Motif ID: Irf3

Z-value: 0.984


Transcription factors associated with Irf3:

Gene SymbolEntrez IDGene Name
Irf3 ENSMUSG00000003184.8 Irf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf3mm10_v2_chr7_+_44997648_449977000.251.3e-01Click!


Activity profile for motif Irf3.

activity profile for motif Irf3


Sorted Z-values histogram for motif Irf3

Sorted Z-values for motif Irf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_142530329 6.590 ENSMUST00000171263.1
ENSMUST00000045097.9
Gbp7

guanylate binding protein 7

chr11_-_49064202 6.028 ENSMUST00000046745.6
Tgtp2
T cell specific GTPase 2
chr8_-_71537402 5.132 ENSMUST00000051672.7
Bst2
bone marrow stromal cell antigen 2
chr3_+_142560108 5.076 ENSMUST00000128609.1
ENSMUST00000029935.7
Gbp3

guanylate binding protein 3

chr3_+_142560351 4.976 ENSMUST00000106221.1
Gbp3
guanylate binding protein 3
chr3_+_142560052 4.642 ENSMUST00000106222.2
Gbp3
guanylate binding protein 3
chr17_+_75178797 3.884 ENSMUST00000112516.1
ENSMUST00000135447.1
Ltbp1

latent transforming growth factor beta binding protein 1

chr2_+_122147680 3.862 ENSMUST00000102476.4
B2m
beta-2 microglobulin
chr11_-_48992226 3.495 ENSMUST00000059930.2
ENSMUST00000068063.3
Gm12185
Tgtp1
predicted gene 12185
T cell specific GTPase 1
chr17_+_75178911 3.487 ENSMUST00000112514.1
Ltbp1
latent transforming growth factor beta binding protein 1
chr5_+_114896936 3.466 ENSMUST00000031542.9
ENSMUST00000146072.1
ENSMUST00000150361.1
Oasl2


2'-5' oligoadenylate synthetase-like 2


chr16_-_35871544 3.338 ENSMUST00000042665.8
Parp14
poly (ADP-ribose) polymerase family, member 14
chr17_-_34187219 3.320 ENSMUST00000173831.1
Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr2_-_173218879 3.159 ENSMUST00000109116.2
ENSMUST00000029018.7
Zbp1

Z-DNA binding protein 1

chr11_-_48871408 3.156 ENSMUST00000097271.2
Irgm1
immunity-related GTPase family M member 1
chr11_+_58199556 2.886 ENSMUST00000058704.8
ENSMUST00000035266.4
ENSMUST00000094169.4
ENSMUST00000168280.1
Irgm2
Igtp


immunity-related GTPase family M member 2
interferon gamma induced GTPase


chr6_-_39118211 2.652 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr6_-_54972603 2.475 ENSMUST00000060655.8
Nod1
nucleotide-binding oligomerization domain containing 1
chr18_-_32559914 2.438 ENSMUST00000174000.1
ENSMUST00000174459.1
Gypc

glycophorin C

chr17_+_34187545 2.187 ENSMUST00000170086.1
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_+_34187789 2.180 ENSMUST00000041633.8
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr11_-_48871344 1.990 ENSMUST00000049519.3
Irgm1
immunity-related GTPase family M member 1
chr3_-_151749877 1.989 ENSMUST00000029671.7
Ifi44
interferon-induced protein 44
chr16_+_35938470 1.753 ENSMUST00000114878.1
Parp9
poly (ADP-ribose) polymerase family, member 9
chr16_+_35938972 1.698 ENSMUST00000023622.6
ENSMUST00000114877.1
Parp9

poly (ADP-ribose) polymerase family, member 9

chr13_+_74639866 1.669 ENSMUST00000169114.1
Erap1
endoplasmic reticulum aminopeptidase 1
chr7_-_141266415 1.666 ENSMUST00000106023.1
ENSMUST00000097952.2
ENSMUST00000026571.4
Irf7


interferon regulatory factor 7


chr19_+_36409719 1.454 ENSMUST00000062389.5
Pcgf5
polycomb group ring finger 5
chr15_+_79892397 1.437 ENSMUST00000175714.1
ENSMUST00000109620.3
ENSMUST00000165537.1
Apobec3


apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3


chr15_+_32920723 1.414 ENSMUST00000022871.5
Sdc2
syndecan 2
chr5_-_137116177 1.386 ENSMUST00000054384.5
ENSMUST00000152207.1
Trim56

tripartite motif-containing 56

chr2_-_62646146 1.373 ENSMUST00000112459.3
ENSMUST00000028259.5
Ifih1

interferon induced with helicase C domain 1

chr3_+_81932601 1.319 ENSMUST00000029649.2
Ctso
cathepsin O
chr15_+_79892436 1.260 ENSMUST00000175752.1
ENSMUST00000176325.1
Apobec3

