone receptor activity(GO:0097003) |
| 0.2 | 1.0 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
| 0.2 | 3.8 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.2 | 1.0 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.1 | 1.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 2.2 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 1.3 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.1 | 3.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 4.4 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.1 | 0.7 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.1 | 7.2 | GO:0046332 | SMAD binding(GO:0046332) |
| 0.1 | 0.8 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.1 | 2.3 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 5.8 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
| 0.0 | 0.1 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
| 0.0 | 2.0 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 1.0 | GO:0031690 | adrenergic receptor binding(GO:0031690) |
| 0.0 | 0.3 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.0 | 1.1 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 0.8 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.7 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.0 | 1.7 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 2.3 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 3.3 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.7 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.0 | 0.5 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 1.1 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.0 | 16.6 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 0.8 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 2.2 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 0.6 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.2 | GO:0032564 | dATP binding(GO:0032564) |
| 0.0 | 0.9 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.0 | 0.7 | GO:0019003 | GDP binding(GO:0019003) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 26.9 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 2.8 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.2 | 2.9 | PID_IL5_PATHWAY | IL5-mediated signaling events |
| 0.1 | 4.4 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.1 | 3.6 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 7.6 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 3.3 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.1 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.5 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 2.1 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
| 0.0 | 1.6 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.4 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.3 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 0.7 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.0 | 0.7 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.5 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 20.9 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 2.9 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.2 | 2.8 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.2 | 1.3 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.2 | 2.0 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 1.5 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 3.6 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 1.8 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 0.5 | REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.1 | 0.7 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 3.3 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 2.9 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.2 | REACTOME_RNA_POL_III_TRANSCRIPTION | Genes involved in RNA Polymerase III Transcription |
| 0.0 | 0.7 | REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 0.7 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.3 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
