ISMARA results: Irx4

Motif ID: Irx4

Z-value: 0.211

Transcription factors associated with Irx4:

Gene Symbol	Entrez ID	Gene Name
Irx4	ENSMUSG00000021604.9	Irx4

Sorted Z-values for motif Irx4

Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr11_-_11970540	1.175	ENSMUST00000109653.1	Grb10	growth factor receptor bound protein 10
chr1_+_45311538	0.711	ENSMUST00000087883.6	Col3a1	collagen, type III, alpha 1
chr6_-_3494587	0.528	ENSMUST00000049985.8	Hepacam2	HEPACAM family member 2
chr8_+_84872105	0.402	ENSMUST00000136026.1 ENSMUST00000170296.1	Syce2	synaptonemal complex central element protein 2
chr9_-_58202281	0.265	ENSMUST00000163897.1	Islr2	immunoglobulin superfamily containing leucine-rich repeat 2
chr3_+_27317028	0.233	ENSMUST00000046383.5 ENSMUST00000174840.1	Tnfsf10	tumor necrosis factor (ligand) superfamily, member 10
chr4_+_48663502	0.156	ENSMUST00000030033.4	Murc	muscle-related coiled-coil protein
chr6_-_83317589	0.154	ENSMUST00000005810.6	Mthfd2	methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
chr3_-_57651667	0.118	ENSMUST00000160959.1	Commd2	COMM domain containing 2
chr15_-_35938186	0.111	ENSMUST00000014457.8	Cox6c	cytochrome c oxidase subunit VIc
chr15_-_35938009	0.101	ENSMUST00000156915.1	Cox6c	cytochrome c oxidase subunit VIc
chr17_-_25785324	0.093	ENSMUST00000150324.1	Haghl	hydroxyacylglutathione hydrolase-like
chr2_-_79908428	0.082	ENSMUST00000102652.3 ENSMUST00000102651.3	Pde1a	phosphodiesterase 1A, calmodulin-dependent
chr17_-_25785533	0.071	ENSMUST00000140738.1 ENSMUST00000145053.1 ENSMUST00000138759.1 ENSMUST00000133071.1 ENSMUST00000077938.3	Haghl	hydroxyacylglutathione hydrolase-like
chr2_-_79908389	0.065	ENSMUST00000090756.4	Pde1a	phosphodiesterase 1A, calmodulin-dependent
chr18_-_37178493	0.051	ENSMUST00000181887.1 ENSMUST00000180516.1	Gm10544	predicted gene 10544

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1	1.2	GO:0070874	negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.4	GO:0007130	synaptonemal complex assembly(GO:0007130)
0.0	0.2	GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0000801	central element(GO:0000801)
0.1	0.7	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0	0.7	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	1.2	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0048101	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0	0.2	GO:0004416	hydroxyacylglutathione hydrolase activity(GO:0004416)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.2	PID_IGF1_PATHWAY	IGF1 pathway
0.0	0.7	NABA_COLLAGENS	Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	REACTOME_SIGNAL_ATTENUATION	Genes involved in Signal attenuation
0.0	0.2	REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.7	REACTOME_NCAM1_INTERACTIONS	Genes involved in NCAM1 interactions