Motif ID: Hsf2
Z-value: 1.411
Transcription factors associated with Hsf2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hsf2 | ENSMUSG00000019878.7 | Hsf2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hsf2 | mm10_v2_chr10_+_57486354_57486414 | 0.51 | 7.3e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 16.8 | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) |
| 2.8 | 8.4 | GO:0030421 | defecation(GO:0030421) |
| 2.2 | 8.7 | GO:0021698 | cerebellar cortex structural organization(GO:0021698) |
| 1.9 | 11.4 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
| 1.6 | 7.9 | GO:0003213 | cardiac right atrium morphogenesis(GO:0003213) |
| 1.6 | 6.3 | GO:0055099 | response to high density lipoprotein particle(GO:0055099) platelet dense granule organization(GO:0060155) |
| 1.3 | 6.4 | GO:0035262 | gonad morphogenesis(GO:0035262) |
| 1.2 | 8.2 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 1.2 | 3.5 | GO:1900275 | negative regulation of phospholipase C activity(GO:1900275) |
| 1.1 | 4.3 | GO:0060032 | notochord regression(GO:0060032) |
| 1.1 | 3.2 | GO:0002489 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) |
| 1.0 | 4.1 | GO:1902724 | positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728) |
| 0.9 | 2.8 | GO:1902071 | positive regulation of cellular response to hypoxia(GO:1900039) regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071) |
| 0.9 | 6.1 | GO:0035745 | T-helper 2 cell cytokine production(GO:0035745) |
| 0.8 | 3.2 | GO:0007056 | spindle assembly involved in female meiosis(GO:0007056) positive regulation of oocyte development(GO:0060282) |
| 0.8 | 4.0 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 0.8 | 3.0 | GO:0046947 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 0.7 | 2.2 | GO:1904975 | response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976) |
| 0.7 | 2.2 | GO:0071603 | endothelial cell-cell adhesion(GO:0071603) |
| 0.7 | 11.5 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.7 | 2.7 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
| 0.7 | 2.0 | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation(GO:1904706) |
| 0.6 | 1.9 | GO:0003360 | brainstem development(GO:0003360) |
| 0.6 | 4.3 | GO:0060907 | positive regulation of macrophage cytokine production(GO:0060907) |
| 0.6 | 1.2 | GO:2000564 | CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) |
| 0.6 | 2.4 | GO:0035021 | negative regulation of Rac protein signal transduction(GO:0035021) |
| 0.6 | 1.8 | GO:0032829 | regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) |
| 0.6 | 3.0 | GO:0060849 | regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849) |
| 0.6 | 2.9 | GO:0019244 | lactate biosynthetic process from pyruvate(GO:0019244) |
| 0.6 | 2.3 | GO:0002337 | B-1a B cell differentiation(GO:0002337) |
| 0.6 | 5.2 | GO:0070874 | negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874) |
| 0.6 | 3.4 | GO:0002326 | B cell lineage commitment(GO:0002326) |
| 0.6 | 5.0 | GO:0014883 | transition between fast and slow fiber(GO:0014883) |
| 0.5 | 1.6 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.5 | 1.6 | GO:1905000 | regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000) |
| 0.5 | 5.3 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.5 | 3.0 | GO:0071883 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) |
| 0.5 | 1.9 | GO:0033326 | cerebrospinal fluid secretion(GO:0033326) |
| 0.5 | 3.3 | GO:0003433 | chondrocyte development involved in endochondral bone morphogenesis(GO:0003433) |
| 0.5 | 1.4 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.5 | 1.9 | GO:0090370 | negative regulation of cholesterol efflux(GO:0090370) |
| 0.4 | 1.3 | GO:1903984 | positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) |
| 0.4 | 1.3 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
| 0.4 | 1.3 | GO:0035574 | histone H4-K20 demethylation(GO:0035574) |
| 0.4 | 2.1 | GO:0002024 | diet induced thermogenesis(GO:0002024) |
| 0.4 | 2.5 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) positive regulation of sister chromatid cohesion(GO:0045876) |
| 0.4 | 13.4 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 0.4 | 5.4 | GO:0032048 | cardiolipin metabolic process(GO:0032048) |
| 0.4 | 1.9 | GO:2000587 | negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587) |
| 0.4 | 3.4 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
| 0.4 | 1.1 | GO:0006434 | seryl-tRNA aminoacylation(GO:0006434) |
| 0.4 | 3.0 | GO:0034770 | histone H4-K20 methylation(GO:0034770) |
| 0.4 | 3.2 | GO:0006104 | succinyl-CoA metabolic process(GO:0006104) |
| 0.4 | 1.1 | GO:0010757 | negative regulation of plasminogen activation(GO:0010757) |
| 0.4 | 3.2 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.3 | 3.3 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.3 | 1.3 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
| 0.3 | 1.6 | GO:0006868 | glutamine transport(GO:0006868) |
| 0.3 | 1.6 | GO:0098706 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
| 0.3 | 0.6 | GO:0072076 | nephrogenic mesenchyme development(GO:0072076) |
| 0.3 | 1.2 | GO:0015793 | glycerol transport(GO:0015793) |
| 0.3 | 2.4 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
| 0.3 | 1.5 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.3 | 0.9 | GO:0036233 | glycine import(GO:0036233) |
| 0.3 | 2.3 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.3 | 0.8 | GO:0045819 | plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819) |
| 0.3 | 2.1 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 0.3 | 0.8 | GO:0032430 | positive regulation of phospholipase A2 activity(GO:0032430) |
| 0.3 | 6.7 | GO:0046596 | regulation of viral entry into host cell(GO:0046596) |
| 0.2 | 1.9 | GO:0006004 | fucose metabolic process(GO:0006004) |
| 0.2 | 1.4 | GO:0060903 | positive regulation of meiosis I(GO:0060903) |
| 0.2 | 2.6 | GO:0070508 | sterol import(GO:0035376) cholesterol import(GO:0070508) |
| 0.2 | 1.4 | GO:0030913 | paranodal junction assembly(GO:0030913) |
| 0.2 | 1.3 | GO:1903847 | regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849) |
| 0.2 | 0.9 | GO:0034239 | regulation of macrophage fusion(GO:0034239) |
| 0.2 | 1.3 | GO:0044806 | G-quadruplex DNA unwinding(GO:0044806) |
| 0.2 | 0.6 | GO:0072717 | cellular response to actinomycin D(GO:0072717) |
| 0.2 | 3.1 | GO:1904293 | negative regulation of ERAD pathway(GO:1904293) |
| 0.2 | 1.0 | GO:0035616 | histone H2B conserved C-terminal lysine deubiquitination(GO:0035616) |
| 0.2 | 1.8 | GO:1902913 | positive regulation of melanocyte differentiation(GO:0045636) positive regulation of neuroepithelial cell differentiation(GO:1902913) |
| 0.2 | 0.8 | GO:0055071 | cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071) |
| 0.2 | 0.4 | GO:2000974 | negative regulation of mechanoreceptor differentiation(GO:0045632) negative regulation of pro-B cell differentiation(GO:2000974) negative regulation of inner ear receptor cell differentiation(GO:2000981) |
| 0.2 | 0.6 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
| 0.2 | 0.8 | GO:0070213 | protein auto-ADP-ribosylation(GO:0070213) |
| 0.2 | 1.4 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.2 | 1.4 | GO:0098535 | de novo centriole assembly(GO:0098535) |
| 0.2 | 2.1 | GO:0032525 | somite rostral/caudal axis specification(GO:0032525) |
| 0.2 | 1.7 | GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431) |
| 0.2 | 0.6 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.2 | 2.8 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 0.2 | 0.5 | GO:1904179 | positive regulation of adipose tissue development(GO:1904179) |
| 0.2 | 0.5 | GO:0048633 | positive regulation of skeletal muscle tissue growth(GO:0048633) |
| 0.2 | 0.7 | GO:0046618 | drug export(GO:0046618) |
| 0.2 | 0.2 | GO:0032472 | Golgi calcium ion transport(GO:0032472) |
| 0.2 | 1.1 | GO:0061668 | mitochondrial ribosome assembly(GO:0061668) |
| 0.2 | 2.3 | GO:0046643 | regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643) |
| 0.2 | 0.5 | GO:0051026 | chiasma assembly(GO:0051026) |
| 0.2 | 0.5 | GO:1990927 | negative regulation of tumor necrosis factor secretion(GO:1904468) negative regulation of membrane invagination(GO:1905154) calcium ion regulated lysosome exocytosis(GO:1990927) |
| 0.2 | 0.3 | GO:0061738 | late endosomal microautophagy(GO:0061738) |
| 0.2 | 1.0 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.2 | 0.8 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
| 0.2 | 1.1 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.2 | 0.6 | GO:0006203 | dGTP catabolic process(GO:0006203) dATP catabolic process(GO:0046061) |
| 0.2 | 2.1 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
| 0.1 | 1.3 | GO:0031339 | negative regulation of vesicle fusion(GO:0031339) |
| 0.1 | 1.9 | GO:0021924 | cell proliferation in external granule layer(GO:0021924) cerebellar granule cell precursor proliferation(GO:0021930) |
| 0.1 | 0.7 | GO:0003420 | regulation of growth plate cartilage chondrocyte proliferation(GO:0003420) |
| 0.1 | 6.2 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.1 | 0.5 | GO:1903750 | MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345) regulation of NK T cell activation(GO:0051133) positive regulation of NK T cell activation(GO:0051135) regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751) |
| 0.1 | 0.4 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.1 | 3.1 | GO:0000132 | establishment of mitotic spindle orientation(GO:0000132) |
| 0.1 | 1.8 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.1 | 0.4 | GO:0090285 | negative regulation of protein glycosylation in Golgi(GO:0090285) |
| 0.1 | 1.8 | GO:0050858 | negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.1 | 0.3 | GO:0021759 | globus pallidus development(GO:0021759) |
| 0.1 | 1.4 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.1 | 0.8 | GO:0034720 | histone H3-K4 demethylation(GO:0034720) |
| 0.1 | 2.4 | GO:0030575 | nuclear body organization(GO:0030575) |
| 0.1 | 0.4 | GO:0006933 | negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933) |
| 0.1 | 0.4 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.1 | 1.3 | GO:0032287 | peripheral nervous system myelin maintenance(GO:0032287) |
| 0.1 | 0.4 | GO:0035752 | lysosomal lumen pH elevation(GO:0035752) |
| 0.1 | 1.0 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879) |
| 0.1 | 2.0 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.1 | 1.0 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.1 | 0.6 | GO:0038166 | angiotensin-activated signaling pathway(GO:0038166) |
| 0.1 | 1.3 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
| 0.1 | 0.7 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.1 | 1.0 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.1 | 0.2 | GO:0030070 | insulin processing(GO:0030070) |
| 0.1 | 0.6 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.1 | 1.7 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.1 | 1.0 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 0.1 | 4.4 | GO:0002066 | columnar/cuboidal epithelial cell development(GO:0002066) |
| 0.1 | 6.6 | GO:0009408 | response to heat(GO:0009408) |
| 0.1 | 0.2 | GO:0072092 | ureteric bud invasion(GO:0072092) metanephric renal vesicle formation(GO:0072093) |
| 0.1 | 0.7 | GO:0040016 | embryonic cleavage(GO:0040016) |
| 0.1 | 1.3 | GO:0030813 | positive regulation of nucleotide catabolic process(GO:0030813) positive regulation of glycolytic process(GO:0045821) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197) |
| 0.1 | 2.8 | GO:0032611 | interleukin-1 beta production(GO:0032611) |
| 0.1 | 0.6 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
| 0.1 | 0.7 | GO:0045906 | negative regulation of vasoconstriction(GO:0045906) |
| 0.1 | 0.5 | GO:1901339 | regulation of store-operated calcium channel activity(GO:1901339) |
| 0.1 | 1.2 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.1 | 0.8 | GO:0036120 | cellular response to platelet-derived growth factor stimulus(GO:0036120) |
| 0.1 | 0.4 | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus(GO:0002862) |
| 0.1 | 2.8 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 0.9 | GO:0046855 | inositol phosphate dephosphorylation(GO:0046855) |
| 0.1 | 1.2 | GO:0097062 | dendritic spine maintenance(GO:0097062) |
| 0.1 | 0.6 | GO:0042989 | sequestering of actin monomers(GO:0042989) |
| 0.1 | 2.6 | GO:0070265 | necrotic cell death(GO:0070265) |
| 0.1 | 2.2 | GO:0015914 | phospholipid transport(GO:0015914) |
| 0.1 | 0.8 | GO:0042182 | ketone catabolic process(GO:0042182) |
| 0.1 | 0.3 | GO:1904659 | glucose transmembrane transport(GO:1904659) |
| 0.1 | 1.6 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.1 | 1.3 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.1 | 1.8 | GO:0006801 | superoxide metabolic process(GO:0006801) |
| 0.1 | 1.2 | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522) |
| 0.1 | 0.4 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.1 | 0.1 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.1 | 3.2 | GO:0035019 | somatic stem cell population maintenance(GO:0035019) |
| 0.1 | 0.3 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
| 0.1 | 1.7 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.1 | 0.7 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.1 | 0.7 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.0 | 0.8 | GO:0046621 | negative regulation of organ growth(GO:0046621) |
| 0.0 | 0.2 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 0.0 | 0.5 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.0 | 0.7 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 0.0 | 0.9 | GO:0031018 | endocrine pancreas development(GO:0031018) |
| 0.0 | 0.4 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
| 0.0 | 0.6 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.0 | 0.2 | GO:0044241 | lipid digestion(GO:0044241) |
| 0.0 | 0.1 | GO:0060040 | retinal bipolar neuron differentiation(GO:0060040) |
| 0.0 | 0.6 | GO:0070544 | histone H3-K36 demethylation(GO:0070544) |
| 0.0 | 1.6 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.0 | 0.5 | GO:0071157 | negative regulation of cell cycle arrest(GO:0071157) |
| 0.0 | 0.2 | GO:0021914 | negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914) |
| 0.0 | 0.5 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.0 | 1.2 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 0.0 | 0.2 | GO:0031282 | regulation of guanylate cyclase activity(GO:0031282) |
| 0.0 | 1.1 | GO:0019915 | lipid storage(GO:0019915) |
| 0.0 | 2.2 | GO:0050728 | negative regulation of inflammatory response(GO:0050728) |
| 0.0 | 1.4 | GO:0060612 | adipose tissue development(GO:0060612) |
| 0.0 | 0.7 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.0 | 0.4 | GO:0048311 | mitochondrion distribution(GO:0048311) |
| 0.0 | 0.4 | GO:0060766 | negative regulation of androgen receptor signaling pathway(GO:0060766) |
| 0.0 | 0.7 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.0 | 0.1 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.0 | 0.9 | GO:0051642 | centrosome localization(GO:0051642) |
| 0.0 | 0.4 | GO:0045292 | mRNA cis splicing, via spliceosome(GO:0045292) |
| 0.0 | 1.2 | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway(GO:2001238) |
| 0.0 | 0.2 | GO:0051490 | negative regulation of filopodium assembly(GO:0051490) |
| 0.0 | 0.6 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230) |
| 0.0 | 0.3 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 0.0 | 0.1 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.0 | 0.4 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.0 | 0.7 | GO:0030901 | midbrain development(GO:0030901) |
| 0.0 | 2.9 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.0 | 0.1 | GO:0046549 | retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549) |
| 0.0 | 0.1 | GO:0097089 | methyl-branched fatty acid metabolic process(GO:0097089) |
| 0.0 | 0.5 | GO:0045668 | negative regulation of osteoblast differentiation(GO:0045668) |
| 0.0 | 0.5 | GO:0033627 | cell adhesion mediated by integrin(GO:0033627) |
| 0.0 | 0.3 | GO:0060148 | positive regulation of posttranscriptional gene silencing(GO:0060148) |
| 0.0 | 0.4 | GO:0045103 | intermediate filament-based process(GO:0045103) |
| 0.0 | 0.2 | GO:1903146 | regulation of mitophagy(GO:1903146) |
| 0.0 | 0.1 | GO:0042474 | middle ear morphogenesis(GO:0042474) |
| 0.0 | 0.9 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.2 | GO:0060351 | cartilage development involved in endochondral bone morphogenesis(GO:0060351) |
| 0.0 | 0.3 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 15.9 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 1.2 | 5.0 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
| 1.1 | 3.2 | GO:0042585 | germinal vesicle(GO:0042585) |
| 1.1 | 8.5 | GO:0005818 | aster(GO:0005818) |
| 0.7 | 3.6 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.7 | 2.8 | GO:0002111 | BRCA2-BRAF35 complex(GO:0002111) |
| 0.6 | 1.9 | GO:0097059 | CNTFR-CLCF1 complex(GO:0097059) |
| 0.6 | 2.8 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.5 | 8.1 | GO:0045180 | basal cortex(GO:0045180) |
| 0.5 | 3.2 | GO:0030062 | mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062) |
| 0.5 | 1.6 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.4 | 6.6 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.4 | 1.8 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 0.3 | 4.0 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.3 | 1.6 | GO:0031523 | Myb complex(GO:0031523) |
| 0.3 | 1.9 | GO:0042825 | TAP complex(GO:0042825) |
| 0.3 | 0.8 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
| 0.2 | 2.1 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
| 0.2 | 1.4 | GO:0098536 | deuterosome(GO:0098536) |
| 0.2 | 1.8 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.2 | 0.6 | GO:0099573 | glutamatergic postsynaptic density(GO:0099573) |
| 0.2 | 2.0 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.2 | 1.0 | GO:0032389 | MutLalpha complex(GO:0032389) |
| 0.2 | 6.0 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.2 | 1.1 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.2 | 2.2 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.2 | 7.8 | GO:0016235 | aggresome(GO:0016235) |
| 0.2 | 1.1 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.2 | 1.4 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.2 | 11.1 | GO:0016459 | myosin complex(GO:0016459) |
| 0.2 | 0.3 | GO:0099524 | region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524) |
| 0.2 | 1.2 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
| 0.1 | 3.3 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.1 | 3.7 | GO:0005921 | gap junction(GO:0005921) |
| 0.1 | 0.7 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.1 | 1.9 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 2.3 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.1 | 1.7 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.1 | 6.3 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 1.6 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.1 | 3.4 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 1.4 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.1 | 0.3 | GO:0031074 | nucleocytoplasmic shuttling complex(GO:0031074) |
| 0.1 | 1.5 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.1 | 1.3 | GO:0032039 | integrator complex(GO:0032039) |
| 0.1 | 0.7 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.1 | 4.8 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.1 | 0.4 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.1 | 1.1 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.1 | 0.4 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.1 | 0.3 | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) |
| 0.1 | 1.0 | GO:0031011 | Ino80 complex(GO:0031011) |
| 0.1 | 9.3 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 0.1 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
| 0.1 | 0.8 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.1 | 2.4 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 0.4 | GO:0045261 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
| 0.1 | 0.5 | GO:0032009 | early phagosome(GO:0032009) |
| 0.1 | 0.5 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.1 | 2.1 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.6 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 1.5 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.0 | 3.5 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 1.5 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 3.3 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.5 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.0 | 2.4 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 0.5 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.0 | 2.3 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.0 | 0.2 | GO:0071203 | WASH complex(GO:0071203) |
| 0.0 | 1.9 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 0.6 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 0.6 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 0.3 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
| 0.0 | 0.5 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 0.3 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 0.9 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 1.0 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 0.4 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 1.8 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 1.4 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.6 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.0 | 0.7 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.0 | 0.5 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.0 | 0.5 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.0 | 1.0 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.4 | GO:0001741 | XY body(GO:0001741) |
| 0.0 | 1.5 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 1.2 | GO:0000502 | proteasome complex(GO:0000502) |
| 0.0 | 0.1 | GO:0034518 | mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518) |
| 0.0 | 1.8 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 0.9 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 0.6 | GO:0005911 | cell-cell junction(GO:0005911) |
| 0.0 | 0.9 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 1.2 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.0 | 1.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 1.2 | GO:0000784 | nuclear chromosome, telomeric region(GO:0000784) |
| 0.0 | 2.1 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 2.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 6.3 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
| 1.4 | 4.3 | GO:0005110 | frizzled-2 binding(GO:0005110) |
| 1.4 | 5.5 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 1.1 | 3.2 | GO:0004774 | succinate-CoA ligase activity(GO:0004774) |
| 1.0 | 8.1 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 1.0 | 3.0 | GO:0005118 | sevenless binding(GO:0005118) |
| 0.9 | 8.5 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 0.9 | 11.4 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.9 | 2.6 | GO:0032052 | bile acid binding(GO:0032052) |
| 0.8 | 3.2 | GO:0003941 | L-serine ammonia-lyase activity(GO:0003941) |
| 0.8 | 3.0 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) |
| 0.7 | 2.9 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.7 | 4.0 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.6 | 3.2 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 0.6 | 1.9 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) protein-disulfide reductase (glutathione) activity(GO:0019153) |
| 0.6 | 2.9 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416) |
| 0.6 | 3.4 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 0.5 | 1.6 | GO:0008823 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
| 0.5 | 11.5 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.5 | 2.5 | GO:0017108 | 5'-flap endonuclease activity(GO:0017108) |
| 0.5 | 1.9 | GO:0042806 | fucose binding(GO:0042806) |
| 0.5 | 1.9 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980) |
| 0.4 | 1.8 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.4 | 1.3 | GO:0035575 | histone demethylase activity (H4-K20 specific)(GO:0035575) |
| 0.4 | 3.7 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.4 | 1.6 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 0.4 | 11.9 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.4 | 1.1 | GO:0004828 | serine-tRNA ligase activity(GO:0004828) |
| 0.4 | 0.7 | GO:0090554 | phosphatidylcholine-translocating ATPase activity(GO:0090554) |
| 0.3 | 3.4 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.3 | 2.0 | GO:0070728 | leucine binding(GO:0070728) |
| 0.3 | 1.7 | GO:0032767 | copper-dependent protein binding(GO:0032767) |
| 0.3 | 3.0 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.3 | 1.9 | GO:0004897 | ciliary neurotrophic factor receptor activity(GO:0004897) |
| 0.3 | 0.9 | GO:0071723 | lipopeptide binding(GO:0071723) |
| 0.3 | 1.2 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.3 | 3.0 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.3 | 3.5 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.3 | 1.1 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.3 | 1.4 | GO:0000982 | transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) |
| 0.3 | 0.8 | GO:0004647 | phosphoserine phosphatase activity(GO:0004647) |
| 0.3 | 0.8 | GO:0000402 | open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402) |
| 0.3 | 1.1 | GO:0008802 | betaine-aldehyde dehydrogenase activity(GO:0008802) |
| 0.3 | 5.0 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
| 0.3 | 0.8 | GO:0000253 | 3-keto sterol reductase activity(GO:0000253) |
| 0.3 | 1.6 | GO:0030284 | estrogen receptor activity(GO:0030284) |
| 0.3 | 1.3 | GO:0004382 | guanosine-diphosphatase activity(GO:0004382) |
| 0.3 | 2.8 | GO:0001163 | RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164) |
| 0.2 | 2.2 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.2 | 4.1 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.2 | 2.7 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.2 | 1.2 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.2 | 3.1 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.2 | 0.8 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
| 0.2 | 0.8 | GO:0034647 | histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647) |
| 0.2 | 1.0 | GO:0000405 | bubble DNA binding(GO:0000405) |
| 0.2 | 2.1 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.2 | 6.0 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.2 | 0.4 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.2 | 9.4 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.2 | 1.4 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
| 0.2 | 1.3 | GO:0031432 | titin binding(GO:0031432) |
| 0.2 | 2.8 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 0.2 | 2.0 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.1 | 0.6 | GO:0045322 | unmethylated CpG binding(GO:0045322) |
| 0.1 | 6.8 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 0.9 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.1 | 0.4 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 0.1 | 1.0 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.1 | 0.5 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 0.1 | 1.1 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.1 | 1.7 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.1 | 0.7 | GO:0003956 | NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956) |
| 0.1 | 0.6 | GO:0050265 | RNA uridylyltransferase activity(GO:0050265) |
| 0.1 | 5.3 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.1 | 0.6 | GO:0042134 | rRNA primary transcript binding(GO:0042134) |
| 0.1 | 2.2 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 1.8 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.1 | 0.4 | GO:0071633 | dihydroceramidase activity(GO:0071633) |
| 0.1 | 1.3 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.1 | 1.2 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.1 | 2.2 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 1.3 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 0.5 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.1 | 3.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 0.4 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.1 | 0.8 | GO:1901612 | phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612) |
| 0.1 | 1.9 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
| 0.1 | 0.4 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
| 0.1 | 3.2 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 1.0 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.1 | 2.4 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.1 | 3.5 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 1.5 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.1 | 0.7 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.1 | 1.1 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.1 | 3.3 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.1 | 3.1 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.1 | 0.5 | GO:0030983 | mismatched DNA binding(GO:0030983) |
| 0.1 | 0.7 | GO:0035242 | protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242) |
| 0.1 | 0.5 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
| 0.1 | 0.4 | GO:0043532 | angiostatin binding(GO:0043532) |
| 0.1 | 0.9 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.1 | 1.2 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.1 | 0.5 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.1 | 2.6 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 0.8 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.1 | 1.7 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 3.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 1.0 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 0.6 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.1 | 0.3 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.1 | 0.3 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.1 | 1.0 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.1 | 0.3 | GO:0045131 | pre-mRNA branch point binding(GO:0045131) |
| 0.1 | 0.5 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.1 | 0.4 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.1 | 0.2 | GO:0030249 | guanylate cyclase regulator activity(GO:0030249) |
| 0.1 | 1.0 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.1 | 0.3 | GO:0070883 | pre-miRNA binding(GO:0070883) |
| 0.1 | 0.3 | GO:1990829 | C-rich single-stranded DNA binding(GO:1990829) |
| 0.1 | 0.2 | GO:1990450 | linear polyubiquitin binding(GO:1990450) |
| 0.1 | 0.5 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.1 | 0.3 | GO:0001069 | regulatory region RNA binding(GO:0001069) mRNA CDS binding(GO:1990715) |
| 0.1 | 4.9 | GO:0003774 | motor activity(GO:0003774) |
| 0.1 | 2.1 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 0.3 | GO:0070492 | galactose binding(GO:0005534) oligosaccharide binding(GO:0070492) |
| 0.1 | 1.3 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.1 | 0.6 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) calcium-dependent protein kinase activity(GO:0010857) |
| 0.1 | 0.3 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.1 | 3.2 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 0.0 | 5.3 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 0.8 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.0 | 0.8 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 0.7 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 0.4 | GO:0008430 | selenium binding(GO:0008430) |
| 0.0 | 2.1 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.0 | 1.2 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 1.0 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 1.2 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.0 | 0.3 | GO:0042301 | phosphate ion binding(GO:0042301) |
| 0.0 | 0.2 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.0 | 0.6 | GO:0010485 | H4 histone acetyltransferase activity(GO:0010485) |
| 0.0 | 0.2 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.0 | 0.8 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.0 | 0.3 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.0 | 0.6 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.8 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 1.4 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 0.0 | 2.4 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.0 | 0.1 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798) |
| 0.0 | 2.2 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 0.9 | GO:0016278 | lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279) |
| 0.0 | 1.0 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.0 | 0.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 4.3 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.9 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.0 | 0.6 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 0.2 | GO:0016671 | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) |
| 0.0 | 0.3 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
| 0.0 | 0.5 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 0.6 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.0 | 0.2 | GO:0000182 | rDNA binding(GO:0000182) |
| 0.0 | 1.0 | GO:0030295 | protein kinase activator activity(GO:0030295) |
| 0.0 | 0.8 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.0 | 0.7 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.0 | 1.1 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 0.5 | GO:0001221 | transcription cofactor binding(GO:0001221) |
| 0.0 | 1.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.7 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 0.3 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.1 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 0.3 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.7 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.0 | GO:0043120 | tumor necrosis factor binding(GO:0043120) |
| 0.0 | 1.1 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.4 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.0 | 4.2 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 0.1 | GO:0031386 | protein tag(GO:0031386) |
| 0.0 | 0.4 | GO:0004601 | peroxidase activity(GO:0004601) |
| 0.0 | 0.3 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 19.3 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.3 | 12.1 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.2 | 5.3 | PID_IL27_PATHWAY | IL27-mediated signaling events |
| 0.2 | 8.0 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 4.0 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.2 | 7.5 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 5.4 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.2 | 6.1 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.2 | 6.3 | PID_PS1_PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.2 | 4.3 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.2 | 5.2 | PID_IGF1_PATHWAY | IGF1 pathway |
| 0.2 | 14.4 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 3.5 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 2.2 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.1 | 4.2 | PID_ATM_PATHWAY | ATM pathway |
| 0.1 | 12.4 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 2.1 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.1 | 1.4 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 1.9 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
| 0.1 | 1.6 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 1.4 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.1 | 1.2 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 1.3 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 1.9 | PID_IL1_PATHWAY | IL1-mediated signaling events |
| 0.1 | 1.1 | PID_VEGFR1_2_PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 2.4 | PID_REELIN_PATHWAY | Reelin signaling pathway |
| 0.1 | 1.5 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.1 | 3.0 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
| 0.1 | 1.5 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 2.1 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 2.2 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.8 | PID_AMB2_NEUTROPHILS_PATHWAY | amb2 Integrin signaling |
| 0.0 | 0.4 | PID_RANBP2_PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.4 | ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 1.4 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.9 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.8 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 1.6 | ST_FAS_SIGNALING_PATHWAY | Fas Signaling Pathway |
| 0.0 | 2.6 | PID_ERBB1_DOWNSTREAM_PATHWAY | ErbB1 downstream signaling |
| 0.0 | 1.3 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 0.3 | PID_INTEGRIN3_PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 1.6 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.8 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.2 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.0 | 2.4 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.7 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 0.1 | PID_CONE_PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.3 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 6.3 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.4 | 5.0 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.4 | 4.1 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.3 | 12.1 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.3 | 19.6 | REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.3 | 11.5 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.3 | 5.9 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.3 | 1.8 | REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.2 | 2.5 | REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.2 | 5.2 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
| 0.2 | 7.5 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 1.7 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.2 | 2.6 | REACTOME_STEROID_HORMONES | Genes involved in Steroid hormones |
| 0.2 | 4.0 | REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.2 | 3.9 | REACTOME_PYRUVATE_METABOLISM | Genes involved in Pyruvate metabolism |
| 0.2 | 1.8 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.2 | 5.0 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.2 | 1.9 | REACTOME_ER_PHAGOSOME_PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.2 | 3.2 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.2 | 3.2 | REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.1 | 0.4 | REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |
| 0.1 | 0.8 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.1 | 5.4 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.1 | 1.0 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.1 | 1.4 | REACTOME_PECAM1_INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.1 | 1.5 | REACTOME_RNA_POL_III_CHAIN_ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.1 | 1.2 | REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.1 | 0.8 | REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 0.6 | REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE | Genes involved in p53-Dependent G1 DNA Damage Response |
| 0.1 | 3.7 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 2.2 | REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 4.2 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.8 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 1.2 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.9 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 3.4 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 1.0 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.5 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 0.5 | REACTOME_MEIOTIC_RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 0.9 | REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.0 | 1.2 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 1.4 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 0.4 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 0.3 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.8 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.2 | REACTOME_IRAK1_RECRUITS_IKK_COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.0 | 1.9 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 2.5 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.2 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 0.3 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.1 | REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING | Genes involved in SHC1 events in EGFR signaling |
