Motif ID: Klf7

Z-value: 0.345


Transcription factors associated with Klf7:

Gene SymbolEntrez IDGene Name
Klf7 ENSMUSG00000025959.7 Klf7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf7mm10_v2_chr1_-_64121389_64121452-0.288.1e-02Click!


Activity profile for motif Klf7.

activity profile for motif Klf7


Sorted Z-values histogram for motif Klf7

Sorted Z-values for motif Klf7



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf7

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_+_897782 2.602 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr1_-_138847579 2.283 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr2_+_172550991 1.713 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr2_+_119047116 1.391 ENSMUST00000152380.1
ENSMUST00000099542.2
 Casc5

cancer susceptibility candidate 5

chr2_+_119047129 1.209 ENSMUST00000153300.1
ENSMUST00000028799.5
 Casc5

cancer susceptibility candidate 5

chr15_+_99074968 1.139 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr9_-_32344237 0.922 ENSMUST00000034533.5
 Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr2_-_151973387 0.896 ENSMUST00000109863.1
 Fam110a
family with sequence similarity 110, member A
chr5_+_33658123 0.804 ENSMUST00000074849.6
ENSMUST00000079534.4
 Tacc3

transforming, acidic coiled-coil containing protein 3

chr5_+_137761680 0.734 ENSMUST00000110983.2
ENSMUST00000031738.4
 Tsc22d4

TSC22 domain family, member 4

chr1_+_167689108 0.714 ENSMUST00000111377.1
 Lmx1a
LIM homeobox transcription factor 1 alpha
chr18_+_35118880 0.674 ENSMUST00000042345.6
 Ctnna1
catenin (cadherin associated protein), alpha 1
chr11_+_68432112 0.666 ENSMUST00000021283.7
 Pik3r5
phosphoinositide-3-kinase, regulatory subunit 5, p101
chr7_-_132776855 0.553 ENSMUST00000106168.1
 Fam53b
family with sequence similarity 53, member B
chr10_+_79682169 0.474 ENSMUST00000020550.5
 Cdc34
cell division cycle 34
chr11_-_40733373 0.460 ENSMUST00000020579.8
 Hmmr
hyaluronan mediated motility receptor (RHAMM)
chrX_+_136270253 0.448 ENSMUST00000178632.1
ENSMUST00000053540.4
 Ngfrap1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr5_+_136136202 0.429 ENSMUST00000143229.1
 Alkbh4
alkB, alkylation repair homolog 4 (E. coli)
chr2_+_34772089 0.406 ENSMUST00000028222.6
ENSMUST00000100171.2
 Hspa5

heat shock protein 5

chr11_+_80383279 0.403 ENSMUST00000165565.1
ENSMUST00000017567.7
 Zfp207

zinc finger protein 207

chr5_-_136135989 0.381 ENSMUST00000150406.1
ENSMUST00000006301.4
 Lrwd1

leucine-rich repeats and WD repeat domain containing 1

chr18_+_88971790 0.359 ENSMUST00000023828.7
 Rttn
rotatin
chr13_+_21722057 0.353 ENSMUST00000110476.3
 Hist1h2bm
histone cluster 1, H2bm
chr8_+_84901928 0.351 ENSMUST00000067060.7
 Klf1
Kruppel-like factor 1 (erythroid)
chr11_-_70654624 0.339 ENSMUST00000018437.2
 Pfn1
profilin 1
chr5_+_136136137 0.324 ENSMUST00000136634.1
ENSMUST00000041100.3
 Alkbh4

alkB, alkylation repair homolog 4 (E. coli)

chr7_-_45154519 0.273 ENSMUST00000007977.7
ENSMUST00000107815.1
 Aldh16a1

aldehyde dehydrogenase 16 family, member A1

chr8_+_105860634 0.244 ENSMUST00000008594.7
 Nutf2
nuclear transport factor 2
chr11_-_89639631 0.244 ENSMUST00000128717.1
 Ankfn1
ankyrin-repeat and fibronectin type III domain containing 1
chr2_+_156312589 0.231 ENSMUST00000073942.5
ENSMUST00000109580.1
 Cnbd2

cyclic nucleotide binding domain containing 2

chr11_+_40733639 0.230 ENSMUST00000020578.4
 Nudcd2
NudC domain containing 2
chr9_+_104002546 0.228 ENSMUST00000035167.8
ENSMUST00000117054.1
 Nphp3

nephronophthisis 3 (adolescent)

chr4_-_87230435 0.223 ENSMUST00000107157.2
 Slc24a2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr12_+_118846329 0.219 ENSMUST00000063918.2
 Sp8
trans-acting transcription factor 8
chr12_-_4592927 0.216 ENSMUST00000170816.1
 Gm3625
predicted gene 3625
chr14_+_30479565 0.204 ENSMUST00000022535.7
 Dcp1a
DCP1 decapping enzyme homolog A (S. cerevisiae)
chr6_-_88874597 0.199 ENSMUST00000061262.4
ENSMUST00000140455.1
ENSMUST00000145780.1
 Podxl2


podocalyxin-like 2


chr5_-_134456702 0.195 ENSMUST00000073161.5
ENSMUST00000171794.2
ENSMUST00000111245.2
ENSMUST00000100654.3
ENSMUST00000167084.2
ENSMUST00000100652.3
ENSMUST00000100650.3
ENSMUST00000074114.5
 Gtf2ird1







general transcription factor II I repeat domain-containing 1







chr5_+_140607334 0.186 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr8_+_70152754 0.185 ENSMUST00000072500.6
ENSMUST00000164040.1
ENSMUST00000110146.2
ENSMUST00000110143.1
ENSMUST00000110141.2
ENSMUST00000110140.1
 2310045N01Rik

Mef2b



RIKEN cDNA 2310045N01 gene

myocyte enhancer factor 2B



chr2_+_158375638 0.179 ENSMUST00000109488.1
 Snhg11
small nucleolar RNA host gene 11
chr1_-_172082757 0.171 ENSMUST00000003550.4
 Ncstn
nicastrin
chr16_-_56717286 0.159 ENSMUST00000121554.1
ENSMUST00000128551.1
 Tfg

Trk-fused gene

chr4_+_152297205 0.142 ENSMUST00000048892.7
 Icmt
isoprenylcysteine carboxyl methyltransferase
chr8_-_84966008 0.133 ENSMUST00000109738.3
ENSMUST00000065049.8
ENSMUST00000128972.1
 Rnaseh2a


ribonuclease H2, large subunit


chr9_-_71485893 0.125 ENSMUST00000034720.5
 Polr2m
polymerase (RNA) II (DNA directed) polypeptide M
chr10_+_127677064 0.119 ENSMUST00000118612.1
ENSMUST00000048099.4
 Tmem194

transmembrane protein 194

chr3_-_103791075 0.114 ENSMUST00000106845.2
ENSMUST00000029438.8
ENSMUST00000121324.1
 Hipk1


homeodomain interacting protein kinase 1


chr4_+_63558748 0.110 ENSMUST00000077709.4
 6330416G13Rik
RIKEN cDNA 6330416G13 gene
chr2_+_181497223 0.110 ENSMUST00000108799.3
 Tpd52l2
tumor protein D52-like 2
chr1_-_120121030 0.105 ENSMUST00000027634.6
 Dbi
diazepam binding inhibitor
chr1_+_163929765 0.100 ENSMUST00000027876.4
ENSMUST00000170359.1
 Scyl3

SCY1-like 3 (S. cerevisiae)

chr2_+_181497165 0.098 ENSMUST00000149163.1
ENSMUST00000000844.8
ENSMUST00000184849.1
ENSMUST00000108800.1
ENSMUST00000069712.2
 Tpd52l2




tumor protein D52-like 2




chr12_+_49383007 0.095 ENSMUST00000021333.3
 Foxg1
forkhead box G1
chr7_-_141414115 0.095 ENSMUST00000106008.1
 Pddc1
Parkinson disease 7 domain containing 1
chr1_-_120120937 0.089 ENSMUST00000151708.1
 Dbi
diazepam binding inhibitor
chr11_+_78176711 0.088 ENSMUST00000098545.5
 Tlcd1
TLC domain containing 1
chr7_+_126976338 0.083 ENSMUST00000032920.3
 Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr17_+_26113286 0.081 ENSMUST00000025010.7
 Tmem8
transmembrane protein 8 (five membrane-spanning domains)
chr1_+_58445531 0.079 ENSMUST00000151272.1
 Nif3l1
Ngg1 interacting factor 3-like 1 (S. pombe)
chr1_+_57406328 0.073 ENSMUST00000027114.5
 9430016H08Rik
RIKEN cDNA 9430016H08 gene
chr10_-_86705485 0.073 ENSMUST00000020238.7
 Hsp90b1
heat shock protein 90, beta (Grp94), member 1
chr17_+_46202740 0.071 ENSMUST00000087031.5
 Xpo5
exportin 5
chr6_-_88875035 0.070 ENSMUST00000145944.1
 Podxl2
podocalyxin-like 2
chr7_-_101011976 0.068 ENSMUST00000178340.1
ENSMUST00000037540.3
 P2ry2

purinergic receptor P2Y, G-protein coupled 2

chr5_+_45520221 0.062 ENSMUST00000156481.1
ENSMUST00000119579.1
ENSMUST00000118833.1
 Med28


mediator of RNA polymerase II transcription, subunit 28 homolog (yeast)


chr17_+_35916977 0.060 ENSMUST00000151664.1
 Ppp1r10
protein phosphatase 1, regulatory subunit 10
chr7_-_133776772 0.056 ENSMUST00000033290.5
 Dhx32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr15_-_50889043 0.055 ENSMUST00000183997.1
ENSMUST00000183757.1
 Trps1

trichorhinophalangeal syndrome I (human)

chr11_-_61494173 0.053 ENSMUST00000101085.2
ENSMUST00000079080.6
ENSMUST00000108714.1
 Mapk7


mitogen-activated protein kinase 7


chr2_-_156180135 0.050 ENSMUST00000126992.1
ENSMUST00000146288.1
ENSMUST00000029149.6
ENSMUST00000109587.2
ENSMUST00000109584.1
 Rbm39




RNA binding motif protein 39




chr8_+_71922810 0.049 ENSMUST00000119003.1
 Zfp617
zinc finger protein 617
chr12_+_49382791 0.048 ENSMUST00000179669.1
 Foxg1
forkhead box G1
chr7_+_28350652 0.045 ENSMUST00000082134.4
 Rps16
ribosomal protein S16
chr10_+_86705811 0.045 ENSMUST00000061458.7
ENSMUST00000075632.6
 BC030307

cDNA sequence BC030307

chr5_+_137778849 0.037 ENSMUST00000126126.1
ENSMUST00000031739.4
 Ppp1r35

protein phosphatase 1, regulatory subunit 35

chr1_-_23383149 0.031 ENSMUST00000027343.5
 Ogfrl1
opioid growth factor receptor-like 1
chr11_-_78536235 0.029 ENSMUST00000017759.2
ENSMUST00000108277.2
 Tnfaip1

tumor necrosis factor, alpha-induced protein 1 (endothelial)

chr14_+_50807915 0.027 ENSMUST00000036126.5
 Parp2
poly (ADP-ribose) polymerase family, member 2
chr7_-_19404082 0.027 ENSMUST00000108458.3
 Klc3
kinesin light chain 3
chr11_-_101302206 0.025 ENSMUST00000140706.1
ENSMUST00000170502.1
ENSMUST00000172233.1
ENSMUST00000130916.1
 Becn1



beclin 1, autophagy related



chr11_-_120991039 0.009 ENSMUST00000070575.7
 Csnk1d
casein kinase 1, delta
chr6_+_52713729 0.008 ENSMUST00000080723.4
ENSMUST00000149588.1
 Tax1bp1

Tax1 (human T cell leukemia virus type I) binding protein 1

chr3_+_106721672 0.008 ENSMUST00000098750.2
ENSMUST00000130105.1
 Lrif1

ligand dependent nuclear receptor interacting factor 1

chr2_+_32775769 0.006 ENSMUST00000066352.5
 Ptrh1
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr19_+_5637475 0.005 ENSMUST00000025867.5
 Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
chr1_+_172082509 0.003 ENSMUST00000135192.1
 Copa
coatomer protein complex subunit alpha

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.5 2.6 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.5 2.3 GO:0035262 gonad morphogenesis(GO:0035262)
0.3 0.8 GO:0036090 cleavage furrow ingression(GO:0036090)
0.2 0.9 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.2 0.7 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 0.4 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.1 0.7 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.2 GO:0090204 protein localization to nuclear pore(GO:0090204) negative regulation of vascular endothelial growth factor production(GO:1904046)
0.1 0.2 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 0.5 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 0.7 GO:0042048 olfactory behavior(GO:0042048)
0.0 0.3 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.1 GO:0021852 pyramidal neuron migration(GO:0021852)
0.0 0.8 GO:0030953 astral microtubule organization(GO:0030953)
0.0 0.2 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.2 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.0 0.2 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.1 GO:0006481 C-terminal protein methylation(GO:0006481)
0.0 0.1 GO:0051643 endoplasmic reticulum localization(GO:0051643)
0.0 0.1 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.2 GO:0050957 equilibrioception(GO:0050957)
0.0 0.2 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.1 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.1 GO:1900368 regulation of RNA interference(GO:1900368)
0.0 0.1 GO:0070375 ERK5 cascade(GO:0070375)
0.0 0.7 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.3 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.0 0.6 GO:0035411 catenin import into nucleus(GO:0035411)
0.0 0.2 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.1 GO:0060406 positive regulation of penile erection(GO:0060406)
0.0 0.4 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0097651 phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.1 0.4 GO:1990047 spindle matrix(GO:1990047)
0.1 0.2 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 0.7 GO:0016600 flotillin complex(GO:0016600)
0.1 0.4 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.8 GO:0070938 contractile ring(GO:0070938)
0.0 0.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.2 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.1 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 0.1 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.2 GO:0070765 gamma-secretase complex(GO:0070765)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.6 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.2 0.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.7 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.2 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.1 0.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.2 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.7 GO:0017166 vinculin binding(GO:0017166)
0.0 0.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.1 GO:0003880 protein C-terminal carboxyl O-methyltransferase activity(GO:0003880)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.0 0.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.4 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.1 GO:0070883 pre-miRNA binding(GO:0070883)
0.0 1.2 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.1 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.9 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.7 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.2 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 3.0 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.5 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.7 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.9 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.2 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR