Motif ID: Klf13
Z-value: 0.606
Transcription factors associated with Klf13:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Klf13 | ENSMUSG00000052040.9 | Klf13 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Klf13 | mm10_v2_chr7_-_63938862_63938933 | -0.48 | 2.0e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.4 | GO:1900133 | renin secretion into blood stream(GO:0002001) regulation of renin secretion into blood stream(GO:1900133) |
| 0.4 | 2.6 | GO:0019262 | N-acetylneuraminate catabolic process(GO:0019262) |
| 0.3 | 1.0 | GO:0071929 | alpha-tubulin acetylation(GO:0071929) |
| 0.3 | 1.2 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 0.2 | 0.7 | GO:1902174 | positive regulation of keratinocyte apoptotic process(GO:1902174) |
| 0.2 | 0.6 | GO:0009826 | unidimensional cell growth(GO:0009826) |
| 0.2 | 1.3 | GO:0010968 | regulation of microtubule nucleation(GO:0010968) |
| 0.2 | 1.3 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.2 | 0.7 | GO:0006788 | heme oxidation(GO:0006788) |
| 0.1 | 0.6 | GO:0046210 | nitrate catabolic process(GO:0043602) nitric oxide catabolic process(GO:0046210) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346) |
| 0.1 | 0.9 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.1 | 0.6 | GO:0010636 | positive regulation of mitochondrial fusion(GO:0010636) |
| 0.1 | 0.4 | GO:0042167 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149) |
| 0.1 | 1.4 | GO:0099628 | receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628) |
| 0.1 | 0.6 | GO:0046600 | negative regulation of centriole replication(GO:0046600) |
| 0.1 | 0.5 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.1 | 0.3 | GO:0010957 | negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137) regulation of cell differentiation involved in embryonic placenta development(GO:0060800) |
| 0.1 | 0.9 | GO:0090084 | negative regulation of inclusion body assembly(GO:0090084) |
| 0.1 | 0.4 | GO:1904751 | positive regulation of protein localization to nucleolus(GO:1904751) |
| 0.1 | 1.0 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.1 | 1.9 | GO:0030903 | notochord development(GO:0030903) |
| 0.1 | 0.4 | GO:2000676 | positive regulation of type B pancreatic cell apoptotic process(GO:2000676) |
| 0.1 | 0.3 | GO:0000379 | tRNA-type intron splice site recognition and cleavage(GO:0000379) |
| 0.1 | 0.6 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.1 | 0.6 | GO:1904668 | positive regulation of ubiquitin protein ligase activity(GO:1904668) |
| 0.1 | 0.9 | GO:0007220 | Notch receptor processing(GO:0007220) |
| 0.1 | 0.2 | GO:0002946 | tRNA C5-cytosine methylation(GO:0002946) |
| 0.1 | 0.4 | GO:1903847 | regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849) |
| 0.1 | 0.8 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.1 | 0.6 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.1 | 0.5 | GO:0061042 | vascular wound healing(GO:0061042) |
| 0.1 | 0.4 | GO:0008611 | ether lipid biosynthetic process(GO:0008611) neutrophil differentiation(GO:0030223) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503) |
| 0.0 | 0.5 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.0 | 1.1 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.0 | 0.7 | GO:0032703 | negative regulation of interleukin-2 production(GO:0032703) |
| 0.0 | 0.6 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 0.0 | 0.5 | GO:0033008 | positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306) |
| 0.0 | 0.2 | GO:0009794 | regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448) |
| 0.0 | 0.5 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.0 | 0.4 | GO:0006098 | pentose-phosphate shunt(GO:0006098) |
| 0.0 | 0.3 | GO:0046512 | sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520) |
| 0.0 | 1.1 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 0.1 | GO:0001180 | transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180) |
| 0.0 | 0.1 | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) |
| 0.0 | 1.2 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.0 | 2.5 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.0 | 0.5 | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) |
| 0.0 | 0.8 | GO:0045739 | positive regulation of DNA repair(GO:0045739) |
| 0.0 | 0.1 | GO:0090166 | Golgi disassembly(GO:0090166) |
| 0.0 | 0.2 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
| 0.0 | 0.1 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
| 0.0 | 0.3 | GO:0019884 | antigen processing and presentation of exogenous antigen(GO:0019884) |
| 0.0 | 0.5 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 0.8 | GO:0043966 | histone H3 acetylation(GO:0043966) |
| 0.0 | 0.1 | GO:0006527 | arginine catabolic process(GO:0006527) |
| 0.0 | 0.3 | GO:0006515 | misfolded or incompletely synthesized protein catabolic process(GO:0006515) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.9 | GO:0099524 | region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524) |
| 0.2 | 0.8 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 0.2 | 0.5 | GO:0044194 | cytolytic granule(GO:0044194) |
| 0.1 | 0.7 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.1 | 0.5 | GO:0045251 | mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251) |
| 0.1 | 0.9 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.1 | 1.0 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.1 | 0.5 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 0.1 | 0.3 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.1 | 1.4 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.1 | 1.3 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.1 | 0.5 | GO:0089701 | U2AF(GO:0089701) |
| 0.0 | 1.0 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.0 | 0.4 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.0 | 0.8 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 0.3 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
| 0.0 | 0.6 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.0 | 1.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.4 | GO:0031011 | Ino80 complex(GO:0031011) |
| 0.0 | 0.6 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 2.5 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.1 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.0 | 0.1 | GO:0070695 | FHF complex(GO:0070695) |
| 0.0 | 1.2 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.3 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 0.6 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 1.3 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.0 | 0.5 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.4 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 0.5 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.6 | GO:0045127 | N-acetylglucosamine kinase activity(GO:0045127) |
| 0.5 | 1.4 | GO:0051379 | epinephrine binding(GO:0051379) |
| 0.3 | 1.3 | GO:0008865 | fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.2 | 0.7 | GO:0004392 | heme oxygenase (decyclizing) activity(GO:0004392) |
| 0.2 | 1.4 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
| 0.2 | 1.0 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.1 | 0.6 | GO:0016708 | nitric oxide dioxygenase activity(GO:0008941) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor(GO:0016708) iron-cytochrome-c reductase activity(GO:0047726) |
| 0.1 | 1.4 | GO:0097027 | ubiquitin-protein transferase activator activity(GO:0097027) |
| 0.1 | 0.4 | GO:0017057 | 6-phosphogluconolactonase activity(GO:0017057) |
| 0.1 | 1.0 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.1 | 1.3 | GO:0016427 | tRNA (cytosine) methyltransferase activity(GO:0016427) |
| 0.1 | 0.5 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.1 | 0.5 | GO:0097003 | adipokinetic hormone receptor activity(GO:0097003) |
| 0.1 | 0.9 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.1 | 0.4 | GO:0004074 | biliverdin reductase activity(GO:0004074) |
| 0.1 | 0.4 | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) |
| 0.1 | 0.7 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.1 | 0.3 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 0.1 | 0.3 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.1 | 0.4 | GO:0010521 | telomerase inhibitor activity(GO:0010521) |
| 0.1 | 0.2 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.1 | 0.6 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.0 | 0.5 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.0 | 0.3 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
| 0.0 | 1.9 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.0 | 0.3 | GO:0000213 | tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892) |
| 0.0 | 0.3 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.0 | 2.5 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.5 | GO:0030628 | pre-mRNA 3'-splice site binding(GO:0030628) |
| 0.0 | 0.3 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.0 | 0.6 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 0.8 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.0 | 0.8 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 0.6 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.0 | 0.7 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.0 | 0.9 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 0.1 | GO:0070404 | NADH binding(GO:0070404) |
| 0.0 | 0.7 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 0.6 | GO:0004521 | endoribonuclease activity(GO:0004521) |
| 0.0 | 0.1 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.0 | 0.7 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.0 | 0.1 | GO:0000990 | transcription factor activity, core RNA polymerase binding(GO:0000990) |
| 0.0 | 0.1 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.0 | 0.1 | GO:0001179 | RNA polymerase I transcription factor binding(GO:0001179) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 0.9 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.8 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.6 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.0 | 0.3 | PID_S1P_S1P1_PATHWAY | S1P1 pathway |
| 0.0 | 0.3 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.0 | 1.3 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.7 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 0.4 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.1 | 0.6 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
| 0.1 | 1.2 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.1 | 0.9 | REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.1 | 1.2 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 1.3 | REACTOME_GLUCOSE_TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 0.4 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.9 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.3 | REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.0 | 0.2 | REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| 0.0 | 0.4 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 1.0 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.5 | REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