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3

chr7_-_78578308 1.145 ENSMUST00000039431.7
Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr13_-_23710714 1.100 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
Hfe


hemochromatosis


chr2_-_173276144 1.099 ENSMUST00000139306.1
Pmepa1
prostate transmembrane protein, androgen induced 1
chr16_+_23609895 0.978 ENSMUST00000038423.5
Rtp4
receptor transporter protein 4
chr11_+_119393060 0.868 ENSMUST00000131035.2
ENSMUST00000093902.5
Rnf213

ring finger protein 213

chr14_-_65833963 0.801 ENSMUST00000022613.9
Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr1_+_61638819 0.681 ENSMUST00000138768.1
ENSMUST00000075374.3
Pard3b

par-3 partitioning defective 3 homolog B (C. elegans)

chr2_-_126933229 0.668 ENSMUST00000028844.4
Sppl2a
signal peptide peptidase like 2A
chr4_-_40239700 0.580 ENSMUST00000142055.1
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr2_-_105399286 0.559 ENSMUST00000006128.6
Rcn1
reticulocalbin 1
chr4_-_40239779 0.552 ENSMUST00000037907.6
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr7_-_104315455 0.516 ENSMUST00000106837.1
ENSMUST00000106839.2
ENSMUST00000070943.6
Trim12a


tripartite motif-containing 12A


chr16_-_10785525 0.501 ENSMUST00000038099.4
Socs1
suppressor of cytokine signaling 1
chr19_+_43752996 0.473 ENSMUST00000026199.7
ENSMUST00000112047.3
ENSMUST00000153295.1
Cutc


cutC copper transporter homolog (E.coli)


chr2_-_145935014 0.404 ENSMUST00000001818.4
Crnkl1
Crn, crooked neck-like 1 (Drosophila)
chr7_-_104353328 0.371 ENSMUST00000130139.1
ENSMUST00000059037.8
Trim12c

tripartite motif-containing 12C

chr13_+_40859768 0.367 ENSMUST00000110191.2
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr16_-_35939082 0.363 ENSMUST00000081933.7
ENSMUST00000114885.1
Dtx3l

deltex 3-like (Drosophila)

chr14_+_14012491 0.305 ENSMUST00000022257.2
Atxn7
ataxin 7
chr14_+_55578123 0.227 ENSMUST00000174484.1
Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr11_+_20647149 0.201 ENSMUST00000109585.1
Sertad2
SERTA domain containing 2
chr7_-_45136231 0.155 ENSMUST00000124300.1
ENSMUST00000085377.5
Rpl13a
Flt3l
ribosomal protein L13A
FMS-like tyrosine kinase 3 ligand
chr14_+_55578360 0.127 ENSMUST00000174259.1
ENSMUST00000174563.1
ENSMUST00000089619.6
ENSMUST00000172738.1
Psme1



proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)



chr6_-_34317442 0.110 ENSMUST00000154655.1
ENSMUST00000102980.4
Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)

chr15_-_39112642 0.108 ENSMUST00000022908.8
Slc25a32
solute carrier family 25, member 32
chr17_-_36020525 0.082 ENSMUST00000174063.1
ENSMUST00000113760.3
H2-T24

histocompatibility 2, T region locus 24

chrX_+_68678541 0.069 ENSMUST00000088546.5
Fmr1
fragile X mental retardation syndrome 1
chr17_+_21008921 0.054 ENSMUST00000088811.5
Zfp160
zinc finger protein 160
chr10_+_83543941 0.052 ENSMUST00000038388.5
A230046K03Rik
RIKEN cDNA A230046K03 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 8.0 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
1.3 21.3 GO:0044406 adhesion of symbiont to host(GO:0044406)
1.2 5.0 GO:0034759 regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759)
1.2 4.8 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
1.1 4.4 GO:0046967 cytosol to ER transport(GO:0046967)
0.8 3.3 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.7 4.0 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.5 2.5 GO:0035547 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)
0.5 2.5 GO:0042228 interleukin-8 biosynthetic process(GO:0042228)
0.5 4.8 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.4 2.7 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.4 1.1 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.4 9.5 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.3 1.7 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.3 1.0 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.3 7.4 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.2 1.1 GO:0010991 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.2 0.8 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.7 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.1 0.9 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.4 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 0.2 GO:0090289 regulation of osteoclast proliferation(GO:0090289)
0.0 0.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 2.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.1 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.0 0.7 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.5 GO:0055070 copper ion homeostasis(GO:0055070)
0.0 3.2 GO:0051607 defense response to virus(GO:0051607)
0.0 2.9 GO:2000116 regulation of cysteine-type endopeptidase activity(GO:2000116)
0.0 0.1 GO:0006544 glycine metabolic process(GO:0006544)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.4 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
1.9 24.2 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.8 3.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.6 4.4 GO:0042825 TAP complex(GO:0042825)
0.5 5.0 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.3 5.1 GO:0044754 autolysosome(GO:0044754)
0.1 0.7 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 0.4 GO:0008537 proteasome activator complex(GO:0008537)
0.1 0.4 GO:1990462 omegasome(GO:1990462)
0.1 0.8 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.4 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.0 5.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.2 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 1.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.1 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 1.5 GO:0031519 PcG protein complex(GO:0031519)
0.0 8.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 1.1 GO:0031901 early endosome membrane(GO:0031901)
0.0 2.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.8 GO:0005923 bicellular tight junction(GO:0005923)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.4 GO:0050436 microfibril binding(GO:0050436)
1.1 4.4 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
1.1 3.2 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.8 3.8 GO:0050700 CARD domain binding(GO:0050700)
0.7 2.7 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.4 9.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.4 5.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 1.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.2 1.7 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.2 3.3 GO:0070628 proteasome binding(GO:0070628)
0.2 3.5 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 0.8 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.4 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 1.1 GO:0039706 co-receptor binding(GO:0039706)
0.1 29.0 GO:0003924 GTPase activity(GO:0003924)
0.1 0.7 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.4 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 1.1 GO:0050699 WW domain binding(GO:0050699)
0.0 2.2 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 1.3 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 14.7 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 3.9 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 3.8 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 2.6 PID_SHP2_PATHWAY SHP2 signaling
0.0 7.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 4.4 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.3 6.0 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3 4.2 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.2 7.1 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.1 3.2 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 0.9 REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.1 1.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 2.3 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 1.1 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling