Motif ID: Irf3

Z-value: 0.984


Transcription factors associated with Irf3:

Gene SymbolEntrez IDGene Name
Irf3 ENSMUSG00000003184.8 Irf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf3mm10_v2_chr7_+_44997648_449977000.251.3e-01Click!


Activity profile for motif Irf3.

activity profile for motif Irf3


Sorted Z-values histogram for motif Irf3

Sorted Z-values for motif Irf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_142530329 6.590 ENSMUST00000171263.1
ENSMUST00000045097.9
 Gbp7

guanylate binding protein 7

chr11_-_49064202 6.028 ENSMUST00000046745.6
 Tgtp2
T cell specific GTPase 2
chr8_-_71537402 5.132 ENSMUST00000051672.7
 Bst2
bone marrow stromal cell antigen 2
chr3_+_142560108 5.076 ENSMUST00000128609.1
ENSMUST00000029935.7
 Gbp3

guanylate binding protein 3

chr3_+_142560351 4.976 ENSMUST00000106221.1
 Gbp3
guanylate binding protein 3
chr3_+_142560052 4.642 ENSMUST00000106222.2
 Gbp3
guanylate binding protein 3
chr17_+_75178797 3.884 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr2_+_122147680 3.862 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr11_-_48992226 3.495 ENSMUST00000059930.2
ENSMUST00000068063.3
 Gm12185
Tgtp1
predicted gene 12185
T cell specific GTPase 1
chr17_+_75178911 3.487 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chr5_+_114896936 3.466 ENSMUST00000031542.9
ENSMUST00000146072.1
ENSMUST00000150361.1
 Oasl2


2'-5' oligoadenylate synthetase-like 2


chr16_-_35871544 3.338 ENSMUST00000042665.8
 Parp14
poly (ADP-ribose) polymerase family, member 14
chr17_-_34187219 3.320 ENSMUST00000173831.1
 Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr2_-_173218879 3.159 ENSMUST00000109116.2
ENSMUST00000029018.7
 Zbp1

Z-DNA binding protein 1

chr11_-_48871408 3.156 ENSMUST00000097271.2
 Irgm1
immunity-related GTPase family M member 1
chr11_+_58199556 2.886 ENSMUST00000058704.8
ENSMUST00000035266.4
ENSMUST00000094169.4
ENSMUST00000168280.1
 Irgm2
Igtp


immunity-related GTPase family M member 2
interferon gamma induced GTPase


chr6_-_39118211 2.652 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr6_-_54972603 2.475 ENSMUST00000060655.8
 Nod1
nucleotide-binding oligomerization domain containing 1
chr18_-_32559914 2.438 ENSMUST00000174000.1
ENSMUST00000174459.1
 Gypc

glycophorin C

chr17_+_34187545 2.187 ENSMUST00000170086.1
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_+_34187789 2.180 ENSMUST00000041633.8
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr11_-_48871344 1.990 ENSMUST00000049519.3
 Irgm1
immunity-related GTPase family M member 1
chr3_-_151749877 1.989 ENSMUST00000029671.7
 Ifi44
interferon-induced protein 44
chr16_+_35938470 1.753 ENSMUST00000114878.1
 Parp9
poly (ADP-ribose) polymerase family, member 9
chr16_+_35938972 1.698 ENSMUST00000023622.6
ENSMUST00000114877.1
 Parp9

poly (ADP-ribose) polymerase family, member 9

chr13_+_74639866 1.669 ENSMUST00000169114.1
 Erap1
endoplasmic reticulum aminopeptidase 1
chr7_-_141266415 1.666 ENSMUST00000106023.1
ENSMUST00000097952.2
ENSMUST00000026571.4
 Irf7


interferon regulatory factor 7


chr19_+_36409719 1.454 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chr15_+_79892397 1.437 ENSMUST00000175714.1
ENSMUST00000109620.3
ENSMUST00000165537.1
 Apobec3


apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3


chr15_+_32920723 1.414 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr5_-_137116177 1.386 ENSMUST00000054384.5
ENSMUST00000152207.1
 Trim56

tripartite motif-containing 56

chr2_-_62646146 1.373 ENSMUST00000112459.3
ENSMUST00000028259.5
 Ifih1

interferon induced with helicase C domain 1

chr3_+_81932601 1.319 ENSMUST00000029649.2
 Ctso
cathepsin O
chr15_+_79892436 1.260 ENSMUST00000175752.1
ENSMUST00000176325.1
 Apobec3

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3

chr7_-_78578308 1.145 ENSMUST00000039431.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr13_-_23710714 1.100 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
 Hfe


hemochromatosis


chr2_-_173276144 1.099 ENSMUST00000139306.1
 Pmepa1
prostate transmembrane protein, androgen induced 1
chr16_+_23609895 0.978 ENSMUST00000038423.5
 Rtp4
receptor transporter protein 4
chr11_+_119393060 0.868 ENSMUST00000131035.2
ENSMUST00000093902.5
 Rnf213

ring finger protein 213

chr14_-_65833963 0.801 ENSMUST00000022613.9
 Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr1_+_61638819 0.681 ENSMUST00000138768.1
ENSMUST00000075374.3
 Pard3b

par-3 partitioning defective 3 homolog B (C. elegans)

chr2_-_126933229 0.668 ENSMUST00000028844.4
 Sppl2a
signal peptide peptidase like 2A
chr4_-_40239700 0.580 ENSMUST00000142055.1
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr2_-_105399286 0.559 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr4_-_40239779 0.552 ENSMUST00000037907.6
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr7_-_104315455 0.516 ENSMUST00000106837.1
ENSMUST00000106839.2
ENSMUST00000070943.6
 Trim12a


tripartite motif-containing 12A


chr16_-_10785525 0.501 ENSMUST00000038099.4
 Socs1
suppressor of cytokine signaling 1
chr19_+_43752996 0.473 ENSMUST00000026199.7
ENSMUST00000112047.3
ENSMUST00000153295.1
 Cutc


cutC copper transporter homolog (E.coli)


chr2_-_145935014 0.404 ENSMUST00000001818.4
 Crnkl1
Crn, crooked neck-like 1 (Drosophila)
chr7_-_104353328 0.371 ENSMUST00000130139.1
ENSMUST00000059037.8
 Trim12c

tripartite motif-containing 12C

chr13_+_40859768 0.367 ENSMUST00000110191.2
 Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr16_-_35939082 0.363 ENSMUST00000081933.7
ENSMUST00000114885.1
 Dtx3l

deltex 3-like (Drosophila)

chr14_+_14012491 0.305 ENSMUST00000022257.2
 Atxn7
ataxin 7
chr14_+_55578123 0.227 ENSMUST00000174484.1
 Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr11_+_20647149 0.201 ENSMUST00000109585.1
 Sertad2
SERTA domain containing 2
chr7_-_45136231 0.155 ENSMUST00000124300.1
ENSMUST00000085377.5
 Rpl13a
Flt3l
ribosomal protein L13A
FMS-like tyrosine kinase 3 ligand
chr14_+_55578360 0.127 ENSMUST00000174259.1
ENSMUST00000174563.1
ENSMUST00000089619.6
ENSMUST00000172738.1
 Psme1



proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)



chr6_-_34317442 0.110 ENSMUST00000154655.1
ENSMUST00000102980.4
 Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)

chr15_-_39112642 0.108 ENSMUST00000022908.8
 Slc25a32
solute carrier family 25, member 32
chr17_-_36020525 0.082 ENSMUST00000174063.1
ENSMUST00000113760.3
 H2-T24

histocompatibility 2, T region locus 24

chrX_+_68678541 0.069 ENSMUST00000088546.5
 Fmr1
fragile X mental retardation syndrome 1
chr17_+_21008921 0.054 ENSMUST00000088811.5
 Zfp160
zinc finger protein 160
chr10_+_83543941 0.052 ENSMUST00000038388.5
 A230046K03Rik
RIKEN cDNA A230046K03 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 8.0 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
1.3 21.3 GO:0044406 adhesion of symbiont to host(GO:0044406)
1.2 5.0 GO:0034759 regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759)
1.2 4.8 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
1.1 4.4 GO:0046967 cytosol to ER transport(GO:0046967)
0.8 3.3 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.7 4.0 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.5 2.5 GO:0035547 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)
0.5 2.5 GO:0042228 interleukin-8 biosynthetic process(GO:0042228)
0.5 4.8 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.4 2.7 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.4 1.1 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.4 9.5 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.3 1.7 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.3 1.0 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.3 7.4 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.2 1.1 GO:0010991 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.2 0.8 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.7 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.1 0.9 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.4 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 0.2 GO:0090289 regulation of osteoclast proliferation(GO:0090289)
0.0 0.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 2.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.1 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.0 0.7 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.5 GO:0055070 copper ion homeostasis(GO:0055070)
0.0 3.2 GO:0051607 defense response to virus(GO:0051607)
0.0 2.9 GO:2000116 regulation of cysteine-type endopeptidase activity(GO:2000116)
0.0 0.1 GO:0006544 glycine metabolic process(GO:0006544)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.4 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
1.9 24.2 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.8 3.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.6 4.4 GO:0042825 TAP complex(GO:0042825)
0.5 5.0 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.3 5.1 GO:0044754 autolysosome(GO:0044754)
0.1 0.7 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 0.4 GO:0008537 proteasome activator complex(GO:0008537)
0.1 0.4 GO:1990462 omegasome(GO:1990462)
0.1 0.8 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.4 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.0 5.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.2 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 1.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.1 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 1.5 GO:0031519 PcG protein complex(GO:0031519)
0.0 8.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 1.1 GO:0031901 early endosome membrane(GO:0031901)
0.0 2.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.8 GO:0005923 bicellular tight junction(GO:0005923)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.4 GO:0050436 microfibril binding(GO:0050436)
1.1 4.4 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
1.1 3.2 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.8 3.8 GO:0050700 CARD domain binding(GO:0050700)
0.7 2.7 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.4 9.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.4 5.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 1.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.2 1.7 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.2 3.3 GO:0070628 proteasome binding(GO:0070628)
0.2 3.5 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 0.8 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.4 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 1.1 GO:0039706 co-receptor binding(GO:0039706)
0.1 29.0 GO:0003924 GTPase activity(GO:0003924)
0.1 0.7 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.4 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 1.1 GO:0050699 WW domain binding(GO:0050699)
0.0 2.2 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 1.3 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 14.7 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 3.9 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 3.8 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 2.6 PID_SHP2_PATHWAY SHP2 signaling
0.0 7.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 4.4 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.3 6.0 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3 4.2 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.2 7.1 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.1 3.2 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 0.9 REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.1 1.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 2.3 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 1.1 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling