Motif ID: Lef1

Z-value: 1.594


Transcription factors associated with Lef1:

Gene SymbolEntrez IDGene Name
Lef1 ENSMUSG00000027985.8 Lef1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lef1mm10_v2_chr3_+_131110350_1311104710.595.9e-05Click!


Activity profile for motif Lef1.

activity profile for motif Lef1


Sorted Z-values histogram for motif Lef1

Sorted Z-values for motif Lef1



Network of associatons between targets according to the STRING database.



First level regulatory network of Lef1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_98169542 11.557 ENSMUST00000069334.7
ENSMUST00000071533.6
Dach1

dachshund 1 (Drosophila)

chr10_-_92165159 10.614 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr12_+_76072016 7.948 ENSMUST00000131480.1
Syne2
spectrin repeat containing, nuclear envelope 2
chr2_+_70474923 7.358 ENSMUST00000100043.2
Sp5
trans-acting transcription factor 5
chr7_-_37772868 7.216 ENSMUST00000176205.1
Zfp536
zinc finger protein 536
chr4_-_91376433 7.044 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr7_-_115824699 7.010 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr18_-_62756275 6.996 ENSMUST00000067450.1
ENSMUST00000048109.5
2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr4_-_91376490 6.931 ENSMUST00000107124.3
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr4_-_34882919 6.307 ENSMUST00000098163.2
ENSMUST00000047950.5
Zfp292

zinc finger protein 292

chr4_+_8691303 6.185 ENSMUST00000051558.3
Chd7
chromodomain helicase DNA binding protein 7
chr2_+_124610573 6.165 ENSMUST00000103239.3
ENSMUST00000103240.2
Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chr7_-_70366735 6.066 ENSMUST00000089565.5
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr8_+_45507768 5.914 ENSMUST00000067065.7
ENSMUST00000098788.3
ENSMUST00000067107.7
ENSMUST00000171337.2
ENSMUST00000138049.1
ENSMUST00000141039.1
Sorbs2





sorbin and SH3 domain containing 2





chr1_-_138842429 5.876 ENSMUST00000112026.2
ENSMUST00000019374.7
Lhx9

LIM homeobox protein 9

chr4_-_63403330 5.739 ENSMUST00000035724.4
Akna
AT-hook transcription factor
chr1_-_165934900 5.454 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
Pou2f1


POU domain, class 2, transcription factor 1


chrX_+_109095359 5.255 ENSMUST00000033598.8
Sh3bgrl
SH3-binding domain glutamic acid-rich protein like
chr2_-_116067391 5.198 ENSMUST00000140185.1
2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr4_-_82705735 5.131 ENSMUST00000155821.1
Nfib
nuclear factor I/B
chr4_-_97584612 5.124 ENSMUST00000107068.2
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr2_+_116067213 5.052 ENSMUST00000152412.1
G630016G05Rik
RIKEN cDNA G630016G05 gene
chr5_+_17574726 5.023 ENSMUST00000169603.1
Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr4_-_97584605 5.005 ENSMUST00000107067.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr7_-_116038734 4.933 ENSMUST00000166877.1
Sox6
SRY-box containing gene 6
chr4_-_20778527 4.932 ENSMUST00000119374.1
Nkain3
Na+/K+ transporting ATPase interacting 3
chr4_+_97777780 4.904 ENSMUST00000107062.2
ENSMUST00000052018.5
ENSMUST00000107057.1
Nfia


nuclear factor I/A


chr3_+_102010138 4.888 ENSMUST00000066187.4
Nhlh2
nescient helix loop helix 2
chr10_-_92164666 4.874 ENSMUST00000183123.1
ENSMUST00000182033.1
Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr5_+_47984793 4.650 ENSMUST00000170109.2
ENSMUST00000174421.1
ENSMUST00000173702.1
ENSMUST00000173107.1
Slit2



slit homolog 2 (Drosophila)



chrX_+_129749740 4.621 ENSMUST00000167619.2
ENSMUST00000037854.8
Diap2

diaphanous homolog 2 (Drosophila)

chr4_-_97778042 4.565 ENSMUST00000146447.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr3_+_131110350 4.555 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
Lef1


lymphoid enhancer binding factor 1


chr3_-_75956888 4.445 ENSMUST00000038563.7
ENSMUST00000167078.1
ENSMUST00000117242.1
Golim4


golgi integral membrane protein 4


chr1_+_6734827 4.392 ENSMUST00000139838.1
St18
suppression of tumorigenicity 18
chr7_-_37773555 4.349 ENSMUST00000176534.1
Zfp536
zinc finger protein 536
chr6_-_148944750 4.341 ENSMUST00000111562.1
ENSMUST00000081956.5
Fam60a

family with sequence similarity 60, member A

chr12_+_52516077 4.280 ENSMUST00000110725.1
Arhgap5
Rho GTPase activating protein 5
chr17_-_70851189 4.255 ENSMUST00000059775.8
Tgif1
TGFB-induced factor homeobox 1
chr7_+_45216671 4.196 ENSMUST00000134420.1
Tead2
TEA domain family member 2
chr11_+_88068242 4.195 ENSMUST00000018521.4
Vezf1
vascular endothelial zinc finger 1
chr5_-_28210022 4.187 ENSMUST00000118882.1
Cnpy1
canopy 1 homolog (zebrafish)
chr18_-_84086379 4.130 ENSMUST00000060303.8
Tshz1
teashirt zinc finger family member 1
chr12_-_54986363 4.128 ENSMUST00000173433.1
ENSMUST00000173803.1
Baz1a
Gm20403
bromodomain adjacent to zinc finger domain 1A
predicted gene 20403
chr4_+_108479081 4.128 ENSMUST00000155068.1
Zcchc11
zinc finger, CCHC domain containing 11
chr1_+_165788681 4.122 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
Cd247



CD247 antigen



chr4_-_24430838 4.121 ENSMUST00000183964.1
RP23-35K5.2
RP23-35K5.2
chr3_-_116424007 4.107 ENSMUST00000090464.4
Cdc14a
CDC14 cell division cycle 14A
chr7_-_37769624 4.091 ENSMUST00000175941.1
Zfp536
zinc finger protein 536
chr18_+_82914632 4.086 ENSMUST00000071233.6
Zfp516
zinc finger protein 516
chr5_+_47984571 4.011 ENSMUST00000174313.1
Slit2
slit homolog 2 (Drosophila)
chr3_-_116423930 3.871 ENSMUST00000106491.2
Cdc14a
CDC14 cell division cycle 14A
chr9_-_71896047 3.870 ENSMUST00000184448.1
Tcf12
transcription factor 12
chrX_+_129749830 3.862 ENSMUST00000113320.2
Diap2
diaphanous homolog 2 (Drosophila)
chr2_-_60125651 3.675 ENSMUST00000112550.1
Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr12_-_54986328 3.649 ENSMUST00000038926.6
Baz1a
bromodomain adjacent to zinc finger domain 1A
chr3_-_116968827 3.569 ENSMUST00000119557.1
Palmd
palmdelphin
chr19_+_55742242 3.564 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box






chr18_+_11633276 3.491 ENSMUST00000115861.2
Rbbp8
retinoblastoma binding protein 8
chr8_+_88521344 3.484 ENSMUST00000034086.5
Nkd1
naked cuticle 1 homolog (Drosophila)
chr11_-_102925086 3.462 ENSMUST00000021311.9
Kif18b
kinesin family member 18B
chr16_+_20097554 3.447 ENSMUST00000023509.3
Klhl24
kelch-like 24
chr1_+_165788746 3.428 ENSMUST00000161559.2
Cd247
CD247 antigen
chr1_-_186705980 3.398 ENSMUST00000045288.8
Tgfb2
transforming growth factor, beta 2
chr2_+_181767283 3.311 ENSMUST00000108757.2
Myt1
myelin transcription factor 1
chr15_-_58214882 3.144 ENSMUST00000022986.6
Fbxo32
F-box protein 32
chr6_+_15185456 3.137 ENSMUST00000115472.1
ENSMUST00000115474.1
ENSMUST00000031545.7
ENSMUST00000137628.1
Foxp2



forkhead box P2



chr9_+_96259246 3.126 ENSMUST00000179065.1
ENSMUST00000165768.2
Tfdp2

transcription factor Dp 2

chr3_-_57575760 3.097 ENSMUST00000029380.7
Wwtr1
WW domain containing transcription regulator 1
chr18_+_82910863 3.094 ENSMUST00000171238.1
Zfp516
zinc finger protein 516
chr2_+_181767040 3.091 ENSMUST00000108756.1
Myt1
myelin transcription factor 1
chr3_+_5218546 3.064 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chr10_-_5805412 3.057 ENSMUST00000019907.7
Fbxo5
F-box protein 5
chr15_-_84855093 3.001 ENSMUST00000016768.5
Phf21b
PHD finger protein 21B
chr9_+_54863742 2.978 ENSMUST00000034843.7
Ireb2
iron responsive element binding protein 2
chr7_-_73541738 2.975 ENSMUST00000169922.2
Chd2
chromodomain helicase DNA binding protein 2
chr17_+_53566971 2.964 ENSMUST00000000724.8
Kat2b
K(lysine) acetyltransferase 2B
chr3_+_5218516 2.899 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr11_+_108921648 2.837 ENSMUST00000144511.1
Axin2
axin2
chr5_+_108065742 2.803 ENSMUST00000081567.4
ENSMUST00000170319.1
ENSMUST00000112626.1
Mtf2


metal response element binding transcription factor 2


chr1_+_136131382 2.794 ENSMUST00000075164.4
Kif21b
kinesin family member 21B
chr9_+_91368970 2.784 ENSMUST00000172646.1
Zic4
zinc finger protein of the cerebellum 4
chr3_-_116968969 2.773 ENSMUST00000143611.1
ENSMUST00000040097.7
Palmd

palmdelphin

chr2_-_116065047 2.750 ENSMUST00000028639.6
ENSMUST00000102538.4
Meis2

Meis homeobox 2

chr1_+_55406163 2.745 ENSMUST00000042986.8
Plcl1
phospholipase C-like 1
chr2_-_18048784 2.741 ENSMUST00000142856.1
Skida1
SKI/DACH domain containing 1
chr3_-_57575907 2.726 ENSMUST00000120977.1
Wwtr1
WW domain containing transcription regulator 1
chr9_+_119402444 2.707 ENSMUST00000035093.8
ENSMUST00000165044.1
Acvr2b

activin receptor IIB

chr2_+_15055274 2.700 ENSMUST00000069870.3
Arl5b
ADP-ribosylation factor-like 5B
chr16_-_91044473 2.625 ENSMUST00000118522.1
Paxbp1
PAX3 and PAX7 binding protein 1
chr7_-_144939823 2.589 ENSMUST00000093962.4
Ccnd1
cyclin D1
chr16_-_64786321 2.587 ENSMUST00000052588.4
Zfp654
zinc finger protein 654
chr12_+_29938036 2.570 ENSMUST00000122328.1
ENSMUST00000118321.1
Pxdn

peroxidasin homolog (Drosophila)

chr15_-_50889691 2.542 ENSMUST00000165201.2
ENSMUST00000184458.1
Trps1

trichorhinophalangeal syndrome I (human)

chr3_-_108226598 2.541 ENSMUST00000029486.7
ENSMUST00000156371.1
ENSMUST00000141387.1
Sypl2


synaptophysin-like 2


chr2_+_152081529 2.515 ENSMUST00000064061.3
Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr16_+_43508118 2.513 ENSMUST00000114690.1
Zbtb20
zinc finger and BTB domain containing 20
chr12_+_71048338 2.499 ENSMUST00000135709.1
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr13_+_14063776 2.473 ENSMUST00000129488.1
ENSMUST00000110536.1
ENSMUST00000110534.1
ENSMUST00000039538.8
ENSMUST00000110533.1
Arid4b




AT rich interactive domain 4B (RBP1-like)




chr2_-_26092149 2.470 ENSMUST00000114159.2
Nacc2
nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
chr13_-_29984219 2.466 ENSMUST00000146092.1
E2f3
E2F transcription factor 3
chr12_-_51829525 2.460 ENSMUST00000179265.1
ENSMUST00000042052.8
Hectd1

HECT domain containing 1

chr6_+_65042575 2.454 ENSMUST00000031984.6
Smarcad1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr12_-_73113407 2.449 ENSMUST00000175693.1
Six4
sine oculis-related homeobox 4
chr2_-_18048347 2.437 ENSMUST00000066885.5
Skida1
SKI/DACH domain containing 1
chr14_+_12189943 2.426 ENSMUST00000119888.1
Ptprg
protein tyrosine phosphatase, receptor type, G
chr5_-_112228633 2.418 ENSMUST00000182699.1
ENSMUST00000182258.1
ENSMUST00000183036.1
Miat


myocardial infarction associated transcript (non-protein coding)


chr4_-_20778852 2.410 ENSMUST00000102998.3
Nkain3
Na+/K+ transporting ATPase interacting 3
chr5_+_108065696 2.382 ENSMUST00000172045.1
Mtf2
metal response element binding transcription factor 2
chr9_+_91368811 2.360 ENSMUST00000173054.1
Zic4
zinc finger protein of the cerebellum 4
chr3_+_20057802 2.359 ENSMUST00000002502.5
Hltf
helicase-like transcription factor
chr4_+_116557658 2.283 ENSMUST00000030460.8
Gpbp1l1
GC-rich promoter binding protein 1-like 1
chr18_-_23038656 2.280 ENSMUST00000081423.6
Nol4
nucleolar protein 4
chr14_+_46760526 2.237 ENSMUST00000067426.4
Cdkn3
cyclin-dependent kinase inhibitor 3
chr3_+_5218589 2.231 ENSMUST00000177488.1
Zfhx4
zinc finger homeodomain 4
chr13_+_104287855 2.190 ENSMUST00000065766.6
Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr15_-_66286224 2.180 ENSMUST00000070256.7
Kcnq3
potassium voltage-gated channel, subfamily Q, member 3
chr12_+_76370266 2.153 ENSMUST00000042779.3
Zbtb1
zinc finger and BTB domain containing 1
chrX_+_18162575 2.150 ENSMUST00000044484.6
ENSMUST00000052368.8
Kdm6a

lysine (K)-specific demethylase 6A

chr10_+_94036001 2.138 ENSMUST00000020208.4
Fgd6
FYVE, RhoGEF and PH domain containing 6
chr6_+_53573364 2.112 ENSMUST00000047450.7
Creb5
cAMP responsive element binding protein 5
chr12_-_119238794 2.110 ENSMUST00000026360.8
Itgb8
integrin beta 8
chr11_+_108920342 2.100 ENSMUST00000052915.7
Axin2
axin2
chr18_+_34625009 2.096 ENSMUST00000166044.1
Kif20a
kinesin family member 20A
chr17_+_47630690 2.079 ENSMUST00000024779.8
Usp49
ubiquitin specific peptidase 49
chr4_+_43875524 2.026 ENSMUST00000030198.6
Reck
reversion-inducing-cysteine-rich protein with kazal motifs
chr5_-_138155694 2.009 ENSMUST00000132318.1
ENSMUST00000049393.8
Zfp113

zinc finger protein 113

chr12_-_98737405 2.005 ENSMUST00000170188.1
Ptpn21
protein tyrosine phosphatase, non-receptor type 21
chr6_+_83137089 2.004 ENSMUST00000121093.1
ENSMUST00000087938.4
Rtkn

rhotekin

chr12_+_111039334 1.984 ENSMUST00000084968.7
Rcor1
REST corepressor 1
chr13_-_75943812 1.966 ENSMUST00000022078.5
ENSMUST00000109606.1
Rhobtb3

Rho-related BTB domain containing 3

chr3_-_51560816 1.940 ENSMUST00000037141.7
Setd7
SET domain containing (lysine methyltransferase) 7
chr19_-_4334001 1.927 ENSMUST00000176653.1
Kdm2a
lysine (K)-specific demethylase 2A
chr14_+_47663756 1.924 ENSMUST00000022391.7
Ktn1
kinectin 1
chr6_+_29735667 1.906 ENSMUST00000001812.4
Smo
smoothened homolog (Drosophila)
chrX_-_38564519 1.894 ENSMUST00000016681.8
Cul4b
cullin 4B
chr1_-_155972887 1.885 ENSMUST00000138762.1
ENSMUST00000124495.1
Cep350

centrosomal protein 350

chr16_+_78930940 1.861 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
Chodl


chondrolectin


chr17_+_74528467 1.849 ENSMUST00000182944.1
ENSMUST00000182597.1
ENSMUST00000182133.1
ENSMUST00000183224.1
Birc6



baculoviral IAP repeat-containing 6



chr18_+_34624621 1.844 ENSMUST00000167161.1
Kif20a
kinesin family member 20A
chr4_+_62965560 1.840 ENSMUST00000030043.6
ENSMUST00000107415.1
ENSMUST00000064814.5
Zfp618


zinc finger protein 618


chr15_+_77084367 1.816 ENSMUST00000181870.1
1700109K24Rik
RIKEN cDNA 1700109K24 gene
chr17_+_52602700 1.810 ENSMUST00000039366.10
Kcnh8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr7_+_82867327 1.810 ENSMUST00000082237.5
Mex3b
mex3 homolog B (C. elegans)
chr11_-_49712674 1.802 ENSMUST00000020624.6
ENSMUST00000145353.1
Cnot6

CCR4-NOT transcription complex, subunit 6

chr8_-_112015036 1.798 ENSMUST00000071732.5
Gm6793
predicted gene 6793
chr11_-_88718078 1.760 ENSMUST00000092794.5
Msi2
musashi RNA-binding protein 2
chr14_-_26442824 1.750 ENSMUST00000136635.1
ENSMUST00000125437.1
Slmap

sarcolemma associated protein

chr13_-_98926374 1.734 ENSMUST00000109401.1
Tnpo1
transportin 1
chr17_-_51810866 1.727 ENSMUST00000176669.1
Satb1
special AT-rich sequence binding protein 1
chr8_+_40511769 1.721 ENSMUST00000098817.2
Vps37a
vacuolar protein sorting 37A (yeast)
chr2_+_92185467 1.694 ENSMUST00000111291.2
Phf21a
PHD finger protein 21A
chr13_-_113046357 1.690 ENSMUST00000022282.3
Gpx8
glutathione peroxidase 8 (putative)
chr4_+_116558056 1.625 ENSMUST00000106475.1
Gpbp1l1
GC-rich promoter binding protein 1-like 1
chr9_+_74976096 1.603 ENSMUST00000081746.5
Fam214a
family with sequence similarity 214, member A
chrX_+_41401128 1.603 ENSMUST00000115103.2
Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr2_+_92185438 1.591 ENSMUST00000128781.2
Phf21a
PHD finger protein 21A
chr5_+_92137896 1.577 ENSMUST00000031355.6
Uso1
USO1 vesicle docking factor
chr2_-_172370506 1.546 ENSMUST00000109139.1
ENSMUST00000028997.7
ENSMUST00000109140.3
Aurka


aurora kinase A


chr1_-_12991109 1.533 ENSMUST00000115403.2
ENSMUST00000115402.1
Slco5a1

solute carrier organic anion transporter family, member 5A1

chr19_-_30549516 1.528 ENSMUST00000025803.8
Dkk1
dickkopf homolog 1 (Xenopus laevis)
chr5_+_110330697 1.528 ENSMUST00000112481.1
Pole
polymerase (DNA directed), epsilon
chr2_+_153031852 1.521 ENSMUST00000037235.6
Xkr7
X Kell blood group precursor related family member 7 homolog
chr14_-_48662740 1.503 ENSMUST00000122009.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr3_-_108210438 1.503 ENSMUST00000117784.1
ENSMUST00000119650.1
ENSMUST00000117409.1
Atxn7l2


ataxin 7-like 2


chr8_-_111027752 1.493 ENSMUST00000040241.8
Ddx19b
DEAD (Asp-Glu-Ala-Asp) box polypeptide 19b
chr17_-_88065028 1.490 ENSMUST00000130379.1
Fbxo11
F-box protein 11
chr17_-_47924460 1.483 ENSMUST00000113262.1
Foxp4
forkhead box P4
chr17_+_74528279 1.476 ENSMUST00000180037.1
ENSMUST00000024879.6
Birc6

baculoviral IAP repeat-containing 6

chr9_+_110132015 1.473 ENSMUST00000088716.5
ENSMUST00000111969.1
ENSMUST00000035057.7
ENSMUST00000111966.1
ENSMUST00000111968.1
Smarcc1




SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1




chr6_-_86733218 1.470 ENSMUST00000113679.1
Gmcl1
germ cell-less homolog 1 (Drosophila)
chr17_-_47924400 1.464 ENSMUST00000113263.1
ENSMUST00000097311.2
Foxp4

forkhead box P4

chr6_-_86733268 1.458 ENSMUST00000001185.7
Gmcl1
germ cell-less homolog 1 (Drosophila)
chr9_-_96752822 1.449 ENSMUST00000152594.1
Zbtb38
zinc finger and BTB domain containing 38
chr6_-_47594967 1.406 ENSMUST00000081721.6
ENSMUST00000114618.1
ENSMUST00000114616.1
Ezh2


enhancer of zeste homolog 2 (Drosophila)


chr1_-_181183739 1.398 ENSMUST00000159290.1
Wdr26
WD repeat domain 26
chr9_+_72925622 1.395 ENSMUST00000038489.5
Pygo1
pygopus 1
chr15_-_72034202 1.380 ENSMUST00000159993.1
Col22a1
collagen, type XXII, alpha 1
chr17_-_80480435 1.366 ENSMUST00000068714.5
Sos1
son of sevenless homolog 1 (Drosophila)
chr19_+_55741810 1.359 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr9_-_122903102 1.355 ENSMUST00000180877.1
ENSMUST00000180486.1
A530083I20Rik

RIKEN cDNA A530083I20 gene

chr11_+_94044111 1.352 ENSMUST00000132079.1
Spag9
sperm associated antigen 9
chr5_-_21785115 1.339 ENSMUST00000115193.1
ENSMUST00000115192.1
ENSMUST00000115195.1
ENSMUST00000030771.5
Dnajc2



DnaJ (Hsp40) homolog, subfamily C, member 2



chr10_-_21160925 1.321 ENSMUST00000020158.6
Myb
myeloblastosis oncogene
chr9_+_31030621 1.318 ENSMUST00000115222.2
Zbtb44
zinc finger and BTB domain containing 44
chr19_-_56822161 1.316 ENSMUST00000118592.1
A630007B06Rik
RIKEN cDNA A630007B06 gene
chr13_-_111490111 1.306 ENSMUST00000047627.7
Gpbp1
GC-rich promoter binding protein 1
chr1_+_180641330 1.301 ENSMUST00000085804.5
Lin9
lin-9 homolog (C. elegans)
chr3_-_122619442 1.299 ENSMUST00000162947.1
Fnbp1l
formin binding protein 1-like
chr2_+_18055203 1.296 ENSMUST00000028076.8
Mllt10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr1_+_74391479 1.296 ENSMUST00000027367.7
Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr1_-_163313661 1.293 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
Prrx1


paired related homeobox 1


chr7_-_73537621 1.292 ENSMUST00000172704.1
Chd2
chromodomain helicase DNA binding protein 2
chr15_-_98871175 1.290 ENSMUST00000178486.2
ENSMUST00000023741.9
Kmt2d

lysine (K)-specific methyltransferase 2D

chr6_+_86628174 1.282 ENSMUST00000043400.6
Asprv1
aspartic peptidase, retroviral-like 1
chrX_-_143933204 1.269 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chr15_+_34238026 1.269 ENSMUST00000022867.3
Laptm4b
lysosomal-associated protein transmembrane 4B
chr17_-_88065291 1.269 ENSMUST00000005504.8
Fbxo11
F-box protein 11
chr4_-_126468580 1.264 ENSMUST00000097888.3
Ago1
argonaute RISC catalytic subunit 1
chr11_+_108920800 1.237 ENSMUST00000140821.1
Axin2
axin2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.6 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
2.9 8.7 GO:0021972 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
2.1 6.2 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
2.1 6.2 GO:0061181 regulation of chondrocyte development(GO:0061181)
1.9 1.9 GO:0061113 pancreas morphogenesis(GO:0061113)
1.8 8.9 GO:0031022 nuclear migration along microfilament(GO:0031022)
1.5 4.6 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
1.4 4.1 GO:0060023 soft palate development(GO:0060023)
1.3 21.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.3 5.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
1.2 6.1 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
1.2 5.9 GO:0035262 gonad morphogenesis(GO:0035262)
1.2 4.6 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
1.1 3.4 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
1.1 3.4 GO:1902256 endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) atrial septum primum morphogenesis(GO:0003289) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
1.1 7.9 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
1.1 11.9 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
1.0 3.1 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
1.0 5.2 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
1.0 3.0 GO:0090649 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.9 7.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.8 5.0 GO:0003350 pulmonary myocardium development(GO:0003350)
0.8 5.8 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.8 5.0 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.8 2.5 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.8 8.0 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.7 3.0 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.7 3.5 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.7 7.2 GO:0060539 diaphragm development(GO:0060539)
0.6 2.5 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.6 1.2 GO:0003357 noradrenergic neuron differentiation(GO:0003357)
0.6 1.8 GO:2000314 negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.5 2.7 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.5 2.2 GO:0002572 pro-T cell differentiation(GO:0002572)
0.5 0.5 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.5 1.5 GO:1904956 regulation of endodermal cell fate specification(GO:0042663) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.5 1.5 GO:0045004 DNA replication proofreading(GO:0045004)
0.5 8.6 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)
0.5 8.3 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.4 1.3 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022) axial mesoderm morphogenesis(GO:0048319)
0.4 3.5 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.4 2.1 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.4 2.5 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.4 4.9 GO:0072189 ureter development(GO:0072189)
0.4 2.0 GO:1904684 negative regulation of metalloendopeptidase activity(GO:1904684)
0.4 1.2 GO:1904245 regulation of polynucleotide adenylyltransferase activity(GO:1904245)
0.4 1.2 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.4 2.7 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
0.4 2.6 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.4 1.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.4 1.1 GO:0044337 canonical Wnt signaling pathway involved in positive regulation of apoptotic process(GO:0044337)
0.4 1.8 GO:2000325 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.4 1.1 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.4 5.3 GO:0098902 regulation of membrane depolarization during action potential(GO:0098902) regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.3 1.0 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.3 3.7 GO:0070933 histone H4 deacetylation(GO:0070933)
0.3 2.3 GO:0007296 vitellogenesis(GO:0007296)
0.3 1.8 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.3 2.6 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.3 6.3 GO:0030903 notochord development(GO:0030903)
0.3 1.9 GO:0033184 positive regulation of histone ubiquitination(GO:0033184)
0.3 7.5 GO:0070207 protein homotrimerization(GO:0070207)
0.3 1.8 GO:0072697 protein localization to cell cortex(GO:0072697)
0.3 0.5 GO:0046013 T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013)
0.2 2.9 GO:0048617 embryonic foregut morphogenesis(GO:0048617)
0.2 1.9 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.2 1.0 GO:0070295 renal water absorption(GO:0070295)
0.2 3.3 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.2 0.7 GO:0071579 regulation of zinc ion transport(GO:0071579)
0.2 5.9 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.2 3.9 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.2 3.7 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.2 1.3 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.2 2.5 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.2 3.3 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.2 9.3 GO:0060612 adipose tissue development(GO:0060612)
0.2 1.3 GO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA(GO:0035280)
0.2 0.9 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.2 2.4 GO:0046548 retinal rod cell development(GO:0046548)
0.2 0.5 GO:1990927 negative regulation of tumor necrosis factor secretion(GO:1904468) negative regulation of membrane invagination(GO:1905154) calcium ion regulated lysosome exocytosis(GO:1990927)
0.2 1.2 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.2 1.4 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.2 1.1 GO:0089700 protein kinase D signaling(GO:0089700)
0.2 4.9 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.2 1.7 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.2 0.8 GO:0035547 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549) CRD-mediated mRNA stabilization(GO:0070934)
0.2 0.9 GO:0051013 microtubule severing(GO:0051013)
0.1 1.9 GO:0070914 UV-damage excision repair(GO:0070914)
0.1 2.2 GO:0060081 membrane hyperpolarization(GO:0060081)
0.1 0.5 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.1 0.5 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.1 1.7 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1 1.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 0.7 GO:0031133 cellular magnesium ion homeostasis(GO:0010961) regulation of axon diameter(GO:0031133)
0.1 1.3 GO:0048664 neuron fate determination(GO:0048664)
0.1 2.6 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.1 0.4 GO:0060431 primary lung bud formation(GO:0060431)
0.1 1.6 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.1 1.1 GO:0042118 endothelial cell activation(GO:0042118)
0.1 0.3 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.1 1.3 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.1 2.1 GO:0021819 layer formation in cerebral cortex(GO:0021819)
0.1 1.7 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 0.5 GO:0046684 response to pyrethroid(GO:0046684)
0.1 1.2 GO:0035988 chondrocyte proliferation(GO:0035988)
0.1 1.5 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 0.9 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 1.1 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 2.4 GO:0006301 postreplication repair(GO:0006301)
0.1 0.6 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.1 0.2 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.1 2.0 GO:0034453 microtubule anchoring(GO:0034453)
0.1 0.9 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.1 0.7 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.1 1.4 GO:0007289 spermatid nucleus differentiation(GO:0007289)
0.1 2.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 3.1 GO:2001222 regulation of neuron migration(GO:2001222)
0.1 1.2 GO:0006465 signal peptide processing(GO:0006465)
0.1 0.7 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.1 0.4 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.1 0.3 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.1 0.4 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 8.3 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.1 7.4 GO:0006338 chromatin remodeling(GO:0006338)
0.1 2.4 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 1.8 GO:0032330 regulation of chondrocyte differentiation(GO:0032330)
0.1 2.4 GO:1901998 toxin transport(GO:1901998)
0.1 0.8 GO:0001573 ganglioside metabolic process(GO:0001573)
0.0 1.0 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.0 1.2 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 1.3 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 0.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 1.0 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.3 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0 1.3 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.3 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.3 GO:0072600 establishment of protein localization to Golgi(GO:0072600)
0.0 2.5 GO:0045638 negative regulation of myeloid cell differentiation(GO:0045638)
0.0 0.8 GO:0048147 negative regulation of fibroblast proliferation(GO:0048147)
0.0 3.0 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.0 0.2 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 2.1 GO:0032204 regulation of telomere maintenance(GO:0032204)
0.0 2.0 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.4 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.0 1.3 GO:0035904 aorta development(GO:0035904)
0.0 0.1 GO:0097401 synaptic vesicle lumen acidification(GO:0097401)
0.0 0.4 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.8 GO:0010842 retina layer formation(GO:0010842)
0.0 6.0 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.2 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.1 GO:1990403 embryonic brain development(GO:1990403)
0.0 0.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.4 GO:0097352 autophagosome maturation(GO:0097352)
0.0 2.4 GO:0060271 cilium morphogenesis(GO:0060271)
0.0 0.7 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.3 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.9 GO:0001824 blastocyst development(GO:0001824)
0.0 1.3 GO:0048864 stem cell development(GO:0048864)
0.0 2.2 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.0 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.8 GO:0008623 CHRAC(GO:0008623)
1.9 7.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
1.4 4.2 GO:0071149 TEAD-2-YAP complex(GO:0071149)
1.1 8.9 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
1.1 11.6 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.6 3.5 GO:0000235 astral microtubule(GO:0000235)
0.3 1.5 GO:0032133 chromosome passenger complex(GO:0032133)
0.3 1.5 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.3 1.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.3 3.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.3 1.9 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.3 3.4 GO:0030057 desmosome(GO:0030057)
0.3 6.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 5.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 4.3 GO:0016580 Sin3 complex(GO:0016580)
0.2 1.3 GO:0042025 host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.2 1.9 GO:0044294 dendritic growth cone(GO:0044294)
0.2 2.0 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.2 3.0 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2 1.7 GO:0000813 ESCRT I complex(GO:0000813)
0.2 5.7 GO:0033268 node of Ranvier(GO:0033268)
0.2 1.1 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.2 0.6 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.2 1.2 GO:0005787 signal peptidase complex(GO:0005787)
0.2 3.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 2.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 5.3 GO:1990391 DNA repair complex(GO:1990391)
0.1 2.5 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 8.2 GO:0072686 mitotic spindle(GO:0072686)
0.1 1.6 GO:0043083 synaptic cleft(GO:0043083)
0.1 6.1 GO:0005871 kinesin complex(GO:0005871)
0.1 1.2 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 2.1 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 1.2 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.1 1.8 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 0.7 GO:0097413 Lewy body(GO:0097413)
0.1 0.3 GO:0031417 NatC complex(GO:0031417)
0.1 2.5 GO:0035861 site of double-strand break(GO:0035861)
0.1 1.5 GO:0071564 npBAF complex(GO:0071564)
0.1 31.7 GO:0005667 transcription factor complex(GO:0005667)
0.1 4.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 1.6 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 1.0 GO:0031105 septin complex(GO:0031105)
0.1 0.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.5 GO:0032009 early phagosome(GO:0032009)
0.1 0.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 3.3 GO:0000922 spindle pole(GO:0000922)
0.0 0.4 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.9 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.4 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 4.4 GO:0032993 protein-DNA complex(GO:0032993)
0.0 2.6 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.2 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.8 GO:0005844 polysome(GO:0005844)
0.0 1.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.9 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.6 GO:0043034 costamere(GO:0043034)
0.0 0.5 GO:0034399 nuclear periphery(GO:0034399)
0.0 0.9 GO:0005643 nuclear pore(GO:0005643)
0.0 1.2 GO:0005819 spindle(GO:0005819)
0.0 0.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.8 GO:0030315 T-tubule(GO:0030315)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)
0.0 2.3 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.3 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 11.6 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
1.3 10.7 GO:0005095 GTPase inhibitor activity(GO:0005095)
1.0 6.1 GO:0001972 retinoic acid binding(GO:0001972)
1.0 14.9 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
1.0 3.0 GO:0030350 iron-responsive element binding(GO:0030350)
0.8 3.4 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.8 4.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.8 4.6 GO:0030284 estrogen receptor activity(GO:0030284)
0.6 11.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.5 1.5 GO:0048019 receptor antagonist activity(GO:0048019)
0.5 1.5 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.5 3.0 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.4 3.1 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.4 8.2 GO:0045295 gamma-catenin binding(GO:0045295)
0.4 1.9 GO:0005113 patched binding(GO:0005113)
0.3 1.3 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.3 6.2 GO:0070411 I-SMAD binding(GO:0070411)
0.3 1.9 GO:0045322 unmethylated CpG binding(GO:0045322)
0.3 1.5 GO:0035174 histone serine kinase activity(GO:0035174)
0.3 2.1 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.3 1.8 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.3 2.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.3 7.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.3 0.8 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.3 2.7 GO:0048185 activin binding(GO:0048185)
0.3 1.1 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.3 0.8 GO:0033680 ATP-dependent DNA/RNA helicase activity(GO:0033680)
0.3 4.3 GO:0070410 co-SMAD binding(GO:0070410)
0.2 3.5 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.2 4.2 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.2 2.8 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.2 1.6 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.2 1.3 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.2 10.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2 7.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 2.7 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.2 3.9 GO:0035497 cAMP response element binding(GO:0035497)
0.2 0.7 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.2 1.4 GO:0043559 insulin binding(GO:0043559)
0.2 3.1 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 1.7 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.2 5.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 1.3 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 1.0 GO:0015288 porin activity(GO:0015288)
0.1 0.5 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.1 1.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 22.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.9 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 4.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 1.0 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 1.6 GO:0008143 poly(A) binding(GO:0008143)
0.1 9.4 GO:0003777 microtubule motor activity(GO:0003777)
0.1 1.4 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 1.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 3.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 4.3 GO:0042169 SH2 domain binding(GO:0042169)
0.1 2.2 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 1.9 GO:0031402 sodium ion binding(GO:0031402)
0.1 1.2 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 3.2 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 4.3 GO:0004601 peroxidase activity(GO:0004601)
0.1 1.8 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 0.5 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.1 2.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 50.3 GO:0000976 transcription regulatory region sequence-specific DNA binding(GO:0000976)
0.1 1.3 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 1.8 GO:0004697 protein kinase C activity(GO:0004697)
0.1 3.3 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 0.2 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.1 4.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 3.4 GO:0030507 spectrin binding(GO:0030507)
0.1 0.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.9 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.6 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 2.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 3.1 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 3.4 GO:0000975 regulatory region DNA binding(GO:0000975) transcription regulatory region DNA binding(GO:0044212)
0.0 1.0 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 1.9 GO:0003684 damaged DNA binding(GO:0003684)
0.0 1.2 GO:0031690 adrenergic receptor binding(GO:0031690)
0.0 0.8 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 9.0 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 0.3 GO:0070513 death domain binding(GO:0070513)
0.0 0.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 6.1 GO:0051015 actin filament binding(GO:0051015)
0.0 2.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.6 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.9 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.2 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 1.9 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 2.7 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.1 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.6 GO:0019894 kinesin binding(GO:0019894)
0.0 2.7 GO:0016887 ATPase activity(GO:0016887)
0.0 1.5 GO:0017124 SH3 domain binding(GO:0017124)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 21.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.4 12.0 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.3 28.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.3 6.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.2 2.1 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 12.0 PID_E2F_PATHWAY E2F transcription factor network
0.1 8.5 PID_PLK1_PATHWAY PLK1 signaling events
0.1 4.9 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 3.5 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 2.1 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 2.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 5.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 4.7 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 2.1 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 3.6 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 7.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.6 PID_ARF_3PATHWAY Arf1 pathway
0.1 1.6 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.1 1.3 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 1.0 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 2.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.3 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.3 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 2.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.4 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.5 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.4 ST_ADRENERGIC Adrenergic Pathway
0.0 0.1 ST_STAT3_PATHWAY STAT3 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 7.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.6 10.0 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.4 13.0 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3 5.7 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.2 10.6 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.2 6.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.2 2.5 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.2 0.8 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE Genes involved in Signaling by FGFR in disease
0.2 3.1 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 2.7 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.2 1.7 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 4.2 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 2.1 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 8.9 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 3.3 REACTOME_KINESINS Genes involved in Kinesins
0.1 1.0 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 4.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.6 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 3.1 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.1 1.2 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 1.5 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 3.5 REACTOME_MEIOSIS Genes involved in Meiosis
0.1 5.8 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.7 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.1 1.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 1.2 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 0.6 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.6 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 2.8 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.7 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.9 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.5 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.0 0.2 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 1.5 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 0.3 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 1.9 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.5 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.2 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.3 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.1 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling